ATE156836T1 - 11,21-bisphenyl-19-nor-pregnan derivate - Google Patents

11,21-bisphenyl-19-nor-pregnan derivate

Info

Publication number: ATE156836T1
Authority: AT; Austria
Prior art keywords: nr5r6; alkyl; bisphenyl; son; optionally substituted
Prior art date: 1994-05-19

Application number

AT95201268T

Other languages

English (en)

Inventor

Ronald Gebhard

Der Voort Hendrikus Adrian Van

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-19

Filing date

1995-05-16

Publication date

1997-08-15

1995-05-16 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1997-08-15 Application granted granted Critical

1997-08-15 Publication of ATE156836T1 publication Critical patent/ATE156836T1/de

Links

125000000217 alkyl group Chemical group 0.000 abstract 4
239000003862 glucocorticoid Substances 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Seasonings (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

AT95201268T 1994-05-19 1995-05-16 11,21-bisphenyl-19-nor-pregnan derivate ATE156836T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP94201431		1994-05-19

Publications (1)

Publication Number	Publication Date
ATE156836T1 true ATE156836T1 (de)	1997-08-15

Family

ID=8216894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95201268T ATE156836T1 (de)	1994-05-19	1995-05-16	11,21-bisphenyl-19-nor-pregnan derivate

Country Status (20)

Country	Link
US (1)	US5620966A (de)
EP (1)	EP0683172B1 (de)
JP (1)	JP3814312B2 (de)
KR (1)	KR100359474B1 (de)
CN (1)	CN1042539C (de)
AT (1)	ATE156836T1 (de)
AU (1)	AU701616B2 (de)
BR (1)	BR9502085A (de)
CA (1)	CA2149496C (de)
DE (1)	DE69500542T2 (de)
DK (1)	DK0683172T3 (de)
ES (1)	ES2106616T3 (de)
FI (1)	FI112491B (de)
GR (1)	GR3025225T3 (de)
HU (1)	HU217429B (de)
NO (1)	NO304379B1 (de)
NZ (1)	NZ272143A (de)
PL (1)	PL180481B1 (de)
RU (1)	RU2152952C2 (de)
ZA (1)	ZA953976B (de)

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IL118974A (en) *	1995-08-17	2001-09-13	Akzo Nobel Nv	History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
MXPA01011018A (es)	1999-04-30	2002-05-06	Pfizer Prod Inc	Moduladores del receptor glucocorticoide.
US7713989B2 (en)	2000-04-27	2010-05-11	Dow Robert L	Glucocorticoid receptor modulators
ES2246292T3 (es)	2000-10-30	2006-02-16	Pfizer Products Inc.	Moduladores de receptor glucocorticoide.
EP1285927A3 (de)	2001-08-16	2005-06-29	Schering Aktiengesellschaft	Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
WO2003043640A2 (en)	2001-11-23	2003-05-30	Akzo Nobel N.V.	Treatment of major depressive disorder using glucocorticoid receptor antagonists
US7250408B2 (en)	2002-12-16	2007-07-31	Bayer Schering Pharma Ag	Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility
CA2517893C (fr) *	2003-03-11	2012-05-15	Trophos	Application a titre de medicaments de derives de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, nouveaux derives et leur procede de preparation
ES2581765T3 (es)	2006-08-24	2016-09-07	University Of Tennessee Research Foundation	Acilanilidas sustituidas y métodos de uso de las mismas
US10987334B2 (en)	2012-07-13	2021-04-27	University Of Tennessee Research Foundation	Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10258596B2 (en)	2012-07-13	2019-04-16	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10314807B2 (en)	2012-07-13	2019-06-11	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9969683B2 (en)	2012-07-13	2018-05-15	Gtx, Inc.	Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
LT2872482T (lt)	2012-07-13	2020-12-28	Oncternal Therapeutics, Inc.	Krūties vėžių gydymo būdas selektyviu androgeno receptoriaus moduliatoriumi
US9622992B2 (en)	2012-07-13	2017-04-18	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9744149B2 (en)	2012-07-13	2017-08-29	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
CN107530435A (zh)	2015-03-02	2018-01-02	科赛普特治疗学股份有限公司	使用糖皮质激素受体拮抗剂和生长抑素治疗acth分泌型肿瘤
WO2016160969A1 (en)	2015-03-30	2016-10-06	Corcept Therapeutics, Inc.	Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
ES2865334T3 (es)	2015-08-13	2021-10-15	Corcept Therapeutics Inc	Método de diagnóstico diferencial de síndrome de Cushing dependiente de ACTH
CN105254697A (zh) *	2015-11-17	2016-01-20	湖南成大生物科技有限公司	△16甾体类化合物的制备方法
CA3011728A1 (en)	2016-01-19	2017-07-27	Corcept Therapeutics, Inc.	Differential diagnosis of ectopic cushing's syndrome
EP3214092A1 (de) *	2016-03-04	2017-09-06	Bayer Pharma Aktiengesellschaft	Prodrugs vom selektiven progesteronrezeptormodulator (sprm) (11.beta.,17.beta.)-17-hydroxy-11-[4-(methylsulphonyl)phenyl]-17-(pentafluoroethyl)estra-4,9-dien-3-on
AU2018289307B2 (en)	2017-06-20	2024-02-01	Corcept Therapeutics, Inc.	Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
CN114456223B (zh) *	2022-01-24	2023-07-21	湖南科益新生物医药有限公司	3-缩酮的合成方法

