CZ2006533A3 - Amorfní ritonavir, způsoby jeho přípravy, jeho použití a farmaceutická kompozice ho obsahující - Google Patents

Amorfní ritonavir, způsoby jeho přípravy, jeho použití a farmaceutická kompozice ho obsahující

Info

Publication number: CZ2006533A3
Authority: CZ; Czechia
Prior art keywords: preparation; methods; pharmaceutical composition; amorphous ritonavir; ritonavir
Prior art date: 1998-07-20

Application number

CZ2006533A

Other languages

English (en)

Other versions

CZ307116B6 (cs

Inventor

John F Bauer

Azita Saleki-Gerhardt

Bikshandarkoil A Narayanan

Sanjay R Chemburkar

Ketan Patel

Harry O Spiwek

Philip E Bauer

Kimberley A Allen

Original Assignee

Abbvie Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-20

Filing date

1999-07-19

Publication date

2001-05-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26817251&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CZ2006533(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-07-19 Application filed by Abbvie Inc filed Critical Abbvie Inc

2001-05-16 Publication of CZ2006533A3 publication Critical patent/CZ2006533A3/cs

2018-01-24 Publication of CZ307116B6 publication Critical patent/CZ307116B6/cs

Links

NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 title 1
229960000311 ritonavir Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

CZ2006-533A 1998-07-20 1999-07-19 Amorfní ritonavir, způsoby jeho přípravy, jeho použití a farmaceutická kompozice ho obsahující CZ307116B6 (cs)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11934598A	1998-07-20	1998-07-20
US32609399A	1999-06-04	1999-06-04

Publications (2)

Publication Number	Publication Date
CZ2006533A3 true CZ2006533A3 (cs)	2001-05-16
CZ307116B6 CZ307116B6 (cs)	2018-01-24

Family

ID=26817251

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CZ2006-533A CZ307116B6 (cs)	1998-07-20	1999-07-19	Amorfní ritonavir, způsoby jeho přípravy, jeho použití a farmaceutická kompozice ho obsahující
CZ20010203A CZ298188B6 (cs)	1998-07-20	1999-07-19	Krystalický polymorf ritonaviru a zpusob jeho prípravy

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CZ20010203A CZ298188B6 (cs)	1998-07-20	1999-07-19	Krystalický polymorf ritonaviru a zpusob jeho prípravy

Country Status (29)

