DD201973A5 - Verfahren zur herstellung von liposomalen arzneimitteln - Google Patents

Verfahren zur herstellung von liposomalen arzneimitteln Download PDF

Info

Publication number: DD201973A5
Authority: DD; German Democratic Republic
Prior art keywords: aqueous phase; associates; bilayer; liposomes; solubilizer
Prior art date: 1981-01-07

Application number

DD82236567A

Other languages

German (de)

English (en)

Inventor

Hans G Weder

Otmar N Zumbuehl

Reto A Schwendener

Maximilian Asanger

Original Assignee

Hans G Weder

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-01-07

Filing date

1982-01-05

Publication date

1983-08-24

1982-01-05 Application filed by Hans G Weder filed Critical Hans G Weder

1983-08-24 Publication of DD201973A5 publication Critical patent/DD201973A5/de

Links

239000003814 drug Substances 0.000 title claims abstract description 74
238000000034 method Methods 0.000 title claims description 33
238000002360 preparation method Methods 0.000 title claims description 17
230000008569 process Effects 0.000 title claims description 11
239000008346 aqueous phase Substances 0.000 claims abstract description 83
239000002904 solvent Substances 0.000 claims abstract description 77
239000000126 substance Substances 0.000 claims abstract description 64
239000002502 liposome Substances 0.000 claims abstract description 63
238000010790 dilution Methods 0.000 claims abstract description 24
239000012895 dilution Substances 0.000 claims abstract description 24
230000008859 change Effects 0.000 claims abstract description 8
229940079593 drug Drugs 0.000 claims description 70
239000000546 pharmaceutical excipient Substances 0.000 claims description 16
229940124531 pharmaceutical excipient Drugs 0.000 claims description 16
238000000502 dialysis Methods 0.000 claims description 13
239000012528 membrane Substances 0.000 claims description 13
239000000385 dialysis solution Substances 0.000 claims description 12
230000007704 transition Effects 0.000 claims description 5
238000006243 chemical reaction Methods 0.000 claims description 4
239000007787 solid Substances 0.000 claims description 3
238000007865 diluting Methods 0.000 claims description 2
238000009792 diffusion process Methods 0.000 claims 1
230000015572 biosynthetic process Effects 0.000 abstract description 10
239000000243 solution Substances 0.000 description 31
-1 NaCl Chemical class 0.000 description 14
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 10
239000000203 mixture Substances 0.000 description 10
125000004432 carbon atom Chemical group C* 0.000 description 9
238000009826 distribution Methods 0.000 description 9
NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 description 8
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
239000008344 egg yolk phospholipid Substances 0.000 description 8
239000008363 phosphate buffer Substances 0.000 description 8
NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 8
235000014113 dietary fatty acids Nutrition 0.000 description 7
238000002474 experimental method Methods 0.000 description 7
239000000194 fatty acid Substances 0.000 description 7
229930195729 fatty acid Natural products 0.000 description 7
150000002632 lipids Chemical class 0.000 description 7
150000003839 salts Chemical class 0.000 description 7
239000002552 dosage form Substances 0.000 description 6
239000010408 film Substances 0.000 description 6
235000012000 cholesterol Nutrition 0.000 description 5
150000002148 esters Chemical class 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
239000003960 organic solvent Substances 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
239000000443 aerosol Substances 0.000 description 4
125000000129 anionic group Chemical group 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
238000005227 gel permeation chromatography Methods 0.000 description 4
238000002156 mixing Methods 0.000 description 4
239000011780 sodium chloride Substances 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000012736 aqueous medium Substances 0.000 description 3
125000002091 cationic group Chemical group 0.000 description 3
239000001913 cellulose Substances 0.000 description 3
229920002678 cellulose Polymers 0.000 description 3
BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 3
230000007423 decrease Effects 0.000 description 3
239000006185 dispersion Substances 0.000 description 3
150000004665 fatty acids Chemical class 0.000 description 3
150000002191 fatty alcohols Chemical class 0.000 description 3
229930182470 glycoside Natural products 0.000 description 3
150000002338 glycosides Chemical class 0.000 description 3
239000000017 hydrogel Substances 0.000 description 3
238000001727 in vivo Methods 0.000 description 3
239000000693 micelle Substances 0.000 description 3
239000012071 phase Substances 0.000 description 3
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 3
239000008389 polyethoxylated castor oil Substances 0.000 description 3
239000000047 product Substances 0.000 description 3
238000000926 separation method Methods 0.000 description 3
238000003756 stirring Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
102000002322 Egg Proteins Human genes 0.000 description 2
108010000912 Egg Proteins Proteins 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
229930186217 Glycolipid Natural products 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
239000013543 active substance Substances 0.000 description 2
150000005215 alkyl ethers Chemical class 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
230000008901 benefit Effects 0.000 description 2
SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 description 2
230000036765 blood level Effects 0.000 description 2
239000000872 buffer Substances 0.000 description 2
239000004359 castor oil Substances 0.000 description 2
235000019438 castor oil Nutrition 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
229940099352 cholate Drugs 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 2
238000003113 dilution method Methods 0.000 description 2
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
235000013345 egg yolk Nutrition 0.000 description 2
210000002969 egg yolk Anatomy 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000007717 exclusion Effects 0.000 description 2
