CY2216B1 - Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof - Google Patents

Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof

Info

Publication number
CY2216B1
CY2216B1 CY0000057A CY0000057A CY2216B1 CY 2216 B1 CY2216 B1 CY 2216B1 CY 0000057 A CY0000057 A CY 0000057A CY 0000057 A CY0000057 A CY 0000057A CY 2216 B1 CY2216 B1 CY 2216B1
Authority
CY
Cyprus
Prior art keywords
hmg
intermediates
preparation
coa reductase
reductase inhibitors
Prior art date
Application number
CY0000057A
Other languages
English (en)
Inventor
Brian L David
Paul M Cino
Laszlo Szarka
Original Assignee
Bristol Myers Quibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Quibb Company filed Critical Bristol Myers Quibb Company
Publication of CY2216B1 publication Critical patent/CY2216B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY0000057A 1993-10-22 2000-11-28 Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof CY2216B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/141,316 US6043064A (en) 1993-10-22 1993-10-22 Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof

Publications (1)

Publication Number Publication Date
CY2216B1 true CY2216B1 (en) 2003-04-18

Family

ID=22495167

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0000057A CY2216B1 (en) 1993-10-22 2000-11-28 Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof

Country Status (19)

Country Link
US (1) US6043064A (de)
EP (1) EP0649907B1 (de)
JP (1) JP3683606B2 (de)
KR (1) KR100342627B1 (de)
CN (1) CN1085250C (de)
AT (1) ATE196166T1 (de)
AU (1) AU679113B2 (de)
CA (1) CA2134025A1 (de)
CY (1) CY2216B1 (de)
DE (1) DE69425801T2 (de)
DK (1) DK0649907T3 (de)
ES (1) ES2150459T3 (de)
FI (1) FI113279B (de)
GR (1) GR3034835T3 (de)
HU (1) HU217104B (de)
IL (1) IL111084A (de)
PT (1) PT649907E (de)
SG (1) SG47504A1 (de)
TW (1) TW438888B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4162848B2 (ja) 1997-08-07 2008-10-08 協和醗酵工業株式会社 ＨＭＧ−ＣｏＡレダクターゼ阻害剤の製造法
AU9264598A (en) * 1997-08-22 1999-03-16 Gist-Brocades B.V. Statin production by fermentation
SI9800144A (sl) 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
EP1146126B1 (de) * 1999-01-20 2007-04-25 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur herstellung von hemmern der hmg-coa reduktase
KR20010108139A (ko) * 1999-01-29 2001-12-07 히라타 다다시 히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
JP2003093045A (ja) * 2001-09-26 2003-04-02 Godo Shusei Co Ltd 有用変換微生物
ATE316146T1 (de) * 2001-09-27 2006-02-15 Biocon Ltd Verfahren zur herstellung von pravastatin- natriumsalz mittels streptomyces flavidovirens dsm 14455
EP1452602A1 (de) * 2003-02-25 2004-09-01 Antibiotic Co., Fermentatives Verfahren zur Herstellung von Pravastatin
TWI252253B (en) * 2004-01-09 2006-04-01 Chinese Petroleum Corp A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same
CN101351551A (zh) * 2005-11-29 2009-01-21 协和发酵工业株式会社 新型蛋白质和编码该蛋白质的dna
WO2007137816A1 (en) * 2006-05-30 2007-12-06 Dsm Ip Assets B.V. Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP1953233A1 (de) * 2007-02-02 2008-08-06 LEK Pharmaceuticals d.d. Fermentationsverfahren zur Herstellung von Pravastatin
JP7350659B2 (ja) 2017-06-06 2023-09-26 ザイマージェン インコーポレイテッド Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａ ｓｐｉｎｏｓａの改良のためのハイスループット（ＨＴＰ）ゲノム操作プラットフォーム

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (de) * 1974-06-07 1981-03-18
US4206206A (en) * 1977-03-24 1980-06-03 Kowa Company, Ltd. Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0069442B1 (de) * 1981-06-06 1985-02-20 Pfizer Limited Fungizide Mittel, Verfahren zu deren Herstellung, und diese enthaltende pharmazeutische Zusammenstellungen
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS60176595A (ja) * 1984-02-21 1985-09-10 Akira Endo 生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
PT85109A (en) * 1986-06-23 1987-07-01 Merck & Co Inc Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
EP0337548A3 (de) * 1988-04-15 1991-08-14 Merck & Co. Inc. Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695)
CA2009043A1 (en) * 1989-02-01 1990-08-01 Michael J. Ferris Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
EP0408806A1 (de) * 1989-07-19 1991-01-23 Merck & Co. Inc. Antihypercholesterolemische Mittel
TW227552B (de) * 1990-07-06 1994-08-01 Squibb & Sons Inc
CA2053000C (en) * 1990-10-15 1995-08-29 Michael J. Conder Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
EP0649907B1 (de) 2000-09-06
ATE196166T1 (de) 2000-09-15
GR3034835T3 (en) 2001-02-28
EP0649907A1 (de) 1995-04-26
HUT69959A (en) 1995-09-28
TW438888B (en) 2001-06-07
HU217104B (hu) 1999-11-29
HK1014740A1 (en) 1999-09-30
US6043064A (en) 2000-03-28
HU9403061D0 (en) 1994-12-28
CA2134025A1 (en) 1995-04-23
IL111084A (en) 1998-01-04
AU7597294A (en) 1995-05-11
SG47504A1 (en) 1998-04-17
FI113279B (fi) 2004-03-31
KR950011616A (ko) 1995-05-15
DE69425801T2 (de) 2001-05-03
FI944926A0 (fi) 1994-10-20
JP3683606B2 (ja) 2005-08-17
AU679113B2 (en) 1997-06-19
CN1106067A (zh) 1995-08-02
FI944926L (fi) 1995-04-23
ES2150459T3 (es) 2000-12-01
DK0649907T3 (da) 2000-10-09
JPH07184670A (ja) 1995-07-25
KR100342627B1 (ko) 2002-11-18
CN1085250C (zh) 2002-05-22
IL111084A0 (en) 1994-11-28
PT649907E (pt) 2000-12-29
DE69425801D1 (de) 2000-10-12

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