DD200347A5 - Verfahren zur herstellung eines umhuellten acetylsalicylsaeurepraeparates - Google Patents

Verfahren zur herstellung eines umhuellten acetylsalicylsaeurepraeparates Download PDF

Info

Publication number: DD200347A5
Authority: DD; German Democratic Republic
Prior art keywords: coated; film; weight; items; coating
Prior art date: 1980-10-16

Application number

DD81233717A

Other languages

German (de)

English (en)

Inventor

Dieter Dreher

Klaus Lehmann

Heide Boessler

Original Assignee

Roehm Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-10-16

Filing date

1981-09-30

Publication date

1983-04-20

1981-09-30 Application filed by Roehm Gmbh filed Critical Roehm Gmbh

1983-04-20 Publication of DD200347A5 publication Critical patent/DD200347A5/de

Links

238000002360 preparation method Methods 0.000 title claims abstract description 25
239000002253 acid Substances 0.000 title description 2
238000004519 manufacturing process Methods 0.000 title description 2
-1 ACETYL SALICYL Chemical class 0.000 title 1
239000011248 coating agent Substances 0.000 claims abstract description 34
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims abstract description 26
238000000576 coating method Methods 0.000 claims abstract description 25
229960001138 acetylsalicylic acid Drugs 0.000 claims abstract description 23
239000006185 dispersion Substances 0.000 claims abstract description 22
238000000034 method Methods 0.000 claims abstract description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
239000003814 drug Substances 0.000 claims description 12
229940079593 drug Drugs 0.000 claims description 10
239000002552 dosage form Substances 0.000 claims description 9
239000004480 active ingredient Substances 0.000 claims description 7
239000008199 coating composition Substances 0.000 claims description 6
229920001577 copolymer Polymers 0.000 claims description 5
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
229920000642 polymer Polymers 0.000 claims description 4
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
210000004051 gastric juice Anatomy 0.000 claims description 2
230000000968 intestinal effect Effects 0.000 claims description 2
125000005395 methacrylic acid group Chemical group 0.000 claims description 2
239000000178 monomer Substances 0.000 claims description 2
238000013268 sustained release Methods 0.000 claims description 2
239000012730 sustained-release form Substances 0.000 claims description 2
230000015572 biosynthetic process Effects 0.000 claims 1
210000001035 gastrointestinal tract Anatomy 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 abstract description 3
239000013543 active substance Substances 0.000 abstract description 2
238000001704 evaporation Methods 0.000 abstract description 2
230000008020 evaporation Effects 0.000 abstract description 2
239000000825 pharmaceutical preparation Substances 0.000 abstract 2
239000008016 pharmaceutical coating Substances 0.000 abstract 1
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 21
239000013078 crystal Substances 0.000 description 12
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 10
229960004889 salicylic acid Drugs 0.000 description 10
239000008187 granular material Substances 0.000 description 6
230000007062 hydrolysis Effects 0.000 description 6
238000006460 hydrolysis reaction Methods 0.000 description 6
238000003860 storage Methods 0.000 description 6
239000003995 emulsifying agent Substances 0.000 description 5
239000008188 pellet Substances 0.000 description 5
239000000243 solution Substances 0.000 description 5
239000000126 substance Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
235000019333 sodium laurylsulphate Nutrition 0.000 description 3
239000007787 solid Substances 0.000 description 3
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical class CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
239000007900 aqueous suspension Substances 0.000 description 2
238000001035 drying Methods 0.000 description 2
238000009505 enteric coating Methods 0.000 description 2
239000002702 enteric coating Substances 0.000 description 2
239000000945 filler Substances 0.000 description 2
239000004922 lacquer Substances 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
239000000454 talc Substances 0.000 description 2
229910052623 talc Inorganic materials 0.000 description 2
235000012222 talc Nutrition 0.000 description 2
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
241000580063 Ipomopsis rubra Species 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
229920001800 Shellac Polymers 0.000 description 1
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
235000019631 acid taste sensations Nutrition 0.000 description 1
238000007605 air drying Methods 0.000 description 1
125000005907 alkyl ester group Chemical group 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
238000001514 detection method Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000008298 dragée Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000007888 film coating Substances 0.000 description 1
238000009501 film coating Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
230000000622 irritating effect Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
229940126601 medicinal product Drugs 0.000 description 1
238000000465 moulding Methods 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000003973 paint Substances 0.000 description 1
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
238000003825 pressing Methods 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000013094 purity test Methods 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
229940024473 salicylic acid emollient and protective preparations Drugs 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
239000004208 shellac Substances 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
QGLITUFXHVRMGV-UHFFFAOYSA-M sodium;tetratriacontyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCOS([O-])(=O)=O QGLITUFXHVRMGV-UHFFFAOYSA-M 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DD81233717A 1980-10-16 1981-09-30 Verfahren zur herstellung eines umhuellten acetylsalicylsaeurepraeparates DD200347A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19803039073 DE3039073A1 (de)	1980-10-16	1980-10-16	Umhuelltes acetylsalicylsaeurepraeparat

