CU23814A3 - Emulsión intravenosa de butilftalida y aplicación de la misma - Google Patents
Emulsión intravenosa de butilftalida y aplicación de la mismaInfo
- Publication number
- CU23814A3 CU23814A3 CU20080114A CU20080114A CU23814A3 CU 23814 A3 CU23814 A3 CU 23814A3 CU 20080114 A CU20080114 A CU 20080114A CU 20080114 A CU20080114 A CU 20080114A CU 23814 A3 CU23814 A3 CU 23814A3
- Authority
- CU
- Cuba
- Prior art keywords
- butilftalida
- application
- same
- emulsion
- intravenous
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Esta invención presenta una emulsión intravenosa de butilftalida que se administra mediante infusión o inyección por vía intravenosa, la cual contiene butilftalida o derivados de ella como ingrediente activo en una cantidad de 0,01- 50 wt% y un excipiente en una cantidad de 50-90wt%, basados en el peso total de la emulsión.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101023552A CN100367951C (zh) | 2005-12-16 | 2005-12-16 | 丁苯酞静脉乳剂及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20080114A7 CU20080114A7 (es) | 2010-08-30 |
| CU23814A3 true CU23814A3 (es) | 2012-06-21 |
Family
ID=36934680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20080114A CU23814A3 (es) | 2005-12-16 | 2008-06-17 | Emulsión intravenosa de butilftalida y aplicación de la misma |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20090281177A1 (es) |
| EP (1) | EP1970050B1 (es) |
| JP (2) | JP5571311B2 (es) |
| KR (1) | KR101061268B1 (es) |
| CN (1) | CN100367951C (es) |
| AU (1) | AU2006324219B2 (es) |
| BR (1) | BRPI0619915B1 (es) |
| CA (1) | CA2633170C (es) |
| CU (1) | CU23814A3 (es) |
| EA (1) | EA014518B1 (es) |
| IL (1) | IL192169A (es) |
| UA (1) | UA89315C2 (es) |
| WO (1) | WO2007068212A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102573475B (zh) | 2009-08-14 | 2016-01-20 | 欧科生医股份有限公司 | 神经激肽-1拮抗剂的静脉内制剂 |
| CN102178643B (zh) * | 2011-04-29 | 2014-05-14 | 石药集团恩必普药业有限公司 | 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法 |
| CN107648222A (zh) * | 2012-06-06 | 2018-02-02 | 石药集团中奇制药技术(石家庄)有限公司 | 一种丁苯酞药物活性组合物及其制备方法 |
| CN103505409B (zh) * | 2012-06-27 | 2017-12-26 | 石药集团中奇制药技术(石家庄)有限公司 | 一种丁苯酞注射液及其制备方法 |
| CN103505414B (zh) * | 2012-06-28 | 2017-08-08 | 石药集团恩必普药业有限公司 | 丁苯酞滴鼻剂及其制备方法 |
| CA2911837C (en) * | 2013-02-06 | 2022-05-31 | Jingjun Huang | Stable pharmaceutical composition of clopidogrel free base for oral and parenteral delivery |
| CN105030760B (zh) | 2014-04-24 | 2018-10-02 | 长弘生物科技股份有限公司 | 稳定医药组合物 |
| TWI547280B (zh) * | 2014-04-24 | 2016-09-01 | 長弘生物科技股份有限公司 | 穩定醫藥組合物 |
| CA2995158C (en) * | 2015-08-28 | 2021-05-11 | Caliway Biopharmaceuticals Co., Ltd. | A pharmaceutical composition for reducing local fat and uses thereof |
