DD258943A5 - Verfahren zur herstellung von zusammensetzungen, die zur intramammaeren infusion an einem saeugetier vorgesehen sind - Google Patents

Verfahren zur herstellung von zusammensetzungen, die zur intramammaeren infusion an einem saeugetier vorgesehen sind Download PDF

Info

Publication number: DD258943A5
Authority: DD; German Democratic Republic
Prior art keywords: mammal; growth; infusion; mammary gland; parenchyma
Prior art date: 1986-03-07

Application number

DD87300534A

Other languages

German (de)

English (en)

Inventor

Robert J Collier

Michael F Mcgrath

Original Assignee

��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-07

Filing date

1987-03-06

Publication date

1988-08-10

1987-03-06 Application filed by ��@��k�� filed Critical ��@��k��

1988-08-10 Publication of DD258943A5 publication Critical patent/DD258943A5/de

Links

238000001802 infusion Methods 0.000 title claims abstract description 63
239000000203 mixture Substances 0.000 title claims description 12
238000004519 manufacturing process Methods 0.000 title claims description 11
239000000126 substance Substances 0.000 claims abstract description 38
241000124008 Mammalia Species 0.000 claims abstract description 31
230000002297 mitogenic effect Effects 0.000 claims abstract description 27
235000013336 milk Nutrition 0.000 claims abstract description 14
239000008267 milk Substances 0.000 claims abstract description 14
210000004080 milk Anatomy 0.000 claims abstract description 14
210000002919 epithelial cell Anatomy 0.000 claims abstract description 6
241000283690 Bos taurus Species 0.000 claims description 46
210000000481 breast Anatomy 0.000 claims description 41
241001465754 Metazoa Species 0.000 claims description 34
210000005075 mammary gland Anatomy 0.000 claims description 33
238000000034 method Methods 0.000 claims description 32
230000000694 effects Effects 0.000 claims description 27
102000009024 Epidermal Growth Factor Human genes 0.000 claims description 24
235000013861 fat-free Nutrition 0.000 claims description 19
235000013365 dairy product Nutrition 0.000 claims description 12
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 10
210000004907 gland Anatomy 0.000 claims description 9
102000004877 Insulin Human genes 0.000 claims description 7
108090001061 Insulin Proteins 0.000 claims description 7
230000001965 increasing effect Effects 0.000 claims description 7
241000282849 Ruminantia Species 0.000 claims description 6
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 6
101800003838 Epidermal growth factor Proteins 0.000 claims description 5
210000004027 cell Anatomy 0.000 claims description 5
229940125396 insulin Drugs 0.000 claims description 5
210000004738 parenchymal cell Anatomy 0.000 claims description 5
238000002360 preparation method Methods 0.000 claims description 5
230000001568 sexual effect Effects 0.000 claims description 5
210000001519 tissue Anatomy 0.000 claims description 5
108010000521 Human Growth Hormone Proteins 0.000 claims description 4
102000002265 Human Growth Hormone Human genes 0.000 claims description 4
239000000854 Human Growth Hormone Substances 0.000 claims description 4
230000002708 enhancing effect Effects 0.000 claims description 4
230000000762 glandular Effects 0.000 claims description 4
229940088597 hormone Drugs 0.000 claims description 4
239000005556 hormone Substances 0.000 claims description 4
239000007788 liquid Substances 0.000 claims description 4
239000003226 mitogen Substances 0.000 claims description 4
229960004532 somatropin Drugs 0.000 claims description 4
102100021809 Chorionic somatomammotropin hormone 1 Human genes 0.000 claims description 3
241000699670 Mus sp. Species 0.000 claims description 3
108010051696 Growth Hormone Proteins 0.000 claims description 2
102000018997 Growth Hormone Human genes 0.000 claims description 2
230000003416 augmentation Effects 0.000 claims description 2
230000036760 body temperature Effects 0.000 claims description 2
229940116977 epidermal growth factor Drugs 0.000 claims description 2
239000003163 gonadal steroid hormone Substances 0.000 claims description 2
230000002611 ovarian Effects 0.000 claims description 2
230000003169 placental effect Effects 0.000 claims description 2
238000010254 subcutaneous injection Methods 0.000 claims 2
239000007929 subcutaneous injection Substances 0.000 claims 2
102000009016 Cholera Toxin Human genes 0.000 claims 1
108010049048 Cholera Toxin Proteins 0.000 claims 1
101000895818 Homo sapiens Chorionic somatomammotropin hormone 1 Proteins 0.000 claims 1
101000956228 Homo sapiens Chorionic somatomammotropin hormone 2 Proteins 0.000 claims 1
241000283973 Oryctolagus cuniculus Species 0.000 claims 1