238000004108 freeze drying Methods 0.000 description 2
239000011521 glass Substances 0.000 description 2
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
235000010445 lecithin Nutrition 0.000 description 2
239000000787 lecithin Substances 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
210000004072 lung Anatomy 0.000 description 2
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
239000012074 organic phase Substances 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
108090000765 processed proteins & peptides Proteins 0.000 description 2
102000004196 processed proteins & peptides Human genes 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
239000000377 silicon dioxide Substances 0.000 description 2
239000011734 sodium Substances 0.000 description 2
210000000952 spleen Anatomy 0.000 description 2
239000003381 stabilizer Substances 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 description 1
CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 description 1
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 description 1
YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
WZUNUACWCJJERC-UHFFFAOYSA-N 2,2-bis(hydroxymethyl)butyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CC)(CO)CO WZUNUACWCJJERC-UHFFFAOYSA-N 0.000 description 1
CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
ACTOXUHEUCPTEW-BWHGAVFKSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2s,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-BWHGAVFKSA-N 0.000 description 1
RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 description 1
BZTDTCNHAFUJOG-UHFFFAOYSA-N 6-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C11OC(=O)C2=CC=C(C(=O)O)C=C21 BZTDTCNHAFUJOG-UHFFFAOYSA-N 0.000 description 1
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
239000004342 Benzoyl peroxide Substances 0.000 description 1
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
229930186147 Cephalosporin Natural products 0.000 description 1
QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 1
239000004380 Cholic acid Substances 0.000 description 1
LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 1
MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
ITRJWOMZKQRYTA-RFZYENFJSA-N Cortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O ITRJWOMZKQRYTA-RFZYENFJSA-N 0.000 description 1
ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 1
DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
229930182566 Gentamicin Natural products 0.000 description 1
108010007979 Glycocholic Acid Proteins 0.000 description 1
SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
SMEROWZSTRWXGI-UHFFFAOYSA-N Lithocholsaeure Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 SMEROWZSTRWXGI-UHFFFAOYSA-N 0.000 description 1
BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
RFDAIACWWDREDC-UHFFFAOYSA-N Na salt-Glycocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)C(O)C2 RFDAIACWWDREDC-UHFFFAOYSA-N 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004721 Polyphenylene oxide Substances 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
239000004187 Spiramycin Substances 0.000 description 1
229930182558 Sterol Natural products 0.000 description 1
WBWWGRHZICKQGZ-UHFFFAOYSA-N Taurocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)C(O)C2 WBWWGRHZICKQGZ-UHFFFAOYSA-N 0.000 description 1
239000004098 Tetracycline Substances 0.000 description 1
SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 description 1
ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 1
AKUJBENLRBOFTD-HIBZCRSPSA-N [2-[(9r,10s,11s,13s,16r,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)C1C1C[C@@H](C)[C@@](C(=O)COC(C)=O)(O)[C@@]1(C)C[C@@H]2O AKUJBENLRBOFTD-HIBZCRSPSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
229940081735 acetylcellulose Drugs 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000003463 adsorbent Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000003973 alkyl amines Chemical class 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
150000001356 alkyl thiols Chemical class 0.000 description 1
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
229960004821 amikacin Drugs 0.000 description 1
LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
229940126575 aminoglycoside Drugs 0.000 description 1
NUZWLKWWNNJHPT-UHFFFAOYSA-N anthralin Chemical compound C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O NUZWLKWWNNJHPT-UHFFFAOYSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
230000001741 anti-phlogistic effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000000427 antigen Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
235000019400 benzoyl peroxide Nutrition 0.000 description 1
229960003328 benzoyl peroxide Drugs 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 description 1
LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
229960002537 betamethasone Drugs 0.000 description 1
UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 1
AKUJBENLRBOFTD-QZIXMDIESA-N betamethasone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(C)=O)(O)[C@@]1(C)C[C@@H]2O AKUJBENLRBOFTD-QZIXMDIESA-N 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
229930183167 cerebroside Natural products 0.000 description 1
150000001784 cerebrosides Chemical class 0.000 description 1
RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 1
229960001091 chenodeoxycholic acid Drugs 0.000 description 1
229960005091 chloramphenicol Drugs 0.000 description 1
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
229960001616 chlormadinone acetate Drugs 0.000 description 1
235000019416 cholic acid Nutrition 0.000 description 1
229960002471 cholic acid Drugs 0.000 description 1
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
229960004022 clotrimazole Drugs 0.000 description 1
230000000536 complexating effect Effects 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
235000008504 concentrate Nutrition 0.000 description 1
MOVRKLZUVNCBIP-RFZYENFJSA-N cortancyl Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O MOVRKLZUVNCBIP-RFZYENFJSA-N 0.000 description 1
ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 description 1
