DD142545A5 - Verfahren zur herstellung neuer omega thiobutyramide - Google Patents

Verfahren zur herstellung neuer omega thiobutyramide Download PDF

Info

Publication number: DD142545A5
Authority: DD; German Democratic Republic
Prior art keywords: group; general formula; acid; formula; molecular weight
Prior art date: 1977-12-22

Application number

DD78210134A

Other languages

German (de)

English (en)

Inventor

Charles Malen

Pierre Roger

Michel Laubie

Original Assignee

Science Union & Cie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-12-22

Filing date

1978-12-22

Publication date

1980-07-02

1978-12-22 Application filed by Science Union & Cie filed Critical Science Union & Cie

1980-07-02 Publication of DD142545A5 publication Critical patent/DD142545A5/de

Links

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238000004821 distillation Methods 0.000 description 1
239000002934 diuretic Substances 0.000 description 1
229940030606 diuretics Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
229960002179 ephedrine Drugs 0.000 description 1
AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 description 1
229960003199 etacrynic acid Drugs 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
WMYNMYVRWWCRPS-UHFFFAOYSA-N ethynoxyethane Chemical group CCOC#C WMYNMYVRWWCRPS-UHFFFAOYSA-N 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
210000001105 femoral artery Anatomy 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
238000004508 fractional distillation Methods 0.000 description 1
ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
229960003883 furosemide Drugs 0.000 description 1
229960002442 glucosamine Drugs 0.000 description 1
150000002337 glycosamines Chemical class 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
125000000623 heterocyclic group Chemical group 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
125000001183 hydrocarbyl group Chemical group 0.000 description 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
229910000041 hydrogen chloride Inorganic materials 0.000 description 1
238000002329 infrared spectrum Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910003002 lithium salt Inorganic materials 0.000 description 1
159000000002 lithium salts Chemical class 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
125000005394 methallyl group Chemical group 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
229960003632 minoxidil Drugs 0.000 description 1
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
RIWRFSMVIUAEBX-UHFFFAOYSA-N n-methyl-1-phenylmethanamine Chemical compound CNCC1=CC=CC=C1 RIWRFSMVIUAEBX-UHFFFAOYSA-N 0.000 description 1
150000002790 naphthalenes Chemical class 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
231100000956 nontoxicity Toxicity 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
239000000810 peripheral vasodilating agent Substances 0.000 description 1
229960002116 peripheral vasodilator Drugs 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229940117803 phenethylamine Drugs 0.000 description 1
LCPDWSOZIOUXRV-UHFFFAOYSA-N phenoxyacetic acid Chemical class OC(=O)COC1=CC=CC=C1 LCPDWSOZIOUXRV-UHFFFAOYSA-N 0.000 description 1
125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
125000004344 phenylpropyl group Chemical group 0.000 description 1
238000000053 physical method Methods 0.000 description 1
229960004310 piribedil Drugs 0.000 description 1
239000012286 potassium permanganate Substances 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
JREMHUJYFXNYSW-UHFFFAOYSA-N s-(2-carbonochloridoyl-3,3,3-trifluoropropyl) ethanethioate Chemical compound CC(=O)SCC(C(Cl)=O)C(F)(F)F JREMHUJYFXNYSW-UHFFFAOYSA-N 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
SLRCCWJSBJZJBV-AJNGGQMLSA-N sparteine Chemical compound C1N2CCCC[C@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 SLRCCWJSBJZJBV-AJNGGQMLSA-N 0.000 description 1
229960001945 sparteine Drugs 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
125000001174 sulfone group Chemical group 0.000 description 1
230000000576 supplementary effect Effects 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003511 tertiary amides Chemical class 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000003451 thiazide diuretic agent Substances 0.000 description 1
150000007970 thio esters Chemical class 0.000 description 1
150000003573 thiols Chemical class 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
238000005809 transesterification reaction Methods 0.000 description 1
230000009466 transformation Effects 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
ZESXUEKAXSBANL-UHFFFAOYSA-N trifluoromethyl prop-2-enoate Chemical class FC(F)(F)OC(=O)C=C ZESXUEKAXSBANL-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)