241000700159 Rattus Species 0.000 claims 1
230000002159 abnormal effect Effects 0.000 claims 1
230000001919 adrenal effect Effects 0.000 claims 1
239000003242 anti bacterial agent Substances 0.000 claims 1
229940088710 antibiotic agent Drugs 0.000 claims 1
239000000122 growth hormone Substances 0.000 claims 1
239000007943 implant Substances 0.000 claims 1
238000002513 implantation Methods 0.000 claims 1
238000000338 in vitro Methods 0.000 claims 1
238000002347 injection Methods 0.000 claims 1
239000007924 injection Substances 0.000 claims 1
210000004216 mammary stem cell Anatomy 0.000 claims 1
230000001817 pituitary effect Effects 0.000 claims 1
230000003248 secreting effect Effects 0.000 claims 1
230000004936 stimulating effect Effects 0.000 claims 1
101000851176 Homo sapiens Pro-epidermal growth factor Proteins 0.000 description 25
GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 25
239000002609 medium Substances 0.000 description 22
108020004414 DNA Proteins 0.000 description 21
101710098940 Pro-epidermal growth factor Proteins 0.000 description 19
235000013372 meat Nutrition 0.000 description 17
150000001413 amino acids Chemical group 0.000 description 13
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
230000035935 pregnancy Effects 0.000 description 12
108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 11
210000002445 nipple Anatomy 0.000 description 11
239000003102 growth factor Substances 0.000 description 10
239000001963 growth medium Substances 0.000 description 10
102000004196 processed proteins & peptides Human genes 0.000 description 10
108090000765 processed proteins & peptides Proteins 0.000 description 10
239000002904 solvent Substances 0.000 description 10
102000013275 Somatomedins Human genes 0.000 description 9
239000000839 emulsion Substances 0.000 description 9
239000000243 solution Substances 0.000 description 9
235000001014 amino acid Nutrition 0.000 description 8
244000309465 heifer Species 0.000 description 8
229920001184 polypeptide Polymers 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
235000015278 beef Nutrition 0.000 description 7
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 7
239000003981 vehicle Substances 0.000 description 7
108020004511 Recombinant DNA Proteins 0.000 description 6
230000003076 paracrine Effects 0.000 description 6
239000008063 pharmaceutical solvent Substances 0.000 description 6
241001494479 Pecora Species 0.000 description 5
238000001514 detection method Methods 0.000 description 5
IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
241000207961 Sesamum Species 0.000 description 4
235000003434 Sesamum indicum Nutrition 0.000 description 4
DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical compound C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 4
239000008188 pellet Substances 0.000 description 4
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 4
101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 3
241000219823 Medicago Species 0.000 description 3
235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
102000044162 human IGF1 Human genes 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
230000009466 transformation Effects 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
101001034686 Bos taurus Insulin-like growth factor I Proteins 0.000 description 2
102000018386 EGF Family of Proteins Human genes 0.000 description 2
108010066486 EGF Family of Proteins Proteins 0.000 description 2
241000588724 Escherichia coli Species 0.000 description 2
102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 2
101000851196 Mus musculus Pro-epidermal growth factor Proteins 0.000 description 2
108010003044 Placental Lactogen Proteins 0.000 description 2
239000000381 Placental Lactogen Substances 0.000 description 2
108010076181 Proinsulin Proteins 0.000 description 2
229960000583 acetic acid Drugs 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
230000033228 biological regulation Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
210000004899 c-terminal region Anatomy 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003814 drug Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000012362 glacial acetic acid Substances 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
230000002608 insulinlike Effects 0.000 description 2
230000001983 lactogenic effect Effects 0.000 description 2
208000004396 mastitis Diseases 0.000 description 2
239000002243 precursor Substances 0.000 description 2
238000011084 recovery Methods 0.000 description 2
238000011160 research Methods 0.000 description 2
239000008159 sesame oil Substances 0.000 description 2
235000011803 sesame oil Nutrition 0.000 description 2
