EE9900355A - Nimesuliidi geelsüsteemid paikseks kasutamiseks - Google Patents

Nimesuliidi geelsüsteemid paikseks kasutamiseks

Info

Publication number: EE9900355A
Authority: EE; Estonia
Prior art keywords: nimesulite; topical use; gel systems; gel; formulations
Prior art date: 1997-02-25

Application number

EEP199900355A

Other languages

English (en)

Inventor

Bader Stefano

H�usermann Enrique

Monti Tiziana

Original Assignee

Helsinn Healthcare S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-25

Filing date

1998-02-20

Publication date

2000-02-15

1998-02-20 Application filed by Helsinn Healthcare S.A. filed Critical Helsinn Healthcare S.A.

2000-02-15 Publication of EE9900355A publication Critical patent/EE9900355A/et

2003-06-16 Publication of EE04041B1 publication Critical patent/EE04041B1/et

Links

230000000699 topical effect Effects 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
229920002125 Sokalan® Polymers 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 abstract 1
229940075557 diethylene glycol monoethyl ether Drugs 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 abstract 1
229960000965 nimesulide Drugs 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000012049 topical pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Orthopedics, Nursing, And Contraception (AREA)

EEP199900355A 1997-02-25 1998-02-20 Nimesuliidi geelsüsteemid paikseks kasutamiseks EE04041B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT97MI000408A IT1289973B1 (it)	1997-02-25	1997-02-25	Sistemi gelificati di nimesulide per uso topico
PCT/EP1998/000990 WO1998037879A1 (en)	1997-02-25	1998-02-20	Nimesulide gel systems for topical use

Publications (2)

Publication Number	Publication Date
EE9900355A true EE9900355A (et)	2000-02-15
EE04041B1 EE04041B1 (et)	2003-06-16

Family

ID=11376173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900355A EE04041B1 (et)	1997-02-25	1998-02-20	Nimesuliidi geelsüsteemid paikseks kasutamiseks

Country Status (32)

