DD210058A5 - Verfahren zur herstellung neuer muramylpeptide - Google Patents

Verfahren zur herstellung neuer muramylpeptide Download PDF

Info

Publication number: DD210058A5
Authority: DD; German Democratic Republic
Prior art keywords: formula; compound; hydrogen; group; reactive
Prior art date: 1982-07-23

Application number

DD83253281A

Other languages

German (de)

English (en)

Inventor

Albert Hartmann

Oskar Wacker

Gerhard Baschang

Lajos Tarcsay

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-07-23

Filing date

1983-07-21

Publication date

1984-05-30

1983-07-21 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1984-05-30 Publication of DD210058A5 publication Critical patent/DD210058A5/de

Links

238000004519 manufacturing process Methods 0.000 title description 12
150000001875 compounds Chemical class 0.000 claims abstract description 144
-1 hydroxy- Chemical class 0.000 claims abstract description 125
238000000034 method Methods 0.000 claims abstract description 82
239000001257 hydrogen Substances 0.000 claims abstract description 45
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 45
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 37
125000000217 alkyl group Chemical group 0.000 claims abstract description 28
230000008569 process Effects 0.000 claims abstract description 23
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 20
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 13
239000001301 oxygen Substances 0.000 claims abstract description 13
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125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract description 7
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 6
125000001589 carboacyl group Chemical group 0.000 claims abstract description 5
229910052727 yttrium Inorganic materials 0.000 claims abstract description 5
150000003839 salts Chemical class 0.000 claims description 59
239000002253 acid Substances 0.000 claims description 57
238000006243 chemical reaction Methods 0.000 claims description 47
239000007858 starting material Substances 0.000 claims description 44
125000006239 protecting group Chemical group 0.000 claims description 40
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125000005843 halogen group Chemical group 0.000 claims description 2
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
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SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical compound ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000007923 nasal drop Substances 0.000 description 1
229940100662 nasal drops Drugs 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
LHKVDVFVJMYULK-UHFFFAOYSA-N nitrosylazide Chemical compound [N-]=[N+]=NN=O LHKVDVFVJMYULK-UHFFFAOYSA-N 0.000 description 1
230000037311 normal skin Effects 0.000 description 1
230000000269 nucleophilic effect Effects 0.000 description 1
239000003883 ointment base Substances 0.000 description 1
238000005580 one pot reaction Methods 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
HBEQXAKJSGXAIQ-UHFFFAOYSA-N oxopalladium Chemical compound [Pd]=O HBEQXAKJSGXAIQ-UHFFFAOYSA-N 0.000 description 1
229910003445 palladium oxide Inorganic materials 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical class OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
150000003016 phosphoric acids Chemical class 0.000 description 1
125000004437 phosphorous atom Chemical group 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920000172 poly(styrenesulfonic acid) Polymers 0.000 description 1
229920002492 poly(sulfone) Polymers 0.000 description 1
229920000223 polyglycerol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011148 porous material Substances 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
239000012286 potassium permanganate Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
OSFBJERFMQCEQY-UHFFFAOYSA-N propylidene Chemical group [CH]CC OSFBJERFMQCEQY-UHFFFAOYSA-N 0.000 description 1
125000004742 propyloxycarbonyl group Chemical group 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
150000003214 pyranose derivatives Chemical class 0.000 description 1
150000003217 pyrazoles Chemical class 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
229940100486 rice starch Drugs 0.000 description 1
125000006413 ring segment Chemical group 0.000 description 1
230000000630 rising effect Effects 0.000 description 1
239000011833 salt mixture Substances 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
230000028327 secretion Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
230000035939 shock Effects 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
NWZBFJYXRGSRGD-UHFFFAOYSA-M sodium;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O NWZBFJYXRGSRGD-UHFFFAOYSA-M 0.000 description 1
239000011343 solid material Substances 0.000 description 1
238000003797 solvolysis reaction Methods 0.000 description 1
229940057429 sorbitan isostearate Drugs 0.000 description 1
229950004959 sorbitan oleate Drugs 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
229960002317 succinimide Drugs 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003509 tertiary alcohols Chemical class 0.000 description 1
238000010998 test method Methods 0.000 description 1
QSUJAUYJBJRLKV-UHFFFAOYSA-M tetraethylazanium;fluoride Chemical compound [F-].CC[N+](CC)(CC)CC QSUJAUYJBJRLKV-UHFFFAOYSA-M 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
150000003527 tetrahydropyrans Chemical class 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
229960004906 thiomersal Drugs 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
238000005809 transesterification reaction Methods 0.000 description 1
150000005691 triesters Chemical class 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
PNQBEPDZQUOCNY-UHFFFAOYSA-N trifluoroacetyl chloride Chemical compound FC(F)(F)C(Cl)=O PNQBEPDZQUOCNY-UHFFFAOYSA-N 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
QDNCLIPKBNMUPP-UHFFFAOYSA-N trimethyloxidanium Chemical compound C[O+](C)C QDNCLIPKBNMUPP-UHFFFAOYSA-N 0.000 description 1
238000001665 trituration Methods 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
241000712461 unidentified influenza virus Species 0.000 description 1
238000010792 warming Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Crystallography & Structural Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Other Liquid Machine Or Engine Such As Wave Power Use (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DD83253281A 1982-07-23 1983-07-21 Verfahren zur herstellung neuer muramylpeptide DD210058A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH452782		1982-07-23

