DD229854A3 - Verfahren zur fermentativen herstellung von sekundaermetaboliten - Google Patents

Verfahren zur fermentativen herstellung von sekundaermetaboliten Download PDF

Info

Publication number: DD229854A3
Authority: DD; German Democratic Republic
Prior art keywords: phosphate; liquor; dosage; rate; dosing
Prior art date: 1983-10-25

Application number

DD25594483A

Other languages

German (de)

English (en)

Inventor

Hans-Helmut Grosse

Klaus-Dieter Menzel

Michael Menner

Peter J Mueller

Hans-Dieter Pohl

Harald Bocker

Wilfried Effenberger

Gunter Plonka

Werner Hess

Original Assignee

Adw Ddr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-25

Filing date

1983-10-25

Publication date

1985-11-13

1983-10-25 Application filed by Adw Ddr filed Critical Adw Ddr

1983-10-25 Priority to DD25594483A priority Critical patent/DD229854A3/de

1984-01-18 Priority to RO84113351A priority patent/RO87736A/ro

1984-01-19 Priority to YU00092/84A priority patent/YU9284A/xx

1984-01-19 Priority to CA000445668A priority patent/CA1212919A/en

1984-01-20 Priority to FI840248A priority patent/FI81833C/fi

1984-01-20 Priority to US06/572,928 priority patent/US4861715A/en

1984-03-23 Priority to EP84810137A priority patent/EP0136256A3/de

1984-10-05 Priority to BG6705984A priority patent/BG49991A1/xx

1984-10-10 Priority to CS847687A priority patent/CS264022B1/cs

1985-11-13 Publication of DD229854A3 publication Critical patent/DD229854A3/de

Links

238000000034 method Methods 0.000 title claims abstract description 15
229930000044 secondary metabolite Natural products 0.000 title claims abstract description 8
238000012262 fermentative production Methods 0.000 title abstract description 3
229910019142 PO4 Inorganic materials 0.000 claims abstract description 31
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 31
239000010452 phosphate Substances 0.000 claims abstract description 31
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims abstract description 17
239000000908 ammonium hydroxide Substances 0.000 claims abstract description 17
239000000758 substrate Substances 0.000 claims abstract description 11
238000004519 manufacturing process Methods 0.000 claims abstract description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
239000000126 substance Substances 0.000 claims description 9
229910052757 nitrogen Inorganic materials 0.000 claims description 7
230000000694 effects Effects 0.000 claims description 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
229910052799 carbon Inorganic materials 0.000 claims description 5
239000012636 effector Substances 0.000 claims description 4
239000011573 trace mineral Substances 0.000 claims description 4
235000013619 trace mineral Nutrition 0.000 claims description 4
238000000855 fermentation Methods 0.000 abstract description 20
230000004151 fermentation Effects 0.000 abstract description 20
230000008569 process Effects 0.000 abstract description 8
238000006243 chemical reaction Methods 0.000 abstract description 6
239000000203 mixture Substances 0.000 abstract description 5
239000000243 solution Substances 0.000 description 18
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 17
239000008103 glucose Substances 0.000 description 17
230000015572 biosynthetic process Effects 0.000 description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 13
230000001954 sterilising effect Effects 0.000 description 9
238000004659 sterilization and disinfection Methods 0.000 description 8
238000010586 diagram Methods 0.000 description 7
235000015097 nutrients Nutrition 0.000 description 7
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
239000002054 inoculum Substances 0.000 description 4
229910052760 oxygen Inorganic materials 0.000 description 4
239000001301 oxygen Substances 0.000 description 4
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 4
238000011218 seed culture Methods 0.000 description 4
230000002349 favourable effect Effects 0.000 description 3
238000011081 inoculation Methods 0.000 description 3
230000002503 metabolic effect Effects 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
230000007704 transition Effects 0.000 description 3
239000002028 Biomass Substances 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
235000019764 Soybean Meal Nutrition 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
235000019486 Sunflower oil Nutrition 0.000 description 2
NRAUADCLPJTGSF-ZPGVOIKOSA-N [(2r,3s,4r,5r,6r)-6-[[(3as,7r,7as)-7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl]amino]-5-[[(3s)-3,6-diaminohexanoyl]amino]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] carbamate Chemical compound NCCC[C@H](N)CC(=O)N[C@@H]1[C@@H](O)[C@H](OC(N)=O)[C@@H](CO)O[C@H]1\N=C/1N[C@H](C(=O)NC[C@H]2O)[C@@H]2N\1 NRAUADCLPJTGSF-ZPGVOIKOSA-N 0.000 description 2
238000005273 aeration Methods 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
238000009395 breeding Methods 0.000 description 2
230000001488 breeding effect Effects 0.000 description 2
230000003139 buffering effect Effects 0.000 description 2
230000008859 change Effects 0.000 description 2
230000001276 controlling effect Effects 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
235000013312 flour Nutrition 0.000 description 2
238000005187 foaming Methods 0.000 description 2
239000007789 gas Substances 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
238000009655 industrial fermentation Methods 0.000 description 2
229960003424 phenylacetic acid Drugs 0.000 description 2
239000003279 phenylacetic acid Substances 0.000 description 2
229920001451 polypropylene glycol Polymers 0.000 description 2
239000004455 soybean meal Substances 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
239000002600 sunflower oil Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
239000008399 tap water Substances 0.000 description 2
235000020679 tap water Nutrition 0.000 description 2
238000009423 ventilation Methods 0.000 description 2
229920000742 Cotton Polymers 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
241000228150 Penicillium chrysogenum Species 0.000 description 1
102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
244000062793 Sorghum vulgare Species 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
239000003518 caustics Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000029087 digestion Effects 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000020169 heat generation Effects 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000036512 infertility Effects 0.000 description 1
230000004941 influx Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000035800 maturation Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
235000019713 millet Nutrition 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
235000019371 penicillin G benzathine Nutrition 0.000 description 1
229940056360 penicillin g Drugs 0.000 description 1
IBIRZFNPWYRWOG-UHFFFAOYSA-N phosphane;phosphoric acid Chemical compound P.OP(O)(O)=O IBIRZFNPWYRWOG-UHFFFAOYSA-N 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
-1 polypropylene Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000007363 regulatory process Effects 0.000 description 1
238000012958 reprocessing Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Electric Propulsion And Braking For Vehicles (AREA)

