DD273855A5 - Verfahren zur Herstellung eines Rekombinanten DNA Moleküls - Google Patents

Verfahren zur Herstellung eines Rekombinanten DNA Moleküls Download PDF

Info

Publication number: DD273855A5
Authority: DD; German Democratic Republic
Prior art keywords: leu; lys; aag; asp; ctg
Prior art date: 1986-05-19

Application number

DD30287387A

Other languages

German (de)

English (en)

Inventor

Georgia Helmer

John Duesing

Steven Rothstein

Liliana Scarafia

Mary-Dell Chilton

Hui-Chen Jean Lai

Chen-Pei David Tu

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-19

Filing date

1987-05-18

Publication date

1989-11-29

1987-05-18 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1989-11-29 Publication of DD273855A5 publication Critical patent/DD273855A5/de

Links

238000000034 method Methods 0.000 title claims abstract description 64
102000053602 DNA Human genes 0.000 title claims abstract description 25
108020004511 Recombinant DNA Proteins 0.000 title claims abstract description 25
230000008569 process Effects 0.000 title claims description 10
238000002360 preparation method Methods 0.000 title claims description 9
108010070675 Glutathione transferase Proteins 0.000 claims abstract description 111
102000005720 Glutathione transferase Human genes 0.000 claims abstract description 102
239000004009 herbicide Substances 0.000 claims abstract description 80
108090000623 proteins and genes Proteins 0.000 claims abstract description 76
239000012634 fragment Substances 0.000 claims abstract description 74
230000002363 herbicidal effect Effects 0.000 claims abstract description 64
108020004414 DNA Proteins 0.000 claims abstract description 50
108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 49
239000002299 complementary DNA Substances 0.000 claims abstract description 38
238000000338 in vitro Methods 0.000 claims abstract description 16
238000012546 transfer Methods 0.000 claims abstract description 13
230000014509 gene expression Effects 0.000 claims abstract description 11
238000004519 manufacturing process Methods 0.000 claims abstract description 9
230000006798 recombination Effects 0.000 claims abstract description 9
238000005215 recombination Methods 0.000 claims abstract description 9
238000001727 in vivo Methods 0.000 claims abstract description 6
241000196324 Embryophyta Species 0.000 claims description 239
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 69
108010024636 Glutathione Proteins 0.000 claims description 35
229960003180 glutathione Drugs 0.000 claims description 32
239000013598 vector Substances 0.000 claims description 28
108090000765 processed proteins & peptides Proteins 0.000 claims description 25
230000000694 effects Effects 0.000 claims description 24
229920001184 polypeptide Polymers 0.000 claims description 23
102000004196 processed proteins & peptides Human genes 0.000 claims description 23
108091026890 Coding region Proteins 0.000 claims description 17
239000002773 nucleotide Substances 0.000 claims description 15
125000003729 nucleotide group Chemical group 0.000 claims description 15
244000068988 Glycine max Species 0.000 claims description 13
235000010469 Glycine max Nutrition 0.000 claims description 12
108010069205 aspartyl-phenylalanine Proteins 0.000 claims description 11
241000894007 species Species 0.000 claims description 11
244000061176 Nicotiana tabacum Species 0.000 claims description 9
235000002637 Nicotiana tabacum Nutrition 0.000 claims description 9
XPGVTUBABLRGHY-BIIVOSGPSA-N Asp-Ala-Pro Chemical compound C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CC(=O)O)N XPGVTUBABLRGHY-BIIVOSGPSA-N 0.000 claims description 7
CUXRXAIAVYLVFD-ULQDDVLXSA-N Leu-Arg-Tyr Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CUXRXAIAVYLVFD-ULQDDVLXSA-N 0.000 claims description 7
108010057821 leucylproline Proteins 0.000 claims description 7
108010057952 lysyl-phenylalanyl-lysine Proteins 0.000 claims description 7