Publications (1)

Publication Number	Publication Date
DD210058A5 true DD210058A5 (de)	1984-05-30

Family

ID=4277755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD83253281A DD210058A5 (de)	1982-07-23	1983-07-21	Verfahren zur herstellung neuer muramylpeptide

Country Status (23)

Country	Link
US (1)	US4548923A (fr)
EP (1)	EP0099578B1 (fr)
JP (1)	JPS5933296A (fr)
KR (1)	KR910003641B1 (fr)
AT (1)	ATE23536T1 (fr)
AU (1)	AU555418B2 (fr)
CA (1)	CA1243305A (fr)
CS (1)	CS245787B2 (fr)
DD (1)	DD210058A5 (fr)
DE (1)	DE3367596D1 (fr)
DK (1)	DK167193B1 (fr)
ES (2)	ES8504676A1 (fr)
FI (1)	FI79330C (fr)
GR (1)	GR79611B (fr)
HU (1)	HU191371B (fr)
IE (1)	IE55838B1 (fr)
IL (1)	IL69292A (fr)
NO (1)	NO167746C (fr)
NZ (1)	NZ205002A (fr)
PL (2)	PL142775B1 (fr)
PT (1)	PT77081B (fr)
SU (1)	SU1299516A3 (fr)
ZA (1)	ZA835357B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5334583A (en) *	1982-07-23	1994-08-02	Ciba-Geigy Corp.	Use of sugar derivatives for the prophylaxis and treatment of virus infections
US5189017A (en) *	1982-07-23	1993-02-23	Ciba-Geigy Corporation	Use of sugar derivatives for the prophylaxis and treatment of virus infections
ZA853989B (en) *	1984-05-29	1986-01-29	Ciba Geigy Ag	Acylated sugar derivatives,processes for their manufacture,and their use
ATE45744T1 (de) *	1984-07-25	1989-09-15	Ciba Geigy Ag	Phosphatidylverbindungen, verfahren zu ihrer herstellung und ihre verwendung.
JPS6157597A (ja) *	1984-08-29	1986-03-24	Toshiyuki Hamaoka	ムラミルペプチド活性エステル誘導体
EP0174912A3 (fr) *	1984-09-13	1986-06-04	Ciba-Geigy Ag	Composés phosphorés, leur procédé de préparation et leur utilisation
US4873322A (en) *	1986-01-24	1989-10-10	Ciba-Geigy Corporation	Saccharide derivatives and processes for their manufacture
US4994440A (en) *	1989-02-13	1991-02-19	Creaven Patrick J	Method for the treatment of renal cell carcinoma
FR2732604B1 (fr) *	1995-04-07	1997-06-06	Vacsyn Sa	Derives et conjugues du mdp presentant une activite stimulatrice de la fonction hematopoietique et compositions les contenant
AU2002950657A0 (en) *	2002-08-08	2002-09-12	Alchemia Limited	Derivatives of monosaccharides for drug discovery
AU2002951995A0 (en) *	2002-10-11	2002-10-31	Alchemia Limited	Classes of compounds that interact with gpcrs
JP2007514648A (ja) *	2003-10-24	2007-06-07	エーザイ株式会社	Ｔｏｌｌ−ｌｉｋｅｒｅｃｅｐｔｏｒ２に関連する疾患及び状態を治療するための化合物及び方法
CN111808131B (zh) *	2019-04-11	2021-09-17	中国科学院大连化学物理研究所	一对有效抑制Aβ(1-40)聚集和纤维化的手性磷脂分子及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2428051A1 (fr) *	1978-06-05	1980-01-04	Anvar	Nouveaux composes du type muramyl-peptide et medicaments les contenant
FI75578C (fi) *	1979-07-25	1988-07-11	Ciba Geigy Ag	Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
FI803077A7 (fi) *	1979-10-12	1981-04-13	Ciba Geigy Ag	Foerfarande foer framstaellning av myramylpeptider
GR78246B (fr) *	1981-01-23	1984-09-26	Ciba Geigy Ag

