DD231949A3 - Verfahren zur fermentativen herstellung von nourseothricin - Google Patents

Verfahren zur fermentativen herstellung von nourseothricin Download PDF

Info

Publication number: DD231949A3
Authority: DD; German Democratic Republic
Prior art keywords: nourseothricin; zimet; fermentation; solution; culture
Prior art date: 1983-10-25

Application number

DD25594583A

Other languages

German (de)

English (en)

Inventor

Michael Menner

Ernst-Joachim Bormann

Matthias Hilliger

Peter-Juergen Mueller

Martin Roth

Harald Bocker

Hans-Helmut Grosse

Friedrich Bergter

Werner Hess

Juliane Koedel

Ingeborg Heller

Gunter Plonka

Original Assignee

Akad Wissenschaften Ddr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-25

Filing date

1983-10-25

Publication date

1986-01-15

1983-10-25 Application filed by Akad Wissenschaften Ddr filed Critical Akad Wissenschaften Ddr

1983-10-25 Priority to DD25594583A priority Critical patent/DD231949A3/de

1984-01-18 Priority to RO84113351A priority patent/RO87736A/ro

1984-01-19 Priority to YU00092/84A priority patent/YU9284A/xx

1984-01-19 Priority to CA000445668A priority patent/CA1212919A/en

1984-01-20 Priority to FI840248A priority patent/FI81833C/fi

1984-01-20 Priority to US06/572,928 priority patent/US4861715A/en

1984-03-23 Priority to EP84810137A priority patent/EP0136256A3/de

1984-10-01 Priority to SU847773571A priority patent/SU1694642A1/ru

1984-10-05 Priority to BG6706284A priority patent/BG45933A1/xx

1984-10-10 Priority to CS847680A priority patent/CS266367B1/cs

1986-01-15 Publication of DD231949A3 publication Critical patent/DD231949A3/de

Links

NRAUADCLPJTGSF-ZPGVOIKOSA-N [(2r,3s,4r,5r,6r)-6-[[(3as,7r,7as)-7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl]amino]-5-[[(3s)-3,6-diaminohexanoyl]amino]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] carbamate Chemical compound NCCC[C@H](N)CC(=O)N[C@@H]1[C@@H](O)[C@H](OC(N)=O)[C@@H](CO)O[C@H]1\N=C/1N[C@H](C(=O)NC[C@H]2O)[C@@H]2N\1 NRAUADCLPJTGSF-ZPGVOIKOSA-N 0.000 title claims abstract description 30
238000000034 method Methods 0.000 title claims description 12
238000004519 manufacturing process Methods 0.000 title description 3
238000000855 fermentation Methods 0.000 claims abstract description 23
230000004151 fermentation Effects 0.000 claims abstract description 23
150000001720 carbohydrates Chemical class 0.000 claims abstract description 8
229920000642 polymer Polymers 0.000 claims abstract description 4
150000002402 hexoses Chemical class 0.000 claims abstract 2
239000008103 glucose Substances 0.000 claims description 13
239000002609 medium Substances 0.000 claims description 12
229920002261 Corn starch Polymers 0.000 claims description 11
241000187310 Streptomyces noursei Species 0.000 claims description 11
239000008120 corn starch Substances 0.000 claims description 8
235000014633 carbohydrates Nutrition 0.000 claims description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
229920002472 Starch Polymers 0.000 claims description 6
239000003112 inhibitor Substances 0.000 claims description 6
235000019698 starch Nutrition 0.000 claims description 6
239000008107 starch Substances 0.000 claims description 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
150000001413 amino acids Chemical class 0.000 claims description 3
230000003625 amylolytic effect Effects 0.000 claims description 3
229910052799 carbon Inorganic materials 0.000 claims description 3
229910052757 nitrogen Inorganic materials 0.000 claims description 3
230000035806 respiratory chain Effects 0.000 claims description 3
238000012262 fermentative production Methods 0.000 claims description 2
239000001963 growth medium Substances 0.000 claims description 2
239000007900 aqueous suspension Substances 0.000 claims 1
238000012258 culturing Methods 0.000 claims 1
229910052500 inorganic mineral Inorganic materials 0.000 claims 1
239000011707 mineral Substances 0.000 claims 1
150000003839 salts Chemical class 0.000 claims 1
235000015097 nutrients Nutrition 0.000 abstract description 23
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1
239000000243 solution Substances 0.000 description 41
230000001954 sterilising effect Effects 0.000 description 17
238000004659 sterilization and disinfection Methods 0.000 description 17
VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 15
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
239000000203 mixture Substances 0.000 description 12
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 11
239000002054 inoculum Substances 0.000 description 9
239000008399 tap water Substances 0.000 description 9
235000020679 tap water Nutrition 0.000 description 9
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 8
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 8
229910052921 ammonium sulfate Inorganic materials 0.000 description 8
235000011130 ammonium sulphate Nutrition 0.000 description 8
229910000019 calcium carbonate Inorganic materials 0.000 description 8
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 7
239000000908 ammonium hydroxide Substances 0.000 description 7
239000001166 ammonium sulphate Substances 0.000 description 7
235000019764 Soybean Meal Nutrition 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 6
239000004455 soybean meal Substances 0.000 description 6
238000009423 ventilation Methods 0.000 description 6
238000000605 extraction Methods 0.000 description 5
238000010438 heat treatment Methods 0.000 description 5
238000011081 inoculation Methods 0.000 description 5
229910001220 stainless steel Inorganic materials 0.000 description 5
239000010935 stainless steel Substances 0.000 description 5
235000017060 Arachis glabrata Nutrition 0.000 description 4
244000105624 Arachis hypogaea Species 0.000 description 4
235000010777 Arachis hypogaea Nutrition 0.000 description 4
235000018262 Arachis monticola Nutrition 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
235000010633 broth Nutrition 0.000 description 4
238000001816 cooling Methods 0.000 description 4
229940088598 enzyme Drugs 0.000 description 4
229910052943 magnesium sulfate Inorganic materials 0.000 description 4
235000019341 magnesium sulphate Nutrition 0.000 description 4
235000020232 peanut Nutrition 0.000 description 4
229920001451 polypropylene glycol Polymers 0.000 description 4
238000003756 stirring Methods 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
235000019759 Maize starch Nutrition 0.000 description 3
240000008042 Zea mays Species 0.000 description 3
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
235000002017 Zea mays subsp mays Nutrition 0.000 description 3
238000009395 breeding Methods 0.000 description 3
230000001488 breeding effect Effects 0.000 description 3
235000005822 corn Nutrition 0.000 description 3
229910000402 monopotassium phosphate Inorganic materials 0.000 description 3
235000019796 monopotassium phosphate Nutrition 0.000 description 3
IBIRZFNPWYRWOG-UHFFFAOYSA-N phosphane;phosphoric acid Chemical compound P.OP(O)(O)=O IBIRZFNPWYRWOG-UHFFFAOYSA-N 0.000 description 3
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 3
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 3
239000011686 zinc sulphate Substances 0.000 description 3
235000009529 zinc sulphate Nutrition 0.000 description 3
235000019486 Sunflower oil Nutrition 0.000 description 2
238000005273 aeration Methods 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
238000011065 in-situ storage Methods 0.000 description 2
235000012054 meals Nutrition 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
239000002600 sunflower oil Substances 0.000 description 2
241000894006 Bacteria Species 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
229930189330 Streptothricin Natural products 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
230000003698 anagen phase Effects 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
BUACSMWVFUNQET-UHFFFAOYSA-H dialuminum;trisulfate;hydrate Chemical compound O.[Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O BUACSMWVFUNQET-UHFFFAOYSA-H 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000007071 enzymatic hydrolysis Effects 0.000 description 1
238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
230000002031 ergotropic effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000009776 industrial production Methods 0.000 description 1
RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
239000011702 manganese sulphate Substances 0.000 description 1
235000007079 manganese sulphate Nutrition 0.000 description 1
SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
239000012533 medium component Substances 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
238000011218 seed culture Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
NRAUADCLPJTGSF-VLSXYIQESA-N streptothricin F Chemical compound NCCC[C@H](N)CC(=O)N[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)O[C@H]1\N=C/1N[C@H](C(=O)NC[C@H]2O)[C@@H]2N\1 NRAUADCLPJTGSF-VLSXYIQESA-N 0.000 description 1
239000000725 suspension Substances 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1