Country	Link
US (2)	US20020119997A1 (et)
EP (1)	EP0971708B1 (et)
JP (1)	JP2001513093A (et)
KR (1)	KR100413143B1 (et)
CN (1)	CN1148174C (et)
AT (1)	ATE210437T1 (et)
AU (1)	AU723843B2 (et)
BG (1)	BG64664B1 (et)
BR (1)	BR9807729A (et)
CA (1)	CA2279277A1 (et)
CU (1)	CU22836A3 (et)
CZ (1)	CZ293665B6 (et)
DE (2)	DE971708T1 (et)
DK (1)	DK0971708T3 (et)
EE (1)	EE04041B1 (et)
ES (1)	ES2169506T3 (et)
GE (1)	GEP20022628B (et)
HU (1)	HU226122B1 (et)
ID (1)	ID22668A (et)
IL (1)	IL131128A (et)
IS (1)	IS2090B (et)
IT (1)	IT1289973B1 (et)
MX (1)	MXPA99007468A (et)
NO (1)	NO994040L (et)
PL (1)	PL190603B1 (et)
PT (1)	PT971708E (et)
RS (1)	RS49700B (et)
RU (1)	RU2181285C2 (et)
SK (1)	SK284809B6 (et)
TR (1)	TR199902034T2 (et)
UA (1)	UA50807C2 (et)
WO (1)	WO1998037879A1 (et)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU718356B2 (en) *	1998-01-12	2000-04-13	Panacea Biotec Limited	A parenteral water-miscible non-intensely coloured injectable composition of non-steroidal anit-inflammatory drugs
GB2340751B (en) *	1998-08-12	2003-11-05	Edko Trading Representation	Pharmaceutical compositions
WO2000072884A1 (en) *	1999-05-31	2000-12-07	Dinesh Shantilal Patel	A novel formulation of n-(4-nitro-2-phenoxyphenyl)methanesulfonamide
US8980290B2 (en)	2000-08-03	2015-03-17	Antares Pharma Ipl Ag	Transdermal compositions for anticholinergic agents
US7198801B2 (en)	2000-08-03	2007-04-03	Antares Pharma Ipl Ag	Formulations for transdermal or transmucosal application
CA2418135C (en)	2000-08-03	2011-09-20	Antares Pharma Ipl Ag	Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
ES2222817B1 (es) *	2003-07-25	2007-03-01	Luis Ucelay Sanz	Gel frio.
EP1670433B1 (en)	2003-10-10	2011-11-23	Antares Pharma IPL AG	Transdermal pharmaceutical formulation for minimizing skin residues
US7425340B2 (en)	2004-05-07	2008-09-16	Antares Pharma Ipl Ag	Permeation enhancing compositions for anticholinergic agents
WO2007124250A2 (en)	2006-04-21	2007-11-01	Antares Pharma Ipl Ag	Methods of treating hot flashes with formulations for transdermal or transmucosal application
US8067399B2 (en)	2005-05-27	2011-11-29	Antares Pharma Ipl Ag	Method and apparatus for transdermal or transmucosal application of testosterone
TR200906775A1 (tr) *	2009-09-02	2011-03-21	Sanovel İlaç San.Ve Ti̇c.A.Ş.	Nimesulid ve kas gevşetici kombinasyonları
CN102068404A (zh) *	2009-11-25	2011-05-25	中国人民武装警察部队医学院	一种尼美舒利温度敏感水凝胶及其制备方法
UA121985C2 (uk) *	2015-01-23	2020-08-25	Др. Редді'З Лабораторіз Лімітед	Нефарбуюча гелева композиція для місцевого застосування, яка містить німесулід
RU2593777C1 (ru) *	2015-04-20	2016-08-10	Общество с ограниченной ответственностью "Трейдсервис"	Гелевая форма нимесулида, обладающая противовоспалительным и анальгетическим действием
CN108158993A (zh) *	2018-01-12	2018-06-15	连云港本草美汇医药科技有限公司	一种祛痘控油微乳凝胶剂及其制备方法与应用
WO2022066803A1 (en)	2020-09-22	2022-03-31	Alphyn Biologics, Llc	Topical croton lechleri compositions and their use in the treatment of a bacterial colonization or primary or secondary bacterial infection of an underlying skin disorder
AU2022226676A1 (en)	2021-02-25	2023-09-28	Alphyn Biologics, Llc	Composition for treatment of topical dermatological bacterial skin conditions
PL244577B1 (pl)	2021-12-16	2024-02-12	Univ Gdanski	Sole nimesulidu i sposób otrzymywania kryształów soli nimesulidu
PL249273B1 (pl)	2023-03-28	2026-03-16	Uniwersytet Gdański	Sól potasowa nimesulidu oraz sposób otrzymywania kryształów soli potasowych nimesulidu

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1251838B (it) *	1991-09-20	1995-05-26	Lpb Ist Farm	Uso della nimesulide nel trattamento della cataratta
BE1008307A3 (fr) *	1994-06-16	1996-04-02	Europharmaceuticals Sa	Sel de nimesulide hydrosoluble, solution aqueuse le contenant, sa preparation et son utilisation.
EP0782855B1 (en) *	1994-10-05	2001-09-12	Helsinn Healthcare S.A.	Nimesulide for external use
HUP9601442A3 (en) *	1995-07-25	1999-03-29	Panacea Biotec Ltd	Nes antinflammatory and analgetic pharmaceutical compositions, containing nimesulid for transdermal use, and process for producing them
HU224686B1 (hu) *	1995-10-05	2005-12-28	Helsinn Healthcare Sa.	Külsőleg alkalmazható, nimeszulidot tartalmazó gyógyszerkészítmény és eljárás előállítására
HUP9601443A3 (en) *	1996-05-29	1999-03-29	Panacea Biotec Ltd	Injectable analgetic pharmaceutical compositions for intramuscular use containing nimesulid, and process for producing them
IT1291278B1 (it) *	1996-07-05	1999-01-07	Errekappa Euroterapici S P A	Preparazione farmaceutica a base di nimesulide per uso topico