DD78210134A 1977-12-22 1978-12-22 Verfahren zur herstellung neuer omega thiobutyramide DD142545A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7738728A FR2412537A1 (fr)	1977-12-22	1977-12-22	Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique

Publications (1)

Publication Number	Publication Date
DD142545A5 true DD142545A5 (de)	1980-07-02

Family

ID=9199179

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD78210134A DD142545A5 (de)	1977-12-22	1978-12-22	Verfahren zur herstellung neuer omega thiobutyramide

Country Status (14)

Country	Link
AR (1)	AR222815A1 (fr)
BE (1)	BE872972A (fr)
DD (1)	DD142545A5 (fr)
DE (1)	DE2854877A1 (fr)
ES (1)	ES476314A1 (fr)
FR (1)	FR2412537A1 (fr)
GB (1)	GB2014132B (fr)
GR (1)	GR66839B (fr)
IT (1)	IT1158184B (fr)
OA (1)	OA06139A (fr)
PT (1)	PT68966A (fr)
SE (1)	SE7813180L (fr)
SU (1)	SU860696A1 (fr)
ZA (1)	ZA787196B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1109475A (fr) *	1978-07-27	1981-09-22	Miguel A. Ondetti	Derives d'acide thiopropanoylamine
US4483861A (en) *	1978-10-31	1984-11-20	Santen Pharmaceutical Co., Ltd.	Antihypertensive sulfur-containing compounds
ZA802420B (en) *	1979-05-18	1981-04-29	Squibb & Sons Inc	Aminoacyl derivatives of mercaptoacyl amino acids
ZA802709B (en) *	1979-05-30	1981-05-27	Merrell Toraude & Co	N-acyl-amino acid derivatives
US4284561A (en)	1979-12-03	1981-08-18	E. R. Squibb & Sons, Inc.	Hydroxamic acid derivatives of mercaptoacyl amino acids
US4308392A (en)	1979-12-03	1981-12-29	E. R. Squibb & Sons, Inc.	Hydroxamic acid derivatives of mercaptoacyl amino acids
JPS5683483A (en) *	1979-12-13	1981-07-08	Santen Pharmaceut Co Ltd	Thiazolidine compound
JPS56139455A (en) *	1980-04-02	1981-10-30	Santen Pharmaceut Co Ltd	Sulfur-containing acylaminoacid
US4482725A (en) *	1980-04-03	1984-11-13	E. R. Squibb & Sons, Inc.	S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
US4438031A (en)	1982-02-24	1984-03-20	American Home Products Corporation	N-(Alkylsulfonyl)-L-proline amide and N-(alkylsulfonyl)-2-carboxylic acid amide-indoline derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU509899B2 (en) *	1976-02-13	1980-05-29	E.R. Squibb & Sons, Inc.	Proline derivatives and related compounds
US4052511A (en) *	1976-02-13	1977-10-04	E. R. Squibb & Sons, Inc.	Carboxyacylproline derivatives

1977
- 1977-12-22 FR FR7738728A patent/FR2412537A1/fr active Granted
1978
- 1978-12-19 DE DE19782854877 patent/DE2854877A1/de not_active Ceased
- 1978-12-21 PT PT68966A patent/PT68966A/fr unknown
- 1978-12-21 ZA ZA00787196A patent/ZA787196B/xx unknown
- 1978-12-21 BE BE192487A patent/BE872972A/fr unknown
- 1978-12-21 AR AR274935A patent/AR222815A1/es active
- 1978-12-21 GR GR57961A patent/GR66839B/el unknown
- 1978-12-21 SE SE7813180A patent/SE7813180L/xx unknown
- 1978-12-21 IT IT52406/78A patent/IT1158184B/it active
- 1978-12-22 ES ES476314A patent/ES476314A1/es not_active Expired
- 1978-12-22 DD DD78210134A patent/DD142545A5/de unknown
- 1978-12-22 SU SU782704624A patent/SU860696A1/ru active
- 1978-12-22 GB GB7849881A patent/GB2014132B/en not_active Expired
- 1978-12-22 OA OA56695A patent/OA06139A/fr unknown

