CY2155B1 - Preparation of d4t from 5-methyluridine - Google Patents

Preparation of d4t from 5-methyluridine

Info

Publication number: CY2155B1
Authority: CY; Cyprus
Prior art keywords: methyluridine; preparation; making; another aspect; relates
Prior art date: 1995-03-10

Application number

CY9900022A

Other languages

English (en)

Inventor

Richard H Spector

Bang-Chi Chen

Sandra L Quinlan

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-10

Filing date

1999-08-03

Publication date

2002-08-23

1999-08-03 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2002-08-23 Publication of CY2155B1 publication Critical patent/CY2155B1/xx

Links

DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 title abstract 2
DWRXFEITVBNRMK-JXOAFFINSA-N ribothymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 DWRXFEITVBNRMK-JXOAFFINSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

CY9900022A 1995-03-10 1999-08-03 Preparation of d4t from 5-methyluridine CY2155B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/402,283 US5608049A (en)	1995-03-10	1995-03-10	Preparation of d4T from 5-methyluridine

Publications (1)

Publication Number	Publication Date
CY2155B1 true CY2155B1 (en)	2002-08-23

Family

ID=23591286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY9900022A CY2155B1 (en)	1995-03-10	1999-08-03	Preparation of d4t from 5-methyluridine

Country Status (17)

Country	Link
US (1)	US5608049A (de)
EP (1)	EP0735044B1 (de)
JP (1)	JP3914279B2 (de)
KR (1)	KR100393913B1 (de)
CN (2)	CN1059213C (de)
AT (1)	ATE181556T1 (de)
AU (1)	AU694320B2 (de)
CA (1)	CA2170968A1 (de)
CY (1)	CY2155B1 (de)
DE (1)	DE69602983T2 (de)
DK (1)	DK0735044T3 (de)
ES (1)	ES2135168T3 (de)
GR (1)	GR3031243T3 (de)
HU (1)	HU220700B1 (de)
IL (1)	IL117225A (de)
SG (1)	SG38948A1 (de)
TW (1)	TW527359B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5608048A (en) *	1995-06-05	1997-03-04	Bristol-Myers Squibb Company	d4 T polymorphic Form 1 process
AU2001285197A1 (en) *	2000-09-06	2002-03-22	Bristol-Myers Squibb Company	Stavudine polymorphic form 1 process
WO2005030258A2 (en) *	2003-09-22	2005-04-07	Acidophil Llc	Small molecule compositions and methods for increasing drug efficiency using compositions thereof
US7160537B2 (en) *	2003-12-15	2007-01-09	Siemens Medical Solutions Usa, Inc.	Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) *	2003-12-15	2005-06-16	Cti Pet Systems, Inc.	Method for preparing radiolabeled thymidine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3817982A (en) *	1971-12-29	1974-06-18	Syntex Inc	2{40 ,3{40 -unsaturated nucleosides and method of making
US4904770A (en) *	1988-03-24	1990-02-27	Bristol-Myers Company	Production of 2',3'-dideoxy-2',3'-didehydronucleosides
JP3128080B2 (ja) *	1991-10-02	2001-01-29	日本製紙株式会社	核酸化合物の新規な製造方法
US5672698A (en) *	1993-11-15	1997-09-30	Bristol-Myers Squibb Co.	Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5539099A (en) *	1993-11-15	1996-07-23	Bristol-Myers Squibb Company	Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides

1995
- 1995-03-10 US US08/402,283 patent/US5608049A/en not_active Expired - Lifetime
1996
- 1996-02-17 TW TW085102080A patent/TW527359B/zh not_active IP Right Cessation
- 1996-02-22 IL IL11722596A patent/IL117225A/en not_active IP Right Cessation
- 1996-03-04 CA CA002170968A patent/CA2170968A1/en not_active Abandoned
- 1996-03-05 JP JP04700596A patent/JP3914279B2/ja not_active Expired - Fee Related
- 1996-03-05 KR KR1019960005683A patent/KR100393913B1/ko not_active Expired - Fee Related
- 1996-03-08 DE DE69602983T patent/DE69602983T2/de not_active Expired - Fee Related
- 1996-03-08 CN CN96105786A patent/CN1059213C/zh not_active Expired - Fee Related
- 1996-03-08 AT AT96301606T patent/ATE181556T1/de not_active IP Right Cessation
- 1996-03-08 HU HU9600607A patent/HU220700B1/hu not_active IP Right Cessation
- 1996-03-08 DK DK96301606T patent/DK0735044T3/da active
- 1996-03-08 AU AU47982/96A patent/AU694320B2/en not_active Ceased
- 1996-03-08 CN CNB001009850A patent/CN1195770C/zh not_active Expired - Fee Related
- 1996-03-08 ES ES96301606T patent/ES2135168T3/es not_active Expired - Lifetime
- 1996-03-08 EP EP96301606A patent/EP0735044B1/de not_active Expired - Lifetime
- 1996-03-09 SG SG1996006654A patent/SG38948A1/en unknown
1999
- 1999-08-03 CY CY9900022A patent/CY2155B1/xx unknown
- 1999-09-16 GR GR990402335T patent/GR3031243T3/el unknown

