DD222332A5 - Verfahren und reagenz zur bestimmung von transaminasen - Google Patents

Verfahren und reagenz zur bestimmung von transaminasen Download PDF

Info

Publication number: DD222332A5
Authority: DD; German Democratic Republic
Prior art keywords: dsm; mmol; item; ldh; amino acid
Prior art date: 1983-08-22

Application number

DD84266444A

Other languages

German (de)

English (en)

Inventor

Gerald Moeller

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-22

Filing date

1984-08-20

Publication date

1985-05-15

1984-08-20 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1985-05-15 Publication of DD222332A5 publication Critical patent/DD222332A5/de

Links

238000000034 method Methods 0.000 title claims description 20
108090000340 Transaminases Proteins 0.000 title claims description 12
102000003929 Transaminases Human genes 0.000 title claims description 10
239000003153 chemical reaction reagent Substances 0.000 title claims description 9
150000001413 amino acids Chemical class 0.000 claims abstract description 10
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims abstract description 5
229930195712 glutamate Natural products 0.000 claims abstract description 5
BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims abstract description 5
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims abstract description 5
102000003855 L-lactate dehydrogenase Human genes 0.000 claims abstract description 4
108700023483 L-lactate dehydrogenases Proteins 0.000 claims abstract description 4
238000005259 measurement Methods 0.000 claims abstract description 3
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract 10
108010001539 D-lactate dehydrogenase Proteins 0.000 claims abstract 7
108010026217 Malate Dehydrogenase Proteins 0.000 claims abstract 6
102000013460 Malate Dehydrogenase Human genes 0.000 claims abstract 6
241000894006 Bacteria Species 0.000 claims abstract 5
235000014655 lactic acid Nutrition 0.000 claims abstract 5
239000004310 lactic acid Substances 0.000 claims abstract 5
101710098398 Probable alanine aminotransferase, mitochondrial Proteins 0.000 claims description 11
229940024606 amino acid Drugs 0.000 claims description 9
235000001014 amino acid Nutrition 0.000 claims description 9
241000186660 Lactobacillus Species 0.000 claims description 5
229940039696 lactobacillus Drugs 0.000 claims description 5
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 4
241000192001 Pediococcus Species 0.000 claims description 4
235000004279 alanine Nutrition 0.000 claims description 4
229940009098 aspartate Drugs 0.000 claims description 4
239000000872 buffer Substances 0.000 claims description 4
KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 claims description 4
LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 3
244000005700 microbiome Species 0.000 claims description 3
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
240000006024 Lactobacillus plantarum Species 0.000 claims description 2
241000192132 Leuconostoc Species 0.000 claims description 2
241000192130 Leuconostoc mesenteroides Species 0.000 claims description 2
229940049920 malate Drugs 0.000 claims description 2
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
241001147746 Lactobacillus delbrueckii subsp. lactis Species 0.000 claims 2
241001134654 Lactobacillus leichmannii Species 0.000 claims 2
RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 1
101000588924 Anthopleura elegantissima Delta-actitoxin-Ael1a Proteins 0.000 claims 1
235000013965 Lactobacillus plantarum Nutrition 0.000 claims 1
-1 amino acid aspartate Chemical class 0.000 claims 1
JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
CKLJMWTZIZZHCS-REOHCLBHSA-L aspartate group Chemical group N[C@@H](CC(=O)[O-])C(=O)[O-] CKLJMWTZIZZHCS-REOHCLBHSA-L 0.000 claims 1
229940072205 lactobacillus plantarum Drugs 0.000 claims 1
239000002253 acid Substances 0.000 abstract description 5
KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 abstract 2
BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 abstract 1
150000004716 alpha keto acids Chemical class 0.000 abstract 1
HWXBTNAVRSUOJR-UHFFFAOYSA-N alpha-hydroxyglutaric acid Natural products OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 abstract 1
229940009533 alpha-ketoglutaric acid Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
208000006454 hepatitis Diseases 0.000 description 3
210000004185 liver Anatomy 0.000 description 3
208000019423 liver disease Diseases 0.000 description 3
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
210000000805 cytoplasm Anatomy 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
208000019622 heart disease Diseases 0.000 description 2
102000014898 transaminase activity proteins Human genes 0.000 description 2
102100033814 Alanine aminotransferase 2 Human genes 0.000 description 1
102100036608 Aspartate aminotransferase, cytoplasmic Human genes 0.000 description 1
206010008909 Chronic Hepatitis Diseases 0.000 description 1
101710088194 Dehydrogenase Proteins 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
206010016654 Fibrosis Diseases 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
206010019799 Hepatitis viral Diseases 0.000 description 1
101001083553 Homo sapiens Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Proteins 0.000 description 1
206010023126 Jaundice Diseases 0.000 description 1
241000192129 Leuconostoc lactis Species 0.000 description 1
102100029107 Long chain 3-hydroxyacyl-CoA dehydrogenase Human genes 0.000 description 1
102000007327 Protamines Human genes 0.000 description 1
108010007568 Protamines Proteins 0.000 description 1
BOPGDPNILDQYTO-NDOGXIPWSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2r,3r,4r,5r)-5-(3-carbamoyl-4h-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NDOGXIPWSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
231100000354 acute hepatitis Toxicity 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
230000005779 cell damage Effects 0.000 description 1
208000037887 cell injury Diseases 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
230000007882 cirrhosis Effects 0.000 description 1
208000019425 cirrhosis of liver Diseases 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
230000004069 differentiation Effects 0.000 description 1
229940111782 egg extract Drugs 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
230000002440 hepatic effect Effects 0.000 description 1
208000018191 liver inflammation Diseases 0.000 description 1
230000004807 localization Effects 0.000 description 1
210000003470 mitochondria Anatomy 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
210000004165 myocardium Anatomy 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
210000004738 parenchymal cell Anatomy 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000008057 potassium phosphate buffer Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
229950008679 protamine sulfate Drugs 0.000 description 1
239000000523 sample Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
201000001862 viral hepatitis Diseases 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/52—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving transaminase
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/857—Lactobacillus plantarum