1997
- 1997-02-25 IT IT97MI000408A patent/IT1289973B1/it active IP Right Grant
1998
- 1998-02-20 BR BR9807729-5A patent/BR9807729A/pt not_active Application Discontinuation
- 1998-02-20 UA UA99084652A patent/UA50807C2/uk unknown
- 1998-02-20 CZ CZ19992986A patent/CZ293665B6/cs not_active IP Right Cessation
- 1998-02-20 CA CA002279277A patent/CA2279277A1/en not_active Abandoned
- 1998-02-20 EE EEP199900355A patent/EE04041B1/et not_active IP Right Cessation
- 1998-02-20 JP JP53727798A patent/JP2001513093A/ja not_active Ceased
- 1998-02-20 EP EP98910713A patent/EP0971708B1/en not_active Expired - Lifetime
- 1998-02-20 RU RU99120392/14A patent/RU2181285C2/ru not_active IP Right Cessation
- 1998-02-20 GE GEAP19984969A patent/GEP20022628B/en unknown
- 1998-02-20 WO PCT/EP1998/000990 patent/WO1998037879A1/en not_active Ceased
- 1998-02-20 SK SK1141-99A patent/SK284809B6/sk not_active IP Right Cessation
- 1998-02-20 ID IDW990895A patent/ID22668A/id unknown
- 1998-02-20 PT PT98910713T patent/PT971708E/pt unknown
- 1998-02-20 DE DE0971708T patent/DE971708T1/de active Pending
- 1998-02-20 RS YUP-385/99A patent/RS49700B/sr unknown
- 1998-02-20 HU HU0001486A patent/HU226122B1/hu not_active IP Right Cessation
- 1998-02-20 ES ES98910713T patent/ES2169506T3/es not_active Expired - Lifetime
- 1998-02-20 US US09/380,044 patent/US20020119997A1/en not_active Abandoned
- 1998-02-20 PL PL98335141A patent/PL190603B1/pl not_active IP Right Cessation
- 1998-02-20 CN CNB988027364A patent/CN1148174C/zh not_active Expired - Fee Related
- 1998-02-20 DE DE69802913T patent/DE69802913T2/de not_active Expired - Lifetime
- 1998-02-20 KR KR10-1999-7007621A patent/KR100413143B1/ko not_active Expired - Fee Related
- 1998-02-20 AT AT98910713T patent/ATE210437T1/de not_active IP Right Cessation
- 1998-02-20 MX MXPA99007468A patent/MXPA99007468A/es active IP Right Grant
- 1998-02-20 AU AU64992/98A patent/AU723843B2/en not_active Ceased
- 1998-02-20 TR TR1999/02034T patent/TR199902034T2/xx unknown
- 1998-02-20 DK DK98910713T patent/DK0971708T3/da active
- 1998-02-20 IL IL13112898A patent/IL131128A/xx not_active IP Right Cessation
1999
- 1999-07-30 IS IS5143A patent/IS2090B/is unknown
- 1999-08-10 BG BG103645A patent/BG64664B1/bg unknown
- 1999-08-20 NO NO994040A patent/NO994040L/no not_active Application Discontinuation
- 1999-08-23 CU CU1999117A patent/CU22836A3/es not_active IP Right Cessation
2002
- 2002-09-26 US US10/254,862 patent/US7186755B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
GEP20022628B (en)	2002-02-25
CU22836A3 (es)	2003-01-29
HK1025265A1 (en)	2000-11-10
TR199902034T2 (xx)	1999-11-22
RS49700B (sr)	2007-12-31
SK114199A3 (en)	2000-11-07
US7186755B2 (en)	2007-03-06
CA2279277A1 (en)	1998-09-03
IT1289973B1 (it)	1998-10-19
CN1248165A (zh)	2000-03-22
JP2001513093A (ja)	2001-08-28
WO1998037879A1 (en)	1998-09-03
IS2090B (is)	2006-03-15
IL131128A0 (en)	2001-01-28
NO994040D0 (no)	1999-08-20
HUP0001486A2 (hu)	2000-10-28
ES2169506T3 (es)	2002-07-01
HUP0001486A3 (en)	2002-11-28
KR20000075561A (ko)	2000-12-15
KR100413143B1 (ko)	2003-12-31
CN1148174C (zh)	2004-05-05
UA50807C2 (uk)	2002-11-15
AU723843B2 (en)	2000-09-07
BG64664B1 (bg)	2005-11-30
EP0971708B1 (en)	2001-12-12
US20020119997A1 (en)	2002-08-29
MXPA99007468A (es)	2004-05-05
DK0971708T3 (da)	2002-03-25
CZ298699A3 (cs)	2000-02-16
ID22668A (id)	1999-12-02
DE69802913T2 (de)	2002-07-04
IS5143A (is)	1999-07-30
CZ293665B6 (cs)	2004-06-16
RU2181285C2 (ru)	2002-04-20
DE971708T1 (de)	2000-08-17
EP0971708A1 (en)	2000-01-19
PT971708E (pt)	2002-05-31
HU226122B1 (en)	2008-04-28
BG103645A (en)	2000-04-28
ATE210437T1 (de)	2001-12-15
IL131128A (en)	2003-11-23
YU38599A (sh)	2002-06-19
ITMI970408A1 (it)	1998-08-25
DE69802913D1 (de)	2002-01-24
PL335141A1 (en)	2000-04-10
NO994040L (no)	1999-10-20
SK284809B6 (sk)	2005-11-03
EE04041B1 (et)	2003-06-16
AU6499298A (en)	1998-09-18
BR9807729A (pt)	2000-02-15
PL190603B1 (pl)	2005-12-30
US20030036563A1 (en)	2003-02-20

