DD216463A5 - Verfahren zur herstellung von als histamin h tief 1-rezeptor-antagonisten wirkenden pyrimidon-derivaten - Google Patents

Verfahren zur herstellung von als histamin h tief 1-rezeptor-antagonisten wirkenden pyrimidon-derivaten Download PDF

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Publication number
DD216463A5
DD216463A5 DD84265516A DD26551684A DD216463A5 DD 216463 A5 DD216463 A5 DD 216463A5 DD 84265516 A DD84265516 A DD 84265516A DD 26551684 A DD26551684 A DD 26551684A DD 216463 A5 DD216463 A5 DD 216463A5
Authority
DD
German Democratic Republic
Prior art keywords
pyridyl
general formula
compound
group
oxo
Prior art date
Application number
DD84265516A
Other languages
German (de)
English (en)
Inventor
George S Sach
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of DD216463A5 publication Critical patent/DD216463A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Impact Printers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Treating Waste Gases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DD84265516A 1983-07-23 1984-07-20 Verfahren zur herstellung von als histamin h tief 1-rezeptor-antagonisten wirkenden pyrimidon-derivaten DD216463A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838319874A GB8319874D0 (en) 1983-07-23 1983-07-23 Compounds

Publications (1)

Publication Number Publication Date
DD216463A5 true DD216463A5 (de) 1984-12-12

Family

ID=10546171

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84265516A DD216463A5 (de) 1983-07-23 1984-07-20 Verfahren zur herstellung von als histamin h tief 1-rezeptor-antagonisten wirkenden pyrimidon-derivaten

Country Status (23)

Country Link
US (1) US4665078A (fr)
EP (1) EP0134091B1 (fr)
JP (1) JPS6048986A (fr)
KR (1) KR850001194A (fr)
AT (1) ATE27818T1 (fr)
AU (1) AU3080984A (fr)
CS (1) CS244446B2 (fr)
DD (1) DD216463A5 (fr)
DE (1) DE3464249D1 (fr)
DK (1) DK359184A (fr)
ES (1) ES8602761A1 (fr)
FI (1) FI842907A7 (fr)
GB (1) GB8319874D0 (fr)
GR (1) GR79961B (fr)
HU (1) HUT34745A (fr)
IL (1) IL72448A0 (fr)
JO (1) JO1326B1 (fr)
NO (1) NO842963L (fr)
NZ (1) NZ208956A (fr)
PL (1) PL248859A1 (fr)
PT (1) PT78961A (fr)
RO (1) RO89219A (fr)
ZA (1) ZA845622B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT78358B (en) * 1983-04-07 1986-05-30 Smith Kline French Lab Chemical process
DE69919707T2 (de) 1998-06-19 2005-09-01 Chiron Corp., Emeryville Glycogen synthase kinase 3 inhibitoren
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US10596401B2 (en) 2016-08-11 2020-03-24 Victaulic Company Modular valve assembly
US20180193681A1 (en) 2017-01-06 2018-07-12 Globe Fire Sprinkler Corporation Control valve assembly with test, drain and adjustable pressure relief valve
WO2019190609A1 (fr) 2018-03-29 2019-10-03 Globe Fire Sprinkler Corporation Ensemble combiné clapet anti-retour et de régulation pour système de tuyauterie sous eau
EP4031788A4 (fr) 2019-09-20 2023-10-18 Victaulic Company Ensemble clapet à bille

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
IN151188B (fr) * 1978-02-13 1983-03-05 Smith Kline French Lab
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
PT75074B (en) * 1981-06-27 1986-02-26 Smith Kline French Lab Process for preparing certain pyrimidone derivatives and compositions containing them

Also Published As

Publication number Publication date
PT78961A (en) 1984-08-01
NO842963L (no) 1985-01-24
ZA845622B (en) 1985-07-31
KR850001194A (ko) 1985-03-16
AU3080984A (en) 1985-01-24
EP0134091B1 (fr) 1987-06-16
DK359184D0 (da) 1984-07-20
JPS6048986A (ja) 1985-03-16
GR79961B (fr) 1984-10-31
CS244446B2 (en) 1986-07-17
EP0134091A1 (fr) 1985-03-13
ES534452A0 (es) 1985-12-01
JO1326B1 (en) 1986-11-30
DK359184A (da) 1985-01-24
US4665078A (en) 1987-05-12
HUT34745A (en) 1985-04-28
FI842907L (fi) 1985-01-24
PL248859A1 (en) 1985-07-16
GB8319874D0 (en) 1983-08-24
IL72448A0 (en) 1984-11-30
CS557184A2 (en) 1985-08-15
DE3464249D1 (de) 1987-07-23
ATE27818T1 (de) 1987-07-15
FI842907A7 (fi) 1985-01-24
ES8602761A1 (es) 1985-12-01
FI842907A0 (fi) 1984-07-19
NZ208956A (en) 1987-03-06
RO89219A (fr) 1986-03-15

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