229960004544 cortisone Drugs 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
239000000824 cytostatic agent Substances 0.000 description 1
230000001085 cytostatic effect Effects 0.000 description 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
229960000975 daunorubicin Drugs 0.000 description 1
KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
229960003964 deoxycholic acid Drugs 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
239000003599 detergent Substances 0.000 description 1
229960003957 dexamethasone Drugs 0.000 description 1
UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 description 1
229940093541 dicetylphosphate Drugs 0.000 description 1
150000005690 diesters Chemical class 0.000 description 1
ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
229960002311 dithranol Drugs 0.000 description 1
239000008298 dragée Substances 0.000 description 1
235000013601 eggs Nutrition 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
229960005309 estradiol Drugs 0.000 description 1
229930182833 estradiol Natural products 0.000 description 1
229940011871 estrogen Drugs 0.000 description 1
239000000262 estrogen Substances 0.000 description 1
229960003399 estrone Drugs 0.000 description 1
125000001033 ether group Chemical group 0.000 description 1
229960002568 ethinylestradiol Drugs 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
238000001914 filtration Methods 0.000 description 1
150000002270 gangliosides Chemical class 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
150000002327 glycerophospholipids Chemical class 0.000 description 1
RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 description 1
229940099347 glycocholic acid Drugs 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Substances CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229960000890 hydrocortisone Drugs 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
229960000905 indomethacin Drugs 0.000 description 1
239000003978 infusion fluid Substances 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
238000009434 installation Methods 0.000 description 1
230000003993 interaction Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229960000318 kanamycin Drugs 0.000 description 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
229930027917 kanamycin Natural products 0.000 description 1
229930182823 kanamycin A Natural products 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000003120 macrolide antibiotic agent Substances 0.000 description 1
239000002609 medium Substances 0.000 description 1
YNBADRVTZLEFNH-UHFFFAOYSA-N methyl nicotinate Chemical group COC(=O)C1=CC=CN=C1 YNBADRVTZLEFNH-UHFFFAOYSA-N 0.000 description 1
229960002509 miconazole Drugs 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
229940100662 nasal drops Drugs 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
229960000808 netilmicin Drugs 0.000 description 1
ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
108020004707 nucleic acids Proteins 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
ZHALDANPYXAMJF-UHFFFAOYSA-N octadecanoate;tris(2-hydroxyethyl)azanium Chemical compound OCC[NH+](CCO)CCO.CCCCCCCCCCCCCCCCCC([O-])=O ZHALDANPYXAMJF-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
239000003791 organic solvent mixture Substances 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
239000000813 peptide hormone Substances 0.000 description 1
150000008103 phosphatidic acids Chemical class 0.000 description 1
150000008105 phosphatidylcholines Chemical class 0.000 description 1
150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
229940067605 phosphatidylethanolamines Drugs 0.000 description 1
150000008106 phosphatidylserines Chemical class 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
150000004291 polyenes Chemical class 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
239000004810 polytetrafluoroethylene Substances 0.000 description 1
229920001343 polytetrafluoroethylene Polymers 0.000 description 1
229920000166 polytrimethylene carbonate Polymers 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229940069338 potassium sorbate Drugs 0.000 description 1
235000010241 potassium sorbate Nutrition 0.000 description 1
239000004302 potassium sorbate Substances 0.000 description 1
229960005205 prednisolone Drugs 0.000 description 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
229960004618 prednisone Drugs 0.000 description 1
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000000583 progesterone congener Substances 0.000 description 1
229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 1
239000003380 propellant Substances 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
239000004627 regenerated cellulose Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
235000015500 sitosterol Nutrition 0.000 description 1
229950005143 sitosterol Drugs 0.000 description 1
NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
239000000344 soap Substances 0.000 description 1
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
235000011121 sodium hydroxide Nutrition 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
238000000527 sonication Methods 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
150000003408 sphingolipids Chemical class 0.000 description 1
229960001294 spiramycin Drugs 0.000 description 1
235000019372 spiramycin Nutrition 0.000 description 1
229930191512 spiramycin Natural products 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
150000003459 sulfonic acid esters Chemical class 0.000 description 1
230000000475 sunscreen effect Effects 0.000 description 1
239000000516 sunscreening agent Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000010409 thin film Substances 0.000 description 1
229960000707 tobramycin Drugs 0.000 description 1
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
229940029614 triethanolamine stearate Drugs 0.000 description 1
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1
238000002525 ultrasonication Methods 0.000 description 1
235000020681 well water Nutrition 0.000 description 1
239000002349 well water Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Dispersion Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Manufacturing Of Micro-Capsules (AREA)

