CY1122020T1 - Μορια δεσμευσης σε cd3 ικανα να δεσμευονται σε ανθρωπινα και μη ανθρωπινα cd3 - Google Patents

Μορια δεσμευσης σε cd3 ικανα να δεσμευονται σε ανθρωπινα και μη ανθρωπινα cd3

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Publication number
CY1122020T1
CY1122020T1 CY20191100442T CY191100442T CY1122020T1 CY 1122020 T1 CY1122020 T1 CY 1122020T1 CY 20191100442 T CY20191100442 T CY 20191100442T CY 191100442 T CY191100442 T CY 191100442T CY 1122020 T1 CY1122020 T1 CY 1122020T1
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CY
Cyprus
Prior art keywords
human
bind
binding molecules
binding
relates
Prior art date
Application number
CY20191100442T
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English (en)
Inventor
Ling Huang
Leslie S. Johnson
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Macrogenics, Inc.
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Filing date
Publication date
Application filed by Macrogenics, Inc. filed Critical Macrogenics, Inc.
Publication of CY1122020T1 publication Critical patent/CY1122020T1/el

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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2809Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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Abstract

Η παρούσα εφεύρεση σχετίζεται με μόρια δέσμευσης του CD3 ικανά να δεσμεύονται σε ανθρώπινο και μη ανθρώπινο CD3, και ειδικότερα με τέτοια μόρια που έχουν διασταυρούμενη αντίδραση με το CD3 ενός μη ανθρώπινου θηλαστικού (π.χ., ένας πίθηκος cynomolgus). Η εφεύρεση επίσης αναφέρεται σε χρήσεις τέτοιων αντισωμάτων και θραυσμάτων δέσμευσης αντιγόνου στη θεραπεία του καρκίνου, αυτοάνοσων και/ή φλεγμονωδών νόσων και άλλων καταστάσεων.
CY20191100442T 2011-05-21 2019-04-23 Μορια δεσμευσης σε cd3 ικανα να δεσμευονται σε ανθρωπινα και μη ανθρωπινα cd3 CY1122020T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161488716P 2011-05-21 2011-05-21
US201161530353P 2011-09-01 2011-09-01
PCT/US2012/038219 WO2012162067A2 (en) 2011-05-21 2012-05-16 Cd3-binding molecules capable of binding to human and non-human cd3

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Publication Number Publication Date
CY1122020T1 true CY1122020T1 (el) 2020-10-14

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ES2892925T3 (es) 2006-03-31 2022-02-07 Chugai Pharmaceutical Co Ltd Métodos para controlar la farmacocinética en sangre de anticuerpos
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
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IL264293A (en) 2019-02-28
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