CU24506B1 - Derivados de diamino piridina útiles paea tratar enfermedades susceptibles a la modulación de jak - Google Patents

Derivados de diamino piridina útiles paea tratar enfermedades susceptibles a la modulación de jak

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Publication number
CU24506B1
CU24506B1 CU2018000044A CU20180044A CU24506B1 CU 24506 B1 CU24506 B1 CU 24506B1 CU 2018000044 A CU2018000044 A CU 2018000044A CU 20180044 A CU20180044 A CU 20180044A CU 24506 B1 CU24506 B1 CU 24506B1
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CU
Cuba
Prior art keywords
pyridine derivatives
helpful
treating diseases
jak
diseases susceptible
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Application number
CU2018000044A
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English (en)
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CU20180044A7 (es
Inventor
Gebhard Thoma
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Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20180044A7 publication Critical patent/CU20180044A7/es
Publication of CU24506B1 publication Critical patent/CU24506B1/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
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  • Obesity (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>La presente invención describe derivados de diamino piridina de fórmula I que muestran propiedades de modulación de JAK. Los compuestos de la invención pueden ser útiles en el tratamiento de enfermedades y/o trastornos susceptibles a la modulación JAK, tales como enfermedades alérgicas y enfermedades de las vías respiratorias.</p>
CU2018000044A 2015-11-26 2016-11-24 Derivados de diamino piridina útiles paea tratar enfermedades susceptibles a la modulación de jak CU24506B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15196542 2015-11-26
PCT/IB2016/057105 WO2017089985A1 (en) 2015-11-26 2016-11-24 Diamino pyridine derivatives

Publications (2)

Publication Number Publication Date
CU20180044A7 CU20180044A7 (es) 2018-10-04
CU24506B1 true CU24506B1 (es) 2021-04-07

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CU2018000044A CU24506B1 (es) 2015-11-26 2016-11-24 Derivados de diamino piridina útiles paea tratar enfermedades susceptibles a la modulación de jak

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US (3) US10570096B2 (es)
EP (2) EP3757097B1 (es)
JP (1) JP6634157B2 (es)
KR (1) KR102097878B1 (es)
CN (2) CN108349937B (es)
AU (1) AU2016359438B2 (es)
BR (1) BR112018009540A2 (es)
CA (1) CA3005159A1 (es)
CL (1) CL2018001370A1 (es)
CO (1) CO2018005354A2 (es)
CR (1) CR20180285A (es)
CU (1) CU24506B1 (es)
CY (1) CY1123543T1 (es)
DK (1) DK3380465T3 (es)
DO (1) DOP2018000127A (es)
EA (1) EA035899B1 (es)
EC (1) ECSP18041731A (es)
ES (2) ES2829052T3 (es)
HR (1) HRP20201662T1 (es)
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PT3757097T (pt) * 2015-11-26 2022-06-20 Novartis Ag Derivados de diamino piridina
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TW202342048A (zh) 2022-02-28 2023-11-01 瑞士商諾華公司 使用ｌｏｕ０６４治療化膿性汗腺炎之方法

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ECSP18041731A (es) 2018-06-30
US20180354904A1 (en) 2018-12-13
CO2018005354A2 (es) 2018-05-31
EP3757097A1 (en) 2020-12-30
LT3380465T (lt) 2020-11-10
ES2829052T3 (es) 2021-05-28
HK1253530A1 (en) 2019-06-21
PH12018501019B1 (en) 2023-03-15
DK3380465T3 (da) 2020-10-26
EP3757097B1 (en) 2022-03-30
US10570096B2 (en) 2020-02-25
IL259360B (en) 2021-05-31
KR20180067681A (ko) 2018-06-20
PE20181071A1 (es) 2018-07-04
CU20180044A7 (es) 2018-10-04
HUE052345T2 (hu) 2021-04-28
ES2916582T3 (es) 2022-07-01
CN108349937B (zh) 2021-02-09
EP3380465A1 (en) 2018-10-03
US11274080B2 (en) 2022-03-15
BR112018009540A2 (pt) 2018-11-06
US20200140386A1 (en) 2020-05-07
SI3380465T1 (sl) 2020-11-30
JP6634157B2 (ja) 2020-01-22
CN108349937A (zh) 2018-07-31
CY1123543T1 (el) 2022-03-24
PT3757097T (pt) 2022-06-20
RU2020124922A (ru) 2020-08-10
DOP2018000127A (es) 2018-10-31
RU2018122953A3 (es) 2020-01-29
PH12018501019A1 (en) 2018-12-17
PL3380465T3 (pl) 2021-01-25
EA201891258A1 (ru) 2018-10-31
SG11201803760VA (en) 2018-06-28
AU2016359438A1 (en) 2018-05-31
EA035899B1 (ru) 2020-08-28
CN112851578A (zh) 2021-05-28
PT3380465T (pt) 2020-10-23
SA518391657B1 (ar) 2021-02-22
CR20180285A (es) 2018-07-16
MX2018006495A (es) 2018-08-15
JP2019503343A (ja) 2019-02-07
WO2017089985A1 (en) 2017-06-01
CA3005159A1 (en) 2017-06-01
MX379776B (es) 2025-03-11
HRP20201662T1 (hr) 2020-12-25
RU2018122953A (ru) 2019-12-26
IL259360A (en) 2018-07-31
US20220177432A1 (en) 2022-06-09
AU2016359438B2 (en) 2019-05-02
RU2730007C2 (ru) 2020-08-14
EP3380465B1 (en) 2020-08-05
MY195905A (en) 2023-02-27
CL2018001370A1 (es) 2018-07-27
RS60946B1 (sr) 2020-11-30
KR102097878B1 (ko) 2020-04-06
PL3757097T3 (pl) 2022-07-25

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