DIIGDGJKTMLQQW-IHRRRGAJSA-N Arg-Lys-His Chemical compound C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N DIIGDGJKTMLQQW-IHRRRGAJSA-N 0.000 claims description 6
241001678517 Ginaia Species 0.000 claims description 6
241000219146 Gossypium Species 0.000 claims description 6
UUBKSZNKJUJQEJ-JRQIVUDYSA-N Tyr-Thr-Asp Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)N)O UUBKSZNKJUJQEJ-JRQIVUDYSA-N 0.000 claims description 6
UGZUVYDKAYNCII-ULQDDVLXSA-N Arg-Phe-Leu Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O UGZUVYDKAYNCII-ULQDDVLXSA-N 0.000 claims description 5
NIKBMHGRNAPJFW-IUCAKERBSA-N His-Arg Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CN=CN1 NIKBMHGRNAPJFW-IUCAKERBSA-N 0.000 claims description 5
VTJUNIYRYIAIHF-IUCAKERBSA-N Leu-Pro Chemical compound CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O VTJUNIYRYIAIHF-IUCAKERBSA-N 0.000 claims description 5
XBZOQGHZGQLEQO-IUCAKERBSA-N Lys-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN XBZOQGHZGQLEQO-IUCAKERBSA-N 0.000 claims description 5
AZOFEHCPMBRNFD-BZSNNMDCSA-N Lys-Phe-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CC=CC=C1 AZOFEHCPMBRNFD-BZSNNMDCSA-N 0.000 claims description 5
FNYBIOGBMWFQRJ-SRVKXCTJSA-N Met-Pro-Met Chemical compound CSCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)O)N FNYBIOGBMWFQRJ-SRVKXCTJSA-N 0.000 claims description 5
AMBLXEMWFARNNQ-DCAQKATOSA-N Pro-Asn-Leu Chemical compound CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]1CCCN1 AMBLXEMWFARNNQ-DCAQKATOSA-N 0.000 claims description 5
LEBTWGWVUVJNTA-FKBYEOEOSA-N Pro-Trp-Phe Chemical compound C1C[C@H](NC1)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O LEBTWGWVUVJNTA-FKBYEOEOSA-N 0.000 claims description 5
PTWIYDNFWPXQSD-GARJFASQSA-N Ser-Lys-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)N)C(=O)O PTWIYDNFWPXQSD-GARJFASQSA-N 0.000 claims description 5
QZOSVNLXLSNHQK-UWVGGRQHSA-N Tyr-Asp Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 QZOSVNLXLSNHQK-UWVGGRQHSA-N 0.000 claims description 5
BTJVOUQWFXABOI-IHRRRGAJSA-N Arg-Lys-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N BTJVOUQWFXABOI-IHRRRGAJSA-N 0.000 claims description 4
QJMCHPGWFZZRID-BQBZGAKWSA-N Asn-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC(N)=O QJMCHPGWFZZRID-BQBZGAKWSA-N 0.000 claims description 4
LTCKTLYKRMCFOC-KKUMJFAQSA-N Asp-Phe-Leu Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O LTCKTLYKRMCFOC-KKUMJFAQSA-N 0.000 claims description 4
MJJIHRWNWSQTOI-VEVYYDQMSA-N Asp-Thr-Arg Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O MJJIHRWNWSQTOI-VEVYYDQMSA-N 0.000 claims description 4
USENATHVGFXRNO-SRVKXCTJSA-N Asp-Tyr-Asp Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CC(O)=O)C(O)=O)CC1=CC=C(O)C=C1 USENATHVGFXRNO-SRVKXCTJSA-N 0.000 claims description 4
WOKXEQLPBLLWHC-IHRRRGAJSA-N Asp-Tyr-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)CC1=CC=C(O)C=C1 WOKXEQLPBLLWHC-IHRRRGAJSA-N 0.000 claims description 4
229920000742 Cotton Polymers 0.000 claims description 4
VRJZMZGGAKVSIQ-SRVKXCTJSA-N Cys-Tyr-Ser Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(O)=O VRJZMZGGAKVSIQ-SRVKXCTJSA-N 0.000 claims description 4
108010065920 Insulin Lispro Proteins 0.000 claims description 4
BPANDPNDMJHFEV-CIUDSAMLSA-N Leu-Asp-Ala Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(O)=O BPANDPNDMJHFEV-CIUDSAMLSA-N 0.000 claims description 4
JQSXWJXBASFONF-KKUMJFAQSA-N Leu-Asp-Phe Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O JQSXWJXBASFONF-KKUMJFAQSA-N 0.000 claims description 4
RZXLZBIUTDQHJQ-SRVKXCTJSA-N Leu-Lys-Asp Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(O)=O RZXLZBIUTDQHJQ-SRVKXCTJSA-N 0.000 claims description 4
KPYAOIVPJKPIOU-KKUMJFAQSA-N Leu-Lys-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O KPYAOIVPJKPIOU-KKUMJFAQSA-N 0.000 claims description 4
VUTWYNQUSJWBHO-BZSNNMDCSA-N Lys-Leu-Tyr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O VUTWYNQUSJWBHO-BZSNNMDCSA-N 0.000 claims description 4
