DD270906A1 - Verfahren zur herstellung neuer imidazolderivate und deren verwendung als pharmazeutische mittel - Google Patents

Verfahren zur herstellung neuer imidazolderivate und deren verwendung als pharmazeutische mittel Download PDF

Info

Publication number: DD270906A1
Authority: DD; German Democratic Republic
Prior art keywords: formula; compound; general formula; dichlorophenyl; alk
Prior art date: 1986-12-29

Application number

DD87311518A

Other languages

German (de)

English (en)

Inventor

Karl Schermanz

Gerald Saischek

Robert Urmann

Kurt Martetschlaeger

Original Assignee

Cl Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-29

Filing date

1987-12-28

Publication date

1989-08-16

1987-12-28 Application filed by Cl Pharma filed Critical Cl Pharma

1989-08-16 Publication of DD270906A1 publication Critical patent/DD270906A1/de

Links

238000002360 preparation method Methods 0.000 title claims abstract description 13
238000000034 method Methods 0.000 title claims abstract description 12
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title claims abstract description 8
239000008177 pharmaceutical agent Substances 0.000 title description 3
RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
-1 biphenylyl Chemical group 0.000 claims abstract description 45
125000000217 alkyl group Chemical group 0.000 claims abstract description 13
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 12
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims abstract description 12
229910052717 sulfur Inorganic materials 0.000 claims abstract description 12
239000011593 sulfur Chemical group 0.000 claims abstract description 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 10
150000003839 salts Chemical class 0.000 claims abstract description 9
229910052736 halogen Inorganic materials 0.000 claims abstract description 8
150000002367 halogens Chemical group 0.000 claims abstract description 8
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
239000001257 hydrogen Substances 0.000 claims abstract description 8
125000001624 naphthyl group Chemical group 0.000 claims abstract description 8
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 7
150000002460 imidazoles Chemical class 0.000 claims abstract description 7
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NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
238000009630 liquid culture Methods 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
239000012280 lithium aluminium hydride Substances 0.000 description 1
239000006210 lotion Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
231100000243 mutagenic effect Toxicity 0.000 description 1
230000003505 mutagenic effect Effects 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
150000002790 naphthalenes Chemical class 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011148 porous material Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
238000010583 slow cooling Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
125000005270 trialkylamine group Chemical group 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
229940055035 trichophyton verrucosum Drugs 0.000 description 1
229940099259 vaseline Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DD87311518A 1986-12-29 1987-12-28 Verfahren zur herstellung neuer imidazolderivate und deren verwendung als pharmazeutische mittel DD270906A1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19863644616 DE3644616A1 (de)	1986-12-29	1986-12-29	Imidazolderivate, verfahren zur herstellung und deren verwendung

Publications (1)

Publication Number	Publication Date
DD270906A1 true DD270906A1 (de)	1989-08-16

Family

ID=6317328

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD87311518A DD270906A1 (de)	1986-12-29	1987-12-28	Verfahren zur herstellung neuer imidazolderivate und deren verwendung als pharmazeutische mittel

Country Status (19)

Country	Link
US (1)	US4925855A (da)
EP (1)	EP0276466A3 (da)
JP (1)	JPS63170366A (da)
KR (1)	KR880007480A (da)
AU (1)	AU593969B2 (da)
CA (1)	CA1324144C (da)
CZ (1)	CZ1009887A3 (da)
DD (1)	DD270906A1 (da)
DE (1)	DE3644616A1 (da)
DK (1)	DK165978C (da)
FI (1)	FI89595C (da)
HU (1)	HU196762B (da)
IL (1)	IL84846A (da)
MY (1)	MY102276A (da)
NO (1)	NO170278C (da)
NZ (1)	NZ223061A (da)
SU (1)	SU1572415A3 (da)
YU (1)	YU45053B (da)
ZA (1)	ZA879697B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5229385A (en) *	1986-01-30	1993-07-20	Takeda Chemical Industries, Ltd.	Quinone derivatives, their production and use
NZ229783A (en) *	1988-07-22	1990-12-21	Cl Pharma	Allylaminoethylazoles; fungicidal and antimycotic compositions, methods for preparation and combating fungi
US6031109A (en) *	1993-06-22	2000-02-29	Knoll Aktiengesellschaft	Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents
GB9312893D0 (en) *	1993-06-22	1993-08-04	Boots Co Plc	Therapeutic agents
GB9409882D0 (en) *	1994-05-18	1994-07-06	Sandoz Ltd	Organic compounds
BR112022024702A2 (pt) *	2020-06-03	2023-02-28	Ishihara Sangyo Kaisha	Agente antifúngico para ser humano

