DK0682663T3 - 4-Hydroxybenzopyran-2-oner og 4-hydroxycycloalkyl[b]pyran-2-oner, der er nyttige til behandling af retrovirale infektioner - Google Patents

4-Hydroxybenzopyran-2-oner og 4-hydroxycycloalkyl[b]pyran-2-oner, der er nyttige til behandling af retrovirale infektioner

Info

Publication number
DK0682663T3
DK0682663T3 DK94908648T DK94908648T DK0682663T3 DK 0682663 T3 DK0682663 T3 DK 0682663T3 DK 94908648 T DK94908648 T DK 94908648T DK 94908648 T DK94908648 T DK 94908648T DK 0682663 T3 DK0682663 T3 DK 0682663T3
Authority
DK
Denmark
Prior art keywords
ones
pyran
pct
hydroxybenzopyran
hydroxycycloalkyl
Prior art date
Application number
DK94908648T
Other languages
English (en)
Inventor
Qingwei Zhang
Gordon L Bundy
Richard Charles Thomas
Harvey Irving Skulnick
Ronald B Gammill
Paul Adrian Aristoff
Paul D Johnson
David John Anderson
Lee S Banitt
Paul Kosta Tomich
Michael John Bohanon
Steven Ronald Turner
Joseph Walter Strohbach
Suvit Thaisrivongs
Chih-Ping Yang
Karen Rene Romines
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0682663T3 publication Critical patent/DK0682663T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK94908648T 1993-02-05 1994-02-03 4-Hydroxybenzopyran-2-oner og 4-hydroxycycloalkyl[b]pyran-2-oner, der er nyttige til behandling af retrovirale infektioner DK0682663T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1445993A 1993-02-05 1993-02-05
US6871593A 1993-05-27 1993-05-27
US16930293A 1993-12-17 1993-12-17
PCT/US1994/000938 WO1994018188A1 (en) 1993-02-05 1994-02-03 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl[b]pyran-2-ones useful to treat retroviral infections

Publications (1)

Publication Number Publication Date
DK0682663T3 true DK0682663T3 (da) 2001-06-18

Family

ID=27360109

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94908648T DK0682663T3 (da) 1993-02-05 1994-02-03 4-Hydroxybenzopyran-2-oner og 4-hydroxycycloalkyl[b]pyran-2-oner, der er nyttige til behandling af retrovirale infektioner

Country Status (22)

Country Link
US (1) US5686486A (da)
EP (1) EP0682663B1 (da)
JP (2) JPH08505641A (da)
CN (1) CN1117291A (da)
AT (1) ATE200669T1 (da)
AU (1) AU6166194A (da)
CA (1) CA2153237A1 (da)
CZ (1) CZ9502002A3 (da)
DE (1) DE69427120T2 (da)
DK (1) DK0682663T3 (da)
FI (1) FI953717A7 (da)
GR (1) GR3036189T3 (da)
HU (1) HUT72755A (da)
IL (1) IL108459A0 (da)
LV (1) LV12863B (da)
NO (1) NO953070L (da)
NZ (1) NZ262255A (da)
PL (1) PL310111A1 (da)
PT (1) PT682663E (da)
RU (1) RU2125999C1 (da)
SK (1) SK95695A3 (da)
WO (1) WO1994018188A1 (da)

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CN102040592B (zh) * 2009-10-10 2015-07-15 西南大学 具有抗微生物活性的香豆素唑类化合物、制备方法和医药用途
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CN106061480B (zh) * 2013-12-30 2020-02-28 莱福斯希医药公司 治疗性抑制性化合物
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CN104374858B (zh) * 2014-11-21 2016-06-29 宜昌人福药业有限责任公司 一种枸橼酸舒芬太尼合成原料及杂质的检测方法
CN105218530B (zh) * 2015-10-20 2019-07-02 青岛农业大学 3-(1-芳基-2-(2-氮杂芳烃)乙基)-4-羟基香豆素及其制备方法
CN109608421A (zh) * 2019-01-22 2019-04-12 河北科技大学 一种5-氨基酮戊酸盐酸盐的合成方法
RU2707103C1 (ru) * 2019-06-15 2019-11-22 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" Кумарины с бициклическими монотерпеновыми заместителями
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WO2022182523A1 (en) * 2021-02-26 2022-09-01 Natural Extraction Systems, LLC Compositions related to bioactive agents that convert from anions to molecules
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Also Published As

Publication number Publication date
FI953717A0 (fi) 1995-08-04
IL108459A0 (en) 1994-04-12
AU6166194A (en) 1994-08-29
CA2153237A1 (en) 1994-08-18
HUT72755A (en) 1996-05-28
LV12863B (en) 2002-11-20
NO953070D0 (no) 1995-08-04
EP0682663A1 (en) 1995-11-22
JP2005002133A (ja) 2005-01-06
PT682663E (pt) 2001-10-30
GR3036189T3 (en) 2001-10-31
US5686486A (en) 1997-11-11
FI953717L (fi) 1995-08-04
PL310111A1 (en) 1995-11-27
JPH08505641A (ja) 1996-06-18
HU9501968D0 (en) 1995-09-28
ATE200669T1 (de) 2001-05-15
CZ9502002A3 (en) 1995-12-13
DE69427120T2 (de) 2001-08-23
RU2125999C1 (ru) 1999-02-10
FI953717A7 (fi) 1995-08-04
CN1117291A (zh) 1996-02-21
SK95695A3 (en) 1995-12-06
NZ262255A (en) 1997-05-26
WO1994018188A1 (en) 1994-08-18
NO953070L (no) 1995-10-04
EP0682663B1 (en) 2001-04-18
DE69427120D1 (de) 2001-05-23

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