SBQDRNOLGSYHQA-YUMQZZPRSA-N Lys-Ser-Gly Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(O)=O SBQDRNOLGSYHQA-YUMQZZPRSA-N 0.000 claims description 4
AXIOGMQCDYVTNY-ACRUOGEOSA-N Phe-Phe-Leu Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 AXIOGMQCDYVTNY-ACRUOGEOSA-N 0.000 claims description 4
RVEVENLSADZUMS-IHRRRGAJSA-N Phe-Pro-Asn Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(O)=O RVEVENLSADZUMS-IHRRRGAJSA-N 0.000 claims description 4
HXOLCSYHGRNXJJ-IHRRRGAJSA-N Pro-Asp-Phe Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O HXOLCSYHGRNXJJ-IHRRRGAJSA-N 0.000 claims description 4
YAZNFQUKPUASKB-DCAQKATOSA-N Pro-Lys-Cys Chemical compound C1C[C@H](NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O YAZNFQUKPUASKB-DCAQKATOSA-N 0.000 claims description 4
WCRFXRIWBFRZBR-GGVZMXCHSA-N Thr-Tyr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 WCRFXRIWBFRZBR-GGVZMXCHSA-N 0.000 claims description 4
RWAYYYOZMHMEGD-XIRDDKMYSA-N Trp-Leu-Ser Chemical compound C1=CC=C2C(C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O)=CNC2=C1 RWAYYYOZMHMEGD-XIRDDKMYSA-N 0.000 claims description 4
NAHUCETZGZZSEX-IHPCNDPISA-N Tyr-Trp-Asp Chemical compound C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)N NAHUCETZGZZSEX-IHPCNDPISA-N 0.000 claims description 4
244000005700 microbiome Species 0.000 claims description 4
230000010076 replication Effects 0.000 claims description 4
108010026333 seryl-proline Proteins 0.000 claims description 4
CAAMSDWKXXPUJR-UHFFFAOYSA-N 3,5-dihydro-4H-imidazol-4-one Chemical compound O=C1CNC=N1 CAAMSDWKXXPUJR-UHFFFAOYSA-N 0.000 claims description 3
UHGUKCOQUNPSKK-CIUDSAMLSA-N Asn-Leu-Cys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CC(=O)N)N UHGUKCOQUNPSKK-CIUDSAMLSA-N 0.000 claims description 3
JLNFZLNDHONLND-GARJFASQSA-N Asn-Leu-Pro Chemical compound CC(C)C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CC(=O)N)N JLNFZLNDHONLND-GARJFASQSA-N 0.000 claims description 3
SNDBKTFJWVEVPO-WHFBIAKZSA-N Asp-Gly-Ser Chemical compound [H]N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(O)=O SNDBKTFJWVEVPO-WHFBIAKZSA-N 0.000 claims description 3
PWAIZUBWHRHYKS-MELADBBJSA-N Asp-Phe-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(=O)O)N)C(=O)O PWAIZUBWHRHYKS-MELADBBJSA-N 0.000 claims description 3
MFNUFCFRAZPJFW-JYJNAYRXSA-N Glu-Lys-Phe Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFNUFCFRAZPJFW-JYJNAYRXSA-N 0.000 claims description 3
HIZYETOZLYFUFF-BQBZGAKWSA-N Leu-Cys Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CS)C(O)=O HIZYETOZLYFUFF-BQBZGAKWSA-N 0.000 claims description 3
KWLWZYMNUZJKMZ-IHRRRGAJSA-N Leu-Pro-Leu Chemical compound CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(O)=O KWLWZYMNUZJKMZ-IHRRRGAJSA-N 0.000 claims description 3
GGAPIOORBXHMNY-ULQDDVLXSA-N Lys-Arg-Tyr Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)N)O GGAPIOORBXHMNY-ULQDDVLXSA-N 0.000 claims description 3
XVAUJOAYHWWNQF-ZLUOBGJFSA-N Ser-Asn-Ala Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(O)=O XVAUJOAYHWWNQF-ZLUOBGJFSA-N 0.000 claims description 3
OLKICIBQRVSQMA-SRVKXCTJSA-N Ser-Ser-Tyr Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O OLKICIBQRVSQMA-SRVKXCTJSA-N 0.000 claims description 3
CEXFELBFVHLYDZ-XGEHTFHBSA-N Thr-Arg-Ser Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(O)=O CEXFELBFVHLYDZ-XGEHTFHBSA-N 0.000 claims description 3
HUPLKEHTTQBXSC-YJRXYDGGSA-N Thr-Ser-Tyr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 HUPLKEHTTQBXSC-YJRXYDGGSA-N 0.000 claims description 3
XGFGVFMXDXALEV-XIRDDKMYSA-N Trp-Leu-Asn Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)N XGFGVFMXDXALEV-XIRDDKMYSA-N 0.000 claims description 3
102000023732 binding proteins Human genes 0.000 claims description 3
108091008324 binding proteins Proteins 0.000 claims description 3
239000013604 expression vector Substances 0.000 claims description 3
108010034529 leucyl-lysine Proteins 0.000 claims description 3
108010083476 phenylalanyltryptophan Proteins 0.000 claims description 3
108010048818 seryl-histidine Proteins 0.000 claims description 3
JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims description 2
WRDANSJTFOHBPI-FXQIFTODSA-N Ala-Arg-Cys Chemical compound C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CS)C(=O)O)N WRDANSJTFOHBPI-FXQIFTODSA-N 0.000 claims description 2
OQCWXQJLCDPRHV-UWVGGRQHSA-N Arg-Gly-Leu Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(O)=O OQCWXQJLCDPRHV-UWVGGRQHSA-N 0.000 claims description 2
IIAXFBUTKIDDIP-ULQDDVLXSA-N Arg-Leu-Phe Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O IIAXFBUTKIDDIP-ULQDDVLXSA-N 0.000 claims description 2
FAEIQWHBRBWUBN-FXQIFTODSA-N Asp-Arg-Ser Chemical compound C(C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC(=O)O)N)CN=C(N)N FAEIQWHBRBWUBN-FXQIFTODSA-N 0.000 claims description 2
108700007698 Genetic Terminator Regions Proteins 0.000 claims description 2
ZPVJJPAIUZLSNE-DCAQKATOSA-N His-Arg-Ser Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(O)=O ZPVJJPAIUZLSNE-DCAQKATOSA-N 0.000 claims description 2
WBSCNDJQPKSPII-KKUMJFAQSA-N Lys-Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O WBSCNDJQPKSPII-KKUMJFAQSA-N 0.000 claims description 2
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DWYAUVCQDTZIJI-VZFHVOOUSA-N Thr-Ala-Ser Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(O)=O DWYAUVCQDTZIJI-VZFHVOOUSA-N 0.000 claims description 2
102000004357 Transferases Human genes 0.000 claims description 2
108090000992 Transferases Proteins 0.000 claims description 2
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XYBNMHRFAUKPAW-IHRRRGAJSA-N Tyr-Ser-Met Chemical compound CSCC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(C=C1)O)N XYBNMHRFAUKPAW-IHRRRGAJSA-N 0.000 claims description 2
108010070944 alanylhistidine Proteins 0.000 claims description 2
108010077245 asparaginyl-proline Proteins 0.000 claims description 2
108010078580 tyrosylleucine Proteins 0.000 claims description 2
102100021277 Beta-secretase 2 Human genes 0.000 claims 2
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HJRIWDYVYNNCFY-UHFFFAOYSA-M potassium;dimethylarsinate Chemical compound [K+].C[As](C)([O-])=O HJRIWDYVYNNCFY-UHFFFAOYSA-M 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
244000062645 predators Species 0.000 description 1
230000000644 propagated effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
235000008160 pyridoxine Nutrition 0.000 description 1
239000011677 pyridoxine Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000004153 renaturation Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
210000001995 reticulocyte Anatomy 0.000 description 1
238000010839 reverse transcription Methods 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
230000037387 scars Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
230000007226 seed germination Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000011451 sequencing strategy Methods 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
108010071207 serylmethionine Proteins 0.000 description 1
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
229940048086 sodium pyrophosphate Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
238000013222 sprague-dawley male rat Methods 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
230000001629 suppression Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
229960003495 thiamine Drugs 0.000 description 1
229960000344 thiamine hydrochloride Drugs 0.000 description 1
235000019190 thiamine hydrochloride Nutrition 0.000 description 1
239000011747 thiamine hydrochloride Substances 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
238000011426 transformation method Methods 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
241001515965 unidentified phage Species 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 description 1
229940011671 vitamin b6 Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- C12N9/1088—Glutathione transferase (2.5.1.18)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
- C12N15/8278—Sulfonylurea