DD82236567A 1981-01-07 1982-01-05 Verfahren zur herstellung von liposomalen arzneimitteln DD201973A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH5381		1981-01-07

Publications (1)

Publication Number	Publication Date
DD201973A5 true DD201973A5 (de)	1983-08-24

Family

ID=4178241

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD82236567A DD201973A5 (de)	1981-01-07	1982-01-05	Verfahren zur herstellung von liposomalen arzneimitteln

Country Status (11)

Country	Link
US (1)	US4731210A (fr)
EP (1)	EP0056781B1 (fr)
JP (1)	JPS57136514A (fr)
AT (1)	ATE15141T1 (fr)
AU (1)	AU551241B2 (fr)
CA (1)	CA1177396A (fr)
DD (1)	DD201973A5 (fr)
DE (1)	DE3265674D1 (fr)
ES (1)	ES8300470A1 (fr)
IL (1)	IL64397A0 (fr)
ZA (1)	ZA818335B (fr)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4981692A (en) *	1983-03-24	1991-01-01	The Liposome Company, Inc.	Therapeutic treatment by intramammary infusion
JPS607932A (ja) *	1983-06-29	1985-01-16	Dai Ichi Seiyaku Co Ltd	リポソーム懸濁液およびその製法
FR2553002B1 (fr) *	1983-10-06	1992-03-27	Centre Nat Rech Scient	Procede perfectionne d'obtention de liposomes unilamellaires de diametres eleves, leur application pharmacologique pour l'encapsulage d'un principe actif en vue de son administration extemporanee et dispositif correspondant
EP0152379A3 (fr) *	1984-02-15	1986-10-29	Ciba-Geigy Ag	Procédé pour la préparation de compositions pharmaceutiques contenant des liposomes unilamellaires
CA1264162A (fr) *	1984-03-15	1990-01-02	Manfred Breuninger	Glycero-oxy-phosphatides
JPS61353A (ja) *	1984-06-13	1986-01-06	テルモ株式会社	薬剤投与装置
CA1260393A (fr) *	1984-10-16	1989-09-26	Lajos Tarcsay	Liposomes de lipides synthetiques
JPS61197513A (ja) *	1985-02-25	1986-09-01	Ichimaru Fuarukosu Kk	主薬物を内包した安定なリポソ−ムの製剤化法
US4921757A (en) *	1985-04-26	1990-05-01	Massachusetts Institute Of Technology	System for delayed and pulsed release of biologically active substances
US4900556A (en) *	1985-04-26	1990-02-13	Massachusetts Institute Of Technology	System for delayed and pulsed release of biologically active substances
US5409704A (en) *	1985-06-26	1995-04-25	The Liposome Company, Inc.	Liposomes comprising aminoglycoside phosphates and methods of production and use
IL79114A (en) *	1985-08-07	1990-09-17	Allergan Pharma	Method and composition for making liposomes
US4837380A (en) *	1985-09-30	1989-06-06	Regents Of University Of California	Liposome-calcitonin preparation
DE3613799C1 (de) *	1986-04-24	1987-09-03	Nattermann A & Cie	Verwendung von Glycofurol zum Verfluessigen von Arzneimittelzubereitungen fuer das Abfuellen in Weichgelatinekapseln
US4962022A (en) *	1986-09-22	1990-10-09	Becton Dickinson And Company	Storage and use of liposomes
DK86988A (da) *	1987-02-25	1988-08-26	Takeda Chemical Industries Ltd	Liposompraeparat og anvendelse deraf
US4917951A (en) *	1987-07-28	1990-04-17	Micro-Pak, Inc.	Lipid vesicles formed of surfactants and steroids
US5023086A (en) *	1987-03-13	1991-06-11	Micro-Pak, Inc.	Encapsulated ionophore growth factors
US5234767A (en) *	1987-03-13	1993-08-10	Micro-Pak, Inc.	Hybrid paucilamellar lipid vesicles
US5628936A (en) *	1987-03-13	1997-05-13	Micro-Pak, Inc.	Hybrid paucilamellar lipid vesicles
US5000960A (en) *	1987-03-13	1991-03-19	Micro-Pak, Inc.	Protein coupling to lipid vesicles
HU203204B (en) *	1987-09-15	1991-06-28	Sandoz Ag	Process for producing suppository containing calcitonin and taurocholic acid
US4950432A (en) *	1987-10-16	1990-08-21	Board Of Regents, The University Of Texas System	Polyene microlide pre-liposomal powders
EP0382777B1 (fr) *	1987-10-19	1994-10-12	The Liposome Company, Inc.	Preparation aqueuse de composition de liposomes