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3839574A (en) *	1968-08-19	1974-10-01	Janssen Pharmaceutica Nv	Antifungal and antibacterial compositions of certain imidazoles and methods of using same
SU557755A3 (ru) *	1968-08-19	1977-05-05	Янссен Фармасьютика Н.В. (Фирма)	Способ получени производных имидазола
DE2041771C3 (de) *	1970-08-22	1979-07-26	Bayer Ag, 5090 Leverkusen	derivate
DE3100260A1 (de) *	1981-01-08	1982-08-05	Basf Ag, 6700 Ludwigshafen	Substituierte azolyl-glykolsulfonate, diese enthaltende fungizide und verfahren zu ihrer herstellung
CA1189857A (en) *	1981-03-27	1985-07-02	Janssen Pharmaceutica Naamloze Vennootschap	Antimicrobial triazole derivatives
DE3125780A1 (de) *	1981-06-30	1983-01-13	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Imidazolyl-propionitrile, verfahren zur herstellung dieser verbindungen sowie diese enthaltende biozide mittel
DE3200414A1 (de) *	1982-01-09	1983-07-21	Bayer Ag, 5090 Leverkusen	Azolyl-thioether-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide und pflanzenwachstumsregulatoren
DE3337937A1 (de) *	1982-10-28	1984-05-03	Sandoz-Patent-GmbH, 7850 Lörrach	Neue azolderivate
US4568687A (en) *	1983-02-28	1986-02-04	American Cyanamid Company	N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
CH655103A5 (de) *	1983-03-11	1986-03-27	Sandoz Ag	Azolderivate, verfahren zu ihrer herstellung und ihre verwendung.
DE3345899A1 (de) *	1983-12-20	1985-06-27	Bayer Ag, 5090 Leverkusen	Iminomethyl-azolyl-derivate
JPS61130272A (ja) *	1984-11-30	1986-06-18	Nippon Tokushu Noyaku Seizo Kk	β―置換アミノ―フェネチルアゾール誘導体、その製法及び農園芸用殺菌剤
DE3530799A1 (de) *	1985-08-29	1987-03-05	Hoechst Ag	Azolyl-cyclopropyl-ethanol-derivate, verfahren zu ihrer herstellung und ihre verwendung

1986
- 1986-12-29 DE DE19863644616 patent/DE3644616A1/de not_active Withdrawn
1987
- 1987-12-15 NO NO875230A patent/NO170278C/no unknown
- 1987-12-16 IL IL84846A patent/IL84846A/xx not_active IP Right Cessation
- 1987-12-17 CA CA000554724A patent/CA1324144C/en not_active Expired - Fee Related
- 1987-12-18 MY MYPI87003224A patent/MY102276A/en unknown
- 1987-12-22 EP EP87119012A patent/EP0276466A3/de not_active Withdrawn
- 1987-12-23 NZ NZ223061A patent/NZ223061A/en unknown
- 1987-12-23 US US07/137,556 patent/US4925855A/en not_active Expired - Fee Related
- 1987-12-25 YU YU2391/87A patent/YU45053B/xx unknown
- 1987-12-28 HU HU876030A patent/HU196762B/hu not_active IP Right Cessation
- 1987-12-28 JP JP62330330A patent/JPS63170366A/ja active Pending
- 1987-12-28 FI FI875720A patent/FI89595C/fi not_active IP Right Cessation
- 1987-12-28 KR KR1019870015048A patent/KR880007480A/ko not_active Ceased
- 1987-12-28 SU SU874203937A patent/SU1572415A3/ru active
- 1987-12-28 DD DD87311518A patent/DD270906A1/de not_active IP Right Cessation
- 1987-12-28 DK DK688087A patent/DK165978C/da active
- 1987-12-28 ZA ZA879697A patent/ZA879697B/xx unknown
- 1987-12-29 CZ CS8710098A patent/CZ1009887A3/cs unknown
- 1987-12-29 AU AU83095/87A patent/AU593969B2/en not_active Ceased

