DD133950A5 - Verfahren zur herstellung von morphinderivaten - Google Patents

Verfahren zur herstellung von morphinderivaten

Info

Publication number
DD133950A5
DD133950A5 DD78204349A DD20434978A DD133950A5 DD 133950 A5 DD133950 A5 DD 133950A5 DD 78204349 A DD78204349 A DD 78204349A DD 20434978 A DD20434978 A DD 20434978A DD 133950 A5 DD133950 A5 DD 133950A5
Authority
DD
German Democratic Republic
Prior art keywords
preparation
morphine derivatives
morphine
derivatives
Prior art date
Application number
DD78204349A
Other languages
German (de)
English (en)
Inventor
Ryszard J Kobylecki
Ian G Guest
John W Lewis
Gordon W Kirby
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of DD133950A5 publication Critical patent/DD133950A5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD78204349A 1977-03-23 1978-03-22 Verfahren zur herstellung von morphinderivaten DD133950A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12325/77A GB1593191A (en) 1977-03-23 1977-03-23 Derivatives of morphine

Publications (1)

Publication Number Publication Date
DD133950A5 true DD133950A5 (de) 1979-01-31

Family

ID=10002423

Family Applications (1)

Application Number Title Priority Date Filing Date
DD78204349A DD133950A5 (de) 1977-03-23 1978-03-22 Verfahren zur herstellung von morphinderivaten

Country Status (24)

Country Link
US (1) US4241066A (2)
JP (1) JPS53119899A (2)
AT (1) AT361139B (2)
AU (1) AU519643B2 (2)
BE (1) BE865183A (2)
CA (1) CA1089456A (2)
CH (1) CH629809A5 (2)
CS (1) CS200542B2 (2)
DD (1) DD133950A5 (2)
DE (1) DE2812580A1 (2)
DK (1) DK149858C (2)
ES (1) ES468173A1 (2)
FI (1) FI68236C (2)
FR (1) FR2384774A1 (2)
GB (1) GB1593191A (2)
IE (1) IE46443B1 (2)
IT (1) IT1105176B (2)
LU (1) LU79294A1 (2)
NL (1) NL7803083A (2)
NZ (1) NZ186692A (2)
PL (1) PL114723B1 (2)
SE (1) SE436131B (2)
SU (1) SU921467A3 (2)
ZA (1) ZA781527B (2)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
EP0103636B1 (en) * 1982-03-16 1990-09-12 Rockefeller University Use of opium antagonists for the manufacture of medicaments for controlling gastrointestinal dysmotility
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
KR970011390B1 (ko) * 1992-01-23 1997-07-10 도레이 가부시키가이샤 모르피난 유도체와 약리학적으로 허용되는 이의 산 부가염 및 이를 함유하는 약제학적 조성물
IT1269826B (it) * 1994-05-24 1997-04-15 Paolo Minoia Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate
HRP20150037T4 (hr) 2003-04-08 2022-09-02 Progenics Pharmaceuticals, Inc. Farmaceutske formulacije koje sadrže metilnaltrekson
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
ES2357216T3 (es) 2005-06-16 2011-04-20 Mallinckrodt, Inc. Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
KR101421747B1 (ko) * 2006-04-21 2014-07-30 넥타르 테라퓨틱스 모르피논의 입체선택적 환원
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
MX2009010550A (es) 2007-03-29 2009-12-14 Progenics Pharm Inc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
SI2565195T1 (sl) 2007-03-29 2015-09-30 Wyeth Llc Periferalni opioidni receptorji in antagonisti in njih uporaba
CL2008000905A1 (es) 2007-03-29 2008-08-22 Progenics Pharm Inc Compuestos derivados de morfina, antagonistas del receptor opioide periferico; metodo de preparacion; composicion farmaceutica; y uso para reducir los efectos de la actividad opioide endogena.
EP2240489A1 (en) 2008-02-06 2010-10-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
CA2738761C (en) 2008-09-30 2019-10-29 Mallinckrodt Inc. Processes for the production of buprenorphine with reduced impurity formation
CA2738758C (en) 2008-09-30 2016-11-29 Mallinckrodt Inc. Processes for the alkylation of norbuprenorphine with reduced impurity formation
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322771A (en) * 1967-05-30 Intermediates for preparing thebaine derivatives
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby

Also Published As

Publication number Publication date
FI780882A7 (fi) 1978-09-24
FR2384774B1 (2) 1981-10-16
FR2384774A1 (fr) 1978-10-20
SU921467A3 (ru) 1982-04-15
CH629809A5 (fr) 1982-05-14
SE436131B (sv) 1984-11-12
IE46443B1 (en) 1983-06-15
AU519643B2 (en) 1981-12-17
GB1593191A (en) 1981-07-15
CS200542B2 (en) 1980-09-15
DK149858C (da) 1987-06-29
ATA204278A (de) 1980-07-15
IE780515L (en) 1978-09-23
ES468173A1 (es) 1979-09-16
AU3435778A (en) 1979-09-27
AT361139B (de) 1981-02-25
BE865183A (fr) 1978-09-22
CA1089456A (en) 1980-11-11
US4241066A (en) 1980-12-23
LU79294A1 (fr) 1979-10-29
PL114723B1 (en) 1981-02-28
IT7848544A0 (it) 1978-03-22
ZA781527B (en) 1979-04-25
DE2812580A1 (de) 1978-10-05
SE7803328L (sv) 1978-09-24
NZ186692A (en) 1980-02-21
NL7803083A (nl) 1978-09-26
FI68236C (fi) 1985-08-12
PL205498A1 (pl) 1979-04-09
FI68236B (fi) 1985-04-30
JPS53119899A (en) 1978-10-19
IT1105176B (it) 1985-10-28
DK130078A (da) 1978-09-24
JPH0112755B2 (2) 1989-03-02
DK149858B (da) 1986-10-13

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