US5290562A (en) *	1987-11-27	1994-03-01	L V M H Recherche	Compositions and methods employing liposomes including tyrosine or a tyrosine derivative
US5104736A (en) *	1988-03-03	1992-04-14	Micro-Pak, Inc.	Reinforced paucilamellar lipid vesicles
US5032457A (en) *	1988-03-03	1991-07-16	Micro Vesicular Systems, Inc.	Paucilamellar lipid vesicles using charge-localized, single chain, nonphospholipid surfactants
US5019392A (en) *	1988-03-03	1991-05-28	Micro-Pak, Inc.	Encapsulation of parasiticides
JP2713718B2 (ja) *	1988-03-03	1998-02-16	日本レダリー株式会社	リポソーム調製法
MX9203504A (es) *	1988-04-20	1992-07-01	Liposome Co Inc	Complejo agente: lipido activo de alta proporcion.
US4952567A (en) *	1988-05-09	1990-08-28	City Of Hope	Inhibition of lipogenesis
US4994213A (en) *	1988-05-17	1991-02-19	Liposome Technology, Inc.	Method of preparing lipid structures
AU3564589A (en) *	1988-05-17	1989-12-12	Liposome Technology, Inc.	Preparation of uniform-size liposomes and other lipid structures
US5000887A (en) *	1988-05-17	1991-03-19	Liposome Technology, Inc.	Preparation of uniform-size liposomes
IL90561A (en) *	1988-06-08	1993-08-18	Fountain Pharm Inc	Method for making solvent dilution microcarriers
US5269979A (en) *	1988-06-08	1993-12-14	Fountain Pharmaceuticals, Inc.	Method for making solvent dilution microcarriers
CA1329761C (fr) *	1988-07-25	1994-05-24	Vettai S. Ananthanarayanan	Composition pharmaceutique comprenant des hormones peptidiques, des peptides chimiotactiques et des composes medicamenteux
US4952405A (en) *	1988-10-20	1990-08-28	Liposome Technology, Inc.	Method of treating M. avium infection
JPH02227132A (ja) *	1988-11-22	1990-09-10	Kao Corp	リポソーム形成剤及びリポソーム
DE69032161T2 (de) *	1989-05-25	1998-11-19	Technology Unlimited Inc	Abstossmittel für insekten
AU701272B2 (en) *	1989-05-25	1999-01-21	Sdg, Inc.	Insect repellant
HU205147B (en) *	1989-06-29	1992-03-30	Sandoz Ag	Process for producing muramyl dipeptide derivative and pharmaceutical compostions comprising same
US5174988A (en) *	1989-07-27	1992-12-29	Scientific Development & Research, Inc.	Phospholipid delivery system
DE3936328A1 (de) *	1989-10-27	1991-05-02	Schering Ag	Pharmazeutische praeparate
US5085864A (en) *	1989-10-30	1992-02-04	Abbott Laboratories	Injectable formulation for lipophilic drugs
CA2033714A1 (fr) *	1990-01-25	1991-07-26	Alberto Ferro	Preparations pharmaceutiques
DE4107152C2 (de) *	1991-03-06	1994-03-24	Gregor Cevc	Präparate zur nichtinvasiven Verabreichung von Antidiabetica
CA2067754C (fr) *	1990-08-24	2002-06-04	Gregor Cevc	Preparation visant l'application d'agents sous forme de mini- gouttelettes
DE4107153A1 (de) *	1991-03-06	1992-09-10	Gregor Cevc	Praeparat zur wirkstoffapplikation in kleinsttroepfchenform
US5213805A (en) *	1991-07-25	1993-05-25	Micro Vesicular Systems, Inc.	Lipid vesicles having n,n-dimethylamide derivatives as their primary lipid
US5260065A (en) *	1991-09-17	1993-11-09	Micro Vesicular Systems, Inc.	Blended lipid vesicles
US5643600A (en) *	1991-09-17	1997-07-01	Micro-Pak, Inc.	Lipid vesicles containing avocado oil unsaponifiables
US5405615A (en) *	1991-09-17	1995-04-11	Micro Vesicular Systems, Inc.	Sucrose distearate lipid vesicles
US5439967A (en) *	1991-09-17	1995-08-08	Micro Vesicular Systems, Inc.	Propylene glycol stearate vesicles
FR2681247B1 (fr) *	1991-09-17	1993-12-03	Oreal	Composition pharmaceutique pour application topique contenant du dithranol et procede de preparation.
WO1994001089A1 (fr)	1992-07-08	1994-01-20	Dianorm-Geräte G. Maierhofer	Liposomes, procede concernant leur fabrication, et leur utilisation dans la fabrication d'un medicament