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FR2528434B1 (fr) *	1982-06-11	1985-07-19	Roussel Uclaf	Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
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BE1004905A4 (fr) *	1987-12-30	1993-02-23	Roussel Uclaf	Nouveaux derives 17beta-oh 19-nor steroides substitues en 17alpha, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
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DE3832303A1 (de) *	1988-09-20	1990-04-12	Schering Ag	11ss-phenyl-14ssh-steroide
FR2643638B1 (fr) *	1989-02-24	1991-06-14	Roussel Uclaf	Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
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EP0411736B1 (de) *	1989-08-04	1994-05-04	Schering Aktiengesellschaft	11 Beta-substituierte 16 alpha, 17alpha-Methylen-estra-4,9-dien-3-one
US5276023A (en) *	1989-08-08	1994-01-04	Roussel Uclaf	19-nor-steroid esters
FR2651435A1 (fr) *	1989-09-07	1991-03-08	Roussel Uclaf	Nouvelle utilisation de composes anti-progestomimetiques.
US5407928A (en) *	1990-08-15	1995-04-18	Schering Aktiengesellschaft	11β-aryl-gona-4,9-dien-3-ones
JP3828926B2 (ja) *	1993-08-04	2006-10-04	アクゾ・ノベル・エヌ・ベー	不安症の治療用抗グルココルチコイドステロイド

1995
- 1995-05-16 DE DE69500542T patent/DE69500542T2/de not_active Expired - Fee Related
- 1995-05-16 ES ES95201268T patent/ES2106616T3/es not_active Expired - Lifetime
- 1995-05-16 EP EP95201268A patent/EP0683172B1/de not_active Expired - Lifetime
- 1995-05-16 DK DK95201268.0T patent/DK0683172T3/da active
- 1995-05-16 AT AT95201268T patent/ATE156836T1/de not_active IP Right Cessation
- 1995-05-16 ZA ZA953976A patent/ZA953976B/xx unknown
- 1995-05-16 CA CA002149496A patent/CA2149496C/en not_active Expired - Fee Related
- 1995-05-17 NZ NZ272143A patent/NZ272143A/en unknown
- 1995-05-18 BR BR9502085A patent/BR9502085A/pt not_active IP Right Cessation
- 1995-05-18 KR KR1019950012374A patent/KR100359474B1/ko not_active Expired - Fee Related
- 1995-05-18 NO NO951968A patent/NO304379B1/no unknown
- 1995-05-18 FI FI952424A patent/FI112491B/fi active
- 1995-05-18 PL PL95308666A patent/PL180481B1/pl not_active IP Right Cessation
- 1995-05-18 AU AU20133/95A patent/AU701616B2/en not_active Ceased
- 1995-05-18 RU RU95107892/04A patent/RU2152952C2/ru not_active IP Right Cessation
- 1995-05-18 CN CN95105395A patent/CN1042539C/zh not_active Expired - Fee Related
- 1995-05-18 HU HU9501461A patent/HU217429B/hu not_active IP Right Cessation
- 1995-05-18 JP JP12005195A patent/JP3814312B2/ja not_active Expired - Fee Related
- 1995-05-19 US US08/445,119 patent/US5620966A/en not_active Expired - Fee Related
1997
- 1997-10-30 GR GR970402861T patent/GR3025225T3/el unknown

Also Published As

Publication number	Publication date
ZA953976B (en)	1996-01-19
US5620966A (en)	1997-04-15
CA2149496A1 (en)	1995-11-20
HU9501461D0 (en)	1995-06-28
KR950032267A (ko)	1995-12-20
CN1126727A (zh)	1996-07-17
RU2152952C2 (ru)	2000-07-20
CA2149496C (en)	2006-12-19
PL180481B1 (pl)	2001-02-28
FI112491B (fi)	2003-12-15
EP0683172A1 (de)	1995-11-22
RU95107892A (ru)	1997-02-10
AU2013395A (en)	1995-11-30
KR100359474B1 (ko)	2003-03-12
NO951968L (no)	1995-11-20
JPH07316187A (ja)	1995-12-05
FI952424A0 (fi)	1995-05-18
DE69500542T2 (de)	1998-01-02
BR9502085A (pt)	1996-03-05
JP3814312B2 (ja)	2006-08-30
DK0683172T3 (da)	1998-03-30
PL308666A1 (en)	1995-11-27
GR3025225T3 (en)	1998-02-27
DE69500542D1 (de)	1997-09-18
NO304379B1 (no)	1998-12-07
CN1042539C (zh)	1999-03-17
HU217429B (hu)	2000-01-28
ES2106616T3 (es)	1997-11-01
EP0683172B1 (de)	1997-08-13
AU701616B2 (en)	1999-02-04
HUT71804A (en)	1996-02-28
FI952424L (fi)	1995-11-20
NZ272143A (en)	1995-11-27
NO951968D0 (no)	1995-05-18

Legal Events

Date	Code	Title	Description
1998-01-15	UEP	Publication of translation of european patent specification
2009-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69500542D1 (de)	1997-09-18	11,21-Bisphenyl-19-nor-pregnan Derivate
BE2018C008I2 (de)	2021-02-04
DK0590919T3 (da)	2000-04-17	Terapeutiske midler mod Parkinsons sygdom
TW427887B (en)	2001-04-01	Pharmaceutical composition comprising a benzimidazole derivative for treating viral infections
DK0390654T3 (da)	1995-04-03	Aminobenzensulfonsyrederivater
PT918776E (pt)	2004-07-30	Sintese total de acilfulvenos antitumorais
DE69312567D1 (de)	1997-09-04	2-Formylpyridin-Thiosemicarbazonderivate, ihre Herstellung und ihre Verwendung als Antitumor Mittel
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