CU23592A1 - Método para prevenir y eliminar las fibrosis y otras formas de depósito patológico en los tejidos aplicando el péptido secretagogo ghrp-6 - Google Patents

Método para prevenir y eliminar las fibrosis y otras formas de depósito patológico en los tejidos aplicando el péptido secretagogo ghrp-6

Info

Publication number
CU23592A1
CU23592A1 CU20060048A CU20060048A CU23592A1 CU 23592 A1 CU23592 A1 CU 23592A1 CU 20060048 A CU20060048 A CU 20060048A CU 20060048 A CU20060048 A CU 20060048A CU 23592 A1 CU23592 A1 CU 23592A1
Authority
CU
Cuba
Prior art keywords
forms
ghrp
peptide
secretagogo
prevent
Prior art date
Application number
CU20060048A
Other languages
English (en)
Inventor
Castillo Mariela Vazquez
Mola Ernesto Lopez
Alba Jose Suarez
Sosa Manuel Selman-Housein
Nieto Gerardo Enrique Guillen
Vera Danay Cibrian
Acosta Jorge Berlanga
Del Barco Herrera Diana Garcia
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20060048A priority Critical patent/CU23592A1/es
Priority to CN2007800140575A priority patent/CN101426517B/zh
Priority to JP2008556642A priority patent/JP5426175B2/ja
Priority to CA2644431A priority patent/CA2644431C/en
Priority to PCT/CU2007/000005 priority patent/WO2007098715A1/es
Priority to KR1020087023744A priority patent/KR101462077B1/ko
Priority to MX2008011140A priority patent/MX2008011140A/es
Priority to ES07711099T priority patent/ES2388879T3/es
Priority to DK07711099.7T priority patent/DK1994939T3/da
Priority to US12/281,018 priority patent/US20090221512A1/en
Priority to EP07711099A priority patent/EP1994939B1/en
Priority to AU2007219568A priority patent/AU2007219568B2/en
Priority to RU2008138561/15A priority patent/RU2465913C2/ru
Priority to BRPI0708349A priority patent/BRPI0708349B8/pt
Priority to EP11170318A priority patent/EP2368563A1/en
Priority to ARP070100804A priority patent/AR059644A1/es
Priority to ZA200807600A priority patent/ZA200807600B/xx
Publication of CU23592A1 publication Critical patent/CU23592A1/es
Priority to US13/150,526 priority patent/US8722626B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se relaciona con un método para prevenir y eliminar los depósitos de material fibrótico patológico en tejidos parenquimatosos internos como hígado, pulmones, esófago, intestino delgado, rinones, vasos sanguíneos, articulaciones, además de formas sistemáticas de fibrosis cutánea de cualquier etiopatogenia. Dicho método consiste en la administración reiterada por vía intramuscular , intatecal, subcutánea o por infiltración, del péptido secretagogo GHRP-6. Este método también elimina el depósito de material amiloideo y hialino en cualquiera de sus formas químicas y manifestaciones tisulares; entre otras del cerebro, cerebelo, vasos sanguíneos, hígado, intestinos, rinones, bazo, páncreas, articulaciones y la piel. De esta forma se corrige la disfunción de células , tejidos y órganos afectados por estos depósitos anormales.
CU20060048A 2006-02-28 2006-02-28 Método para prevenir y eliminar las fibrosis y otras formas de depósito patológico en los tejidos aplicando el péptido secretagogo ghrp-6 CU23592A1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CU20060048A CU23592A1 (es) 2006-02-28 2006-02-28 Método para prevenir y eliminar las fibrosis y otras formas de depósito patológico en los tejidos aplicando el péptido secretagogo ghrp-6
US12/281,018 US20090221512A1 (en) 2006-02-28 2007-02-23 Pharmaceutical composition containing ghrp-6 to prevent and eliminate fibrosis and other pathological deposits in tissues
EP07711099A EP1994939B1 (en) 2006-02-28 2007-02-23 Pharmaceutical composition containing GHRP-6 for preventing and eliminating fibrosis and other pathological deposits in tissue
CA2644431A CA2644431C (en) 2006-02-28 2007-02-23 Pharmaceutical composition containing ghrp-6 capable of preventing and eliminating fibrosis and other forms of pathological deposit in tissue
PCT/CU2007/000005 WO2007098715A1 (es) 2006-02-28 2007-02-23 Composición farmacéutica conteniendo ghrp-6 capaz de prevenir y eliminar las fibrosis y otras formas de depósito patológico en los tejidos
KR1020087023744A KR101462077B1 (ko) 2006-02-28 2007-02-23 조직에서의 섬유증 및 병리학적 저장부의 다른 형태를 예방하고 방지할 수 있는 ｇｈｒｐ-6을 포함하는 약학적 조성물
MX2008011140A MX2008011140A (es) 2006-02-28 2007-02-23 Composicion farmaceutica conteniendo ghrp-6 capaz de prevenir y eliminar las fibrosis y otras formas de deposito patologico en los tejidos.
ES07711099T ES2388879T3 (es) 2006-02-28 2007-02-23 Composición farmacéutica que contiene GHRP-6 para prevenir y eliminar las fibrosis y otros depósitos patológicos en tejidos
DK07711099.7T DK1994939T3 (da) 2006-02-28 2007-02-23 Farmaceutisk sammensætning indeholdende GHRP-6 til forebyggelse og eliminering af fibrose og øvrige patologiske deponeringer i væv
CN2007800140575A CN101426517B (zh) 2006-02-28 2007-02-23 用于预防和消除组织中纤维样和其他病理性沉积的、含ghrp-6的药物组合物
JP2008556642A JP5426175B2 (ja) 2006-02-28 2007-02-23 線維症及び組織における他の形の病理学的沈着を予防及び除去することができるｇｈｒｐ−６を含む薬剤組成物
AU2007219568A AU2007219568B2 (en) 2006-02-28 2007-02-23 Pharmaceutical composition containing GHRP-6 capable of preventing and eliminating fibrosis and other forms of pathological deposit in tissue
RU2008138561/15A RU2465913C2 (ru) 2006-02-28 2007-02-23 Фармацевтическая композиция, содержащая ghrp-6, для предотвращения и устранения фиброза и других патологических отложений в тканях
BRPI0708349A BRPI0708349B8 (pt) 2006-02-28 2007-02-23 uso do peptídeo secretagogo ghrp-6
EP11170318A EP2368563A1 (en) 2006-02-28 2007-02-23 Pharmaceutical composition containing GHRP-6 or GHRP-2 or hexarelin to prevent and eliminate fibrosis and other pathological deposits in tissues
ARP070100804A AR059644A1 (es) 2006-02-28 2007-02-27 Composicion farmaceutica conteniendo ghrp -6 capaz de prevenir y eliminar las fibrosis y otras formas de deposito patologico en los tejidos
ZA200807600A ZA200807600B (en) 2006-02-28 2008-09-03 Pharmaceutical composition containing GHRP-6 capable of preventing and elimanting fibrosis and other forms of pathological deposit in tissue
US13/150,526 US8722626B2 (en) 2006-02-28 2011-06-01 Method for controlling fibrosis and other pathological deposits in tissues comprising administering a GHRP-6 composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20060048A CU23592A1 (es) 2006-02-28 2006-02-28 Método para prevenir y eliminar las fibrosis y otras formas de depósito patológico en los tejidos aplicando el péptido secretagogo ghrp-6

