DD249480A5 - 3-amino-dihydro-(1)-benzopyrane und benzothiopyrane - Google Patents

3-amino-dihydro-(1)-benzopyrane und benzothiopyrane Download PDF

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Publication number: DD249480A5
Authority: DD; German Democratic Republic
Prior art keywords: formula; compound; hydroxy; pharmaceutically acceptable; hydrogen
Prior art date: 1985-09-03

Application number

DD86294093A

Other languages

German (de)

English (en)

Inventor

Alan J Hutchison

Original Assignee

��`��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-09-03

Filing date

1986-09-02

Publication date

1987-09-09

1986-09-02 Application filed by ��`��@��k�� filed Critical ��`��@��k��

1987-09-09 Publication of DD249480A5 publication Critical patent/DD249480A5/de

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ONJRTQUWKRDCTA-UHFFFAOYSA-N 2h-thiochromene Chemical compound C1=CC=C2C=CCSC2=C1 ONJRTQUWKRDCTA-UHFFFAOYSA-N 0.000 title description 10
SVWDNDQOXZHBRM-UHFFFAOYSA-N 3,4-dihydro-2h-chromen-3-amine Chemical compound C1=CC=C2CC(N)COC2=C1 SVWDNDQOXZHBRM-UHFFFAOYSA-N 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 144
150000003839 salts Chemical class 0.000 claims abstract description 52
125000000217 alkyl group Chemical group 0.000 claims abstract description 49
239000001257 hydrogen Substances 0.000 claims abstract description 38
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 38
125000003545 alkoxy group Chemical group 0.000 claims abstract description 33
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 31
229910052717 sulfur Inorganic materials 0.000 claims abstract description 31
239000011593 sulfur Substances 0.000 claims abstract description 31
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 30
229910052760 oxygen Inorganic materials 0.000 claims abstract description 30
239000001301 oxygen Substances 0.000 claims abstract description 30
125000004423 acyloxy group Chemical group 0.000 claims abstract description 15
229910052736 halogen Inorganic materials 0.000 claims abstract description 12
150000002367 halogens Chemical class 0.000 claims abstract description 12
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 10
125000004104 aryloxy group Chemical group 0.000 claims abstract description 8
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 7
238000000034 method Methods 0.000 claims description 72
238000002360 preparation method Methods 0.000 claims description 40
230000008569 process Effects 0.000 claims description 39
239000000203 mixture Substances 0.000 claims description 35
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
150000002431 hydrogen Chemical group 0.000 claims description 26
229910052757 nitrogen Inorganic materials 0.000 claims description 22
150000002148 esters Chemical class 0.000 claims description 19
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 11
125000000524 functional group Chemical group 0.000 claims description 8
230000010933 acylation Effects 0.000 claims description 6
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238000003776 cleavage reaction Methods 0.000 claims description 6
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims description 4
230000003287 optical effect Effects 0.000 claims description 4
125000002947 alkylene group Chemical group 0.000 claims description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
238000006266 etherification reaction Methods 0.000 claims description 3
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 2
SFLCTKUTPODWQY-UHFFFAOYSA-N 3-(dipropylamino)-3,4-dihydro-2h-thiochromen-5-ol Chemical compound C1=CC(O)=C2CC(N(CCC)CCC)CSC2=C1 SFLCTKUTPODWQY-UHFFFAOYSA-N 0.000 claims description 2
VIKRKVIGFPSDLR-UHFFFAOYSA-N [3-(dipropylamino)-3,4-dihydro-2h-thiochromen-5-yl] 2,2-dimethylpropanoate Chemical compound C1=CC(OC(=O)C(C)(C)C)=C2CC(N(CCC)CCC)CSC2=C1 VIKRKVIGFPSDLR-UHFFFAOYSA-N 0.000 claims description 2
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238000006482 condensation reaction Methods 0.000 claims description 2
125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 claims description 2
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
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125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
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QMGVPVSNSZLJIA-FVWCLLPLSA-N strychnine Chemical class O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 QMGVPVSNSZLJIA-FVWCLLPLSA-N 0.000 description 1
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VYHUPEVKUKGKDO-UHFFFAOYSA-N tert-butyl n-(7-methoxy-3,4-dihydro-2h-thiochromen-3-yl)carbamate Chemical compound C1C(NC(=O)OC(C)(C)C)CSC2=CC(OC)=CC=C21 VYHUPEVKUKGKDO-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Dental Preparations (AREA)

DD86294093A 1985-09-03 1986-09-02 3-amino-dihydro-(1)-benzopyrane und benzothiopyrane DD249480A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US77206885A	1985-09-03	1985-09-03

Publications (1)

Publication Number	Publication Date
DD249480A5 true DD249480A5 (de)	1987-09-09

Family

ID=25093804

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD86294093A DD249480A5 (de)	1985-09-03	1986-09-02	3-amino-dihydro-(1)-benzopyrane und benzothiopyrane

Country Status (18)

