CU20140140A7 - 7H-PIRROLO [2,3-d] PYRIMIDINS 4- (AMINO-SUBSTITUTES) NOVELTY AS INHIBITORS OF LRRK2 - Google Patents

7H-PIRROLO [2,3-d] PYRIMIDINS 4- (AMINO-SUBSTITUTES) NOVELTY AS INHIBITORS OF LRRK2

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Publication number
CU20140140A7
CU20140140A7 CU2014000140A CU20140140A CU20140140A7 CU 20140140 A7 CU20140140 A7 CU 20140140A7 CU 2014000140 A CU2014000140 A CU 2014000140A CU 20140140 A CU20140140 A CU 20140140A CU 20140140 A7 CU20140140 A7 CU 20140140A7
Authority
CU
Cuba
Prior art keywords
lrrk2
pyrimidins
pirrolo
novelty
substitutes
Prior art date
Application number
CU2014000140A
Other languages
Spanish (es)
Inventor
Paul Galatsis
Matthew Merrill Hayward
Jaclyn Henderson
Bethany Lyn Kormos
Ravi G Kurumbail
Antonia Friederike Stepan
Patrick Robert Verhoest
Travis T Wager
Lei Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2013/055039 external-priority patent/WO2014001973A1/en
Application filed by Pfizer filed Critical Pfizer
Publication of CU20140140A7 publication Critical patent/CU20140140A7/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención proporciona derivados novedosos de 7H-pirrolo[2,3-d]pirimidina 4,5-disubstituida de la fórmula I, y las sales farmacéuticamente aceptables de los mismos en donde R1, R2, R3, R4 y R5 son como se definieron en la especificación. La invención también está dirigida a composiciones farmacéuticas que comprenden los compuestos de la fórmula I y al uso de los compuestos en el tratamiento de enfermedades asociadas con LRRK2, tales como enfermedades neurodegenerativas que incluyen enfermedad de Parkinson o enfermedad de Alzheimer, cáncer, enfermedad de Crohn o lepra.The present invention provides novel derivatives of 4,5-disubstituted 7H-pyrrolo [2,3-d] pyrimidine of the formula I, and the pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4 and R5 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and the use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases that include Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy

CU2014000140A 2013-05-08 2014-12-08 7H-PIRROLO [2,3-d] PYRIMIDINS 4- (AMINO-SUBSTITUTES) NOVELTY AS INHIBITORS OF LRRK2 CU20140140A7 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361820828P 2013-05-08 2013-05-08
PCT/IB2013/055039 WO2014001973A1 (en) 2012-06-29 2013-06-19 NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS

Publications (1)

Publication Number Publication Date
CU20140140A7 true CU20140140A7 (en) 2015-03-30

Family

ID=53365660

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2014000140A CU20140140A7 (en) 2013-05-08 2014-12-08 7H-PIRROLO [2,3-d] PYRIMIDINS 4- (AMINO-SUBSTITUTES) NOVELTY AS INHIBITORS OF LRRK2

Country Status (1)

Country Link
CU (1) CU20140140A7 (en)

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