DD263532A5 - Verfahren zur herstellung von 11 beta-(4-isopropenylphenyl)-estra-4,9-dienen - Google Patents

Verfahren zur herstellung von 11 beta-(4-isopropenylphenyl)-estra-4,9-dienen Download PDF

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Publication number
DD263532A5
DD263532A5 DD87305297A DD30529787A DD263532A5 DD 263532 A5 DD263532 A5 DD 263532A5 DD 87305297 A DD87305297 A DD 87305297A DD 30529787 A DD30529787 A DD 30529787A DD 263532 A5 DD263532 A5 DD 263532A5
Authority
DD
German Democratic Republic
Prior art keywords
hydroxy
isopropenylphenyl
estradien
methyl
enyl
Prior art date
Application number
DD87305297A
Other languages
German (de)
English (en)
Inventor
Eckhard Ottow
Rudolf Wiechert
Guenter Neef
Sybille Beier
Walter Elger
David Henderson
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ������@������������k�� filed Critical ������@������������k��
Publication of DD263532A5 publication Critical patent/DD263532A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
DD87305297A 1986-07-25 1987-07-23 Verfahren zur herstellung von 11 beta-(4-isopropenylphenyl)-estra-4,9-dienen DD263532A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863625315 DE3625315A1 (de) 1986-07-25 1986-07-25 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate

Publications (1)

Publication Number Publication Date
DD263532A5 true DD263532A5 (de) 1989-01-04

Family

ID=6306037

Family Applications (1)

Application Number Title Priority Date Filing Date
DD87305297A DD263532A5 (de) 1986-07-25 1987-07-23 Verfahren zur herstellung von 11 beta-(4-isopropenylphenyl)-estra-4,9-dienen

Country Status (20)

Country Link
US (2) US4814327A (fr)
EP (1) EP0254670B1 (fr)
JP (1) JPH0822871B2 (fr)
CN (1) CN1026324C (fr)
AT (1) ATE48003T1 (fr)
AU (1) AU602521B2 (fr)
CA (1) CA1289944C (fr)
DD (1) DD263532A5 (fr)
DE (2) DE3625315A1 (fr)
DK (1) DK162101C (fr)
ES (1) ES2014034B3 (fr)
FI (2) FI85274C (fr)
GR (2) GR890300034T1 (fr)
HU (1) HU196829B (fr)
IE (1) IE60316B1 (fr)
IL (1) IL83301A (fr)
NO (2) NO168891C (fr)
NZ (1) NZ221185A (fr)
PT (1) PT85385B (fr)
ZA (1) ZA875518B (fr)