Publications (1)

Publication Number Publication Date
CU23592A1 true CU23592A1 (es) 2010-11-11

Family

ID=37964643

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20060048A CU23592A1 (es) 2006-02-28 2006-02-28 Método para prevenir y eliminar las fibrosis y otras formas de depósito patológico en los tejidos aplicando el péptido secretagogo ghrp-6

Country Status (16)

Country Link
US (2) US20090221512A1 (es)
EP (2) EP1994939B1 (es)
JP (1) JP5426175B2 (es)
KR (1) KR101462077B1 (es)
CN (1) CN101426517B (es)
AR (1) AR059644A1 (es)
AU (1) AU2007219568B2 (es)
BR (1) BRPI0708349B8 (es)
CA (1) CA2644431C (es)
CU (1) CU23592A1 (es)
DK (1) DK1994939T3 (es)
ES (1) ES2388879T3 (es)
MX (1) MX2008011140A (es)
RU (1) RU2465913C2 (es)
WO (1) WO2007098715A1 (es)
ZA (1) ZA200807600B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
KR101667383B1 (ko) * 2012-03-28 2016-10-18 주식회사 인코스팜 비오틴이 결합된 ｈｅｘａｐｅｐｔｉｄｅ-２ 유도체 및 이의 용도
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
KR102051433B1 (ko) * 2013-08-27 2020-01-08 (주)네오팜 근육 분화 촉진 및 근육 강화용 조성물 및 외용제
US9119832B2 (en) * 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
FR3034662B1 (fr) * 2015-04-10 2020-08-28 Isp Investments Inc Nouvelles utilisations du peptide de sequence his-d-trp-ala-trp-d-phe-lys-nh2 pour diminuer ou retarder l'apparition de la senescence cellulaire et des signes du vieillissement cutane
WO2017114316A1 (zh) * 2015-12-30 2017-07-06 南京中硼联康医疗科技有限公司 用于消除β淀粉样蛋白的中子捕获治疗系统
KR102394643B1 (ko) * 2016-10-18 2022-05-09 (주)아모레퍼시픽 후발효차 유래의 신규한 캄페롤계 화합물을 포함하는 인지기능 개선용 조성물
CN109908331A (zh) * 2019-04-30 2019-06-21 青岛大学附属医院 海沙瑞林在制备保护肾脏缺血再灌注损伤药物/药物组合物中的应用

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Also Published As

Publication number Publication date
EP2368563A1 (en) 2011-09-28
CA2644431C (en) 2016-08-30
BRPI0708349B8 (pt) 2021-05-25
KR101462077B1 (ko) 2014-11-20
AR059644A1 (es) 2008-04-16
KR20080100378A (ko) 2008-11-17
EP1994939B1 (en) 2012-05-30
US8722626B2 (en) 2014-05-13
JP5426175B2 (ja) 2014-02-26
AU2007219568B2 (en) 2012-10-04
US20110230415A1 (en) 2011-09-22
CN101426517B (zh) 2013-04-03
DK1994939T3 (da) 2012-09-10
MX2008011140A (es) 2008-09-08
US20090221512A1 (en) 2009-09-03
RU2008138561A (ru) 2010-04-10
ES2388879T3 (es) 2012-10-19
AU2007219568A1 (en) 2007-09-07
JP2009528302A (ja) 2009-08-06
EP1994939A1 (en) 2008-11-26
ZA200807600B (en) 2009-06-24
CN101426517A (zh) 2009-05-06
RU2465913C2 (ru) 2012-11-10
CA2644431A1 (en) 2007-09-07
BRPI0708349A2 (pt) 2011-05-24
BRPI0708349B1 (pt) 2019-04-24
WO2007098715A1 (es) 2007-09-07

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