DD25594483A 1983-01-20 1983-10-25 Verfahren zur fermentativen herstellung von sekundaermetaboliten DD229854A3 (de)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
DD25594483A DD229854A3 (de)	1983-10-25	1983-10-25	Verfahren zur fermentativen herstellung von sekundaermetaboliten
RO84113351A RO87736A (ro)	1983-01-20	1984-01-18	Procedeu pentru prepararea antibioticului nourseothricin
YU00092/84A YU9284A (en)	1983-01-20	1984-01-19	Process for making nouseothricyn and its adsorbates
CA000445668A CA1212919A (en)	1983-01-20	1984-01-19	Process for the production of nourseothrioin and its adsorbates
FI840248A FI81833C (fi)	1983-01-20	1984-01-20	Foerfarande foer framstaellning av nourseotricin, dess salter och adsorbat.
US06/572,928 US4861715A (en)	1983-01-20	1984-01-20	Process for the production of nourseothricine and its adsorbate
EP84810137A EP0136256A3 (de)	1983-09-28	1984-03-23	Verfahren zur Herstellung von Nourseothricin und seiner Adsorbate
BG6705984A BG49991A1 (en)	1983-10-25	1984-10-05	Method for fermentation preparing of secondary methabolites
CS847687A CS264022B1 (en)	1983-10-25	1984-10-10	Process for fermentative preparing of secondary metabolites

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DD25594483A DD229854A3 (de)	1983-10-25	1983-10-25	Verfahren zur fermentativen herstellung von sekundaermetaboliten

Publications (1)

Publication Number	Publication Date
DD229854A3 true DD229854A3 (de)	1985-11-13

Family

ID=5551321

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD25594483A DD229854A3 (de)	1983-01-20	1983-10-25	Verfahren zur fermentativen herstellung von sekundaermetaboliten

Country Status (3)

Country	Link
BG (1)	BG49991A1 (cs)
CS (1)	CS264022B1 (cs)
DD (1)	DD229854A3 (cs)

1983
- 1983-10-25 DD DD25594483A patent/DD229854A3/de not_active IP Right Cessation
1984
- 1984-10-05 BG BG6705984A patent/BG49991A1/xx unknown
- 1984-10-10 CS CS847687A patent/CS264022B1/cs unknown

Also Published As

Publication number	Publication date
CS264022B1 (en)	1989-05-12
BG49991A1 (en)	1992-04-15
CS768784A1 (en)	1988-08-16

Legal Events

Date	Code	Title	Description
1995-08-31	ENJ	Ceased due to non-payment of renewal fee

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