ATE181556T1 - Darstellung von d4t aus 5-methyluridin - Google Patents

Darstellung von d4t aus 5-methyluridin

Info

Publication number
ATE181556T1
ATE181556T1 AT96301606T AT96301606T ATE181556T1 AT E181556 T1 ATE181556 T1 AT E181556T1 AT 96301606 T AT96301606 T AT 96301606T AT 96301606 T AT96301606 T AT 96301606T AT E181556 T1 ATE181556 T1 AT E181556T1
Authority
AT
Austria
Prior art keywords
methyluridine
preparation
making
another aspect
relates
Prior art date
Application number
AT96301606T
Other languages
English (en)
Inventor
Richard H Spector
Bang-Chi Chen
Sandra L Quinlan
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE181556T1 publication Critical patent/ATE181556T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AT96301606T 1995-03-10 1996-03-08 Darstellung von d4t aus 5-methyluridin ATE181556T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/402,283 US5608049A (en) 1995-03-10 1995-03-10 Preparation of d4T from 5-methyluridine

Publications (1)

Publication Number Publication Date
ATE181556T1 true ATE181556T1 (de) 1999-07-15

Family

ID=23591286

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96301606T ATE181556T1 (de) 1995-03-10 1996-03-08 Darstellung von d4t aus 5-methyluridin

Country Status (17)

Country Link
US (1) US5608049A (de)
EP (1) EP0735044B1 (de)
JP (1) JP3914279B2 (de)
KR (1) KR100393913B1 (de)
CN (2) CN1059213C (de)
AT (1) ATE181556T1 (de)
AU (1) AU694320B2 (de)
CA (1) CA2170968A1 (de)
CY (1) CY2155B1 (de)
DE (1) DE69602983T2 (de)
DK (1) DK0735044T3 (de)
ES (1) ES2135168T3 (de)
GR (1) GR3031243T3 (de)
HU (1) HU220700B1 (de)
IL (1) IL117225A (de)
SG (1) SG38948A1 (de)
TW (1) TW527359B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
AU2001285197A1 (en) * 2000-09-06 2002-03-22 Bristol-Myers Squibb Company Stavudine polymorphic form 1 process
WO2005030258A2 (en) * 2003-09-22 2005-04-07 Acidophil Llc Small molecule compositions and methods for increasing drug efficiency using compositions thereof
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
US4904770A (en) * 1988-03-24 1990-02-27 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides
JP3128080B2 (ja) * 1991-10-02 2001-01-29 日本製紙株式会社 核酸化合物の新規な製造方法
US5672698A (en) * 1993-11-15 1997-09-30 Bristol-Myers Squibb Co. Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5539099A (en) * 1993-11-15 1996-07-23 Bristol-Myers Squibb Company Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides

Also Published As

Publication number Publication date
EP0735044B1 (de) 1999-06-23
EP0735044A1 (de) 1996-10-02
CY2155B1 (en) 2002-08-23
AU4798296A (en) 1996-09-19
JPH08269051A (ja) 1996-10-15
IL117225A0 (en) 1996-06-18
CN1270172A (zh) 2000-10-18
TW527359B (en) 2003-04-11
KR100393913B1 (ko) 2003-12-18
US5608049A (en) 1997-03-04
CN1195770C (zh) 2005-04-06
DK0735044T3 (da) 2000-01-10
HUP9600607A1 (en) 1996-12-30
SG38948A1 (en) 1997-04-17
HK1002979A1 (en) 1998-09-30
HU220700B1 (hu) 2002-04-29
CN1147519A (zh) 1997-04-16
IL117225A (en) 2001-04-30
GR3031243T3 (en) 1999-12-31
AU694320B2 (en) 1998-07-16
CN1059213C (zh) 2000-12-06
DE69602983D1 (de) 1999-07-29
DE69602983T2 (de) 2000-03-09
JP3914279B2 (ja) 2007-05-16
CA2170968A1 (en) 1996-09-11
ES2135168T3 (es) 1999-10-16
KR960034212A (ko) 1996-10-22

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee