CU22661A1 - Nuevos candidatos vacunales de vibrio cholerae y método de obtención - Google Patents

Nuevos candidatos vacunales de vibrio cholerae y método de obtención

Info

Publication number
CU22661A1
CU22661A1 CU1997142A CU1997142A CU22661A1 CU 22661 A1 CU22661 A1 CU 22661A1 CU 1997142 A CU1997142 A CU 1997142A CU 1997142 A CU1997142 A CU 1997142A CU 22661 A1 CU22661 A1 CU 22661A1
Authority
CU
Cuba
Prior art keywords
vibrio cholerae
obtaining
vaccine candidates
new vaccine
thya
Prior art date
Application number
CU1997142A
Other languages
English (en)
Inventor
Cabrera Anisia Juana Silva
Calzada Rafael Alfredo Fando
Robles Jorge Antonio Benitez
Perez Talena Yamile Ledon
Diaz Edgar Valle
Gonzalez Boris Luis Rodriguez
Gomez Javier Campos
Original Assignee
Cnic Ct Nac Investigaciones
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cnic Ct Nac Investigaciones filed Critical Cnic Ct Nac Investigaciones
Priority to CU1997142A priority Critical patent/CU22661A1/es
Priority to EP98964347A priority patent/EP1099759B1/en
Priority to DE69839161T priority patent/DE69839161T2/de
Priority to PCT/CU1998/000008 priority patent/WO1999035271A2/es
Priority to ES98964347T priority patent/ES2303727T3/es
Priority to AT98964347T priority patent/ATE386797T1/de
Priority to BR9814600-9A priority patent/BR9814600A/pt
Priority to JP2000527655A priority patent/JP2002500047A/ja
Priority to CNB98813442XA priority patent/CN100372936C/zh
Priority to DK98964347T priority patent/DK1099759T3/da
Priority to US09/582,772 priority patent/US6723323B1/en
Priority to AU19591/99A priority patent/AU1959199A/en
Publication of CU22661A1 publication Critical patent/CU22661A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/107—Vibrio
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

En la presente invención se describen nuevas cepas vacunales de Vibrio Cholerae en las cuales se ha eliminado la actividad mucinasa codificada por el gen de la hemaglutinina proteasa. Dicho gen ha sido interrumpido con la inserción de un gen marcador. Se describe otro mutante de Vibrio cholerae con mejores atributos de bioseguridad.
CU1997142A 1997-12-30 1997-12-30 Nuevos candidatos vacunales de vibrio cholerae y método de obtención CU22661A1 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CU1997142A CU22661A1 (es) 1997-12-30 1997-12-30 Nuevos candidatos vacunales de vibrio cholerae y método de obtención
EP98964347A EP1099759B1 (en) 1997-12-30 1998-12-30 Vibrio cholerae vaccine candidates and methods of their constructing
DE69839161T DE69839161T2 (de) 1997-12-30 1998-12-30 Vibrio cholerae impfstoffkandidaten und verfahren zu deren herstellung
PCT/CU1998/000008 WO1999035271A2 (es) 1997-12-30 1998-12-30 Nuevos candidatos vacunales de vibrio cholerae y metodos de obtencion
ES98964347T ES2303727T3 (es) 1997-12-30 1998-12-30 Candidatos de vacuna de vibrio cholerae y procedimientos para su construccion.
AT98964347T ATE386797T1 (de) 1997-12-30 1998-12-30 Vibrio cholerae impfstoffkandidaten und verfahren zu deren herstellung
BR9814600-9A BR9814600A (pt) 1997-12-30 1998-12-30 candidatos a vacina de vibrio cholerae e os métodos de sua construção
JP2000527655A JP2002500047A (ja) 1997-12-30 1998-12-30 新規なコレラ菌ワクチン候補と構築方法
CNB98813442XA CN100372936C (zh) 1997-12-30 1998-12-30 霍乱弧菌疫苗候选物及其构建方法
DK98964347T DK1099759T3 (da) 1997-12-30 1998-12-30 Vibrio cholerae-vaccinekandidater og fremgangsmåde til konstruktion deraf
US09/582,772 US6723323B1 (en) 1997-12-30 1998-12-30 Vibrio Cholerae vaccine candidates and method of their constructing
AU19591/99A AU1959199A (en) 1997-12-30 1998-12-30 (vibrio cholerae) vaccine candidates and method of their constructing