Country	Link
EP (4)	EP1097148B1 (cs)
JP (4)	JP4815050B2 (cs)
KR (3)	KR100793046B1 (cs)
CN (5)	CN1310715B (cs)
AR (5)	AR019431A1 (cs)
AT (3)	ATE425974T1 (cs)
AU (1)	AU768207B2 (cs)
BG (4)	BG65150B1 (cs)
BR (1)	BR9912010A (cs)
CA (3)	CA2674800A1 (cs)
CO (1)	CO5090830A1 (cs)
CY (2)	CY1111600T1 (cs)
CZ (2)	CZ307116B6 (cs)
DE (2)	DE69915628T2 (cs)
DK (3)	DK1418174T3 (cs)
ES (3)	ES2372990T3 (cs)
HU (3)	HU227540B1 (cs)
ID (1)	ID27996A (cs)
IL (4)	IL140492A0 (cs)
MY (2)	MY121765A (cs)
NO (2)	NO318385B1 (cs)
NZ (2)	NZ522690A (cs)
PL (2)	PL213978B1 (cs)
PT (3)	PT1418174E (cs)
SI (3)	SI2017269T1 (cs)
SK (3)	SK287381B6 (cs)
TR (1)	TR200100171T2 (cs)
TW (3)	TWI362382B (cs)
WO (1)	WO2000004016A2 (cs)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6894171B1 (en)	1998-07-20	2005-05-17	Abbott Laboratories	Polymorph of a pharmaceutical
MY121765A (en) *	1998-07-20	2006-02-28	Abbott Lab	Polymorph of ritonavir
PT1183026E (pt) *	1999-06-04	2006-11-30	Abbott Lab	Formulações farmacêuticas melhoradas incluindo ritonavir
MXPA03010771A (es) *	2001-05-25	2004-07-01	Abbott Lab	Capsulas elasticas blandas que comprenden ritonavir y/o lopinavir.
AR037797A1 (es) *	2001-12-12	2004-12-01	Tibotec Pharm Ltd	Combinacion de inhibidores de proteasa dependientes del citocromo p450
US7205413B2 (en)	2002-05-03	2007-04-17	Transform Pharmaceuticals, Inc.	Solvates and polymorphs of ritonavir and methods of making and using the same
US8377952B2 (en) *	2003-08-28	2013-02-19	Abbott Laboratories	Solid pharmaceutical dosage formulation
BRPI0401742B8 (pt)	2004-05-13	2021-05-25	Cristalia Produtos Quim Farmaceuticos Ltda	composto análogo do ritonavir útil como inibidor de protease retroviral, preparação do composto análogo do ritonavir e composição farmacêutica do composto análogo do ritonavir
US20080312300A1 (en) *	2005-05-30	2008-12-18	Yoginder Pal Sachdeva	Processes for the Preparation of Stable Polymorphic Form I of Ritonavir
WO2008041176A2 (en) *	2006-10-03	2008-04-10	Ranbaxy Laboratories Limited	Process for the preparation of form i and form ii of ritonavir
CN102898398B (zh) *	2011-07-27	2015-01-14	上海迪赛诺药业有限公司	一种制备i型利托那韦多晶型结晶的方法
CA2866203A1 (en)	2012-03-07	2013-09-12	Ratiopharm Gmbh	Dosage form comprising non-crystalline lopinavir and crystalline ritonavir
US9370578B2 (en)	2012-03-07	2016-06-21	Ratiopharm Gmbh	Dosage form comprising lopinavir and ritonavir
HK1220390A1 (zh)	2013-08-29	2017-05-05	Teva Pharmaceutical Industries Ltd.	包括恩曲他滨，替诺福韦，达芦那韦和利托那韦的单位剂型以及包含达芦那韦和利托那韦的单体片剂
EP3129009A1 (en)	2014-04-08	2017-02-15	Teva Pharmaceutical Industries Ltd	Unit dosage form comprising emtricitabine, tenofovir, darunavir and ritonavir
CN106749085B (zh) *	2016-12-23	2019-05-24	东北制药集团股份有限公司	一种制备利托那韦的方法
EP3569225A1 (en)	2018-05-18	2019-11-20	Pharmaceutical Oriented Services Ltd	Solid dispersion containing ritonavir
RU2759544C1 (ru) *	2021-01-29	2021-11-15	Общество с ограниченной ответственностью "АМЕДАРТ"	Твёрдая фармацевтическая композиция для изготовления перорального терапевтического средства для профилактики и/или лечения ВИЧ-инфекции

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5354866A (en)	1989-05-23	1994-10-11	Abbott Laboratories	Retroviral protease inhibiting compounds
US5696270A (en)	1989-05-23	1997-12-09	Abbott Laboratories	Intermediate for making retroviral protease inhibiting compounds
DE69334250D1 (de) *	1992-12-29	2009-01-29	Abbott Lab	Verfahren und Intermediate zur Herstellung von retroviralen Proteasehemmern
IL110752A (en)	1993-09-13	2000-07-26	Abbott Lab	Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en) *	1993-10-01	1996-09-24	Abbott Laboratories	Pharmaceutical composition
US5491253A (en)	1993-10-22	1996-02-13	Abbott Laboratories	Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
IL111991A (en)	1994-01-28	2000-07-26	Abbott Lab	Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
US5567823A (en) *	1995-06-06	1996-10-22	Abbott Laboratories	Process for the preparation of an HIV protease inhibiting compound
US6037157A (en)	1995-06-29	2000-03-14	Abbott Laboratories	Method for improving pharmacokinetics
US6160122A (en)	1996-06-28	2000-12-12	Abbott Laboratories	Process for the preparation of a disubstituted thiazole
ZA9710071B (en)	1996-11-21	1998-05-25	Abbott Lab	Pharmaceutical composition.
MY121765A (en) *	1998-07-20	2006-02-28	Abbott Lab	Polymorph of ritonavir
DE19856432A1 (de) *	1998-12-08	2000-06-15	Basf Ag	Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen
PT1183026E (pt) *	1999-06-04	2006-11-30	Abbott Lab	Formulações farmacêuticas melhoradas incluindo ritonavir