Also Published As

Publication number	Publication date
ES476314A1 (es)	1979-04-16
GB2014132A (en)	1979-08-22
SU860696A1 (ru)	1981-08-30
GB2014132B (en)	1982-08-11
PT68966A (fr)	1979-01-01
IT1158184B (it)	1987-02-18
ZA787196B (en)	1979-11-28
IT7852406A0 (it)	1978-12-21
FR2412537B1 (fr)	1981-10-16
GR66839B (fr)	1981-05-04
OA06139A (fr)	1981-06-30
FR2412537A1 (fr)	1979-07-20
SE7813180L (sv)	1979-06-23
DE2854877A1 (de)	1979-06-28
AR222815A1 (es)	1981-06-30
BE872972A (fr)	1979-06-21

Publication	Publication Date	Title
DE69107250T2 (de)	1995-09-21	Neue 4-Aminobuttersäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneizubereitungen.
EP0074070A1 (fr)	1983-03-16	Dérivés de l'urée, leur procédé de préparation et médicaments les contenant ainsi que leur application
EP0111873A1 (fr)	1984-06-27	Dérivés de l'acide cis, endo-aza-2 bicyclo(5.3.0)décane-carboxylique-3, procédé pour leur préparation, compositions les contenant et leur application
DE2951200A1 (de)	1980-07-10	Ketal- und thioketalderivate von mercaptoacylprolinen und -pipecolinsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur behandlung von hochdruck
DE2846251C2 (fr)	1988-08-04
EP0003056A1 (fr)	1979-07-25	Acides oméga-aminoalcanoyl-oméga-aminoalcanecarboxyliques N-substitués, leur utilisation et procédé pour leur préparation ainsi que médicaments contenant ces composés
EP0271795A2 (fr)	1988-06-22	Dérivés de l'octahydro-10-oxo-6H-pyridazo[1,2-a][112]diazépine, intermédiaires et procédé pour leur préparation ainsi que médicament les contenant
EP0025192A2 (fr)	1981-03-18	Acides oxiranne-carboxyliques substitués, procédé pour leur préparation, leur utilisation et médicaments les contenant
EP0432595A1 (fr)	1991-06-19	Nouveaux peptides, leur préparation et leur utilisation dans des médicaments
DE1795022C3 (de)	1981-06-19	Lysergsäurederivate
EP0119428A2 (fr)	1984-09-26	Biscarboxamides pour le traitement de maladies et procédé pour leur préparation
EP0431371B1 (fr)	1997-09-10	3-Aminopyrroles, procédé pour leur préparation et leur utilisation comme anticonvulsifs
DE2854877A1 (de)	1979-06-28	N-substituierte omega-thiobutyramide, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2842100A1 (de)	1979-04-05	Omega -thiopropionamide, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE3785104T2 (de)	1993-09-02	Pharmazeutisch nuetzliche thiazolidin-4-karbonsaeure-derivate.
EP0086453B1 (fr)	1988-09-28	Dérivés de thiazaspiro, procédé pour leur préparation et compositions pharmaceutiques les contenant
DE2413125C2 (de)	1983-06-30	Indolylacetylaminosäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneipräparate
DE3347658A1 (de)	1985-07-11	1.4-naphthochinonderivate mit entzuendungshemmender wirkung
DE2716172C2 (de)	1985-09-05	Bis(6-[(hexahydro-1H-azepin-1-yl)-methylenamino]-penicillanoyloxy)-methan, seine Herstellung und dieses enthaltendes Arzneimittel
EP0088323B1 (fr)	1987-05-06	Amides d'acides imidazothiadiazolealcanecarboxyliques, produits intermédiaires pour leur fabrication, leur fabrication et leur application en médicaments
DE60001706T2 (de)	2004-02-05	Aminopyrrolidin-Derivate, Verfahren zur ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
EP0149818A2 (fr)	1985-07-31	Dérivés de 1,4-naphtoquinone, procédé pour leur préparation et leur utilisation comme médicaments
EP0003286B1 (fr)	1982-03-24	Dérivés d'alcaloides ergopeptidiques, procédé pour leur préparation et compositions pharmaceutiques les contenant
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