DD141410A5 - Verfahren zur herstellung von farb-und ph-stabilen waessrigen zubereitungen - Google Patents

Verfahren zur herstellung von farb-und ph-stabilen waessrigen zubereitungen Download PDF

Info

Publication number: DD141410A5
Authority: DD; German Democratic Republic
Prior art keywords: solution; sulfate; items; preparations; brought
Prior art date: 1978-01-16

Application number

DD79210480A

Other languages

German (de)

English (en)

Inventor

Bernard E Rosenkrantz

Elliot I Stupak

Original Assignee

Scherico Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-01-16

Filing date

1979-01-15

Publication date

1980-04-30

1979-01-15 Application filed by Scherico Ltd filed Critical Scherico Ltd

1980-04-30 Publication of DD141410A5 publication Critical patent/DD141410A5/de

Links

238000002360 preparation method Methods 0.000 title claims description 15
238000000034 method Methods 0.000 title claims description 10
238000004519 manufacturing process Methods 0.000 title description 2
239000000203 mixture Substances 0.000 claims description 8
229940126575 aminoglycoside Drugs 0.000 claims description 7
239000003963 antioxidant agent Substances 0.000 claims description 7
BWRBVBFLFQKBPT-UHFFFAOYSA-N (2-nitrophenyl)methanol Chemical compound OCC1=CC=CC=C1[N+]([O-])=O BWRBVBFLFQKBPT-UHFFFAOYSA-N 0.000 claims description 5
229960001435 sisomicin sulfate Drugs 0.000 claims description 5
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
238000009472 formulation Methods 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 3
125000004103 aminoalkyl group Chemical group 0.000 claims description 2
LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims 3
230000003078 antioxidant effect Effects 0.000 claims 1
239000000243 solution Substances 0.000 description 12
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
238000003860 storage Methods 0.000 description 7
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
239000003242 anti bacterial agent Substances 0.000 description 6
230000003115 biocidal effect Effects 0.000 description 6
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 6
229940088710 antibiotic agent Drugs 0.000 description 5
CZPLANDPABRVHX-UHFFFAOYSA-N cascade blue Chemical compound C=1C2=CC=CC=C2C(NCC)=CC=1C(C=1C=CC(=CC=1)N(CC)CC)=C1C=CC(=[N+](CC)CC)C=C1 CZPLANDPABRVHX-UHFFFAOYSA-N 0.000 description 5
229960004832 netilmicin sulfate Drugs 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 description 4
229930192786 Sisomicin Natural products 0.000 description 4
239000012153 distilled water Substances 0.000 description 4
229910052757 nitrogen Inorganic materials 0.000 description 4
229960005456 sisomicin Drugs 0.000 description 4
URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 description 4
239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 3
235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 3
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
229960002216 methylparaben Drugs 0.000 description 3
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 3
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 3
229960003415 propylparaben Drugs 0.000 description 3
239000011734 sodium Substances 0.000 description 3
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 3
229940001584 sodium metabisulfite Drugs 0.000 description 3
235000010262 sodium metabisulphite Nutrition 0.000 description 3
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
241001550224 Apha Species 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
235000019445 benzyl alcohol Nutrition 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
239000000126 substance Substances 0.000 description 2
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 2
CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
URWAJWIAIPFPJE-VHLNBGGKSA-N (2r,3r,4r,5r)-2-[(1s,2r,3r,4s,6r)-4,6-diamino-3-[[(2s,3r)-3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-VHLNBGGKSA-N 0.000 description 1
XUSXOPRDIDWMFO-CTMSJIKGSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[[(2s,3r)-3-amino-6-[(1s)-1-aminoethyl]-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(O2)[C@H](C)N)N)[C@@H](N)C[C@H]1N XUSXOPRDIDWMFO-CTMSJIKGSA-N 0.000 description 1
DYIOSHGVFJTOAR-JGWLITMVSA-N (2r,3r,4s,5r)-6-sulfanylhexane-1,2,3,4,5-pentol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CS DYIOSHGVFJTOAR-JGWLITMVSA-N 0.000 description 1
VIAXDDBFFSKHGA-UHFFFAOYSA-N Antibiotic G52 Natural products CNC1CC(N)C(OC2OCC(C)(O)C(NC)C2O)C(O)C1OC3OC(=CCC3N)CN VIAXDDBFFSKHGA-UHFFFAOYSA-N 0.000 description 1
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
CIWBSHSKHKDKBQ-DUZGATOHSA-N D-isoascorbic acid Chemical compound OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
-1 Parabens Substances 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
XUSXOPRDIDWMFO-UHFFFAOYSA-N Verdamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(O2)C(C)N)N)C(N)CC1N XUSXOPRDIDWMFO-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
ARCVBMPERJRMKB-UHFFFAOYSA-N antibiotic g-52 Chemical compound O1C(CNC)=CCC(N)C1OC1C(O)C(OC2C(C(NC)C(C)(O)CO2)O)C(N)CC1N ARCVBMPERJRMKB-UHFFFAOYSA-N 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
235000018417 cysteine Nutrition 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
GXMCPHJLTWJFLD-UHFFFAOYSA-L disodium sulfurous acid sulfate Chemical compound S(=O)(=O)([O-])[O-].[Na+].S(=O)(O)O.[Na+] GXMCPHJLTWJFLD-UHFFFAOYSA-L 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
235000010350 erythorbic acid Nutrition 0.000 description 1
239000012535 impurity Substances 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
229940026239 isoascorbic acid Drugs 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
229960000808 netilmicin Drugs 0.000 description 1
ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000005180 public health Effects 0.000 description 1
125000003132 pyranosyl group Chemical group 0.000 description 1
XWGJFPHUCFXLBL-UHFFFAOYSA-M rongalite Chemical compound [Na+].OCS([O-])=O XWGJFPHUCFXLBL-UHFFFAOYSA-M 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000010959 steel Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
229940035024 thioglycerol Drugs 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
239000002351 wastewater Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DD79210480A 1978-01-16 1979-01-15 Verfahren zur herstellung von farb-und ph-stabilen waessrigen zubereitungen DD141410A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/869,741 US4223022A (en)	1978-01-16	1978-01-16	Stabilized aminoglycoside antibiotic formulations