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Reinforced Plastic Materials (AREA)
Solid State Image Pick-Up Elements (AREA)
Photovoltaic Devices (AREA)
Semiconductor Lasers (AREA)

DD84266444A 1983-08-22 1984-08-20 Verfahren und reagenz zur bestimmung von transaminasen DD222332A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19833330246 DE3330246A1 (de)	1983-08-22	1983-08-22	Verfahren und reagenz zur bestimmung von transaminasen

Publications (1)

Publication Number	Publication Date
DD222332A5 true DD222332A5 (de)	1985-05-15

Family

ID=6207132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD84266444A DD222332A5 (de)	1983-08-22	1984-08-20	Verfahren und reagenz zur bestimmung von transaminasen

Country Status (13)

Country	Link
US (1)	US4728604A (cs)
EP (1)	EP0139985B1 (cs)
JP (1)	JPS6078598A (cs)
AT (1)	ATE31427T1 (cs)
AU (1)	AU548110B2 (cs)
CA (1)	CA1225316A (cs)
CS (1)	CS257782B2 (cs)
DD (1)	DD222332A5 (cs)
DE (2)	DE3330246A1 (cs)
ES (1)	ES535299A0 (cs)
SU (1)	SU1431690A3 (cs)
YU (1)	YU143584A (cs)
ZA (1)	ZA846478B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0387697A3 (en) *	1989-03-13	1991-11-13	Abbott Laboratories	Determination of aminotranferases
JPH05505108A (ja) *	1990-03-01	1993-08-05	バクスター、ダイアグノスティックス、インコーポレイテッド	反応副生成物を酵素アッセイのための校正試薬として使用する方法
DE4427492A1 (de) *	1994-08-03	1996-02-08	Boehringer Mannheim Gmbh	Verfahren zur Analyse einer medizinischen Probe unter Vermeidung von Störbeiträgen aufgrund von Hämolyse
JP6339789B2 (ja) *	2013-10-23	2018-06-06	株式会社カイノス	Ａｌｔ活性測定試薬およびその試薬を用いたアラニンアミノトランスフェラーゼ活性の測定方法。

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3527332A (en) *	1966-06-30	1970-09-08	Calbiochem	Method for assaying glutamate pyruvate transaminase
BE786291A (fr) *	1971-07-20	1973-01-15	Technicon Instr	Compositions de diagnostic pour determination de la glutamate-oxalate-transaminase (got) et de la glutamate-pyruvate-transaminase (gpt)
IT1162349B (it) *	1979-07-17	1987-03-25	Biodata Spa	Metodo per la determinazione delle transaminasi e relativo kit diagnostico