Publications (1)

Publication Number	Publication Date
DD200347A5 true DD200347A5 (de)	1983-04-20

Family

ID=6114505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD81233717A DD200347A5 (de)	1980-10-16	1981-09-30	Verfahren zur herstellung eines umhuellten acetylsalicylsaeurepraeparates

Country Status (5)

Country	Link
EP (1)	EP0050191B1 (fr)
AT (1)	ATE9957T1 (fr)
DD (1)	DD200347A5 (fr)
DE (2)	DE3039073A1 (fr)
HU (1)	HU186431B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3208791A1 (de) *	1982-03-11	1983-09-22	Röhm GmbH, 6100 Darmstadt	Verfahren zum ueberziehen von arzneiformen mittes eines in wasser dispergierten ueberzugsmittels
US4507276A (en) *	1982-08-20	1985-03-26	Bristol-Myers Company	Analgesic capsule
US4874613A (en) *	1987-03-06	1989-10-17	Baker Cummins Pharmaceuticals, Inc.	Taste concealing pharmaceutical dosage unit
DE3739690A1 (de) *	1987-11-24	1989-06-08	Hoechst Ag	Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen
US4983401A (en) *	1989-05-22	1991-01-08	Kinaform Technology, Inc.	Sustained release pharmaceutical preparations having pH controlled membrane coatings

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL164212C (nl) *	1969-09-11	1980-12-15	Unie Van Kunstmestfab Bv	Werkwijze voor het granuleren van poedervormige stoffen.
BE785702A (fr) *	1971-07-14	1972-10-16	Roehm Gmbh	Produits de revetement de formes medicamenteuses et leur utilisation

1980
- 1980-10-16 DE DE19803039073 patent/DE3039073A1/de not_active Withdrawn
1981
- 1981-07-15 DE DE8181105566T patent/DE3166825D1/de not_active Expired
- 1981-07-15 AT AT81105566T patent/ATE9957T1/de not_active IP Right Cessation
- 1981-07-15 EP EP81105566A patent/EP0050191B1/fr not_active Expired
- 1981-09-30 DD DD81233717A patent/DD200347A5/de not_active IP Right Cessation
- 1981-10-15 HU HU812986A patent/HU186431B/hu unknown

Also Published As

Publication number	Publication date
DE3039073A1 (de)	1982-05-19
DE3166825D1 (en)	1984-11-29
HU186431B (en)	1985-07-29
EP0050191B1 (fr)	1984-10-24
EP0050191A1 (fr)	1982-04-28
ATE9957T1 (de)	1984-11-15

Legal Events

Date	Code	Title	Description
1995-08-31	ENJ	Ceased due to non-payment of renewal fee

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EP0164669B1 (fr)	1991-01-23	Procédé pour enrober des formes pharmaceutiques
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