Legal Events

Date	Code	Title	Description
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2011-10-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20110220

Publication	Publication Date	Title
EE04041B1 (et)	2003-06-16	Nimesuliidi geelsüsteemid paikseks kasutamiseks
PT991407E (pt)	2002-05-31	Estabilizacao de benzimidazoles sensiveis a acidos com combinacoes de amino/ciclodextrinas
PT969856E (pt)	2005-04-29	Sistemas binarios hidr¿filos para administracao de ciclosporina
DK0758248T3 (da)	2003-10-27	Formuleringer til faktor IX
PA8575701A1 (es)	2004-02-07	Preparaciones acidas de insulina con estabilidad mejorada
DE69711637D1 (de)	2002-05-08	Aerosolformulierungen
CY1108914T1 (el)	2014-07-02	Μητρα για παρατεταμενη, αμεταβλητη και ανεξαρτητη απελευθερωση δραστικων ενωσεων
DK1073467T3 (da)	2005-01-03	Formuleringer med co-oplösningsmiddel omfattende en forbindelse af vitamin D
TR199801861T2 (xx)	1998-12-21	Farmas�tik olarak yararl� bile�imler.
BR0007589A (pt)	2002-10-15	Inibidores da proliferação de células
DE69818806D1 (de)	2003-11-13	Antimikrobielle kosmetische präparate
MY101536A (en)	1991-11-30	Anti-inflammatory and analgesic tape for external use
ES2188909T3 (es)	2003-07-01	Nuevos derivados de cis-3,4-cromano utiles para la prevencion o tratamiento de sindromes o enfermedades relacionados con el estrogeno. os
BR9713060A (pt)	2000-04-11	Análogos de lh-rh estruturalmente submetidos, os seus usos e as composições farmacêuticas contendo-os.
AR009322A1 (es)	2000-04-12	Nuevas aril-piridazinas
SE9803107D0 (sv)	1998-09-14	Novel Compunds
ES2087178T3 (es)	1996-07-16	Disulfato de ws7622a, procedimiento para su preparacion y su uso.
ES2192034T3 (es)	2003-09-16	Feniluracilos substituidos con efecto herbicida.
IT1306187B1 (it)	2001-05-30	Metodo per l'eradicazione selettiva di cellule tumorali aventi lafunzione di p53 inattiva.
AU2001279693A1 (en)	2002-01-14	Anthelmintic agents for preventing parasitic infections in humans and animals iii
TH22662A (th)	1996-12-27	สารสูตรผสมของ 2-คลอโร-2'-ดีออกซิแอดีโนซินชนิดละลายได้
TH13522A (th)	1993-12-15	การเข้าสูตรไลโพโซมับ อิทราโคนาโซล
GR1003969B (el)	2002-08-14	Σταθερα φαρμακευτικα διαλυματα νιμεσουλιδης.