US6663885B1 (en) *	1993-03-15	2003-12-16	A. Natterman & Cie Gmbh	Aqueous liposome system and a method for the preparation of such a liposome system
IT1269569B (it) *	1994-04-22	1997-04-08	Ugo Citernesi	Procedimento per la preparazione di complessi fra fosfolipidi e principi attivi utili per la produzione di liposomi e principi attivi e liposomi ottenuti con il procedimento
IT1270678B (it) *	1994-10-20	1997-05-07	Bayer Ag	Liposomi al chetoprofen
US20020048596A1 (en) *	1994-12-30	2002-04-25	Gregor Cevc	Preparation for the transport of an active substance across barriers
CN1192766C (zh) *	1998-10-23	2005-03-16	伊迪亚股份公司	开发、测试和使用用于改进的有效负载和可控制性解缔/缔合速度的大分子和复合聚集体的缔合物的方法
SI1031346T1 (en)	1999-01-27	2002-08-31	Idea Ag	Noninvasive vaccination through the skin
ES2173679T3 (es)	1999-01-27	2002-10-16	Idea Ag	Inmunizacion/transporte transnasal con vehiculos altamente adaptables.
MXPA02000053A (es) *	1999-07-05	2003-07-21	Idea Ag	Un metodo para mejorar el tratamiento a traves de barreras adaptables semipermeables.
US20040082521A1 (en) *	2002-03-29	2004-04-29	Azaya Therapeutics Inc.	Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases
US7473432B2 (en) *	2002-10-11	2009-01-06	Idea Ag	NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery
US7179484B2 (en) *	2002-11-06	2007-02-20	Azaya Therapeutics, Inc.	Protein-stabilized liposomal formulations of pharmaceutical agents
EP1730516A1 (fr) *	2004-03-30	2006-12-13	Pfizer Products Incorporated	Procede et dispositif pour l'evaluation de compositions pharmaceutiques
CA2584475A1 (fr) *	2004-11-12	2006-05-18	Idea Ag	Agregats a grande surface pour le traitement de troubles cutanes
US20100062073A1 (en) *	2006-11-29	2010-03-11	Ronald Arthur Beyerinck	Pharmaceutical compositions comprising nanoparticles comprising enteric polymers casein
WO2008125940A2 (fr) *	2007-04-17	2008-10-23	Pfizer Products Inc.	Nanoparticules comprenant un médicament non cristallin
WO2008135828A2 (fr) *	2007-05-03	2008-11-13	Pfizer Products Inc.	Nanoparticules comprenant un médicament, de l'éthylcellulose et un sel biliaire
WO2008135855A2 (fr) *	2007-05-03	2008-11-13	Pfizer Products Inc.	Nanoparticules contenant un inhibiteur de la protéine de transfert d'ester de cholestéryle et un polymère non ionisable
US20100080852A1 (en) *	2007-05-03	2010-04-01	Ronald Arthur Beyerinck	Phamaceutical composition comprising nanoparticles and casein
WO2008149230A2 (fr)	2007-06-04	2008-12-11	Pfizer Products Inc.	Nanoparticules comprenant un médicament, un polymère cellulosique non ionisable et du tocophéryl polyéthylène glycol succinate
WO2008149192A2 (fr) *	2007-06-04	2008-12-11	Pfizer Products Inc.	Nanoparticules comportant un polymère cellulosique non ionisable et un copolymère bloc amphiphile non ionisable
WO2009010842A2 (fr) *	2007-07-13	2009-01-22	Pfizer Products Inc.	Nanoparticules comprenant des polymères cellulosiques ionisables faiblement solubles dans l'eau
EP2240162A4 (fr) *	2007-12-06	2013-10-09	Bend Res Inc	Nanoparticules comprenant un polymère non ionisable et un copolymère de méthacrylate fonctionnalisé par amine
US9724362B2 (en) *	2007-12-06	2017-08-08	Bend Research, Inc.	Pharmaceutical compositions comprising nanoparticles and a resuspending material
EP2712314A1 (fr) *	2011-03-21	2014-04-02	Gregor Cevc	Compositions sans médicament et méthodes pour diminuer l'inflammation périphérique et la douleur
WO2012126966A2 (fr) *	2011-03-21	2012-09-27	Gregor Cevc	Préparations optimisées d'agrégats à haut pouvoir d'adaptation
CN104812372A (zh) *	2012-10-04	2015-07-29	约翰内斯堡金山大学	脂质体药物递送系统
EP3283045B1 (fr)	2015-04-13	2021-02-17	Fountain Technologies International, LLC	Procédé en une étape pour la production de structures lipidiques ultra-petites