1983
- 1983-08-22 DE DE19833330246 patent/DE3330246A1/de not_active Withdrawn
1984
- 1984-08-15 CA CA000461074A patent/CA1225316A/en not_active Expired
- 1984-08-16 AU AU31974/84A patent/AU548110B2/en not_active Ceased
- 1984-08-20 CS CS846297A patent/CS257782B2/cs unknown
- 1984-08-20 ES ES535299A patent/ES535299A0/es active Granted
- 1984-08-20 US US06/642,423 patent/US4728604A/en not_active Expired - Lifetime
- 1984-08-20 YU YU01435/84A patent/YU143584A/xx unknown
- 1984-08-20 DD DD84266444A patent/DD222332A5/de not_active IP Right Cessation
- 1984-08-21 SU SU843784992A patent/SU1431690A3/ru active
- 1984-08-21 ZA ZA846478A patent/ZA846478B/xx unknown
- 1984-08-22 AT AT84110018T patent/ATE31427T1/de not_active IP Right Cessation
- 1984-08-22 DE DE8484110018T patent/DE3468126D1/de not_active Expired
- 1984-08-22 JP JP59173461A patent/JPS6078598A/ja active Granted
- 1984-08-22 EP EP84110018A patent/EP0139985B1/de not_active Expired

Also Published As

Publication number	Publication date
DE3330246A1 (de)	1985-03-14
AU548110B2 (en)	1985-11-21
CS629784A2 (en)	1987-11-12
US4728604A (en)	1988-03-01
DE3468126D1 (en)	1988-01-28
JPS6078598A (ja)	1985-05-04
CS257782B2 (en)	1988-06-15
YU143584A (en)	1988-10-31
AU3197484A (en)	1985-02-28
SU1431690A3 (ru)	1988-10-15
CA1225316A (en)	1987-08-11
ES8504939A1 (es)	1985-05-16
EP0139985A1 (de)	1985-05-08
ZA846478B (en)	1986-04-30
ATE31427T1 (de)	1988-01-15
EP0139985B1 (de)	1987-12-16
ES535299A0 (es)	1985-05-16
JPH0453519B2 (cs)	1992-08-26

Legal Events

Date	Code	Title	Description
2002-03-28	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
Tygstrup et al.	1965	The mechanism of the fructose effect on the ethanol metabolism of the human liver
DE2315501A1 (de)	1974-10-17	Verfahren zur bestimmung von cholesterin
DE2050714C2 (de)	1985-09-19	Polysaccharid mit Antitumoraktivität, Verfahren zu seiner Gewinnung und seine Verwendung als Wirkstoff in Antitumormitteln
DE2224133B2 (de)	1974-06-20	Verwendung von bestimmten Mikroorganismen-Stämmen zur Gewinnung von Cholesterinoxydase, welche Cholesterin mit O tief 2 zu Cholestenon + H tief 2 O tief 2 oxydiert
Van der Hoeven et al.	1978	Symbiotic relationship of Veillonella alcalescens and Streptococcus mutans in dental plaque in gnotobiotic rats
Fryer	1970	Utilization of citrate by lactobacilli isolated from dairy products
DE2649749C2 (cs)	1987-08-27
DD222332A5 (de)	1985-05-15	Verfahren und reagenz zur bestimmung von transaminasen
EP0170880A1 (de)	1986-02-12	Verfahren zur Herstellung von Aminooxydase enthaltendem Material, bzw. Aminooxydase, aus Mikroorganismen, solche Produkte und deren Verwendung zum Abbau von Histamin in Nahrungsmitteln, Getränken und Futtermitteln
DE69029061T2 (de)	1997-05-07	Antihypertonika und Lebensmittel und Getränke, die solche Antihypertonika enthalten
DE1230751B (de)	1966-12-22	Verfahren zur Herstellung von Lipase durch Zuechten von Mikroorganismen
DE3320495A1 (de)	1984-12-13	Mikrobiologisch hergestellte d-2-hydroxy-4-methylpentansaeure-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung
DE69720381T2 (de)	2004-02-12	Verfahren zur Verbesserung der optischen Reinheit einer Amin-Verbindung
DE3151616C2 (de)	1985-10-31	Verfahren zur Herstellung einer Cholesterinoxidase
Rosenberg et al.	1960	Properties of a purified sialidase and its action on brain mucolipid
DE3026854A1 (de)	1981-02-12	Kinetische uv-methode zur gleichzeitigen bestimmung von glutamat-oxalacetat- transaminase und glutamat-pyruvat- transaminase
DE2637671B2 (de)	1978-11-09	Verfahren zur Herstellung von Kreatinin-Desimidase auf mikrobiologischem Wege
DE2146674C3 (de)	1981-10-29	Faktor und seine Verwendung als Arzneimittel
DE2712004C2 (de)	1979-05-23	Verfahren zur Bestimmung von Formiat oder in Formiat überführbaren Verbindungen und hierfür geeignetes Reagens
DE3841914C1 (cs)	1990-06-07
AT246332B (de)	1966-04-12	Verfahren zur Gewinnung des Antibiotikums Tetracyclin
Neesby et al.	1957	The absorption of sulfur compounds from externally deposited polythionates by the skin of the rat
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