239000007787 solid Substances 0.000 description 2
241000894007 species Species 0.000 description 2
210000001541 thymus gland Anatomy 0.000 description 2
210000002700 urine Anatomy 0.000 description 2
108010001897 Anterior Pituitary Hormones Proteins 0.000 description 1
102000000827 Anterior Pituitary Hormones Human genes 0.000 description 1
235000017060 Arachis glabrata Nutrition 0.000 description 1
244000105624 Arachis hypogaea Species 0.000 description 1
235000010777 Arachis hypogaea Nutrition 0.000 description 1
235000018262 Arachis monticola Nutrition 0.000 description 1
241000283699 Bos indicus Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
206010011732 Cyst Diseases 0.000 description 1
102000006771 Gonadotropins Human genes 0.000 description 1
108010086677 Gonadotropins Proteins 0.000 description 1
102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 1
108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
241001529936 Murinae Species 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
108010047386 Pituitary Hormones Proteins 0.000 description 1
102000006877 Pituitary Hormones Human genes 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
241000549435 Pria Species 0.000 description 1
102100024819 Prolactin Human genes 0.000 description 1
108010057464 Prolactin Proteins 0.000 description 1
108010076504 Protein Sorting Signals Proteins 0.000 description 1
108010094028 Prothrombin Proteins 0.000 description 1
241000282887 Suidae Species 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
108010067390 Viral Proteins Proteins 0.000 description 1
230000009471 action Effects 0.000 description 1
239000003329 adenohypophysis hormone Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
230000037037 animal physiology Effects 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
210000003719 b-lymphocyte Anatomy 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
230000007321 biological mechanism Effects 0.000 description 1
244000309466 calf Species 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
238000005277 cation exchange chromatography Methods 0.000 description 1
230000024245 cell differentiation Effects 0.000 description 1
AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
208000031513 cyst Diseases 0.000 description 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
239000002158 endotoxin Substances 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
229940011871 estrogen Drugs 0.000 description 1
239000000262 estrogen Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012847 fine chemical Substances 0.000 description 1
239000004459 forage Substances 0.000 description 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000002622 gonadotropin Substances 0.000 description 1
244000144980 herd Species 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
210000004408 hybridoma Anatomy 0.000 description 1
239000000960 hypophysis hormone Substances 0.000 description 1
238000007654 immersion Methods 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
230000006651 lactation Effects 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
210000003041 ligament Anatomy 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
238000002156 mixing Methods 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
210000003098 myoblast Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
231100000344 non-irritating Toxicity 0.000 description 1
230000009701 normal cell proliferation Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
235000020232 peanut Nutrition 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
230000002265 prevention Effects 0.000 description 1
229940097325 prolactin Drugs 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
210000003079 salivary gland Anatomy 0.000 description 1
230000028327 secretion Effects 0.000 description 1
210000002955 secretory cell Anatomy 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000003068 static effect Effects 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
210000001913 submandibular gland Anatomy 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
230000008961 swelling Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000004474 valine Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Reproductive Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Cosmetics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)
Dairy Products (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Seasonings (AREA)
Catching Or Destruction (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Mushroom Cultivation (AREA)
Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
Prostheses (AREA)
Farming Of Fish And Shellfish (AREA)

