CU20160001A7 - Una formulación farmacéutica que comprende una versión quimérica, una versión de fragmentos no humanos o humanizados del anticuerpo 9e4 - Google Patents

Una formulación farmacéutica que comprende una versión quimérica, una versión de fragmentos no humanos o humanizados del anticuerpo 9e4

Info

Publication number
CU20160001A7
CU20160001A7 CUP2016000001A CU20160001A CU20160001A7 CU 20160001 A7 CU20160001 A7 CU 20160001A7 CU P2016000001 A CUP2016000001 A CU P2016000001A CU 20160001 A CU20160001 A CU 20160001A CU 20160001 A7 CU20160001 A7 CU 20160001A7
Authority
CU
Cuba
Prior art keywords
range
version
present
concentration
antibody
Prior art date
Application number
CUP2016000001A
Other languages
English (en)
Inventor
Patrick Garidel
Andreas Langer
Michael Grundman
Original Assignee
Prothena Biosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51355583&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20160001(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Prothena Biosciences Ltd filed Critical Prothena Biosciences Ltd
Publication of CU20160001A7 publication Critical patent/CU20160001A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Analytical Chemistry (AREA)
  • Inorganic Chemistry (AREA)

Abstract

Una formulación farmacéutica que comprende una versión quimérica, una versión de fragmentos no humanos o humanizados el anticuerpo 9E4 (número de acceso ATCC, PTA-8221), o un fragmento de la misma que compite específicamente con la unión al antígeno con 9E4, en donde el anticuerpo está presenteen una concentración dentro del intervalo desde 10mg/ml hasta aproximadamente 50 mg/mL; amortiguador de citrato o de succinato que está presente en una concentración dentro del intervalo desde a 10mM hasta aproximadamente 30mM; uno o más azucares y polioles ("azúcar/poliol") seleccionado de: trehalosa presente en una concentración dentro del intervalo desde 220mM hasta aproximadamente 260mM, y una mezcla de sacarosa presente en una concentración dentro del intervalo desde 20mM hasta aproximadamente 40mM y manitol presente en una concentración dentro del intervalo desde 200mM hasta aproximadamente 220mM; y polisorbato 20 presente en una concentración dentro del intervalo desde 0.005% hasta aproximadamente 0.05% en peso; en donde la formulación se caracteriza por un pH dentro del intervalo desde 5.5 hasta aproximadamente 7. La presente invención también proporciona formulaciones de anticuerpos para uso en la profilaxis o tratamiento de sinucleinopatías incluyendo la enfermedad de Parkinson.
CUP2016000001A 2013-07-04 2016-01-04 Una formulación farmacéutica que comprende una versión quimérica, una versión de fragmentos no humanos o humanizados del anticuerpo 9e4 CU20160001A7 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361843011P 2013-07-04 2013-07-04
US201461979886P 2014-04-15 2014-04-15
PCT/IB2014/062806 WO2015001504A2 (en) 2013-07-04 2014-07-03 Antibody formulations and methods

Publications (1)

Publication Number Publication Date
CU20160001A7 true CU20160001A7 (es) 2016-08-31

Family

ID=51355583

Family Applications (2)

Application Number Title Priority Date Filing Date
CUP2017000039A CU20170039A7 (es) 2013-07-04 2014-07-03 Método de purificación del anticuerpo humanizado 9e4
CUP2016000001A CU20160001A7 (es) 2013-07-04 2016-01-04 Una formulación farmacéutica que comprende una versión quimérica, una versión de fragmentos no humanos o humanizados del anticuerpo 9e4

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CUP2017000039A CU20170039A7 (es) 2013-07-04 2014-07-03 Método de purificación del anticuerpo humanizado 9e4

Country Status (17)

Country Link
US (2) US10513555B2 (es)
EP (2) EP3524264A1 (es)
JP (3) JP6404338B2 (es)
KR (1) KR20160030247A (es)
CN (1) CN105492019B (es)
AU (1) AU2014285719A1 (es)
CA (1) CA2917097C (es)
CL (1) CL2015003801A1 (es)
CU (2) CU20170039A7 (es)
ES (1) ES2704440T3 (es)
IL (1) IL243425A0 (es)
MX (1) MX2016000201A (es)
PE (1) PE20160868A1 (es)
PH (1) PH12015502788A1 (es)
RU (1) RU2016103079A (es)
SG (1) SG11201510601TA (es)
WO (1) WO2015001504A2 (es)

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Publication number Publication date
RU2016103079A (ru) 2017-08-07
WO2015001504A2 (en) 2015-01-08
JP2016534052A (ja) 2016-11-04
EP3016677A2 (en) 2016-05-11
CA2917097C (en) 2022-05-03
JP6404338B2 (ja) 2018-10-10
KR20160030247A (ko) 2016-03-16
SG11201510601TA (en) 2016-01-28
US10513555B2 (en) 2019-12-24
US20150079074A1 (en) 2015-03-19
CL2015003801A1 (es) 2016-07-15
ES2704440T3 (es) 2019-03-18
HK1223544A1 (zh) 2017-08-04
JP2021020941A (ja) 2021-02-18
CN105492019B (zh) 2020-02-11
WO2015001504A3 (en) 2015-08-06
PE20160868A1 (es) 2016-09-24
CA2917097A1 (en) 2015-01-08
JP6854266B2 (ja) 2021-04-07
AU2014285719A1 (en) 2016-01-21
CN105492019A (zh) 2016-04-13
EP3524264A1 (en) 2019-08-14
CU20170039A7 (es) 2017-06-05
JP2019011339A (ja) 2019-01-24
US20200140534A1 (en) 2020-05-07
PH12015502788A1 (en) 2016-03-21
EP3016677B1 (en) 2018-12-19
MX2016000201A (es) 2016-05-31
IL243425A0 (en) 2016-03-31

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