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU1997142A CU22661A1 (es) 1997-12-30 1997-12-30 Nuevos candidatos vacunales de vibrio cholerae y método de obtención

Publications (1)

Publication Number Publication Date
CU22661A1 true CU22661A1 (es) 2001-04-27

Family

ID=5459446

Family Applications (1)

Application Number Title Priority Date Filing Date
CU1997142A CU22661A1 (es) 1997-12-30 1997-12-30 Nuevos candidatos vacunales de vibrio cholerae y método de obtención

Country Status (12)

Country Link
US (1) US6723323B1 (es)
EP (1) EP1099759B1 (es)
JP (1) JP2002500047A (es)
CN (1) CN100372936C (es)
AT (1) ATE386797T1 (es)
AU (1) AU1959199A (es)
BR (1) BR9814600A (es)
CU (1) CU22661A1 (es)
DE (1) DE69839161T2 (es)
DK (1) DK1099759T3 (es)
ES (1) ES2303727T3 (es)
WO (1) WO1999035271A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801852D0 (sv) * 1998-05-26 1998-05-26 Sbl Vaccin Ab Method of producing thy A-strains of Vibro cholerae, suck strains and their use
AU2000278267A1 (en) 2000-09-01 2002-03-22 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Vibrio cholerae o139 conjugate vaccines
GB0325494D0 (en) * 2003-10-31 2003-12-03 Sbl Vaccin Ab Expression system
US20060003454A1 (en) * 2004-07-02 2006-01-05 Conjugon, Inc. Non-dividing donor cells for gene transfer
US20060270040A1 (en) * 2005-05-26 2006-11-30 Conjugon, Inc. Compositions and methods for treating tissue
MY190074A (en) * 2018-01-09 2022-03-24 Aimst Univ A monovalent vaccine formulation and a method for preparation thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1017726A1 (ru) * 1981-09-07 1983-05-15 Ростовский-На-Дону Государственный Научно-Исследовательский Противочумный Институт Штамм @ @ @ 673/67 @ используемый в качестве тест-культуры дл определени тимидина в питательных средах
EP0251579A3 (en) * 1986-06-24 1989-03-22 Enterovax Research Pty. Ltd. Non-antibiotic marker system
GB9007194D0 (en) * 1990-03-30 1990-05-30 Wellcome Found Live vaccines
JPH0630766A (ja) * 1992-07-15 1994-02-08 Res Dev Corp Of Japan 弱毒化された安全性の高い赤痢生ワクチン
EP0692031B1 (en) * 1993-02-22 2007-04-11 The General Hospital Corporation Heterologous antigens in live cell vaccine strains
US5434065A (en) * 1993-05-06 1995-07-18 President And Fellows Of Harvard College In vivo selection of microbial virulence genes
WO1995018633A1 (en) * 1994-01-06 1995-07-13 President And Fellows Of Harvard College Soft agar penetration-defective mutants
WO1997008955A1 (en) * 1995-09-06 1997-03-13 Department Of The Army, Us Government Bacterial delivery system
SE9801852D0 (sv) * 1998-05-26 1998-05-26 Sbl Vaccin Ab Method of producing thy A-strains of Vibro cholerae, suck strains and their use

Also Published As

Publication number Publication date
AU1959199A (en) 1999-07-26
DK1099759T3 (da) 2008-06-23
US6723323B1 (en) 2004-04-20
DE69839161T2 (de) 2009-03-26
EP1099759A2 (en) 2001-05-16
ATE386797T1 (de) 2008-03-15
CN1301301A (zh) 2001-06-27
EP1099759B1 (en) 2008-02-20
CN100372936C (zh) 2008-03-05
DE69839161D1 (de) 2008-04-03
WO1999035271A3 (es) 1999-11-25
ES2303727T3 (es) 2008-08-16
JP2002500047A (ja) 2002-01-08
BR9814600A (pt) 2002-02-19
WO1999035271A2 (es) 1999-07-15

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