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DD30287387A 1986-05-19 1987-05-18 Verfahren zur Herstellung eines Rekombinanten DNA Moleküls DD273855A5 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86446786A	1986-05-19	1986-05-19
US91275586A	1986-09-26	1986-09-26

Publications (1)

Publication Number	Publication Date
DD273855A5 true DD273855A5 (de)	1989-11-29

Family

ID=27127840

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD30287387A DD273855A5 (de)	1986-05-19	1987-05-18	Verfahren zur Herstellung eines Rekombinanten DNA Moleküls

Country Status (20)

Country	Link
EP (1)	EP0256223A1 (da)
JP (1)	JP2511036B2 (da)
KR (1)	KR870011250A (da)
CN (1)	CN1024021C (da)
AU (1)	AU610825B2 (da)
BR (1)	BR8702542A (da)
CA (1)	CA1339629C (da)
CH (1)	CH689454A5 (da)
DD (1)	DD273855A5 (da)
DK (1)	DK250687A (da)
FI (1)	FI872178A7 (da)
HU (1)	HU210505B (da)
IL (1)	IL82557A (da)
MA (1)	MA20977A1 (da)
MY (1)	MY102446A (da)
NO (1)	NO872075L (da)
NZ (1)	NZ220351A (da)
PL (1)	PL265769A1 (da)
PT (1)	PT84888B (da)
ZW (1)	ZW8987A1 (da)