1999
- 1999-07-16 MY MYPI9903007 patent/MY121765A/en unknown
- 1999-07-16 MY MYPI0402546 patent/MY145265A/en unknown
- 1999-07-16 CO CO99045166A patent/CO5090830A1/es unknown
- 1999-07-19 SI SI9931066T patent/SI2017269T1/sl unknown
- 1999-07-19 TR TR200100171T patent/TR200100171T2/xx unknown
- 1999-07-19 SI SI9930586T patent/SI1097148T1/xx unknown
- 1999-07-19 IL IL14049299A patent/IL140492A0/xx unknown
- 1999-07-19 PT PT03029709T patent/PT1418174E/pt unknown
- 1999-07-19 CA CA 2674800 patent/CA2674800A1/en not_active Abandoned
- 1999-07-19 SI SI9931030T patent/SI1418174T1/sl unknown
- 1999-07-19 CZ CZ2006-533A patent/CZ307116B6/cs not_active IP Right Cessation
- 1999-07-19 EP EP19990934143 patent/EP1097148B1/en not_active Expired - Lifetime
- 1999-07-19 SK SK5029-2008A patent/SK287381B6/sk not_active IP Right Cessation
- 1999-07-19 EP EP20080007622 patent/EP2017269B1/en not_active Expired - Lifetime
- 1999-07-19 ES ES08007622T patent/ES2372990T3/es not_active Expired - Lifetime
- 1999-07-19 CN CN998089273A patent/CN1310715B/zh not_active Expired - Lifetime
- 1999-07-19 DK DK03029709T patent/DK1418174T3/da active
- 1999-07-19 CA CA 2337846 patent/CA2337846C/en not_active Expired - Lifetime
- 1999-07-19 KR KR1020017000857A patent/KR100793046B1/ko not_active Expired - Lifetime
- 1999-07-19 ES ES99934143T patent/ES2214038T3/es not_active Expired - Lifetime
- 1999-07-19 CN CNA2008100805471A patent/CN101259128A/zh active Pending
- 1999-07-19 BR BR9912010A patent/BR9912010A/pt not_active Application Discontinuation
- 1999-07-19 HU HU0103823A patent/HU227540B1/hu unknown
- 1999-07-19 ES ES03029709T patent/ES2322759T3/es not_active Expired - Lifetime
- 1999-07-19 DK DK08007622T patent/DK2017269T3/da active
- 1999-07-19 NZ NZ522690A patent/NZ522690A/en not_active IP Right Cessation
- 1999-07-19 HU HU0800266A patent/HU230150B1/hu unknown
- 1999-07-19 CZ CZ20010203A patent/CZ298188B6/cs not_active IP Right Cessation
- 1999-07-19 NZ NZ50912599A patent/NZ509125A/xx not_active IP Right Cessation
- 1999-07-19 PT PT99934143T patent/PT1097148E/pt unknown
- 1999-07-19 JP JP2000560122A patent/JP4815050B2/ja not_active Expired - Lifetime
- 1999-07-19 KR KR1020047011204A patent/KR100740796B1/ko not_active Expired - Lifetime
- 1999-07-19 CN CN2011100389228A patent/CN102153524A/zh active Pending
- 1999-07-19 PL PL381194A patent/PL213978B1/pl unknown
- 1999-07-19 EP EP20100179472 patent/EP2298751A3/en not_active Withdrawn
- 1999-07-19 DK DK99934143T patent/DK1097148T3/da active
- 1999-07-19 AT AT03029709T patent/ATE425974T1/de active
- 1999-07-19 KR KR1020067022587A patent/KR100853371B1/ko not_active Expired - Lifetime
- 1999-07-19 CA CA 2510949 patent/CA2510949C/en not_active Expired - Lifetime