| CN105796486A (zh) * | 2016-03-17 | 2016-07-27 | 南京天翔医药科技有限公司 | 丁苯酞脂肪乳注射剂及其制备工艺 |
| CN110101658B (zh) * | 2018-02-01 | 2021-09-07 | 北京睿悦生物医药科技有限公司 | 丁苯酞脂微球注射液及其制备方法 |
| CN110548004B (zh) * | 2018-05-30 | 2023-05-16 | 成都施贝康生物医药科技有限公司 | 一种稳定的丁苯酞大容量注射液及其制备方法 |
| JP7752051B2 (ja) * | 2019-05-24 | 2025-10-09 | デクラ ベテリナリー プロダクツ リミテッド ライアビリティー カンパニー | 長時間作用型注射用製剤およびその使用 |
| CN111407725B (zh) * | 2020-04-13 | 2024-07-19 | 中山大学 | 一种拉莫三嗪乳剂及其制备方法 |
| CN114073694B (zh) * | 2020-08-14 | 2024-03-12 | 北京科莱博医药开发有限责任公司 | 丁苯酞制剂及其制备方法 |
| CN115177614A (zh) * | 2021-04-01 | 2022-10-14 | 长春藤生物科技股份有限公司 | 正丁基苯酞的应用 |
| CN114010595A (zh) * | 2021-10-14 | 2022-02-08 | 山东诚创蓝海医药科技有限公司 | 一种丁苯酞乳剂及其制备方法 |
| CN116407510B (zh) * | 2021-12-29 | 2025-11-21 | 河北赛谱睿思医药科技有限公司 | 一种丁苯酞舌下片及其制备方法 |
| CN114886848B (zh) * | 2022-05-20 | 2024-03-08 | 山东泰合医药科技有限公司 | 一种纳米胶束组合物制备方法及制备的纳米胶束组合物 |
| CN116459224A (zh) * | 2023-05-15 | 2023-07-21 | 济南大学 | 一种丁苯酞纳米脂质体冻干粉针剂及其制备方法 |
| CN116549388A (zh) * | 2023-06-08 | 2023-08-08 | 华北制药集团新药研究开发有限责任公司 | 7-羟基-丁苯酞纳米乳制剂、其制备方法及应用 |
| CN116942604A (zh) * | 2023-08-16 | 2023-10-27 | 合肥亿帆生物制药有限公司 | 一种丁苯酞注射液及其制备方法 |
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| JPH0647533B2 (ja) * | 1984-08-10 | 1994-06-22 | 裕 水島 | 4−ビフエニリル酢酸系化合物含有脂肪乳剤 |
| US4950567A (en) | 1988-01-15 | 1990-08-21 | E. I. Du Pont De Nemours And Company | Holographic optical combiners for head-up displays |
| JPH01226807A (ja) * | 1988-03-04 | 1989-09-11 | Tsumura & Co | 脂肪乳剤およびその製造方法 |
| US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| DE4015108A1 (de) * | 1990-05-11 | 1991-11-14 | Leopold Pharma Gmbh | Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe |
| CN1029293C (zh) * | 1993-01-01 | 1995-07-12 | 浙江省中医院 | 薏苡仁中性油脂乳剂 |
| CN1048158C (zh) * | 1993-09-09 | 2000-01-12 | 中国医学科学院药物研究所 | 芹菜甲素在制备预防和治疗哺乳动物或人类脑缺血引起的疾病的药中的应用 |
| JP2000128786A (ja) * | 1998-10-28 | 2000-05-09 | Kobayashi Seiyaku Kogyo Kk | ミコナゾール含有水性注射剤およびその製造方法 |
| CN1086942C (zh) | 1998-12-18 | 2002-07-03 | 中国医学科学院药物研究所 | 丁基苯酞在制备抗血栓形成及抗血小板聚集药物中的应用 |
| JP2003277281A (ja) * | 2002-03-20 | 2003-10-02 | Kumamoto Technology & Industry Foundation | 静脈炎の予防及び治療のための医薬 |
| CN1375288A (zh) * | 2002-05-13 | 2002-10-23 | 周桂荣 | 一种治疗脑血管疾病的药物组合物 |
| DK1535916T3 (da) * | 2002-08-21 | 2011-03-14 | Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd | Inklusionskomplekser af butylphthalid med cyclodextrin-derivater og fremgangsmåder til fremstilling af disse |
| CN1565441B (zh) | 2003-06-20 | 2010-05-26 | 中国医学科学院药物研究所 | 左旋正丁基苯酞在制备预防或治疗痴呆的药物中的用途 |
| US7115230B2 (en) * | 2003-06-26 | 2006-10-03 | Intel Corporation | Hydrodynamic focusing devices |
| US20050049209A1 (en) * | 2003-08-06 | 2005-03-03 | Chen Andrew Xian | Pharmaceutical compositions for delivering macrolides |
| CN1254245C (zh) * | 2003-08-26 | 2006-05-03 | 曹永强 | 羟喜树碱乳剂及其制备方法 |
