SG38948A1 - Preparation of D4T from 5-methyluridine - Google Patents

Preparation of D4T from 5-methyluridine

Info

Publication number: SG38948A1
Authority: SG; Singapore
Prior art keywords: methyluridine; preparation; making; another aspect; relates
Prior art date: 1995-03-10

Application number

SG1996006654A

Other languages

English (en)

Inventor

Richard H Spector

Bang-Chi Chen

La Sandra Ouinlan

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-10

Filing date

1996-03-09

Publication date

1997-04-17

1996-03-09 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1997-04-17 Publication of SG38948A1 publication Critical patent/SG38948A1/en

Links

DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 title abstract 2
DWRXFEITVBNRMK-JXOAFFINSA-N ribothymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 DWRXFEITVBNRMK-JXOAFFINSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

SG1996006654A 1995-03-10 1996-03-09 Preparation of D4T from 5-methyluridine SG38948A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/402,283 US5608049A (en)	1995-03-10	1995-03-10	Preparation of d4T from 5-methyluridine

Publications (1)

Publication Number	Publication Date
SG38948A1 true SG38948A1 (en)	1997-04-17

Family

ID=23591286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996006654A SG38948A1 (en)	1995-03-10	1996-03-09	Preparation of D4T from 5-methyluridine

Country Status (17)

Country	Link
US (1)	US5608049A (de)
EP (1)	EP0735044B1 (de)
JP (1)	JP3914279B2 (de)
KR (1)	KR100393913B1 (de)
CN (2)	CN1059213C (de)
AT (1)	ATE181556T1 (de)
AU (1)	AU694320B2 (de)
CA (1)	CA2170968A1 (de)
CY (1)	CY2155B1 (de)
DE (1)	DE69602983T2 (de)
DK (1)	DK0735044T3 (de)
ES (1)	ES2135168T3 (de)
GR (1)	GR3031243T3 (de)
HU (1)	HU220700B1 (de)
IL (1)	IL117225A (de)
SG (1)	SG38948A1 (de)
TW (1)	TW527359B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5608048A (en) *	1995-06-05	1997-03-04	Bristol-Myers Squibb Company	d4 T polymorphic Form 1 process
WO2002020538A2 (en) *	2000-09-06	2002-03-14	Bristol-Myers Squibb Company	Stavudine polymorphic form 1 process
JP2007522094A (ja) *	2003-09-22	2007-08-09	アシドフィルエルエルシー	小分子組成物、及びその組成物を使用して薬物効率を高めるための方法
US7160537B2 (en) *	2003-12-15	2007-01-09	Siemens Medical Solutions Usa, Inc.	Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) *	2003-12-15	2005-06-16	Cti Pet Systems, Inc.	Method for preparing radiolabeled thymidine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3817982A (en) *	1971-12-29	1974-06-18	Syntex Inc	2{40 ,3{40 -unsaturated nucleosides and method of making
US4904770A (en) *	1988-03-24	1990-02-27	Bristol-Myers Company	Production of 2',3'-dideoxy-2',3'-didehydronucleosides
JP3128080B2 (ja) *	1991-10-02	2001-01-29	日本製紙株式会社	核酸化合物の新規な製造方法
US5672698A (en) *	1993-11-15	1997-09-30	Bristol-Myers Squibb Co.	Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5539099A (en) *	1993-11-15	1996-07-23	Bristol-Myers Squibb Company	Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides

1995
- 1995-03-10 US US08/402,283 patent/US5608049A/en not_active Expired - Lifetime
1996
- 1996-02-17 TW TW085102080A patent/TW527359B/zh not_active IP Right Cessation
- 1996-02-22 IL IL11722596A patent/IL117225A/en not_active IP Right Cessation
- 1996-03-04 CA CA002170968A patent/CA2170968A1/en not_active Abandoned
- 1996-03-05 JP JP04700596A patent/JP3914279B2/ja not_active Expired - Fee Related
- 1996-03-05 KR KR1019960005683A patent/KR100393913B1/ko not_active Expired - Fee Related
- 1996-03-08 AT AT96301606T patent/ATE181556T1/de not_active IP Right Cessation
- 1996-03-08 EP EP96301606A patent/EP0735044B1/de not_active Expired - Lifetime
- 1996-03-08 CN CN96105786A patent/CN1059213C/zh not_active Expired - Fee Related
- 1996-03-08 AU AU47982/96A patent/AU694320B2/en not_active Ceased
- 1996-03-08 DE DE69602983T patent/DE69602983T2/de not_active Expired - Fee Related
- 1996-03-08 ES ES96301606T patent/ES2135168T3/es not_active Expired - Lifetime
- 1996-03-08 HU HU9600607A patent/HU220700B1/hu not_active IP Right Cessation
- 1996-03-08 DK DK96301606T patent/DK0735044T3/da active
- 1996-03-08 CN CNB001009850A patent/CN1195770C/zh not_active Expired - Fee Related
- 1996-03-09 SG SG1996006654A patent/SG38948A1/en unknown
1999
- 1999-08-03 CY CY9900022A patent/CY2155B1/xx unknown
- 1999-09-16 GR GR990402335T patent/GR3031243T3/el unknown