1983
- 1983-07-20 DE DE8383107112T patent/DE3367596D1/de not_active Expired
- 1983-07-20 AT AT83107112T patent/ATE23536T1/de not_active IP Right Cessation
- 1983-07-20 EP EP83107112A patent/EP0099578B1/fr not_active Expired
- 1983-07-20 FI FI832639A patent/FI79330C/fi not_active IP Right Cessation
- 1983-07-21 IL IL69292A patent/IL69292A/xx not_active IP Right Cessation
- 1983-07-21 GR GR71996A patent/GR79611B/el unknown
- 1983-07-21 CS CS835484A patent/CS245787B2/cs unknown
- 1983-07-21 PL PL1983250150A patent/PL142775B1/pl unknown
- 1983-07-21 DD DD83253281A patent/DD210058A5/de not_active IP Right Cessation
- 1983-07-21 PL PL1983243132A patent/PL142641B1/pl unknown
- 1983-07-22 KR KR1019830003389A patent/KR910003641B1/ko not_active Expired
- 1983-07-22 PT PT77081A patent/PT77081B/pt not_active IP Right Cessation
- 1983-07-22 HU HU832598A patent/HU191371B/hu not_active IP Right Cessation
- 1983-07-22 IE IE1727/83A patent/IE55838B1/en not_active IP Right Cessation
- 1983-07-22 ES ES524386A patent/ES8504676A1/es not_active Expired
- 1983-07-22 SU SU833622707A patent/SU1299516A3/ru active
- 1983-07-22 AU AU17218/83A patent/AU555418B2/en not_active Ceased
- 1983-07-22 CA CA000433038A patent/CA1243305A/fr not_active Expired
- 1983-07-22 NZ NZ205002A patent/NZ205002A/en unknown
- 1983-07-22 JP JP58133009A patent/JPS5933296A/ja active Pending
- 1983-07-22 NO NO832691A patent/NO167746C/no unknown
- 1983-07-22 ZA ZA835357A patent/ZA835357B/xx unknown
- 1983-07-22 DK DK337883A patent/DK167193B1/da not_active IP Right Cessation
1984
- 1984-05-09 US US06/608,911 patent/US4548923A/en not_active Expired - Lifetime
1985
- 1985-01-11 ES ES539505A patent/ES8607980A1/es not_active Expired

Also Published As

Publication number	Publication date
PT77081A (en)	1983-08-01
DK337883D0 (da)	1983-07-22
HU191371B (en)	1987-02-27
PL243132A1 (en)	1985-03-12
PL142641B1 (en)	1987-11-30
NZ205002A (en)	1987-11-27
CS548483A2 (en)	1985-09-17
ES8607980A1 (es)	1986-06-01
DK167193B1 (da)	1993-09-13
IE831727L (en)	1984-01-23
ES524386A0 (es)	1985-04-16
NO167746B (no)	1991-08-26
ES539505A0 (es)	1986-06-01
ATE23536T1 (de)	1986-11-15
IE55838B1 (en)	1991-01-30
FI79330B (fi)	1989-08-31
NO167746C (no)	1991-12-04
DE3367596D1 (en)	1987-01-02
EP0099578A1 (fr)	1984-02-01
ZA835357B (en)	1984-03-28
AU555418B2 (en)	1986-09-25
AU1721883A (en)	1984-01-26
FI832639A0 (fi)	1983-07-20
PL250150A1 (en)	1985-06-04
IL69292A0 (en)	1983-11-30
SU1299516A3 (ru)	1987-03-23
EP0099578B1 (fr)	1986-11-12
GR79611B (fr)	1984-10-31
KR840005733A (ko)	1984-11-16
PT77081B (en)	1986-04-11
IL69292A (en)	1987-03-31
DK337883A (da)	1984-01-24
ES8504676A1 (es)	1985-04-16
US4548923A (en)	1985-10-22
FI832639A7 (fi)	1984-01-24
JPS5933296A (ja)	1984-02-23
CS245787B2 (en)	1986-10-16
PL142775B1 (en)	1987-11-30
NO832691L (no)	1984-01-24
KR910003641B1 (ko)	1991-06-07
CA1243305A (fr)	1988-10-18
FI79330C (fi)	1989-12-11

Legal Events

Date	Code	Title	Description
2000-01-20	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DE69835223T2 (de)	2007-05-31	Sphingosinderivate und medizinische zubereitung
EP0548024B1 (fr)	1997-01-08	Dérivés d'acides aminosulfoniques et procédé pour leur préparation
CH677672A5 (fr)	1991-06-14
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