Country	Link
EP (1)	EP0222996B1 (fr)
JP (1)	JPS6259273A (fr)
KR (1)	KR900003883B1 (fr)
AT (1)	ATE63744T1 (fr)
AU (1)	AU596113B2 (fr)
DD (1)	DD249480A5 (fr)
DE (1)	DE3679378D1 (fr)
DK (1)	DK418486A (fr)
ES (1)	ES2001923A6 (fr)
FI (1)	FI86720C (fr)
GR (1)	GR862239B (fr)
HU (1)	HU202853B (fr)
IL (1)	IL79920A (fr)
NO (1)	NO863507L (fr)
NZ (1)	NZ217432A (fr)
PH (1)	PH22522A (fr)
PT (1)	PT83300B (fr)
ZA (1)	ZA866685B (fr)

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US4957928A (en) *	1986-06-26	1990-09-18	Ciba-Geigy Corporation	Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
US4801605A (en) *	1986-08-29	1989-01-31	Ciba-Geigy Corporation	3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) *	1986-12-19	1986-12-19	Astra Laekemedel Ab	Novel chroman derivatives
EP0322361A3 (fr) *	1987-12-23	1990-01-24	Ciba-Geigy Ag	Composés d'acides 1-benzooxacycloalkylpyridinecarboxyliques hydrogénés
PT92669B (pt) *	1988-12-23	1995-09-12	Beecham Group Ltd	Processo para a preparacao de compostos biciclicos, de preferencia derivados debenzopirano
CA2047236C (fr) *	1989-04-27	1997-07-22	Bengt Ronny Andersson	Derives de substitution de 3-aminochromanes
SE8904127D0 (sv) *	1989-12-07	1989-12-07	Astra Ab	New biocyclic amino-substituted compounds
SE8904361D0 (sv)	1989-12-22	1989-12-22	Astra Ab	New chroman and thiochroman derivatives
US5616610A (en) *	1989-12-22	1997-04-01	Astra Aktiebolag	(R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
US5420151A (en) *	1989-12-22	1995-05-30	Aktiebolaget Astra	Chroman derivatives
US5273994A (en) *	1990-04-09	1993-12-28	Adir Et Compagnie	3-aminochroman compounds
FR2660657B1 (fr) *	1990-04-09	1993-05-07	Adir	Nouveaux derives du 3-aminochromane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2678617B1 (fr) *	1991-07-01	1995-01-20	Adir	Nouveau procede de synthese d'enantiomeres de derives du 3-amino chromane.
FR2681325B1 (fr) *	1991-09-16	1993-12-17	Fabre Medicament Pierre	Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
HRP920935A2 (en) *	1991-10-08	1995-08-31	Astra Ab	New therapeutically active compound
FR2689509B1 (fr) *	1992-04-01	1994-06-03	Adir	Nouveaux derives spiraniques du 3-amino chromane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
SK281507B6 (sk) *	1992-11-30	2001-04-09	Smithkline Beecham Plc	Použitie benzopyránových analógov, benzopyránové analógy, spôsob ich prípravy a farmaceutický prostriedok s ich obsahom
US7125904B2 (en) *	2002-10-11	2006-10-24	Portela & C.A., S.A.	Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation

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US3607886A (en) *	1969-04-24	1971-09-21	Parke Davis & Co	Chromanamines
US3629289A (en) *	1969-04-24	1971-12-21	Parke Davis & Co	Chromanamines
US4203895A (en) *	1978-04-14	1980-05-20	Warner-Lambert Company	Process for the preparation of cis-(±)-3,4-dihydro-N,N,2-trimethyl-2H-1-benzopyran-3-amine and intermediates produced thereby

1986
- 1986-09-01 DE DE8686112104T patent/DE3679378D1/de not_active Expired - Lifetime
- 1986-09-01 EP EP86112104A patent/EP0222996B1/fr not_active Expired - Lifetime
- 1986-09-01 GR GR862239A patent/GR862239B/el unknown
- 1986-09-01 AT AT86112104T patent/ATE63744T1/de not_active IP Right Cessation
- 1986-09-01 PH PH34204A patent/PH22522A/en unknown
- 1986-09-02 ES ES8601568A patent/ES2001923A6/es not_active Expired
- 1986-09-02 DK DK418486A patent/DK418486A/da unknown
- 1986-09-02 HU HU863786A patent/HU202853B/hu not_active IP Right Cessation
- 1986-09-02 IL IL79920A patent/IL79920A/xx unknown
- 1986-09-02 DD DD86294093A patent/DD249480A5/de not_active IP Right Cessation
- 1986-09-02 ZA ZA866685A patent/ZA866685B/xx unknown
- 1986-09-02 NZ NZ217432A patent/NZ217432A/xx unknown
- 1986-09-02 NO NO863507A patent/NO863507L/no unknown
- 1986-09-03 AU AU62317/86A patent/AU596113B2/en not_active Ceased
- 1986-09-03 PT PT83300A patent/PT83300B/pt not_active IP Right Cessation
- 1986-09-03 JP JP61206047A patent/JPS6259273A/ja active Pending
- 1986-09-03 KR KR1019860007357A patent/KR900003883B1/ko not_active Expired
- 1986-09-03 FI FI863558A patent/FI86720C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
GR862239B (en)	1986-12-31
HU202853B (en)	1991-04-29
FI86720C (fi)	1992-10-12
DE3679378D1 (de)	1991-06-27
PH22522A (en)	1988-10-17
EP0222996A3 (en)	1987-12-02
EP0222996A2 (fr)	1987-05-27
FI863558A7 (fi)	1987-03-04
AU6231786A (en)	1987-03-05
NO863507D0 (no)	1986-09-02
KR900003883B1 (ko)	1990-06-04
KR870003088A (ko)	1987-04-15
DK418486A (da)	1987-03-04
IL79920A0 (en)	1986-12-31
DK418486D0 (da)	1986-09-02
PT83300A (en)	1986-10-01
ES2001923A6 (es)	1988-07-01
PT83300B (pt)	1989-05-12
JPS6259273A (ja)	1987-03-14
ATE63744T1 (de)	1991-06-15
IL79920A (en)	1991-07-18
FI86720B (fi)	1992-06-30
HUT44771A (en)	1988-04-28
AU596113B2 (en)	1990-04-26
ZA866685B (en)	1987-04-29
NZ217432A (en)	1990-03-27
FI863558A0 (fi)	1986-09-03
EP0222996B1 (fr)	1991-05-22
NO863507L (no)	1987-03-04