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3932657A (en) *	1973-11-12	1976-01-13	The United States Of America As Represented By The United States Energy Research And Development Administration	Liposome encapsulation of chelating agents
US3957971A (en) *	1974-07-29	1976-05-18	Lever Brothers Company	Moisturizing units and moisturizing compositions containing the same
US3993754A (en) *	1974-10-09	1976-11-23	The United States Of America As Represented By The United States Energy Research And Development Administration	Liposome-encapsulated actinomycin for cancer chemotherapy
US4310506A (en) *	1979-02-22	1982-01-12	California Institute Of Technology	Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
ATE8584T1 (de) *	1980-01-16	1984-08-15	Hans Georg Prof. Dr. Weder	Verfahren und dialysiereinrichtung zur herstellung von bilayer-vesikeln und verwendung der bilayer-vesikel.

1981
- 1981-11-27 IL IL64397A patent/IL64397A0/xx not_active IP Right Cessation
- 1981-12-01 ZA ZA818335A patent/ZA818335B/xx unknown
1982
- 1982-01-04 EP EP82810001A patent/EP0056781B1/fr not_active Expired
- 1982-01-04 DE DE8282810001T patent/DE3265674D1/de not_active Expired
- 1982-01-04 AT AT82810001T patent/ATE15141T1/de not_active IP Right Cessation
- 1982-01-05 DD DD82236567A patent/DD201973A5/de not_active IP Right Cessation
- 1982-01-06 AU AU79216/82A patent/AU551241B2/en not_active Ceased
- 1982-01-06 CA CA000393620A patent/CA1177396A/fr not_active Expired
- 1982-01-07 ES ES508556A patent/ES8300470A1/es not_active Expired
- 1982-01-07 US US06/337,806 patent/US4731210A/en not_active Expired - Fee Related
- 1982-01-07 JP JP57000654A patent/JPS57136514A/ja active Pending