Also Published As

Publication number	Publication date
EP0735044B1 (de)	1999-06-23
EP0735044A1 (de)	1996-10-02
AU4798296A (en)	1996-09-19
JPH08269051A (ja)	1996-10-15
IL117225A0 (en)	1996-06-18
ATE181556T1 (de)	1999-07-15
CN1270172A (zh)	2000-10-18
TW527359B (en)	2003-04-11
KR100393913B1 (ko)	2003-12-18
US5608049A (en)	1997-03-04
CN1195770C (zh)	2005-04-06
DK0735044T3 (da)	2000-01-10
HUP9600607A1 (en)	1996-12-30
SG38948A1 (en)	1997-04-17
HK1002979A1 (en)	1998-09-30
HU220700B1 (hu)	2002-04-29
CN1147519A (zh)	1997-04-16
IL117225A (en)	2001-04-30
GR3031243T3 (en)	1999-12-31
AU694320B2 (en)	1998-07-16
CN1059213C (zh)	2000-12-06
DE69602983D1 (de)	1999-07-29
DE69602983T2 (de)	2000-03-09
JP3914279B2 (ja)	2007-05-16
CA2170968A1 (en)	1996-09-11
ES2135168T3 (es)	1999-10-16
KR960034212A (ko)	1996-10-22

Publication	Publication Date	Title
SI0787115T1 (en)	2000-04-30	PROCESS FOR PRODUCING DERIVATIVES OF 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO(3a,3,2-ef)(2)BENZAZEPINE
ZA985146B (en)	1998-12-21	Process for the production of vanillin
NO910712L (no)	1991-08-26	Fremgangsmaate ved fremstilling av oksetanoner.
IL135590A (en)	2003-09-17	Process for the reduction of oxiranyl epothilones to olefinic epothilones
AU694320B2 (en)	1998-07-16	Preparation of D4T from 5-methyluridine
AU694653B2 (en)	1998-07-23	D4T polymorphic form I process
HUP9902443A3 (en)	2001-05-28	New process for making phenyl substituted 2(5h)-furanones, intermediates
EP0688770A3 (de)	1996-03-06	Verfahren zur Herstellung von Hydroxyflavanverbindungen
EP0685435A3 (de)	1996-07-24	Verfahren zur Herstellung von anorganischen Pulvern.
EP0755910A3 (de)	1997-08-20	Verfahren zur Herstellung von 4-tert-Butylcyclohexanol
WO1999032507A3 (en)	1999-09-10	Intermediates and process for the synthesis of 17-unsubstituted 16.beta.-aryloxy 4-azasteroids
BG102563A (en)	1999-04-30	Method and intermediate compounds for the production of pesticidal fluorolefinic compounds
FR2721028B1 (fr)	1996-07-12	Procédé de synthèse d'halogénoalkylferrocènes.
EP0747364A3 (de)	1997-02-26	Verfahren zur Herstellung von 2,4,6-Trichlorpyrimidin
DE3470304D1 (en)	1988-05-11	A process for the preparation of 1,5-diprotected-1,5,10-triazadecane, intermediates thereof and their preparation
HU9501132D0 (en)	1995-06-28	Process for producing of 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphtalene
MX9601818A (es)	1997-07-31	Conversion de 8-cloroquinolinas sustituidas a 8-hidroxiquinolinas sustituidas.
FR2717475B1 (fr)	1996-04-12	Procédé de préparation d'aryltétrazoles.
ITRM940330A0 (it)	1994-05-26	"procedimento migliorato per la preparazione della 14b-idrossi-etianaldeide".
ITMI951910A0 (it)	1995-09-14	Procedimento migliorato per la produzione di copolimeri etilene- propilene