Legal Events

Date	Code	Title	Description
1995-06-22	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DD249480A5 (de)	1987-09-09	3-amino-dihydro-(1)-benzopyrane und benzothiopyrane
EP0280269B1 (fr)	1992-02-12	3-Amino-dihydro-[1]-benzopyranes et benzothiopyranes
EP1487834B1 (fr)	2007-04-25	N-biarylamides aza-bicycliques ayant une affinite au recepteur d'acetyle-choline alpha7 nicotinique
DE60102581T2 (de)	2005-02-03	Azabizyklische carbamate und ihre anwendung als antagonisten des alpha-7 nikotinischen acetylcholin rezeptors
DE69426327T2 (de)	2001-04-12	Bicyclische amid-derivate und ihre verwendung als muskel entspannende verbindungen
EP0026848A1 (fr)	1981-04-15	Dérivés de tétraline, leur préparation et médicaments contenant ces composés
EP0271795A2 (fr)	1988-06-22	Dérivés de l'octahydro-10-oxo-6H-pyridazo[1,2-a][112]diazépine, intermédiaires et procédé pour leur préparation ainsi que médicament les contenant
EP0161218B1 (fr)	1991-06-26	Benzo-(pyrano et thiopyrano)pyridines
DE3882679T2 (de)	1993-11-04	Kardiovaskulaer aktive verbindungen.
EP0149840A1 (fr)	1985-07-31	Dihydro-5,11 6h-dibenzo[b,e]azépinones-6 substituées, procédé pour leur préparation et médicaments contenant ces composés
DE69617700T2 (de)	2002-07-18	Neue kondensierten isochinoline als dopamin-rezeptor-liganden
DE69402463T2 (de)	1997-11-27	(7S)-7-(2R)-2-(3-Chlorophenyl)-2-Hydoxyethylamino-5,6,7,8-Tetrahydronaphtalen-2-yloxy Essigsäure, ihre pharmazeutisch akzeptablen Salze, mit Beta-3-adrenergischer agonistischer Aktivität und diese enthaltende pharmazeutische Zusammensetzungen
EP0000395B1 (fr)	1981-01-07	Dérivés de 2-pipérazinotétraline, leur préparation et leur utilisation comme médicament
DD143613A5 (de)	1980-09-03	Verfahren zur herstellung von 4-amino-2-piperidino-chinazolin-derivaten
DE69611303T2 (de)	2001-07-05	Benzolsulfonamidderivate, ihre herstellung und ihre therapeutische verwendung
EP0298919A2 (fr)	1989-01-11	Dérivés de 1,2-dihydroxynaphtalène 4-amino substitué
EP1335720A1 (fr)	2003-08-20	Sulfonamides pour le traitement de maladies du systeme nerveux central
EP0455596B1 (fr)	1994-11-02	Indoles substitués
EP0389425B1 (fr)	1995-04-26	Benzothiopyranylamines
EP0298921B1 (fr)	1992-12-23	1,2-Benzisoxazoles et 1,2-benzisothiazoles
DE68905363T2 (de)	1993-08-05	Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
EP0037990B1 (fr)	1984-12-05	Phénylquinolizidines, compositions pharmaceutiques correspondantes, préparation d'ingrédients actifs et produits de départ correspondants
DE2207430C3 (de)	1982-05-13	1,2,4,5-Tetrahydro-3H-3-benzazepin, ein Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Mittel
EP0273168A1 (fr)	1988-07-06	Dérivés de triazaspirodécanylméthylindolone
EP0187619A2 (fr)	1986-07-16	Tétrahydropyridines 1,3-disubstituées