CZ9502002A3 - 4-HYDROXYBENZOPYRAN-2-ONES AND 4-HYDROXYCYCLOALKYL(b)PYRAN-2 ONES USEFUL FOR TREATING RETROVIRAL INFECTIONS - Google Patents

4-HYDROXYBENZOPYRAN-2-ONES AND 4-HYDROXYCYCLOALKYL(b)PYRAN-2 ONES USEFUL FOR TREATING RETROVIRAL INFECTIONS

Info

Publication number
CZ9502002A3
CZ9502002A3 CZ952002A CZ200295A CZ9502002A3 CZ 9502002 A3 CZ9502002 A3 CZ 9502002A3 CZ 952002 A CZ952002 A CZ 952002A CZ 200295 A CZ200295 A CZ 200295A CZ 9502002 A3 CZ9502002 A3 CZ 9502002A3
Authority
CZ
Czechia
Prior art keywords
ones
pyran
pct
hydroxybenzopyran
hydroxycycloalkyl
Prior art date
Application number
CZ952002A
Other languages
English (en)
Inventor
David John Anderson
Lee S Banitt
Paul Kosta Tomich
Michael John Bohanon
Steven Ronald Turner
Joseph Walter Strohbach
Suvit Thaisrivongs
Chih-Ping Yang
Richard Charles Thomas
Karen Rene Romines
Paul Adrian Aristoff
Harvey Irving Skulnick
Paul D Johnson
Ronald B Gammill
Qingwei Zhang
Gordon L Bundy
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of CZ9502002A3 publication Critical patent/CZ9502002A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CZ952002A 1993-02-05 1994-02-03 4-HYDROXYBENZOPYRAN-2-ONES AND 4-HYDROXYCYCLOALKYL(b)PYRAN-2 ONES USEFUL FOR TREATING RETROVIRAL INFECTIONS CZ9502002A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1445993A 1993-02-05 1993-02-05
US6871593A 1993-05-27 1993-05-27
US16930293A 1993-12-17 1993-12-17

Publications (1)

Publication Number Publication Date
CZ9502002A3 true CZ9502002A3 (en) 1995-12-13

Family

ID=27360109

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ952002A CZ9502002A3 (en) 1993-02-05 1994-02-03 4-HYDROXYBENZOPYRAN-2-ONES AND 4-HYDROXYCYCLOALKYL(b)PYRAN-2 ONES USEFUL FOR TREATING RETROVIRAL INFECTIONS

Country Status (22)

Country Link
US (1) US5686486A (cs)
EP (1) EP0682663B1 (cs)
JP (2) JPH08505641A (cs)
CN (1) CN1117291A (cs)
AT (1) ATE200669T1 (cs)
AU (1) AU6166194A (cs)
CA (1) CA2153237A1 (cs)
CZ (1) CZ9502002A3 (cs)
DE (1) DE69427120T2 (cs)
DK (1) DK0682663T3 (cs)
FI (1) FI953717A7 (cs)
GR (1) GR3036189T3 (cs)
HU (1) HUT72755A (cs)
IL (1) IL108459A0 (cs)
LV (1) LV12863B (cs)
NO (1) NO953070L (cs)
NZ (1) NZ262255A (cs)
PL (1) PL310111A1 (cs)
PT (1) PT682663E (cs)
RU (1) RU2125999C1 (cs)
SK (1) SK95695A3 (cs)
WO (1) WO1994018188A1 (cs)

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US20110306605A1 (en) * 2008-12-22 2011-12-15 Sloan-Kettering Institute For Cancer Research Coumarin-based compounds for the treatment of alzheimer's disease and cancer
CN102040592B (zh) * 2009-10-10 2015-07-15 西南大学 具有抗微生物活性的香豆素唑类化合物、制备方法和医药用途
CA2892606A1 (en) * 2012-12-06 2014-06-12 Baruch S. Blumberg Institute Functionalized benzamide derivatives as antiviral agents against hbv infection
CA2902624C (en) 2013-02-28 2021-05-18 Takeda Pharmaceutical Company Limited Method for producing sulfonyl chloride compound
CN105050983A (zh) 2013-03-15 2015-11-11 微麦德斯公司 用于制备烷基呋喃的方法
BR112016015449A8 (pt) * 2013-12-30 2020-06-09 Lifesci Pharmaceuticals Inc compostos inibidores terapêuticos, composição farmacêutica os compreendendo e uso dos mesmos
WO2016040527A1 (en) * 2014-09-09 2016-03-17 Vanderbilt University Metabolism probes for therapy and diagnosis
CN104374858B (zh) * 2014-11-21 2016-06-29 宜昌人福药业有限责任公司 一种枸橼酸舒芬太尼合成原料及杂质的检测方法
CN105218530B (zh) * 2015-10-20 2019-07-02 青岛农业大学 3-(1-芳基-2-(2-氮杂芳烃)乙基)-4-羟基香豆素及其制备方法
CN109608421A (zh) * 2019-01-22 2019-04-12 河北科技大学 一种5-氨基酮戊酸盐酸盐的合成方法
RU2707103C1 (ru) * 2019-06-15 2019-11-22 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" Кумарины с бициклическими монотерпеновыми заместителями
WO2021158575A1 (en) * 2020-02-03 2021-08-12 Natural Extraction Systems, LLC Compositions related to bioactive agents that convert from anions to molecules
WO2022182523A1 (en) * 2021-02-26 2022-09-01 Natural Extraction Systems, LLC Compositions related to bioactive agents that convert from anions to molecules
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Also Published As

Publication number Publication date
EP0682663B1 (en) 2001-04-18
US5686486A (en) 1997-11-11
PL310111A1 (en) 1995-11-27
DK0682663T3 (da) 2001-06-18
HU9501968D0 (en) 1995-09-28
JP2005002133A (ja) 2005-01-06
NZ262255A (en) 1997-05-26
NO953070D0 (no) 1995-08-04
FI953717L (fi) 1995-08-04
AU6166194A (en) 1994-08-29
CA2153237A1 (en) 1994-08-18
CN1117291A (zh) 1996-02-21
NO953070L (no) 1995-10-04
WO1994018188A1 (en) 1994-08-18
GR3036189T3 (en) 2001-10-31
FI953717A0 (fi) 1995-08-04
ATE200669T1 (de) 2001-05-15
RU2125999C1 (ru) 1999-02-10
HUT72755A (en) 1996-05-28
FI953717A7 (fi) 1995-08-04
LV12863B (en) 2002-11-20
SK95695A3 (en) 1995-12-06
JPH08505641A (ja) 1996-06-18
IL108459A0 (en) 1994-04-12
PT682663E (pt) 2001-10-30
DE69427120D1 (de) 2001-05-23
DE69427120T2 (de) 2001-08-23
EP0682663A1 (en) 1995-11-22

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