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NZ224663A (en) *	1987-05-28	1990-11-27	Amrad Corp Ltd	Fusion proteins containing glutathione-s-transferase and expression of foreign polypeptides using glutathione-s-transferase encoding vectors
FR2629098B1 (fr) *	1988-03-23	1990-08-10	Rhone Poulenc Agrochimie	Gene chimerique de resistance herbicide
GB8818706D0 (en) *	1988-08-05	1988-09-07	Ici Plc	Dna constructs & plants incorporating them
GB9114259D0 (en) *	1991-07-02	1991-08-21	Ici Plc	Plant derived enzyme and dna sequences
US6066456A (en) *	1993-12-30	2000-05-23	Zeneca Limited	Plant-derived enzyme and DNA sequences and uses thereof
DE19501840A1 (de) *	1995-01-23	1996-07-25	Bayer Ag	Desoxyribonukleinsäure und ihre Verwendung
JP3761628B2 (ja) *	1995-07-14	2006-03-29	住友化学株式会社	植物プロモーターおよびその利用
CN1064405C (zh) *	1996-04-08	2001-04-11	中国农业科学院上海家畜寄生虫病研究所	利用家蚕系统生产重组日本血吸虫谷胱甘肽－转移酶
US6096504A (en) *	1997-09-05	2000-08-01	E. I. Du Pont Nemours And Company	Maize glutathione-S-transferase enzymes
US6168954B1 (en)	1997-09-05	2001-01-02	E. I. Du Pont De Nemours & Company	Soybean glutathione-S-transferase enzymes
US6063570A (en)	1997-09-05	2000-05-16	E. I. Du Pont De Nemours And Company	Soybean glutathione-S-transferase enzymes
US7041877B2 (en)	2001-02-08	2006-05-09	Hexima, Ltd.	Defensin-encoding nucleic acid molecules derived from nicotiana alata, uses therfor and transgenic plants comprising same
AU2003902253A0 (en)	2003-05-12	2003-05-29	The University Of Queensland	Method for increasing product yield
AU2008329557B2 (en)	2007-11-27	2014-08-14	Commonwealth Scientific And Industrial Research Organisation	Plants with modified starch metabolism
EP2315519B1 (en)	2008-07-21	2016-08-17	Commonwealth Scientific and Industrial Research Organisation	Improved cottonseed oil and uses
BRPI0921467B1 (pt)	2008-11-18	2021-12-14	Commonwealth Scientific And Industrial Research Organisation	Processo para a produção de óleo compreendendo ácido eicosapentaenóico (epa), ácido docosapentaenóico (dpa) e ácido docosahexaenóico (dha)
AU2011274301B2 (en)	2010-06-28	2015-06-11	Nuseed Global Innovation Ltd	Methods of producing lipids
CN102718851B (zh) *	2011-03-31	2014-04-02	中国农业科学院作物科学研究所	培育转植物耐逆相关蛋白GmG2编码基因的转基因植物的方法
ES2744240T3 (es)	2011-12-27	2020-02-24	Commw Scient Ind Res Org	Silenciamiento génico y supresión del silenciamiento génico simultáneos en la misma célula
AU2012327162A1 (en)	2011-12-27	2013-07-11	Commonwealth Scientific And Industrial Research Organisation	Production of dihydrosterculic acid and derivatives thereof
UA119739C2 (uk)	2011-12-27	2019-08-12	Коммонвелт Сайнтіфік Енд Індастріел Рісерч Організейшн	Метод отримання ліпідів
WO2013185184A2 (en)	2012-06-15	2013-12-19	Commonwealth Scientific And Industrial Research Organisation	Production of long chain polyunsaturated fatty acids in plant cells
CN103026962A (zh) *	2012-12-11	2013-04-10	江苏省农业科学院	一种紫色辣椒新品种的培育方法
CN103194466B (zh) *	2013-04-24	2014-05-07	昆明理工大学	一种岷江百合谷胱甘肽S-转移酶基因LrGSTU5及其应用
CN120738239A (zh)	2013-08-21	2025-10-03	联邦科学工业研究组织	锈病抗性基因
EP3082405A4 (en)	2013-12-18	2017-12-13	Commonwealth Scientific and Industrial Research Organisation	Lipid comprising long chain polyunsaturated fatty acids
SG11201610596PA (en)	2014-06-27	2017-01-27	Commw Scient Ind Res Org	Lipid comprising docosapentaenoic acid
MY178434A (en)	2014-07-07	2020-10-13	Commw Scient Ind Res Org	Processes for producing industrial products from plant lipids
MX2018006192A (es)	2015-11-18	2018-12-19	Commw Scient Ind Res Org	Grano de arroz con aleurona engrosada.
AR108940A1 (es) *	2016-07-04	2018-10-10	Kumiai Chemical Industry Co	Planta transgénica que tiene resistencia a herbicidas
CN109182292B (zh) *	2018-09-25	2022-02-08	安徽农业大学	一种草莓谷胱甘肽转移酶FaGST基因及其表达蛋白和应用
CN114144527A (zh)	2019-03-08	2022-03-04	联邦科学技术研究组织	固氮酶多肽在植物细胞中的表达
AU2020272127B2 (en)	2019-04-12	2022-12-08	Ecolab Usa Inc.	Antimicrobial multi-purpose cleaner and methods of making and using the same
CN111118025B (zh) *	2020-01-16	2021-04-27	四川农业大学	基因Zm00001d040827在提高玉米产量中的应用

