CY1124541T1 - Πρωτεϊνες που περιλαμβανουν αμινο-τερματικες εγγυτερες τελεστικες περιοχες υπομοναδων τοξινης shiga α και περιοχες δεσμευσης τυπου-ανοσοσφαιρινων στοχευσης-κυτταρων δυναμενες της κατα συγκεκριμενο τροπο δεσμευσης cd38 - Google Patents

Πρωτεϊνες που περιλαμβανουν αμινο-τερματικες εγγυτερες τελεστικες περιοχες υπομοναδων τοξινης shiga α και περιοχες δεσμευσης τυπου-ανοσοσφαιρινων στοχευσης-κυτταρων δυναμενες της κατα συγκεκριμενο τροπο δεσμευσης cd38

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Publication number
CY1124541T1
CY1124541T1 CY20211100692T CY211100692T CY1124541T1 CY 1124541 T1 CY1124541 T1 CY 1124541T1 CY 20211100692 T CY20211100692 T CY 20211100692T CY 211100692 T CY211100692 T CY 211100692T CY 1124541 T1 CY1124541 T1 CY 1124541T1
Authority
CY
Cyprus
Prior art keywords
binding
shiga toxin
proteins
target cells
subunits
Prior art date
Application number
CY20211100692T
Other languages
English (en)
Inventor
Eric POMA
Erin WILLERT
Original Assignee
Molecular Templates, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Templates, Inc. filed Critical Molecular Templates, Inc.
Publication of CY1124541T1 publication Critical patent/CY1124541T1/el

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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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Abstract

Η παρούσα εφεύρεση παρέχει πρωτεΐνες περιλαμβάνοντας περιοχές δέσμευσης τύπου-ανοσοσφαιρινών για συγκεκριμένη για τύπο κυττάρων στόχευση και τελεστικές περιοχές Υπομονάδων τοξίνης Shiga Α για τελεστικές λειτουργίες τοξινών Shiga (π.χ. κυτταρική εσωτερικοποίηση, κατεύθυνση υπο-κυτταρικής δρομολόγησης, και/ή κυτταροτοξικότητα), όπου περιοχές δέσμευσης και τελεστικές περιοχές τοξινών Shiga συνδυάζονται ούτως ώστε οι τελεστικές περιοχές τοξινών Shiga να είναι εγγύτερες ως προς τα αμινο-τερματικά των πρωτεϊνών. Οι επί του παρόντος αποκαλυπτόμενες πρωτεΐνες μπορούν να περιλαμβάνουν επιπρόσθετα εξωγενή υλικά, όπως είναι, π.χ., τα αντιγόνα, οι κυτταροτοξικοί παράγοντες, και οι παράγοντες προαγωγής-ανίχνευσης. και είναι δυνάμενες στοχευμένης απελευθέρωσης αυτών των επιπρόσθετων εξωγενών υλικών μέσα στα εσωτερικά των κυττάρων στόχων. Οι πρωτεΐνες της παρούσας εφεύρεσης έχουν χρήσεις σε μεθόδους όπως είναι, π.χ., οι μέθοδοι ενέχοντας στοχευμένη θανάτωση των κυττάρων στόχων, η απελευθέρωση εξωγενών υλικών μέσα σε κύτταρα στόχους, η σήμανση υπο-κυτταρικών διαμερισμάτων των κυττάρων στόχων, και η διάγνωση και/ή αγωγή μιας ποικιλίας καταστάσεων συμπεριλαμβάνοντας καρκίνους, όγκους, άλλα μη-φυσιολογικά ευρήματα αύξησης, ανοσιακές διαταραχές, και μικροβιακές λοιμώξεις.
CY20211100692T 2014-03-11 2021-08-03 Πρωτεϊνες που περιλαμβανουν αμινο-τερματικες εγγυτερες τελεστικες περιοχες υπομοναδων τοξινης shiga α και περιοχες δεσμευσης τυπου-ανοσοσφαιρινων στοχευσης-κυτταρων δυναμενες της κατα συγκεκριμενο τροπο δεσμευσης cd38 CY1124541T1 (el)

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