Landscapes

Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Crystals, And After-Treatments Of Crystals (AREA)

DD25594583A 1983-01-20 1983-10-25 Verfahren zur fermentativen herstellung von nourseothricin DD231949A3 (de)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
DD25594583A DD231949A3 (de)	1983-10-25	1983-10-25	Verfahren zur fermentativen herstellung von nourseothricin
RO84113351A RO87736A (ro)	1983-01-20	1984-01-18	Procedeu pentru prepararea antibioticului nourseothricin
YU00092/84A YU9284A (en)	1983-01-20	1984-01-19	Process for making nouseothricyn and its adsorbates
CA000445668A CA1212919A (en)	1983-01-20	1984-01-19	Process for the production of nourseothrioin and its adsorbates
FI840248A FI81833C (fi)	1983-01-20	1984-01-20	Foerfarande foer framstaellning av nourseotricin, dess salter och adsorbat.
US06/572,928 US4861715A (en)	1983-01-20	1984-01-20	Process for the production of nourseothricine and its adsorbate
EP84810137A EP0136256A3 (de)	1983-09-28	1984-03-23	Verfahren zur Herstellung von Nourseothricin und seiner Adsorbate
SU847773571A SU1694642A1 (ru)	1983-10-25	1984-10-01	Способ получени ноурзеотрицина
BG6706284A BG45933A1 (en)	1983-10-25	1984-10-05	Method for fermentational preparing a nourzeotrizin
CS847680A CS266367B1 (en)	1983-10-25	1984-10-10	Process for fermentation preparing nourseotricine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DD25594583A DD231949A3 (de)	1983-10-25	1983-10-25	Verfahren zur fermentativen herstellung von nourseothricin

Publications (1)

Publication Number	Publication Date
DD231949A3 true DD231949A3 (de)	1986-01-15

Family

ID=5551322

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD25594583A DD231949A3 (de)	1983-01-20	1983-10-25	Verfahren zur fermentativen herstellung von nourseothricin

Country Status (4)

Country	Link
BG (1)	BG45933A1 (cs)
CS (1)	CS266367B1 (cs)
DD (1)	DD231949A3 (cs)
SU (1)	SU1694642A1 (cs)

1983
- 1983-10-25 DD DD25594583A patent/DD231949A3/de not_active IP Right Cessation
1984
- 1984-10-01 SU SU847773571A patent/SU1694642A1/ru active
- 1984-10-05 BG BG6706284A patent/BG45933A1/xx unknown
- 1984-10-10 CS CS847680A patent/CS266367B1/cs unknown

Also Published As

Publication number	Publication date
CS266367B1 (en)	1989-12-13
CS768084A1 (en)	1987-02-12
SU1694642A1 (ru)	1991-11-30
BG45933A1 (en)	1989-09-15

Legal Events

Date	Code	Title	Description
1995-08-31	ENJ	Ceased due to non-payment of renewal fee

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