CU22836A3 - Sistema de gel de nimesulida para uso tópico - Google Patents

Sistema de gel de nimesulida para uso tópico

Info

Publication number
CU22836A3
CU22836A3 CU1999117A CU1999117A CU22836A3 CU 22836 A3 CU22836 A3 CU 22836A3 CU 1999117 A CU1999117 A CU 1999117A CU 1999117 A CU1999117 A CU 1999117A CU 22836 A3 CU22836 A3 CU 22836A3
Authority
CU
Cuba
Prior art keywords
topical use
nimesulide
gel system
formulations
nimesulide gel
Prior art date
Application number
CU1999117A
Other languages
English (en)
Inventor
Tiziana Monti
Enrique Hausermann
Stefano Bader
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of CU22836A3 publication Critical patent/CU22836A3/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)

Abstract

La presente invención concierne a formulaciones tópicas de Nimesulida que comprenden un carboxivinilpolímero neutralizado como un agente de formación de gel ó una poliacrilamida-isoparafina y un solvente seleccionado del grupo consistente de etanol, isopropanol y dietilenglicol monoetil éter, y al proceso de preparación de éstas. Dichas formulaciones tienen ventajas tales como más alta estabilidad del sistema y biodisponibilidad del ingrediente activo.
CU1999117A 1997-02-25 1999-08-23 Sistema de gel de nimesulida para uso tópico CU22836A3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000408A IT1289973B1 (it) 1997-02-25 1997-02-25 Sistemi gelificati di nimesulide per uso topico

Publications (1)

Publication Number Publication Date
CU22836A3 true CU22836A3 (es) 2003-01-29

Family

ID=11376173

Family Applications (1)

Application Number Title Priority Date Filing Date
CU1999117A CU22836A3 (es) 1997-02-25 1999-08-23 Sistema de gel de nimesulida para uso tópico

Country Status (32)

Country Link
US (2) US20020119997A1 (es)
EP (1) EP0971708B1 (es)
JP (1) JP2001513093A (es)
KR (1) KR100413143B1 (es)
CN (1) CN1148174C (es)
AT (1) ATE210437T1 (es)
AU (1) AU723843B2 (es)
BG (1) BG64664B1 (es)
BR (1) BR9807729A (es)
CA (1) CA2279277A1 (es)
CU (1) CU22836A3 (es)
CZ (1) CZ293665B6 (es)
DE (2) DE971708T1 (es)
DK (1) DK0971708T3 (es)
EE (1) EE04041B1 (es)
ES (1) ES2169506T3 (es)
GE (1) GEP20022628B (es)
HU (1) HU226122B1 (es)
ID (1) ID22668A (es)
IL (1) IL131128A (es)
IS (1) IS2090B (es)
IT (1) IT1289973B1 (es)
MX (1) MXPA99007468A (es)
NO (1) NO994040L (es)
PL (1) PL190603B1 (es)
PT (1) PT971708E (es)
RS (1) RS49700B (es)
RU (1) RU2181285C2 (es)
SK (1) SK284809B6 (es)
TR (1) TR199902034T2 (es)
UA (1) UA50807C2 (es)
WO (1) WO1998037879A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU718356B2 (en) * 1998-01-12 2000-04-13 Panacea Biotec Limited A parenteral water-miscible non-intensely coloured injectable composition of non-steroidal anit-inflammatory drugs
GB2340751B (en) * 1998-08-12 2003-11-05 Edko Trading Representation Pharmaceutical compositions
WO2000072884A1 (en) * 1999-05-31 2000-12-07 Dinesh Shantilal Patel A novel formulation of n-(4-nitro-2-phenoxyphenyl)methanesulfonamide
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
CA2418135C (en) 2000-08-03 2011-09-20 Antares Pharma Ipl Ag Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
ES2222817B1 (es) * 2003-07-25 2007-03-01 Luis Ucelay Sanz Gel frio.
EP1670433B1 (en) 2003-10-10 2011-11-23 Antares Pharma IPL AG Transdermal pharmaceutical formulation for minimizing skin residues
US7425340B2 (en) 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2007124250A2 (en) 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
US8067399B2 (en) 2005-05-27 2011-11-29 Antares Pharma Ipl Ag Method and apparatus for transdermal or transmucosal application of testosterone
TR200906775A1 (tr) * 2009-09-02 2011-03-21 Sanovel İlaç San.Ve Ti̇c.A.Ş. Nimesulid ve kas gevşetici kombinasyonları
CN102068404A (zh) * 2009-11-25 2011-05-25 中国人民武装警察部队医学院 一种尼美舒利温度敏感水凝胶及其制备方法
UA121985C2 (uk) * 2015-01-23 2020-08-25 Др. Редді'З Лабораторіз Лімітед Нефарбуюча гелева композиція для місцевого застосування, яка містить німесулід
RU2593777C1 (ru) * 2015-04-20 2016-08-10 Общество с ограниченной ответственностью "Трейдсервис" Гелевая форма нимесулида, обладающая противовоспалительным и анальгетическим действием
CN108158993A (zh) * 2018-01-12 2018-06-15 连云港本草美汇医药科技有限公司 一种祛痘控油微乳凝胶剂及其制备方法与应用
WO2022066803A1 (en) 2020-09-22 2022-03-31 Alphyn Biologics, Llc Topical croton lechleri compositions and their use in the treatment of a bacterial colonization or primary or secondary bacterial infection of an underlying skin disorder
AU2022226676A1 (en) 2021-02-25 2023-09-28 Alphyn Biologics, Llc Composition for treatment of topical dermatological bacterial skin conditions
PL244577B1 (pl) 2021-12-16 2024-02-12 Univ Gdanski Sole nimesulidu i sposób otrzymywania kryształów soli nimesulidu
PL249273B1 (pl) 2023-03-28 2026-03-16 Uniwersytet Gdański Sól potasowa nimesulidu oraz sposób otrzymywania kryształów soli potasowych nimesulidu