Also Published As

Publication number	Publication date
YU45053B (en)	1991-06-30
CA1324144C (en)	1993-11-09
MY102276A (en)	1992-05-15
CZ1009887A3 (en)	1994-02-16
ZA879697B (en)	1988-06-23
FI89595B (fi)	1993-07-15
SU1572415A3 (ru)	1990-06-15
NZ223061A (en)	1990-01-29
FI89595C (fi)	1993-10-25
AU8309587A (en)	1988-06-30
HUT45507A (en)	1988-07-28
EP0276466A3 (de)	1988-09-07
FI875720A0 (fi)	1987-12-28
KR880007480A (ko)	1988-08-27
DK165978C (da)	1993-07-26
NO170278C (no)	1992-09-30
US4925855A (en)	1990-05-15
HU196762B (en)	1989-01-30
EP0276466A2 (de)	1988-08-03
NO170278B (no)	1992-06-22
NO875230L (no)	1988-06-30
NO875230D0 (no)	1987-12-15
IL84846A0 (en)	1988-06-30
DK688087D0 (da)	1987-12-28
JPS63170366A (ja)	1988-07-14
AU593969B2 (en)	1990-02-22
DE3644616A1 (de)	1988-07-07
YU239187A (en)	1989-02-28
FI875720L (fi)	1988-06-30
DK165978B (da)	1993-02-22
IL84846A (en)	1991-08-16
DK688087A (da)	1988-06-30

Legal Events

Date	Code	Title	Description
1995-12-07	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DE2037610C3 (da)	1979-07-12
DE2041771B2 (de)	1978-11-23	derivate
EP0001654B1 (de)	1981-07-22	Imidazolyläthyl-oxyalkoxy-Derivate und ihre Thio-Analoge, pharmazeutische Zubereitungen mit diesen Stoffen und Verfahren zu ihrer Herstellung
DE2350123C2 (de)	1983-04-14	1-Propyl-imidazol-Derivate und deren Salze, Verfahren zu ihrer Herstellung und ihre Verwendung als Fungizide
CH630077A5 (de)	1982-05-28	Verfahren zur herstellung neuer tertiaerer imidazolylalkohole.
DE2654665C3 (de)	1982-04-22	1-Aryl-2-(1-imidazolyl)-alkylsulfide, Verfahren zu ihrer Herstellung und diese enthaltende Antimycotica
EP0036153B1 (de)	1983-11-02	1,1-Diphenyl-2-(1,2,4-triazol-1-yl)-äthan-1-ole als Antimykotika
EP0411735B1 (de)	1995-05-17	Cycloakylenazole, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese enthalten sowie ihre Verwendung zur Herstellung von Arzneimitteln
DD270906A1 (de)	1989-08-16	Verfahren zur herstellung neuer imidazolderivate und deren verwendung als pharmazeutische mittel
DD207375A1 (de)	1984-02-29	Verfahren zur herstellung von imidazolen und imidazolinen
DE2242454A1 (de)	1974-03-07	1-aethyl-imidazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
EP0277348A2 (de)	1988-08-10	Imidazol- und Triazolderivate zur Verwendung als antimykotische Mittel
DE2053080A1 (de)	1972-05-04	N substituierte Imidazole, Ver fahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE1620018B2 (de)	1976-04-15	1-methyl-5-nitroimidazol-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und antiparasitaere mittel
DE69012742T2 (de)	1995-03-16	Azolderivate und fungizide Medikamente, diese als wirkende Komponente enthaltend.
DE2917244A1 (de)	1979-11-22	4'-substituierte 2,4-dichlor- alpha (imidazol-n-ylmethyl)-dibenzylaether, verfahren zu deren herstellung sowie solche enthaltende arzneimittel
EP0073931B1 (de)	1985-02-13	Neue Anilino-1,2,3-triazol-Derivate, diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung und deren Verwendung
DE2044621C3 (de)	1979-07-05	33-Diphenyl-3-i]nidazol-l-yl-propine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2229128C2 (de)	1983-02-10	1-(Dialkylphenyl-phenyl-pyridyl-)methyl-imidazole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0022969A1 (de)	1981-01-28	Antimykotische Mittel, die Azolyl-alkenole enthalten und ihre Herstellung
EP0434982B1 (de)	1995-03-15	5-(Amino)-triazolylcarbothioamidderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel sowie Verwendung der ersteren
DE1617481C3 (de)	1976-04-08	N-Trityl-imidazole, Verfahren zu ihrer Herstellung sowie Arzneimittel
DE1620018C3 (de)	1976-12-02	i-Methyl-5-nitroimidazol-derivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und antiparasitäre Mittel
DE2651084A1 (de)	1978-12-14	Basisch substituirte o-(2-hydroxypropyl) -aldoxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2635664A1 (de)	1978-02-09	Antimikrobielle mittel