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DE3822770A1 (de) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
WO1990002781A1 (fr) * 1988-09-16 1990-03-22 Lithium Corporation Of America Compositions organo-metalliques reactives, thermiquement stables et contenant du cuivre
US5316856A (en) * 1988-12-03 1994-05-31 Ngk Spark Plug Co., Ltd. Silicon nitride base sintered body
KR970005888B1 (ko) * 1989-01-12 1997-04-21 닛뽕 도꾸슈 도오교오 가부시끼가이샤 질화규소에 기초한 소결체
DE59010853D1 (de) * 1989-08-04 1998-12-03 Schering Ag 11 Beta-Aryl-gona-4,9-dien-3-one
US5100575A (en) * 1989-09-08 1992-03-31 Fmc Corporation Thermally stable, reactive organometallic compositions containing copper
FR2659233B1 (fr) * 1990-03-06 1994-01-21 Roussel Uclaf Nouvelle utilisation de composes anti-progestomimetiques chez les animaux d'elevage.
DE4042004A1 (de) * 1990-12-22 1992-06-25 Schering Ag 14(beta)-h-, 14- u. 15-en-11(beta)-aryl-4-estrene
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
US5468741A (en) * 1993-05-28 1995-11-21 The Regents Of The University Of California Use of low levels of mifepristone to treat leiomyomata
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US6908910B2 (en) 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
US5504074A (en) 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
ATE156836T1 (de) * 1994-05-19 1997-08-15 Akzo Nobel Nv 11,21-bisphenyl-19-nor-pregnan derivate
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
DE69702450T2 (de) * 1996-05-01 2001-03-08 The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer 21-substituierte progesteron derivate als antigestagene
US6028064A (en) * 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6090798A (en) * 1997-12-19 2000-07-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with glucocorticoid antagonists
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
DE69922684T2 (de) 1998-08-11 2005-10-06 Entremed, Inc. Verwendung von 2-methoxyestradiol als fungizide
US7087592B1 (en) 1999-08-23 2006-08-08 Entre Med, Inc. Compositions comprising purified 2-methoxyestradiol and methods of producing same
CN1117759C (zh) * 1999-09-02 2003-08-13 上海中西药业股份有限公司 甾体化合物,其制备方法和其药物组合物及其应用
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US7135581B2 (en) 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
US6995278B2 (en) 2000-08-18 2006-02-07 Entre Med, Inc. Antiangiogenic agents
AU2004217988C1 (en) * 2003-02-28 2010-06-03 Southwest Foundation For Biomedical Research Method for preparing 17 alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates
JP2006526025A (ja) 2003-05-28 2006-11-16 エントレメッド インコーポレイテッド 抗血管新生剤
WO2004112720A2 (fr) * 2003-06-20 2004-12-29 Viral Genomix, Inc. Compositions antivirales et procedes d'utilisation de ces compositions
EP1756139A4 (fr) 2004-03-12 2009-07-29 Entremed Inc Agents anti-angiogeniques
CA2646065C (fr) 2006-03-20 2014-01-14 Entremed, Inc. 2-methoxyestradiol presentant une activite anti-arthritique pouvant modifier l'evolution de la maladie
WO2008039482A2 (fr) * 2006-09-26 2008-04-03 The Regents Of The University Of California Méthodes et compositions pour la prévention et le traitement du cancer
US9517240B2 (en) 2006-09-26 2016-12-13 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
ES2643318T3 (es) 2006-10-24 2017-11-22 Repros Therapeutics Inc. Composiciones y métodos para suprimir la proliferación endometrial
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
DE102009034367A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
BR112012023281A2 (pt) 2010-03-22 2016-05-17 Repros Therapeutics Inc composto ou sal do mesmo, composição farmacêutica, métodos para produzir efeito antiprogestacional em paciente e para tratar condição dependente de progesterona e usos de composto ou sal do mesmo farmaceuticamente aceitável do mesmo e de composição
PL2576582T3 (pl) 2010-05-26 2020-06-29 Corcept Therapeutics, Inc. Leczenie dystrofii mięśniowej
WO2016140867A1 (fr) 2015-03-02 2016-09-09 Corcept Therapeutics, Inc. Utilisation d'un antagoniste du récepteur des glucocorticoïdes et d'analogues de la somatostatine pour le traitement de tumeurs secrétant de l'hormone adrénocorticotrope (acth)
US10610534B2 (en) 2015-03-30 2020-04-07 Corcept Therapeutics, Inc. Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
KR20180052120A (ko) 2015-08-13 2018-05-17 코어셉트 쎄라퓨틱스, 잉크. Acth-의존성 쿠싱 증후군을 감별 진단하는 방법
KR102197526B1 (ko) 2016-01-19 2020-12-31 코어셉트 쎄라퓨틱스 인코포레이티드 이소성 쿠싱 증후군의 감별 진단
SG11201908790PA (en) 2017-03-31 2019-10-30 Corcept Therapeutics Inc Glucocorticoid receptor modulators to treat cervical cancer
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FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
FR2377419A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 11b-substitues 1,3,5 (10) trieniques, leur procede de preparation et leur application comme medicament
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
DE3205686A1 (de) * 1982-02-17 1983-08-25 Robert Bosch Gmbh, 7000 Stuttgart Hoergeraet
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
DE3231827A1 (de) * 1982-08-24 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate
EP0116974B1 (fr) * 1983-02-18 1986-10-29 Schering Aktiengesellschaft 11-Bêta-aryl-estradiènes, procédé de préparation et compositions pharmaceutiques les contenant
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
HU196829B (en) 1989-01-30
DK162101B (da) 1991-09-16
NO168891C (no) 1992-04-15
CA1289944C (fr) 1991-10-01
IE872017L (en) 1988-01-25
FI913387A7 (fi) 1991-07-12
HUT44272A (en) 1988-02-29
AU602521B2 (en) 1990-10-18
NO880742L (no) 1988-01-26
DK387187A (da) 1988-01-26
DE3760995D1 (en) 1989-12-21
US4814327A (en) 1989-03-21
IE60316B1 (en) 1994-06-29
ES2014034B3 (es) 1990-06-16
FI873001A7 (fi) 1988-01-26
GR3000269T3 (en) 1991-03-15
JPH0822871B2 (ja) 1996-03-06
PT85385B (pt) 1990-04-30
DK387187D0 (da) 1987-07-24
NO873117D0 (no) 1987-07-24
GR890300034T1 (en) 1989-04-12
ZA875518B (en) 1988-03-30
DK162101C (da) 1992-02-24
JPS6335594A (ja) 1988-02-16
IL83301A (en) 1991-09-16
FI85274B (fi) 1991-12-13
EP0254670A1 (fr) 1988-01-27
PT85385A (de) 1987-08-01
NZ221185A (en) 1989-05-29
NO167864C (no) 1991-12-18
FI873001A0 (fi) 1987-07-07
DE3625315A1 (de) 1988-01-28
CN1026324C (zh) 1994-10-26
ATE48003T1 (de) 1989-12-15
NO873117L (no) 1988-01-26
IL83301A0 (en) 1987-12-31
AU7621887A (en) 1988-01-28
US5089488A (en) 1992-02-18
CN87105307A (zh) 1988-05-11
EP0254670B1 (fr) 1989-11-15
FI85274C (fi) 1992-03-25
NO167864B (no) 1991-09-09
FI913387A0 (fi) 1991-07-12
NO880742D0 (no) 1988-02-19
NO168891B (no) 1992-01-06

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Legal Events

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ENJ Ceased due to non-payment of renewal fee