Publications (1)

Publication Number	Publication Date
DD141410A5 true DD141410A5 (de)	1980-04-30

Family

ID=25354179

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD79210480A DD141410A5 (de)	1978-01-16	1979-01-15	Verfahren zur herstellung von farb-und ph-stabilen waessrigen zubereitungen

Country Status (24)

Country	Link
US (1)	US4223022A (da)
EP (1)	EP0003150B1 (da)
JP (1)	JPS5914447B2 (da)
AR (1)	AR223967A1 (da)
AT (1)	AT364715B (da)
AU (1)	AU524288B2 (da)
BG (1)	BG32561A3 (da)
CA (1)	CA1129344A (da)
DD (1)	DD141410A5 (da)
DE (1)	DE2961370D1 (da)
DK (1)	DK155306C (da)
ES (1)	ES476754A1 (da)
FI (1)	FI64287B (da)
GR (1)	GR73655B (da)
IE (1)	IE48254B1 (da)
IL (1)	IL56409A (da)
MY (1)	MY8500050A (da)
NO (1)	NO153876C (da)
NZ (1)	NZ189363A (da)
PH (1)	PH18571A (da)
PL (1)	PL119296B1 (da)
PT (1)	PT69063A (da)
SU (1)	SU976837A3 (da)
ZA (1)	ZA7962B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4327087A (en) *	1978-01-16	1982-04-27	Schering Corporation	Stabilized Netilmicin formulations
HU197514B (en) *	1985-03-07	1989-04-28	Chinoin Gyogyszer Es Vegyeszet	Process for production of injection sulution containing acid-additional salts od sysomicin
US5977082A (en)	1985-08-02	1999-11-02	Pharmacia & Upjohn Company	Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en)	1985-08-02	1992-06-23	Farmitalia Carlo Erba S.P.A.	Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
EP0236822B1 (en) *	1986-03-07	1990-12-27	American Cyanamid Company	Stable injectable pharmaceutical formulation for 1,4-dihydroxy-5,8-bis((2-(hydroxyethylamino)-ethyl)amino)anthraquinone, dihydrochloride
JPH05236765A (ja) *	1992-02-20	1993-09-10	Okuma Mach Works Ltd	ローテータブル・リニア・アクチュエータ
JPH0630206U (ja) *	1992-09-14	1994-04-19	川崎重工業株式会社	締固め機械の安全ガード装置
US5912228A (en) *	1995-01-13	1999-06-15	Xoma Corporation	Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products
US7794713B2 (en)	2004-04-07	2010-09-14	Lpath, Inc.	Compositions and methods for the treatment and prevention of hyperproliferative diseases
US7862812B2 (en)	2006-05-31	2011-01-04	Lpath, Inc.	Methods for decreasing immune response and treating immune conditions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4911403B1 (da) *	1970-12-29	1974-03-16
US3832286A (en) *	1971-02-03	1974-08-27	Schering Corp	Sisomicin and methods for its production
US3995635A (en) *	1971-09-09	1976-12-07	Alza Corporation	Ocular insert
US3956068A (en)	1972-07-14	1976-05-11	Schering Corporation	Antibiotic G-52 and method for the production thereof
GB1405283A (en)	1972-08-17	1975-09-10	Scherico Ltd	Antibiotics and processes for their preparation
US3880828A (en)	1973-02-23	1975-04-29	Schering Corp	Antibiotics 66-40B and 66-40D from micromonospora inyoensis
US3962429A (en)	1973-08-01	1976-06-08	Chugai Seiyaku Kabushiki Kaisha	Method for reducing side effects of aminoglycoside antibiotics and composition therefor
US3898330A (en) *	1973-08-01	1975-08-05	Squibb & Sons Inc	Corticosteroid phosphate salts/neomycin sulfate ophthalmic
US3944064A (en) *	1973-10-26	1976-03-16	Alza Corporation	Self-monitored device for releasing agent at functional rate
US4011390A (en) *	1974-02-15	1977-03-08	Schering-Plough Corporation	Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof
US4002742A (en) *	1974-03-19	1977-01-11	Schering Corporation	1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor
US4009328A (en) *	1975-05-02	1977-02-22	Schering Corporation	Aminoglycoside 66-40C, method for its manufacture, method for its use as an intermediate in the preparation of known antibiotics and novel antibacterials
GB1529243A (en) *	1976-02-25	1978-10-18	Pfizer Ltd	Process for the preparation of aminoglycoside derivatives and cyclic urethane intermediates for use therein