| CN1605336A (zh) | 2003-10-10 | 2005-04-13 | 中国医学科学院药物研究所 | 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用 |
| CN1647796A (zh) | 2004-01-20 | 2005-08-03 | 中奇制药技术(石家庄)有限公司 | 左旋丁苯酞在制备预防和治疗脑缺血疾病药物中的应用 |
| EP1757286B1 (en) * | 2004-06-18 | 2017-09-06 | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The application of l-n-butylphthalide in preventing and treating alzheimer's disease |
| CN100361656C (zh) * | 2004-08-27 | 2008-01-16 | 石药集团中奇制药技术(石家庄)有限公司 | 丁苯酞自乳化释药体系及其制备方法和应用 |
| CN1290491C (zh) * | 2004-09-20 | 2006-12-20 | 周桂荣 | 一种治疗急性缺血性脑卒中的药剂及其制备方法 |
-
2005
- 2005-12-16 CN CNB2005101023552A patent/CN100367951C/zh not_active Expired - Lifetime
-
2006
- 2006-12-15 EA EA200870060A patent/EA014518B1/ru not_active IP Right Cessation
- 2006-12-15 KR KR1020087016969A patent/KR101061268B1/ko active Active
- 2006-12-15 US US12/086,665 patent/US20090281177A1/en not_active Abandoned
- 2006-12-15 EP EP06828348.0A patent/EP1970050B1/en active Active
- 2006-12-15 WO PCT/CN2006/003434 patent/WO2007068212A1/zh not_active Ceased
- 2006-12-15 AU AU2006324219A patent/AU2006324219B2/en not_active Ceased
- 2006-12-15 JP JP2008544744A patent/JP5571311B2/ja active Active
- 2006-12-15 CA CA2633170A patent/CA2633170C/en not_active Expired - Fee Related
- 2006-12-15 BR BRPI0619915-1A patent/BRPI0619915B1/pt active IP Right Grant
- 2006-12-15 UA UAA200808969A patent/UA89315C2/ru unknown
-
2008
- 2008-06-15 IL IL192169A patent/IL192169A/en not_active IP Right Cessation
- 2008-06-17 CU CU20080114A patent/CU23814A3/es not_active IP Right Cessation
-
2011
- 2011-05-20 US US13/112,180 patent/US10463614B2/en active Active
-
2012
- 2012-07-12 JP JP2012156784A patent/JP2012193206A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20090281177A1 (en) | 2009-11-12 |
| IL192169A (en) | 2016-02-29 |
| CA2633170C (en) | 2011-05-24 |
| EP1970050A1 (en) | 2008-09-17 |
| AU2006324219A1 (en) | 2007-06-21 |
| EA200870060A1 (ru) | 2009-02-27 |
| CA2633170A1 (en) | 2007-06-21 |
| KR20080091141A (ko) | 2008-10-09 |
| IL192169A0 (en) | 2008-12-29 |
| CN1823729A (zh) | 2006-08-30 |
| WO2007068212A1 (fr) | 2007-06-21 |
| KR101061268B1 (ko) | 2011-08-31 |
| JP5571311B2 (ja) | 2014-08-13 |
| CU20080114A7 (es) | 2010-08-30 |
| AU2006324219B2 (en) | 2010-03-04 |
| CN100367951C (zh) | 2008-02-13 |
| EP1970050B1 (en) | 2016-05-11 |
| JP2009519253A (ja) | 2009-05-14 |
| JP2012193206A (ja) | 2012-10-11 |
| UA89315C2 (en) | 2010-01-11 |
| US10463614B2 (en) | 2019-11-05 |
| EA014518B1 (ru) | 2010-12-30 |
| US20110288167A1 (en) | 2011-11-24 |
| EP1970050A4 (en) | 2009-12-09 |
| BRPI0619915A2 (pt) | 2011-10-25 |
| BRPI0619915B1 (pt) | 2021-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant of patent | ||
| FD | Lapse (for not paying fees) |