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EP0154204B1 (en) *	1984-03-06	1994-01-12	Mgi Pharma, Inc.	Herbicide resistance in plants
AU576402B2 (en) *	1984-10-01	1988-08-25	General Hospital Corporation, The	Plant cells resistant to herbicidal glutamine synthetase inhibitors
DE3783105T2 (de) *	1986-03-13	1993-04-22	Rhone Poulenc Rorer Int	Chinolinylaether tetrazole als mittel zur behandlung von hyperempfindlichen krankheiten.

1987
- 1987-03-18 MA MA21215A patent/MA20977A1/fr unknown
- 1987-05-15 CH CH01874/87A patent/CH689454A5/de not_active IP Right Cessation
- 1987-05-15 MY MYPI87000660A patent/MY102446A/en unknown
- 1987-05-18 ZW ZW89/87A patent/ZW8987A1/xx unknown
- 1987-05-18 PT PT84888A patent/PT84888B/pt not_active IP Right Cessation
- 1987-05-18 EP EP87107137A patent/EP0256223A1/de not_active Withdrawn
- 1987-05-18 AU AU73146/87A patent/AU610825B2/en not_active Ceased
- 1987-05-18 NO NO872075A patent/NO872075L/no unknown
- 1987-05-18 IL IL82557A patent/IL82557A/xx unknown
- 1987-05-18 DD DD30287387A patent/DD273855A5/de not_active IP Right Cessation
- 1987-05-18 NZ NZ220351A patent/NZ220351A/en unknown
- 1987-05-18 HU HU872208A patent/HU210505B/hu not_active IP Right Cessation
- 1987-05-18 DK DK250687A patent/DK250687A/da not_active Application Discontinuation
- 1987-05-18 FI FI872178A patent/FI872178A7/fi not_active IP Right Cessation
- 1987-05-19 PL PL1987265769A patent/PL265769A1/xx unknown
- 1987-05-19 KR KR870004956A patent/KR870011250A/ko not_active Withdrawn
- 1987-05-19 BR BR8702542A patent/BR8702542A/pt unknown
- 1987-05-19 JP JP62120327A patent/JP2511036B2/ja not_active Expired - Lifetime
- 1987-05-19 CA CA000537339A patent/CA1339629C/en not_active Expired - Fee Related
- 1987-05-19 CN CN87104489A patent/CN1024021C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT84888B (pt)	1990-02-08
DK250687A (da)	1987-11-20
MY102446A (en)	1992-06-30
FI872178L (fi)	1987-11-20
HUT44075A (en)	1988-01-28
CN1024021C (zh)	1994-03-16
IL82557A (en)	1993-02-21
NO872075D0 (no)	1987-05-18
PT84888A (en)	1987-06-01
JP2511036B2 (ja)	1996-06-26
CN87104489A (zh)	1988-05-04
AU7314687A (en)	1987-11-26
HU210505B (en)	1995-04-28
NZ220351A (en)	1991-07-26
ZW8987A1 (en)	1987-12-16
IL82557A0 (en)	1987-11-30
NO872075L (no)	1987-11-20
FI872178A0 (fi)	1987-05-18
BR8702542A (pt)	1988-02-23
KR870011250A (ko)	1987-12-22
MA20977A1 (fr)	1987-12-31
CA1339629C (en)	1998-01-20
EP0256223A1 (de)	1988-02-24
CH689454A5 (de)	1999-04-30
PL265769A1 (en)	1988-05-12
AU610825B2 (en)	1991-05-30
JPS62296882A (ja)	1987-12-24
FI872178A7 (fi)	1987-11-20
DK250687D0 (da)	1987-05-18