1978
- 1978-01-16 US US05/869,741 patent/US4223022A/en not_active Expired - Lifetime
1979
- 1979-01-08 ZA ZA00790062A patent/ZA7962B/xx unknown
- 1979-01-10 DE DE7979200014T patent/DE2961370D1/de not_active Expired
- 1979-01-10 EP EP79200014A patent/EP0003150B1/en not_active Expired
- 1979-01-11 CA CA319,474A patent/CA1129344A/en not_active Expired
- 1979-01-11 NZ NZ189363A patent/NZ189363A/en unknown
- 1979-01-11 ES ES476754A patent/ES476754A1/es not_active Expired
- 1979-01-11 PT PT69063A patent/PT69063A/pt unknown
- 1979-01-11 IL IL56409A patent/IL56409A/xx unknown
- 1979-01-11 IE IE45/79A patent/IE48254B1/en unknown
- 1979-01-11 AT AT0020479A patent/AT364715B/de not_active IP Right Cessation
- 1979-01-11 GR GR58067A patent/GR73655B/el unknown
- 1979-01-11 PH PH22047A patent/PH18571A/en unknown
- 1979-01-11 NO NO790085A patent/NO153876C/no unknown
- 1979-01-11 FI FI790086A patent/FI64287B/sv not_active Application Discontinuation
- 1979-01-12 DK DK014579A patent/DK155306C/da not_active IP Right Cessation
- 1979-01-12 JP JP54002871A patent/JPS5914447B2/ja not_active Expired
- 1979-01-12 AU AU43320/79A patent/AU524288B2/en not_active Expired
- 1979-01-15 SU SU792709256A patent/SU976837A3/ru active
- 1979-01-15 DD DD79210480A patent/DD141410A5/de not_active IP Right Cessation
- 1979-01-15 PL PL1979212809A patent/PL119296B1/pl unknown
- 1979-01-16 BG BG042100A patent/BG32561A3/bg unknown
- 1979-02-11 AR AR275143A patent/AR223967A1/es active
1985
- 1985-12-30 MY MY50/85A patent/MY8500050A/xx unknown

Also Published As

Publication number	Publication date
PT69063A (en)	1979-02-01
EP0003150A1 (en)	1979-07-25
GR73655B (da)	1984-03-27
US4223022A (en)	1980-09-16
NO153876C (no)	1989-08-22
FI64287B (fi)	1983-07-29
PL212809A1 (da)	1980-02-11
NO153876B (no)	1986-03-03
DK155306B (da)	1989-03-28
BG32561A3 (bg)	1982-08-16
AT364715B (de)	1981-11-10
JPS54100346A (en)	1979-08-08
ZA7962B (en)	1979-12-27
NZ189363A (en)	1984-07-06
ATA20479A (de)	1981-04-15
DE2961370D1 (en)	1982-01-28
IE48254B1 (en)	1984-11-14
DK14579A (da)	1979-07-17
CA1129344A (en)	1982-08-10
SU976837A3 (ru)	1982-11-23
JPS5914447B2 (ja)	1984-04-04
DK155306C (da)	1989-08-28
ES476754A1 (es)	1979-12-16
IL56409A (en)	1981-09-13
IE790045L (en)	1979-07-16
AU524288B2 (en)	1982-09-09
FI790086A7 (fi)	1979-07-17
NO790085L (no)	1979-07-17
AR223967A1 (es)	1981-10-15
MY8500050A (en)	1985-12-31
IL56409A0 (en)	1979-03-12
PL119296B1 (en)	1981-12-31
PH18571A (en)	1985-08-12
AU4332079A (en)	1979-07-26
EP0003150B1 (en)	1981-11-25

Legal Events

Date	Code	Title	Description
1998-08-27	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
EP0177870B1 (de)	1991-04-10	Stabilisierte Injektionslösungen von Piroxicam
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EP0801948A1 (de)	1997-10-22	Ophtalmische Zusammensetzung mit verlängerter Verweilzeit am Auge
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AT401469B (de)	1996-09-25	Pharmazeutische wässrige lösung zur parenteralen anwendung enthaltend einen in situ gebildeten komplex von einem alkaloid mit bis-indol-gerüst, sowie verfahren zu deren herstellung
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DE1262512B (de)	1968-03-07	Stabilisierte germicide Massen auf der Basis von Halogensalicylaniliden
AT344328B (de)	1978-07-10	Verfahren zur herstellung einer stabilisierten waesserigen loesung zur topischen anwendung auflebendes gewebe mit einem gehalt an brenzcatechinaminderivaten
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