CU20160156A7 - Compuestos de isoquinolinas 2-sustituidas o sus análogos que poseen hasta cinco átomos de carbono sustituidos por nitrógeno,útiles como ligandos de dopamina d1 - Google Patents

Compuestos de isoquinolinas 2-sustituidas o sus análogos que poseen hasta cinco átomos de carbono sustituidos por nitrógeno,útiles como ligandos de dopamina d1

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Publication number
CU20160156A7
CU20160156A7 CUP2016000156A CU20160156A CU20160156A7 CU 20160156 A7 CU20160156 A7 CU 20160156A7 CU P2016000156 A CUP2016000156 A CU P2016000156A CU 20160156 A CU20160156 A CU 20160156A CU 20160156 A7 CU20160156 A7 CU 20160156A7
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CU
Cuba
Prior art keywords
digamin
attitudes
dopamine
analogs
nitrogen
Prior art date
Application number
CUP2016000156A
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English (en)
Inventor
David Lawrence Firman Gray
Lei Zhang
Michael Aaron Brodney
Michael Eric Green
Chakrapani Subramanyam
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Pfizer
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53276921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20160156(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CU20160156A7 publication Critical patent/CU20160156A7/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

La presente invención proporciona, en parte, compuestos de Ia Formula I: ESPACIO PARA FÓRMULA y las sales de estos aceptables desde el punta de vista farmacéutico; procesos para Ia preparación de; intermediarios usados en Ia preparación de; y composiciones que contienen estos compuestos o sales, y sus usos para tratar trastornos mediados por D1(o asociadas a D1) que incluyen, por ejemplo, esquizofrenia (por ejemplo, sus síntomas cognitivos y negativos), trastorno esquizotípico de Ia personalidad, deficiencia cognitiva (por ejemplo, deficiencia cognitiva asociada a esquizofrenia, AD, PD o tratamiento de farmacoterapia), ADHD, enfermedad de Parkinson, ansiedad y depresión.
CUP2016000156A 2014-04-25 2016-10-24 Compuestos de isoquinolinas 2-sustituidas o sus análogos que poseen hasta cinco átomos de carbono sustituidos por nitrógeno,útiles como ligandos de dopamina d1 CU20160156A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461984079P 2014-04-25 2014-04-25
PCT/IB2015/052604 WO2015162516A1 (en) 2014-04-25 2015-04-09 Heteroaromatic compounds and their use as dopamine d1 ligands

Publications (1)

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CU20160156A7 true CU20160156A7 (es) 2017-02-02

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ID=53276921

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CUP2016000156A CU20160156A7 (es) 2014-04-25 2016-10-24 Compuestos de isoquinolinas 2-sustituidas o sus análogos que poseen hasta cinco átomos de carbono sustituidos por nitrógeno,útiles como ligandos de dopamina d1

Country Status (26)

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US (2) US9540352B2 (es)
EP (1) EP3134404A1 (es)
JP (1) JP6239149B2 (es)
KR (1) KR20160142402A (es)
CN (1) CN107074843A (es)
AP (1) AP2016009512A0 (es)
AU (1) AU2015249497A1 (es)
BR (1) BR112016023740A2 (es)
CA (1) CA2946475A1 (es)
CL (1) CL2016002677A1 (es)
CR (1) CR20160494A (es)
CU (1) CU20160156A7 (es)
DO (1) DOP2016000289A (es)
EA (1) EA201691788A1 (es)
IL (1) IL248132A0 (es)
MA (1) MA39914A (es)
MD (1) MD20160109A2 (es)
MX (1) MX2016013969A (es)
NI (1) NI201600161A (es)
PE (1) PE20170009A1 (es)
PH (1) PH12016501993A1 (es)
SG (1) SG11201608468TA (es)
SV (1) SV2016005305A (es)
TN (1) TN2016000447A1 (es)
TW (1) TWI561517B (es)
WO (1) WO2015162516A1 (es)

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TN2016000447A1 (en) 2018-04-04
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CA2946475A1 (en) 2015-10-29
PE20170009A1 (es) 2017-03-17
US9850232B2 (en) 2017-12-26
US20160200711A1 (en) 2016-07-14
CN107074843A (zh) 2017-08-18
MA39914A (fr) 2017-03-01
TW201604188A (zh) 2016-02-01
NI201600161A (es) 2016-11-25
MX2016013969A (es) 2017-01-11
KR20160142402A (ko) 2016-12-12
EA201691788A1 (ru) 2017-03-31
US20150307494A1 (en) 2015-10-29
IL248132A0 (en) 2016-11-30
TWI561517B (en) 2016-12-11
SV2016005305A (es) 2017-07-19
AP2016009512A0 (en) 2016-10-31
CL2016002677A1 (es) 2017-02-10
EP3134404A1 (en) 2017-03-01
WO2015162516A1 (en) 2015-10-29
JP6239149B2 (ja) 2017-11-29
MD20160109A2 (ro) 2017-04-30
CR20160494A (es) 2016-12-20
PH12016501993A1 (en) 2017-01-09
US9540352B2 (en) 2017-01-10
BR112016023740A2 (pt) 2017-08-15
DOP2016000289A (es) 2017-02-15

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