Also Published As

Publication number	Publication date
US4731210A (en)	1988-03-15
ZA818335B (en)	1982-10-27
DE3265674D1 (en)	1985-10-03
EP0056781A2 (fr)	1982-07-28
AU551241B2 (en)	1986-04-24
ATE15141T1 (de)	1985-09-15
ES508556A0 (es)	1982-11-01
AU7921682A (en)	1982-07-29
EP0056781B1 (fr)	1985-08-28
EP0056781A3 (en)	1983-06-15
IL64397A0 (en)	1982-02-28
ES8300470A1 (es)	1982-11-01
CA1177396A (fr)	1984-11-06
JPS57136514A (en)	1982-08-23

Legal Events

Date	Code	Title	Description
1994-01-27	PJ	Ceased due to non-payment of renewal fee (addendum to changes before extension act)

Publication	Publication Date	Title
EP0056781B1 (fr)	1985-08-28	Procédé de préparation de médicaments liposomaux
EP0032578B1 (fr)	1984-07-25	Procédé et installation de dialyse pour la préparation de vésicules à deux couches et leur utilisation
DE3785198T2 (de)	1993-07-15	Liposomes praeparat und antibiotikum.
DE69809074T2 (de)	2003-06-26	Herstellung von arzneimitteln
DE3650302T2 (de)	1995-09-07	Auf alpha-tocopherol basierte bläschen.
DE3851090T2 (de)	1995-01-12	Prostaglandin-Lipid-Formulierungen.
DE69616523T2 (de)	2002-05-08	Verfahren zur baladung von lipidvesikeln
DE2818655C2 (de)	1987-05-14	Verfahren zur Herstellung eines gefriergetrockneten Gemischs von potentiellen Liposomen, durch dieses Verfahren erhaltenes Gemisch sowie Verfahren zur Herstellung eines wäßrigen Liposompräparats
DE69822176T2 (de)	2004-09-16	Peptid/lipid-komplexbildung durch co-lyophilisation
DE3853191T2 (de)	1995-10-19	Arzneimittelträger.
DE69426418T2 (de)	2001-05-10	Feste fettnanoemulsionen als wirkstoffabgabevehikel
DE3586242T2 (de)	1993-01-28	Steroid-liposome.
DE69713615T2 (de)	2003-01-02	Ionophorenvermitteltes aufladen von liposomen mit schwach basischen arzneistoffen
EP1581185B1 (fr)	2009-10-14	Glucocorticoides liposomaux
EP0069307B1 (fr)	1986-03-05	Procédé de préparation de solutions de liposomes
EP0736299B1 (fr)	2001-11-14	Procédé de préparation d'une formulation thérapeutique, solide et sèche de liposomes, dispersible dans l'eau pour administration orale
DE69429511T2 (de)	2002-05-16	Reduzierung von durch liposome induzierte physiologischen gegenreaktionen
DE2907303A1 (de)	1979-09-06	Verfahren zur einkapselung biologisch aktiver substanzen
DE4447287C1 (de)	1996-11-07	Präparat zum Wirkstofftransport durch Barrieren
DE60208454T2 (de)	2006-09-07	Polyalkylenoxid-modifizierte Phospholipide und Verfahren zu ihrer Herstellung
EP0776194B1 (fr)	2003-05-02	Preparations liposomales unilamellaires, avec une teneur elevee en principe actif
DE69026820T2 (de)	1996-11-28	Zubereitung von liposomen- und lipid-komplexzusammensetzungen
EP0707847A1 (fr)	1996-04-24	Liposomes de kétoprofène
DE69710803T2 (de)	2002-11-28	Verfahren zur Herstellung von geschlossenen Vesikeln durch Rehydratisierung von dehydratisierten Vesikeln
EP0488142B1 (fr)	1995-01-25	Procédé pour encapsuler des principes actifs lipophiles solides ou liquides dans des liposomes phospholipidiques ainsi que des médicaments contenant ces liposomes