CU20210073A7 - Anticuerpos que se unen dentro de la región de unión a microtúbulos de tau definida por cdrs - Google Patents

Anticuerpos que se unen dentro de la región de unión a microtúbulos de tau definida por cdrs

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Publication number
CU20210073A7
CU20210073A7 CU2021000073A CU20210073A CU20210073A7 CU 20210073 A7 CU20210073 A7 CU 20210073A7 CU 2021000073 A CU2021000073 A CU 2021000073A CU 20210073 A CU20210073 A CU 20210073A CU 20210073 A7 CU20210073 A7 CU 20210073A7
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Prior art keywords
tau
cdr
antibodies
bind
cdrs
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CU2021000073A
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English (en)
Inventor
Svetlana Alexander
Robin Barbour
Philip Dolan
Yue Liu
Tarlochan S Nijjar
Mark E Renz
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Prothena Biosciences Ltd
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Publication of CU20210073A7 publication Critical patent/CU20210073A7/es

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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A—HUMAN NECESSITIES
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Abstract

<p>La invención proporciona anticuerpos que se unen específicamente a tau.Los anticuerpos que se unen dentro de Ia región de unión a microtúbulos de tau definida por CDRs. Los anticuerpos inhiben o retrasan las patologías asociadas a tau y el deterioro sintomático asociado. La invención proporciona un anticuerpo aislado que se une específicamente a tau humana, que comprende una región variable de cadena pesada madura que comprende CDR-H1, CDR-H2 y CDR-H3 y una región variable de cadena ligera madura que comprende CDR-L 1, CDR-L2, y CDR-L3.</p>
CU2021000073A 2019-03-03 2020-03-02 Anticuerpos que se unen dentro de la región de unión a microtúbulos de tau definida por cdrs CU20210073A7 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962813126P 2019-03-03 2019-03-03
US201962813137P 2019-03-03 2019-03-03
US201962838159P 2019-04-24 2019-04-24
PCT/US2020/020704 WO2020180819A1 (en) 2019-03-03 2020-03-02 Antibodies recognizing tau

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CU20210073A7 true CU20210073A7 (es) 2022-04-07

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US (3) US10961302B2 (es)
EP (1) EP3935083A4 (es)
JP (2) JP7630834B2 (es)
KR (1) KR20210134943A (es)
CN (2) CN119371527A (es)
AU (1) AU2020231366A1 (es)
BR (1) BR112021016947A2 (es)
CA (1) CA3131531A1 (es)
CO (1) CO2021011644A2 (es)
CU (1) CU20210073A7 (es)
IL (1) IL285973A (es)
PE (1) PE20212324A1 (es)
PY (1) PY2014556A (es)
SG (1) SG11202108414UA (es)
TW (1) TWI859197B (es)
UY (1) UY38601A (es)
WO (1) WO2020180819A1 (es)
ZA (2) ZA202107214B (es)

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TW202246320A (zh) * 2021-02-14 2022-12-01 愛爾蘭商普羅帝納生物科學公司 使用識別ｔａｕ之抗體之方法
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