- 1999-07-19 PT PT08007622T patent/PT2017269E/pt unknown
- 1999-07-19 HU HUP0800267A patent/HU229999B1/hu unknown
- 1999-07-19 SK SK92-2001A patent/SK286388B6/sk not_active IP Right Cessation
- 1999-07-19 DE DE1999615628 patent/DE69915628T2/de not_active Expired - Lifetime
- 1999-07-19 SK SK5028-2008A patent/SK287586B6/sk not_active IP Right Cessation
- 1999-07-19 AT AT99934143T patent/ATE261947T1/de active
- 1999-07-19 EP EP20030029709 patent/EP1418174B1/en not_active Expired - Lifetime
- 1999-07-19 CN CNA2003101181720A patent/CN1502613A/zh active Pending
- 1999-07-19 DE DE69940616T patent/DE69940616D1/de not_active Expired - Lifetime
- 1999-07-19 AT AT08007622T patent/ATE534636T1/de active
- 1999-07-19 AU AU50037/99A patent/AU768207B2/en not_active Expired
- 1999-07-19 WO PCT/US1999/016334 patent/WO2000004016A2/en not_active Ceased
- 1999-07-19 ID ID20010165A patent/ID27996A/id unknown
- 1999-07-19 PL PL99348033A patent/PL194710B1/pl unknown
- 1999-07-19 CN CN2010101669679A patent/CN101966180A/zh active Pending
- 1999-07-20 AR ARP990103557 patent/AR019431A1/es active IP Right Grant
- 1999-07-31 TW TW95132288A patent/TWI362382B/zh not_active IP Right Cessation
- 1999-07-31 TW TW88112226A patent/TWI227713B/zh not_active IP Right Cessation
- 1999-07-31 TW TW90127014A patent/TWI271400B/zh not_active IP Right Cessation
2000
- 2000-12-22 IL IL14049200A patent/IL140492A/en not_active IP Right Cessation
2001
- 2001-01-18 NO NO20010298A patent/NO318385B1/no not_active IP Right Cessation
- 2001-01-30 BG BG105197A patent/BG65150B1/bg unknown
2004
- 2004-04-20 AR ARP040101329 patent/AR044029A2/es not_active Application Discontinuation
- 2004-06-09 NO NO20042393A patent/NO327320B1/no not_active IP Right Cessation
2005
- 2005-06-29 AR ARP050102703 patent/AR049658A2/es not_active Application Discontinuation
2006
- 2006-09-20 BG BG109682A patent/BG65963B1/bg unknown
- 2006-09-20 BG BG110080A patent/BG110080A/bg unknown
2007
- 2007-03-06 AR ARP070100928 patent/AR059763A2/es unknown
- 2007-03-06 AR ARP070100929 patent/AR059764A2/es not_active Application Discontinuation
- 2007-11-05 IL IL18718107A patent/IL187181A/en not_active IP Right Cessation
2008
- 2008-03-12 BG BG10110080A patent/BG66140B1/bg unknown
- 2008-05-20 IL IL191582A patent/IL191582A/en not_active IP Right Cessation
2009
- 2009-06-11 CY CY20091100614T patent/CY1111600T1/el unknown
2010
- 2010-07-22 JP JP2010164769A patent/JP5732212B2/ja not_active Expired - Lifetime
2011
- 2011-12-05 CY CY20111101205T patent/CY1112139T1/el unknown
2013
- 2013-12-11 JP JP2013255680A patent/JP2014074047A/ja active Pending
2016
- 2016-10-21 JP JP2016206663A patent/JP2017061475A/ja active Pending

