SG47504A1 - Enzymatic hydroxylation process for the preparation of hmgcoa reductase inhibitors and intermediates thereof - Google Patents

Enzymatic hydroxylation process for the preparation of hmgcoa reductase inhibitors and intermediates thereof

Info

Publication number: SG47504A1
Authority: SG; Singapore
Prior art keywords: preparation; reductase inhibitors; intermediates; hydroxylation process; hmgcoa reductase
Prior art date: 1993-10-22

Application number

SG1996002486A

Other languages

English (en)

Inventor

Brian L Davis

Laszlo Szarka

Paul M Cino

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1994-10-18

Publication date

1998-04-17

1994-10-18 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1998-04-17 Publication of SG47504A1 publication Critical patent/SG47504A1/en

Links

229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 3
230000033444 hydroxylation Effects 0.000 title abstract 3
238000005805 hydroxylation reaction Methods 0.000 title abstract 3
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title abstract 3
230000002255 enzymatic effect Effects 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title abstract 2
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
244000005700 microbiome Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SG1996002486A 1993-10-22 1994-10-18 Enzymatic hydroxylation process for the preparation of hmgcoa reductase inhibitors and intermediates thereof SG47504A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/141,316 US6043064A (en)	1993-10-22	1993-10-22	Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof

Publications (1)

Publication Number	Publication Date
SG47504A1 true SG47504A1 (en)	1998-04-17

Family

ID=22495167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996002486A SG47504A1 (en)	1993-10-22	1994-10-18	Enzymatic hydroxylation process for the preparation of hmgcoa reductase inhibitors and intermediates thereof

Country Status (19)

Country	Link
US (1)	US6043064A (de)
EP (1)	EP0649907B1 (de)
JP (1)	JP3683606B2 (de)
KR (1)	KR100342627B1 (de)
CN (1)	CN1085250C (de)
AT (1)	ATE196166T1 (de)
AU (1)	AU679113B2 (de)
CA (1)	CA2134025A1 (de)
CY (1)	CY2216B1 (de)
DE (1)	DE69425801T2 (de)
DK (1)	DK0649907T3 (de)
ES (1)	ES2150459T3 (de)
FI (1)	FI113279B (de)
GR (1)	GR3034835T3 (de)
HU (1)	HU217104B (de)
IL (1)	IL111084A (de)
PT (1)	PT649907E (de)
SG (1)	SG47504A1 (de)
TW (1)	TW438888B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2299634C (en)	1997-08-07	2007-10-16	Kyowa Hakko Kogyo Co., Ltd.	Process for the preparation of hmg-coa reductase inhibitors
AU9264598A (en) *	1997-08-22	1999-03-16	Gist-Brocades B.V.	Statin production by fermentation
SI9800144A (sl) *	1998-05-21	1999-12-31	LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d.	Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
IL144405A0 (en) *	1999-01-20	2002-05-23	Kyowa Hakko Kogyo Kk	Process for producing hmg-coa reductase inhibitors
US7049111B1 (en) *	1999-01-29	2006-05-23	Kyowa Hakko Kogyo Co., Ltd.	Process for producing HMG-CoA reductase inhibitor
HUP9902352A1 (hu) *	1999-07-12	2000-09-28	Gyógyszerkutató Intézet Kft.	Eljárás pravasztatin mikrobiológiai előállítására
JP2003093045A (ja) *	2001-09-26	2003-04-02	Godo Shusei Co Ltd	有用変換微生物
CA2461951C (en) *	2001-09-27	2011-08-09	Biocon Limited	Process for producing pravastatin sodium salt using streptomyces flavidovirens dsm 14455
EP1452602A1 (de) *	2003-02-25	2004-09-01	Antibiotic Co.,	Fermentatives Verfahren zur Herstellung von Pravastatin
TWI252253B (en) *	2004-01-09	2006-04-01	Chinese Petroleum Corp	A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same
JP5631534B2 (ja)	2005-11-29	2014-11-26	協和発酵バイオ株式会社	新規蛋白質および該蛋白質をコードするｄｎａ
WO2007137816A1 (en) *	2006-05-30	2007-12-06	Dsm Ip Assets B.V.	Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP1953233A1 (de) *	2007-02-02	2008-08-06	LEK Pharmaceuticals d.d.	Fermentationsverfahren zur Herstellung von Pravastatin
KR102741381B1 (ko)	2017-06-06	2024-12-11	지머젠 인코포레이티드	사카로폴리스포라 스피노사를 개량하기 위한 고 처리량(htp) 게놈 공학 플랫폼

