CU24341B1 - Compuestos y composiciones orgánicas inhibidores del ácido graso sintetasa (fasn) útiles para el tratamiento del cáncer, infecciones virales, obesidad y diabetes - Google Patents

Compuestos y composiciones orgánicas inhibidores del ácido graso sintetasa (fasn) útiles para el tratamiento del cáncer, infecciones virales, obesidad y diabetes

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Publication number
CU24341B1
CU24341B1 CUP2015000120A CU20150120A CU24341B1 CU 24341 B1 CU24341 B1 CU 24341B1 CU P2015000120 A CUP2015000120 A CU P2015000120A CU 20150120 A CU20150120 A CU 20150120A CU 24341 B1 CU24341 B1 CU 24341B1
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CU
Cuba
Prior art keywords
fasn
synthease
obesity
diabetes
cancer
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CUP2015000120A
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English (en)
Other versions
CU20150120A7 (es
Inventor
Kenneth W Bair
David R Lancia
Hongbin Li
James Loch
Wei Lu
Matthew W Martin
David S Millan
Shawn E R Schiller
Mark J Tebbe
Original Assignee
Forma Therapeutics Inc
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Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of CU20150120A7 publication Critical patent/CU20150120A7/es
Publication of CU24341B1 publication Critical patent/CU24341B1/es

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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Abstract

<p>La presente invención se refiere a compuestos y composiciones orgánicas inhibidores del ácido graso sintasa (FASN), su síntesis, aplicaciones y antídotos. A continuación se muestra un compuesto ilustrativo de la invención:</p> <p>ESPACIO PARA FÓRMULA</p>
CUP2015000120A 2013-03-13 2014-03-11 Compuestos y composiciones orgánicas inhibidores del ácido graso sintetasa (fasn) útiles para el tratamiento del cáncer, infecciones virales, obesidad y diabetes CU24341B1 (es)

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PCT/US2014/023388 WO2014164749A1 (en) 2013-03-13 2014-03-11 Novel compounds and compositions for inhibition of fasn

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