Also Published As

Publication number	Publication date
KR960034212A (ko)	1996-10-22
CN1270172A (zh)	2000-10-18
JP3914279B2 (ja)	2007-05-16
CN1147519A (zh)	1997-04-16
IL117225A (en)	2001-04-30
AU694320B2 (en)	1998-07-16
HK1002979A1 (en)	1998-09-30
KR100393913B1 (ko)	2003-12-18
DE69602983T2 (de)	2000-03-09
IL117225A0 (en)	1996-06-18
CA2170968A1 (en)	1996-09-11
CY2155B1 (en)	2002-08-23
AU4798296A (en)	1996-09-19
CN1059213C (zh)	2000-12-06
DK0735044T3 (da)	2000-01-10
CN1195770C (zh)	2005-04-06
US5608049A (en)	1997-03-04
DE69602983D1 (de)	1999-07-29
EP0735044A1 (de)	1996-10-02
ATE181556T1 (de)	1999-07-15
EP0735044B1 (de)	1999-06-23
HU220700B1 (hu)	2002-04-29
GR3031243T3 (en)	1999-12-31
ES2135168T3 (es)	1999-10-16
JPH08269051A (ja)	1996-10-15
TW527359B (en)	2003-04-11
HUP9600607A1 (en)	1996-12-30

Publication	Publication Date	Title
NO971645L (no)	1997-05-07	Fremgangsmåte for fremstilling av derivater av 4a,5,9,10,11,12,-heksahydro-6H-benzofuro£3a,3,2-ef\|£2\|-benzacepin
IL124800A0 (en)	1999-01-26	Process for the production of vanillin
NO910712L (no)	1991-08-26	Fremgangsmaate ved fremstilling av oksetanoner.
IL135590A0 (en)	2001-05-20	A process for the reduction of oxiranyl epothilones to olefinic epothilones
IL117225A0 (en)	1996-06-18	Preparation of d4t from 5-methyluridine
IL118527A (en)	2000-07-16	Process for the preparation of D4T polymorphic form I of stavudine
EP0688770A3 (de)	1996-03-06	Verfahren zur Herstellung von Hydroxyflavanverbindungen
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EP0755910A3 (de)	1997-08-20	Verfahren zur Herstellung von 4-tert-Butylcyclohexanol
WO1999032507A3 (en)	1999-09-10	Intermediates and process for the synthesis of 17-unsubstituted 16.beta.-aryloxy 4-azasteroids
BG102563A (en)	1999-04-30	Method and intermediate compounds for the production of pesticidal fluorolefinic compounds
EP0747364A3 (de)	1997-02-26	Verfahren zur Herstellung von 2,4,6-Trichlorpyrimidin
DE3470304D1 (en)	1988-05-11	A process for the preparation of 1,5-diprotected-1,5,10-triazadecane, intermediates thereof and their preparation
MX9601818A (es)	1997-07-31	Conversion de 8-cloroquinolinas sustituidas a 8-hidroxiquinolinas sustituidas.
FR2717475B1 (fr)	1996-04-12	Procédé de préparation d'aryltétrazoles.
PL312728A1 (en)	1997-08-18	Method of obtaining (r) - (+) - (s) - (-) - 3 - (4-aminophenyl) - 3 - ethylopieridino 2,6 - dione as well as novel intermediate compounds __
ITRM940330A0 (it)	1994-05-26	"procedimento migliorato per la preparazione della 14b-idrossi-etianaldeide".
ITMI951910A0 (it)	1995-09-14	Procedimento migliorato per la produzione di copolimeri etilene- propilene