Legal Events

Date	Code	Title	Description
1997-11-06	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DD273855A5 (de)	1989-11-29	Verfahren zur Herstellung eines Rekombinanten DNA Moleküls
DE69637402T2 (de)	2009-01-02	Chimaeres gen, das ein hydroxy-phenylpyruvat dioxygenase-gen kodierende dna-sequenz enthält, und herstellung diese enthaltende herbizid-resistenzen pflanzen
DE3751963T2 (de)	1997-05-28	Herbizid-resistante Pflanzen-Acetolactatsynthase kodierendes Nucleinsäurefragment
DE3687682T2 (de)	1993-08-19	Glyphosat resistente pflanzen.
EP0240792A1 (en)	1987-10-14	Expression of wild type and mutant glutamine synthetase in foreign hosts
DE3750826T2 (de)	1995-05-11	Gegen unkrautvertilgende Glutaminsynthetase-Inhibitoren resistente Pflanzenzellen.
MX2008015742A (es)	2008-12-19	Metodo de seleccion de celulas transformadas.
CZ11399A3 (cs)	1999-05-12	Chimérické geny s několika geny rezistence k herbicidům, rostlinné buňky a rostliny rezistentní k herbicidům a způsob přípravy takových rostlin
DD284048A5 (de)	1990-10-31	Verfahren zur herstellung einer pflanzenzelle bzw. eines pflanzenteils oder einer pflanze mit einer derartigen pflanzenzelle
US5073677A (en)	1991-12-17	Herbicidal tolerant plants containing rat glutathione S-transferase gene
EP0462065B1 (de)	2005-03-02	Neue Signalsequenzen
DE69132935T2 (de)	2002-10-17	Histidinol Dehydrogenase Protein, DNS und Muteine und diese enthaltende transgenische Pflanzen
AU4952985A (en)	1986-04-17	Plant cells resistant to herbicidal glutamine synthetase inhibitors
DE69332148T2 (de)	2003-03-27	Verwendung einer dna sequenz, kodierende für ein protein mit der fäligkeit oxalsäure abzubauen, zur genselektion
US5098838A (en)	1992-03-24	Expression of wild type and mutant glutamine synthetase in foreign hosts
US6395963B1 (en)	2002-05-28	Nematode-inducible regulatory DNA sequences
AU718210B2 (en)	2000-04-13	Disease resistant plant including thionin gene
DE19501840A1 (de)	1996-07-25	Desoxyribonukleinsäure und ihre Verwendung
US7241878B1 (en)	2007-07-10	Modified cellulose synthase gene from Arabidopsis thaliana confers herbicide resistance to plants
EP4450617A1 (en)	2024-10-23	Mutated hydroxyphenylpyruvate dioxygenase polypeptide, and coding gene and use thereof
DD279269A5 (de)	1990-05-30	Verfahren zur herstellung einer herbizid-toleranten pflanze
WO2003014364A1 (de)	2003-02-20	Verfahren zur beeinflussung der mineralstoffaufnahme in transgenen pflanzen
DE60028751T2 (de)	2007-05-24	Herbizidresistente pflanzen
DE10104721B4 (de)	2006-02-09	Verfahren zur Erhöhung des Gehalts von Schwefelverbindungen in Pflanzen
AU713434B2 (en)	1999-12-02	Fungus resistant transgenic plants