NO20092048L - Nye benzamidderivater som bradykininantagonister - Google Patents

Nye benzamidderivater som bradykininantagonister

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Publication number
NO20092048L
NO20092048L NO20092048A NO20092048A NO20092048L NO 20092048 L NO20092048 L NO 20092048L NO 20092048 A NO20092048 A NO 20092048A NO 20092048 A NO20092048 A NO 20092048A NO 20092048 L NO20092048 L NO 20092048L
Authority
NO
Norway
Prior art keywords
benzamide derivatives
bradykinin antagonists
new benzamide
bradykinin
derivatives
Prior art date
Application number
NO20092048A
Other languages
English (en)
Other versions
NO342588B1 (no
Inventor
Sandor Farkas
Eva Schmidt
Istvan Vago
Gyorgy Keseru
Eva Dr Bozo
Gyula Beke
Katalin Hornok
Eva Szentirmay
Monika Vastag
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of NO20092048L publication Critical patent/NO20092048L/no
Publication of NO342588B1 publication Critical patent/NO342588B1/no

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Foreliggende oppfinnelse gjelder nye fenylsulfamoylbenzamidderivater med formel (I) Hvori R1-R5 og Z er som definert i kravene, og optiske antipoder eller racemater, salter, hydrater og/eller solvater derav som er selektive antagonister av brady-kinin Bl, fremgangsmåter for fremstilling av disse forbindelsene, farmakologiske preparater som inneholder dem og anvendelse av dem for behandling eller forebyggelse av smertefulle tilstander og betenn-elsestilstander.
NO20092048A 2006-10-27 2009-05-26 Fenylsulfamoylbenzamid-derivater, fremgangsmåte for deres fremstilling, farmasøytisk sammensetning der av, deres anvendelse ved fremstilling av et medikament, og deres anvendelse som bradykinin-antagonister NO342588B1 (no)

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HU0600808A HUP0600808A3 (en) 2006-10-27 2006-10-27 New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
PCT/HU2007/000102 WO2008068540A1 (en) 2006-10-27 2007-10-27 New benzamide derivatives as bradykinin antagonists

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HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
MY161831A (en) * 2007-10-27 2017-05-15 Richter Gedeon Nyrt New non-peptide derivatives as bradykinin b1 antagonists
WO2010022300A1 (en) * 2008-08-21 2010-02-25 Forest Laboratories Holdings Limited Methods for treating neuropathic pain
AU2009282822A1 (en) * 2008-08-21 2010-02-25 Richter Gedeon Nyrt. Methods for treating CNS disorders
WO2010097372A1 (de) * 2009-02-26 2010-09-02 Boehringer Ingelheim International Gmbh Verbindungen als bradykinin-b1-antagonisten
ES2350077B1 (es) 2009-06-04 2011-11-04 Laboratorios Salvat, S.A. Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
WO2015175171A1 (en) * 2014-04-23 2015-11-19 X-Rx Discovery, Inc. Substituted n-(2-(amino)-2-oxoethyl)benzamide inhibitors of autotaxin and their preparation and use in the treatment of lpa-dependent or lpa-mediated diseases
KR101676850B1 (ko) 2015-04-23 2016-11-18 한일화섬 주식회사 내구성이 우수한 스피커용 댐퍼 및 그 제조 방법
TWI901650B (zh) 2020-03-26 2025-10-21 匈牙利商羅特格登公司 啶及吡啶并〔３，４－ｃ〕嗒衍生物
HU231691B1 (hu) 2021-09-29 2025-10-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok

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HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
MY161831A (en) * 2007-10-27 2017-05-15 Richter Gedeon Nyrt New non-peptide derivatives as bradykinin b1 antagonists
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HUP0600808A3 (en) 2008-09-29
AU2007330575A1 (en) 2008-06-12
CA2667387C (en) 2012-04-17
EA200900604A1 (ru) 2009-08-28
CA2667387A1 (en) 2008-06-12
CU20090064A7 (es) 2011-07-11
KR20090074050A (ko) 2009-07-03
HU0600808D0 (en) 2006-12-28
GEP20125382B (en) 2012-01-25
KR101321257B1 (ko) 2013-10-25
ES2431143T3 (es) 2013-11-25
WO2008068540A1 (en) 2008-06-12
HUP0600808A2 (en) 2008-08-28
UA101602C2 (ru) 2013-04-25
BRPI0718436B1 (pt) 2020-11-17
CN101528685A (zh) 2009-09-09
EA014498B1 (ru) 2010-12-30
NO342588B1 (no) 2018-06-18
CN101528685B (zh) 2012-09-05
HRP20130836T1 (en) 2013-10-11
SI2076491T1 (sl) 2014-02-28
MY148476A (en) 2013-04-30
BRPI0718436A2 (pt) 2013-11-19
AU2007330575B2 (en) 2012-09-20
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JP5274470B2 (ja) 2013-08-28
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