Also Published As

Publication number	Publication date
PT2017269E (pt)	2011-12-20
TWI271400B (en)	2007-01-21
HUP0103823A2 (hu)	2002-02-28
SI1097148T1 (en)	2004-10-31
KR100853371B1 (ko)	2008-08-22
PT1097148E (pt)	2004-05-31
PL213978B1 (pl)	2013-05-31
HU0800266D0 (en)	2008-06-30
CA2510949A1 (en)	2000-01-27
SK286388B6 (sk)	2008-09-05
ID27996A (id)	2001-05-03
JP5732212B2 (ja)	2015-06-10
EP1097148A2 (en)	2001-05-09
DK1418174T3 (da)	2009-05-18
CA2337846A1 (en)	2000-01-27
EP2017269A3 (en)	2009-06-10
KR100793046B1 (ko)	2008-01-10
DK1097148T3 (da)	2004-04-26
JP2002520410A (ja)	2002-07-09
EP2017269A9 (en)	2009-10-14
CY1111600T1 (el)	2015-10-07
MY121765A (en)	2006-02-28
BG105197A (en)	2001-10-31
AR049658A2 (es)	2006-08-23
ES2372990T3 (es)	2012-01-30
DE69915628T2 (de)	2004-08-12
JP2014074047A (ja)	2014-04-24
CN1310715A (zh)	2001-08-29
NO327320B1 (no)	2009-06-08
SK287586B6 (sk)	2011-03-04
IL140492A0 (en)	2002-02-10
HU229999B1 (hu)	2015-04-28
KR20040081137A (ko)	2004-09-20
CZ2001203A3 (en)	2001-05-16
NO20010298L (no)	2001-01-18
IL187181A0 (en)	2008-02-09
WO2000004016A3 (en)	2000-03-30
SI2017269T1 (sl)	2012-02-29
BR9912010A (pt)	2001-04-10
EP1418174A3 (en)	2004-06-23
SK922001A3 (en)	2001-07-10
JP2017061475A (ja)	2017-03-30
CA2674800A1 (en)	2000-01-27
EP2298751A2 (en)	2011-03-23
TW200716550A (en)	2007-05-01
AU5003799A (en)	2000-02-07
HU230150B1 (hu)	2015-09-28
EP2017269B1 (en)	2011-11-23
ES2322759T3 (es)	2009-06-26
HU227540B1 (en)	2011-08-29
IL191582A0 (en)	2008-12-29
TWI362382B (en)	2012-04-21
WO2000004016A2 (en)	2000-01-27
NZ522690A (en)	2004-04-30
NO20010298D0 (no)	2001-01-18
DE69915628D1 (en)	2004-04-22
PT1418174E (pt)	2009-06-08
IL191582A (en)	2016-02-29
KR20010072003A (ko)	2001-07-31
CO5090830A1 (es)	2001-10-30
KR100740796B1 (ko)	2007-07-20
BG65150B1 (bg)	2007-04-30
TR200100171T2 (tr)	2001-05-21
HK1037918A1 (en)	2002-02-22
EP1097148B1 (en)	2004-03-17
MY145265A (en)	2012-01-13
ES2214038T3 (es)	2004-09-01
JP4815050B2 (ja)	2011-11-16
HK1121155A1 (en)	2009-04-17
PL194710B1 (pl)	2007-06-29
AU768207B2 (en)	2003-12-04
CA2510949C (en)	2009-11-17
CA2337846C (en)	2006-02-21
EP2298751A3 (en)	2011-08-17
HU0800267D0 (en)	2008-06-30
PL348033A1 (en)	2002-05-06
HUP0103823A3 (en)	2003-05-28
NO20042393L (no)	2001-01-18
EP1418174A2 (en)	2004-05-12
EP2017269A2 (en)	2009-01-21
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AR044029A2 (es)	2005-08-24
CZ307116B6 (cs)	2018-01-24
SI1418174T1 (sl)	2009-08-31
CN1502613A (zh)	2004-06-09
EP1418174B1 (en)	2009-03-18
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Legal Events

Date	Code	Title	Description
2019-07-31	MK4A	Patent expired	Effective date: 20190719

Publication	Publication Date	Title
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GB9817470D0 (en)	1998-10-07	Pharmaceutical formulation
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HUP9803041A3 (en)	2001-04-28	Thiazole derivatives, process for the preparation thereof, use thereof and pharmaceutical compositions containing them
AU2880699A (en)	1999-10-25	Pharmaceutical compositions and methods for use