DD87300534A 1986-03-07 1987-03-06 Verfahren zur herstellung von zusammensetzungen, die zur intramammaeren infusion an einem saeugetier vorgesehen sind DD258943A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US83747786A	1986-03-07	1986-03-07

Publications (1)

Publication Number	Publication Date
DD258943A5 true DD258943A5 (de)	1988-08-10

Family

ID=25274560

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD87300534A DD258943A5 (de)	1986-03-07	1987-03-06	Verfahren zur herstellung von zusammensetzungen, die zur intramammaeren infusion an einem saeugetier vorgesehen sind

Country Status (22)

Country	Link
US (1)	US5059586A (fr)
EP (1)	EP0237514B1 (fr)
JP (1)	JPS62221635A (fr)
KR (1)	KR900000545B1 (fr)
CN (1)	CN87102601A (fr)
AT (1)	ATE93730T1 (fr)
AU (1)	AU595295B2 (fr)
BG (1)	BG50926A3 (fr)
CA (1)	CA1299103C (fr)
CS (1)	CS272772B2 (fr)
DD (1)	DD258943A5 (fr)
DE (1)	DE3787185T2 (fr)
DK (1)	DK116287A (fr)
ES (1)	ES2000437T3 (fr)
HU (1)	HU205007B (fr)
IL (1)	IL81809A (fr)
MX (1)	MX170911B (fr)
NO (1)	NO870946L (fr)
NZ (1)	NZ219530A (fr)
PL (1)	PL154182B1 (fr)
RU (1)	RU2033178C1 (fr)
ZA (1)	ZA871654B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5182302A (en) *	1986-03-07	1993-01-26	Monsanto Company	Method for enhancing growth of mammary parenchyma using a prostaglandin
US5130300A (en) *	1986-03-07	1992-07-14	Monsanto Company	Method for enhancing growth of mammary parenchyma
US5130299A (en) *	1986-03-07	1992-07-14	Monsanto Company	Method for enhancing growth of mammary parenchyma
IE912345A1 (en) *	1990-08-03	1992-02-12	Pharmacia Ab	Treatment of human lactation failure
US5336488A (en) *	1991-08-07	1994-08-09	American Cyanamid Company	Method of treating or preventing mastitis in animals with involuting mammary glands by administering recombinant cytokines
US6828111B2 (en)	2000-01-13	2004-12-07	Wayne State University	Three-dimensional in vitro model of human preneoplastic breast disease
RU2185198C2 (ru) *	2000-05-15	2002-07-20	Российский Университет Дружбы Народов	Способ лечения кисты молочной железы
US6967090B2 (en) *	2001-05-18	2005-11-22	Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food	Nucleic acid and protein sequences of bovine epidermal growth factor
JP2017046688A (ja) *	2015-08-31	2017-03-09	株式会社みやぎヘルスイノベーション	体重増加抑制用飲料組成物
CN105194642B (zh) *	2015-10-09	2018-04-17	深圳市容大生物技术有限公司	一种疏通乳房微循环养护自体腺胞的组合物及制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4011312A (en) *	1975-06-25	1977-03-08	American Home Products Corporation	Prolonged release drug form for the treatment of bovine mastitis
EP0085036A1 (fr) *	1982-01-18	1983-08-03	Monsanto Company	Méthode pour une production améliorée de lait de bovins
US4521409A (en) *	1983-10-03	1985-06-04	Cornell Research Foundation, Inc.	Use of growth hormone to enhance ruminant mammary development

1987
- 1987-02-19 CA CA000530136A patent/CA1299103C/fr not_active Expired - Lifetime
- 1987-03-04 AT AT87870029T patent/ATE93730T1/de not_active IP Right Cessation
- 1987-03-04 EP EP87870029A patent/EP0237514B1/fr not_active Expired - Lifetime
- 1987-03-04 DE DE87870029T patent/DE3787185T2/de not_active Expired - Fee Related
- 1987-03-04 ES ES87870029T patent/ES2000437T3/es not_active Expired - Lifetime
- 1987-03-06 ZA ZA871654A patent/ZA871654B/xx unknown
- 1987-03-06 KR KR1019870002026A patent/KR900000545B1/ko not_active Expired
- 1987-03-06 HU HU87973A patent/HU205007B/hu not_active IP Right Cessation
- 1987-03-06 NO NO870946A patent/NO870946L/no unknown
- 1987-03-06 DK DK116287A patent/DK116287A/da not_active Application Discontinuation
- 1987-03-06 JP JP62051831A patent/JPS62221635A/ja active Pending
- 1987-03-06 CN CN198787102601A patent/CN87102601A/zh active Pending
- 1987-03-06 NZ NZ219530A patent/NZ219530A/xx unknown
- 1987-03-06 MX MX005494A patent/MX170911B/es unknown
- 1987-03-06 PL PL1987264490A patent/PL154182B1/pl unknown
- 1987-03-06 BG BG078775A patent/BG50926A3/bg unknown
- 1987-03-06 AU AU69788/87A patent/AU595295B2/en not_active Ceased
- 1987-03-06 DD DD87300534A patent/DD258943A5/de not_active IP Right Cessation
- 1987-03-06 CS CS151887A patent/CS272772B2/cs unknown
- 1987-03-06 IL IL81809A patent/IL81809A/xx not_active IP Right Cessation
- 1987-03-06 RU SU874202227A patent/RU2033178C1/ru active
- 1987-09-02 US US07/092,009 patent/US5059586A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BG50926A3 (bg)	1992-12-15
PL264490A1 (en)	1988-02-18
HU205007B (en)	1992-03-30
DE3787185T2 (de)	1994-02-03
ES2000437A4 (es)	1988-03-01
DE3787185D1 (de)	1993-10-07
EP0237514A1 (fr)	1987-09-16
CS151887A2 (en)	1990-06-13
KR880010773A (ko)	1988-10-24
EP0237514B1 (fr)	1993-09-01
CN87102601A (zh)	1987-12-16
JPS62221635A (ja)	1987-09-29
ZA871654B (en)	1987-08-28
RU2033178C1 (ru)	1995-04-20
NO870946L (no)	1987-09-08
DK116287D0 (da)	1987-03-06
KR900000545B1 (ko)	1990-01-31
IL81809A (en)	1993-01-31
MX170911B (es)	1993-09-22
IL81809A0 (en)	1987-10-20
AU6978887A (en)	1987-09-10
CS272772B2 (en)	1991-02-12
NZ219530A (en)	1992-12-23
US5059586A (en)	1991-10-22
HUT47031A (en)	1989-01-30
DK116287A (da)	1987-09-08
AU595295B2 (en)	1990-03-29
CA1299103C (fr)	1992-04-21
ATE93730T1 (de)	1993-09-15
NO870946D0 (no)	1987-03-06
PL154182B1 (en)	1991-07-31
ES2000437T3 (es)	1994-01-16