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (de) *	1974-06-07	1981-03-18
US4206206A (en) *	1977-03-24	1980-06-03	Kowa Company, Ltd.	Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
US4444784A (en) *	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
MX7065E (es) *	1980-06-06	1987-04-10	Sankyo Co	Un procedimiento microbiologico para preparar derivados de ml-236b
US4450171A (en) *	1980-08-05	1984-05-22	Merck & Co., Inc.	Antihypercholesterolemic compounds
EP0069442B1 (de) *	1981-06-06	1985-02-20	Pfizer Limited	Fungizide Mittel, Verfahren zu deren Herstellung, und diese enthaltende pharmazeutische Zusammenstellungen
JPS5889191A (ja) *	1981-11-20	1983-05-27	Sankyo Co Ltd	３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS60176595A (ja) *	1984-02-21	1985-09-10	Akira Endo	生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
PT85109A (en) *	1986-06-23	1987-07-01	Merck & Co Inc	Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4857547A (en) *	1988-01-07	1989-08-15	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
EP0337548A3 (de) *	1988-04-15	1991-08-14	Merck & Co. Inc.	Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695)
JPH02245191A (ja) *	1989-02-01	1990-09-28	Merck & Co Inc	６―α―ヒドロキシメチルロバスタチン誘導体の製造方法
EP0408806A1 (de) *	1989-07-19	1991-01-23	Merck & Co. Inc.	Antihypercholesterolemische Mittel
MY106564A (en) *	1990-07-06	1995-06-30	Squibb & Sons Inc	Sulfur-substituted mevinic acid derivatives.
CA2053000C (en) *	1990-10-15	1995-08-29	Michael J. Conder	Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
IL108432A (en) *	1993-01-29	1997-09-30	Sankyo Co	DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL\| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

1993
- 1993-10-22 US US08/141,316 patent/US6043064A/en not_active Expired - Fee Related
1994
- 1994-09-29 IL IL111084A patent/IL111084A/en not_active IP Right Cessation
- 1994-10-01 TW TW083109094A patent/TW438888B/zh not_active IP Right Cessation
- 1994-10-18 PT PT94116409T patent/PT649907E/pt unknown
- 1994-10-18 DK DK94116409T patent/DK0649907T3/da active
- 1994-10-18 SG SG1996002486A patent/SG47504A1/en unknown
- 1994-10-18 ES ES94116409T patent/ES2150459T3/es not_active Expired - Lifetime
- 1994-10-18 EP EP94116409A patent/EP0649907B1/de not_active Expired - Lifetime
- 1994-10-18 DE DE69425801T patent/DE69425801T2/de not_active Expired - Fee Related
- 1994-10-18 AT AT94116409T patent/ATE196166T1/de not_active IP Right Cessation
- 1994-10-20 FI FI944926A patent/FI113279B/fi not_active IP Right Cessation
- 1994-10-21 KR KR1019940026933A patent/KR100342627B1/ko not_active Expired - Fee Related
- 1994-10-21 CA CA002134025A patent/CA2134025A1/en not_active Abandoned
- 1994-10-21 AU AU75972/94A patent/AU679113B2/en not_active Ceased
- 1994-10-21 HU HU9403061A patent/HU217104B/hu not_active IP Right Cessation
- 1994-10-21 JP JP25654894A patent/JP3683606B2/ja not_active Expired - Fee Related
- 1994-10-22 CN CN94117167A patent/CN1085250C/zh not_active Expired - Fee Related
2000
- 2000-11-13 GR GR20000402523T patent/GR3034835T3/el not_active IP Right Cessation
- 2000-11-28 CY CY0000057A patent/CY2216B1/xx unknown