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251838B (it) * 1991-09-20 1995-05-26 Lpb Ist Farm Uso della nimesulide nel trattamento della cataratta
BE1008307A3 (fr) * 1994-06-16 1996-04-02 Europharmaceuticals Sa Sel de nimesulide hydrosoluble, solution aqueuse le contenant, sa preparation et son utilisation.
EP0782855B1 (en) * 1994-10-05 2001-09-12 Helsinn Healthcare S.A. Nimesulide for external use
HUP9601442A3 (en) * 1995-07-25 1999-03-29 Panacea Biotec Ltd Nes antinflammatory and analgetic pharmaceutical compositions, containing nimesulid for transdermal use, and process for producing them
HU224686B1 (hu) * 1995-10-05 2005-12-28 Helsinn Healthcare Sa. Külsőleg alkalmazható, nimeszulidot tartalmazó gyógyszerkészítmény és eljárás előállítására
HUP9601443A3 (en) * 1996-05-29 1999-03-29 Panacea Biotec Ltd Injectable analgetic pharmaceutical compositions for intramuscular use containing nimesulid, and process for producing them
IT1291278B1 (it) * 1996-07-05 1999-01-07 Errekappa Euroterapici S P A Preparazione farmaceutica a base di nimesulide per uso topico

Also Published As

Publication number Publication date
GEP20022628B (en) 2002-02-25
HK1025265A1 (en) 2000-11-10
TR199902034T2 (xx) 1999-11-22
RS49700B (sr) 2007-12-31
SK114199A3 (en) 2000-11-07
US7186755B2 (en) 2007-03-06
CA2279277A1 (en) 1998-09-03
IT1289973B1 (it) 1998-10-19
CN1248165A (zh) 2000-03-22
JP2001513093A (ja) 2001-08-28
WO1998037879A1 (en) 1998-09-03
IS2090B (is) 2006-03-15
IL131128A0 (en) 2001-01-28
NO994040D0 (no) 1999-08-20
HUP0001486A2 (hu) 2000-10-28
ES2169506T3 (es) 2002-07-01
HUP0001486A3 (en) 2002-11-28
KR20000075561A (ko) 2000-12-15
KR100413143B1 (ko) 2003-12-31
CN1148174C (zh) 2004-05-05
UA50807C2 (uk) 2002-11-15
AU723843B2 (en) 2000-09-07
BG64664B1 (bg) 2005-11-30
EP0971708B1 (en) 2001-12-12
US20020119997A1 (en) 2002-08-29
MXPA99007468A (es) 2004-05-05
DK0971708T3 (da) 2002-03-25
CZ298699A3 (cs) 2000-02-16
ID22668A (id) 1999-12-02
DE69802913T2 (de) 2002-07-04
IS5143A (is) 1999-07-30
CZ293665B6 (cs) 2004-06-16
RU2181285C2 (ru) 2002-04-20
DE971708T1 (de) 2000-08-17
EP0971708A1 (en) 2000-01-19
PT971708E (pt) 2002-05-31
HU226122B1 (en) 2008-04-28
BG103645A (en) 2000-04-28
ATE210437T1 (de) 2001-12-15
IL131128A (en) 2003-11-23
EE9900355A (et) 2000-02-15
YU38599A (sh) 2002-06-19
ITMI970408A1 (it) 1998-08-25
DE69802913D1 (de) 2002-01-24
PL335141A1 (en) 2000-04-10
NO994040L (no) 1999-10-20
SK284809B6 (sk) 2005-11-03
EE04041B1 (et) 2003-06-16
AU6499298A (en) 1998-09-18
BR9807729A (pt) 2000-02-15
PL190603B1 (pl) 2005-12-30
US20030036563A1 (en) 2003-02-20

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