Legal Events

Date	Code	Title	Description
1997-11-06	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DE69209277T2 (de)	1996-10-31	Kombination von igf-i und igfbp für den aufbaustoffwechsel (anabolismus)
DE69435033T2 (de)	2008-05-29	Parathormonarzneizusammensetzung
DE3650499T2 (de)	1996-07-25	Verwendung von "Cartilage-inducing Factor" (CIF) zur Behandlung von hemato- oder lymphopoietischen Krankheiten
DE69312947T2 (de)	1998-01-08	Proteinhaftige arzneimittel mit verzögerter wirkstoffabgabe
DE69219607T2 (de)	1997-09-04	Verfahren zur anregung der immunresponz
DE3782420T2 (de)	1993-03-11	Wachstumhormonzubereitungen mit verzoegerter wirkstoffabgabe fuer eine parenterale verabreichung und ihre verwendung.
DE69614849T2 (de)	2002-05-16	Chimäre lipidkörper-pro-grf analoge mit erhöheter biologischer potenz
DE69719360T2 (de)	2003-12-04	Zusammensetzungen und methoden zur steigerung der darmfunktion
EP0357978B1 (fr)	1992-05-13	Préparation pharmaceutique pour le traitement du diabète sucré
DE69915204T2 (de)	2004-07-29	Stabilisierte Proteinzusammensetzung
DE2732175C2 (de)	1986-04-24	Oxytocin-Strukturanaloga und diese Verbindungen enthaltende pharmazeutische Mittel
DE69331802T2 (de)	2002-11-07	Verfahren zur systemischen behandlung katabolischer zustände und systemischer gewebeschädigung
DE69633396T2 (de)	2005-09-22	Activin stimulator enthaltende pharmazeutische zusammensetzung
DE69100376T2 (de)	1994-03-17	Verfahren zur hemmung der follikelreifung.
DE3787185T2 (de)	1994-02-03	Methode zur Erhöhung des Wachstums des Brustzellgewebes.
EP0867186B1 (fr)	2002-02-06	Composition injectable parasiticide à activité de longue durée et procédé de préparation
DE69423506T2 (de)	2000-09-21	Methode zur behandlung von reproduktionserkrankungen
DE3872614T2 (de)	1992-12-17	Verfahren zur behandlung der unfruchtbarkeit und mittel zur verwendung dabei.
CH650678A5 (de)	1985-08-15	Pharmazeutisches mittel aus human-insulin und human-proinsulin.
DE69305091T2 (de)	1997-03-13	Methode zur behandlung oder verhütung von fettleibigkeit
DE69211723T2 (de)	1996-10-31	Mit einem Zellwachstumsfaktor bewirkte Anregung von Wachstum im Knocheninneren
EP0083925B1 (fr)	1986-10-08	Méthode de traitement pour provoquer l'ovulation chez les brebis ou les génisses
DE69005108T2 (de)	1994-04-14	Somatotropin zur steigerung der fertilität bei tieren.
US6193989B1 (en)	2001-02-27	Long acting injectable parasiticidal composition and the process for its preparation
DE2616462A1 (de)	1976-10-28	Polypeptidhaltige pharmazeutische zubereitungen