Also Published As

Publication number	Publication date
HU217104B (hu)	1999-11-29
CA2134025A1 (en)	1995-04-23
FI944926L (fi)	1995-04-23
FI944926A0 (fi)	1994-10-20
AU679113B2 (en)	1997-06-19
DE69425801D1 (de)	2000-10-12
JP3683606B2 (ja)	2005-08-17
CN1085250C (zh)	2002-05-22
KR100342627B1 (ko)	2002-11-18
HUT69959A (en)	1995-09-28
JPH07184670A (ja)	1995-07-25
CN1106067A (zh)	1995-08-02
FI113279B (fi)	2004-03-31
IL111084A0 (en)	1994-11-28
EP0649907B1 (de)	2000-09-06
TW438888B (en)	2001-06-07
HK1014740A1 (en)	1999-09-30
DE69425801T2 (de)	2001-05-03
AU7597294A (en)	1995-05-11
IL111084A (en)	1998-01-04
EP0649907A1 (de)	1995-04-26
US6043064A (en)	2000-03-28
ATE196166T1 (de)	2000-09-15
ES2150459T3 (es)	2000-12-01
GR3034835T3 (en)	2001-02-28
CY2216B1 (en)	2003-04-18
PT649907E (pt)	2000-12-29
HU9403061D0 (en)	1994-12-28
KR950011616A (ko)	1995-05-15
DK0649907T3 (da)	2000-10-09

Publication	Publication Date	Title
HU9403061D0 (en)	1994-12-28	Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof
AU3075697A (en)	1997-12-05	Enzymatic process for the manufacture of ascorbic acid, 2-keto-l-gulonic acid and esters of 2-keto-l-gulonic acid
CA2311756A1 (en)	1999-06-17	Reduction of hair growth
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AU7610200A (en)	2001-05-10	Improved fermentation process
WO2000039276A3 (en)	2000-11-09	Microbial transformation method for the preparation of an epothilone
CA2235590A1 (en)	1997-05-29	Improved microbial production of indigo
DK0826773T3 (da)	2005-04-25	Fremgangsmåde til fremstilling af trans-4-hydroxy-L-prolin
EP0896057A3 (de)	2000-06-28	D-Aminoacylase
EP0927755A3 (de)	2002-09-18	Haloacetoacetatreductase,Verfahren zur Herstellung und Verfahren zur Herstellung von Alcoholen damit
AU1273000A (en)	2000-06-05	Process for preparing optically active-3-hydroxy-pyrrolidine derivatives by enzymatic hydroxylation
AU8978398A (en)	1999-02-16	Process for preparing amides
AU2818392A (en)	1993-01-14	Method for enhancing enzyme activities and the synthetic performance of organisms
EP0950706A3 (de)	1999-12-15	D-Aminoacylase
ATE161584T1 (de)	1998-01-15	Esterase und ihre verwendung in bioumwandlung
DK0645457T3 (da)	1998-12-07	Fremgangsmåde til fremstilling af cis-3-hydroxy-L-prolin
EP0909757A3 (de)	1999-04-28	Verfahren zur Herstellung optisch aktiver Pentatetraole
CA2131776A1 (en)	1995-10-06	Process for producing cis-3-hydroxy-l-proline
IL60449A0 (en)	1980-09-16	Process for obtaining cholesterol esterase from micro-organisms of the genus pseudomonas
AU2001265994A1 (en)	2001-12-03	Method for microbial production of difructose anhydride iii, micro-organism usedtherefor and enzyme with inulase ii activity and dna sequences coding therefor
AU2001291811A1 (en)	2002-03-13	Method for an enzymatic reaction of compounds having at least one nitrile function and/or at least one amide function
WO2000018950A3 (en)	2000-07-27	Assay method for ntp hydrolising enzymes
DK0806479T3 (da)	2003-10-06	Produktion af biotin ved fermentering
IT1255470B (it)	1995-11-02	Composti attivi come inibitori dell'enzima hmg-coa reduttasi
CA2131775A1 (en)	1995-06-28	Process for producing trans-4-hydroxy-l-proline