DD219771A5 - Verfahren zur herstellung neuer konjugierter verbindungen von vinblastin und seinen derivaten - Google Patents

Verfahren zur herstellung neuer konjugierter verbindungen von vinblastin und seinen derivaten Download PDF

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Publication number
DD219771A5
DD219771A5 DD84263250A DD26325084A DD219771A5 DD 219771 A5 DD219771 A5 DD 219771A5 DD 84263250 A DD84263250 A DD 84263250A DD 26325084 A DD26325084 A DD 26325084A DD 219771 A5 DD219771 A5 DD 219771A5
Authority
DD
German Democratic Republic
Prior art keywords
vinblastine
items
protein
solution
group
Prior art date
Application number
DD84263250A
Other languages
German (de)
English (en)
Inventor
Andre B L Trouet
Kandukuri S B Rao
Jean A A Hannart
Jean-Paul De Jonghe
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of DD219771A5 publication Critical patent/DD219771A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DD84263250A 1983-12-29 1984-05-22 Verfahren zur herstellung neuer konjugierter verbindungen von vinblastin und seinen derivaten DD219771A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU85161A LU85161A1 (fr) 1983-12-29 1983-12-29 Nouveaux conjugues de la vinblastine,leur procede de preparation et leur utilisation therapeutique

Publications (1)

Publication Number Publication Date
DD219771A5 true DD219771A5 (de) 1985-03-13

Family

ID=19730204

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84263250A DD219771A5 (de) 1983-12-29 1984-05-22 Verfahren zur herstellung neuer konjugierter verbindungen von vinblastin und seinen derivaten

Country Status (4)

Country Link
DD (1) DD219771A5 (fr)
IL (1) IL71642A (fr)
LU (1) LU85161A1 (fr)
PH (1) PH21394A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008098788A3 (fr) * 2007-02-16 2009-06-11 Ktb Tumorforschungs Gmbh Récepteur et promédicament ciblé par l'antigène

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008098788A3 (fr) * 2007-02-16 2009-06-11 Ktb Tumorforschungs Gmbh Récepteur et promédicament ciblé par l'antigène
US9216228B2 (en) 2007-02-16 2015-12-22 KTB Tumorforschungsgesellschaft MBM Receptor and antigen targeted prodrug

Also Published As

Publication number Publication date
LU85161A1 (fr) 1985-09-12
PH21394A (en) 1987-10-15
IL71642A (en) 1990-11-05

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