DD284676A5 - Verfahren zur herstellung neuer chinolinthioaether - Google Patents

Verfahren zur herstellung neuer chinolinthioaether Download PDF

Info

Publication number: DD284676A5
Authority: DD; German Democratic Republic
Prior art keywords: general formula; compound; quinoline; carries out; hydrogen
Prior art date: 1987-04-24

Application number

DD88315011A

Other languages

German (de)

English (en)

Inventor

Jozsef Knoll

Katalin Budai

Edit Berenyi

Ildiko Miklya

Marton Fekete

Gabrielle Zsilla

Berta Knoll

Attila Mandi

Lujza Petoecz

Istvan Gyertyan

Istvan Gacsalyi

Original Assignee

��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-24

Filing date

1988-04-22

Publication date

1990-11-21

1988-04-22 Application filed by ��@��k�� filed Critical ��@��k��

1990-11-21 Publication of DD284676A5 publication Critical patent/DD284676A5/de

Links

238000000034 method Methods 0.000 title claims abstract description 29
238000002360 preparation method Methods 0.000 title claims abstract description 12
150000001875 compounds Chemical class 0.000 claims abstract description 62
150000003839 salts Chemical class 0.000 claims abstract description 31
239000002253 acid Substances 0.000 claims abstract description 29
230000000949 anxiolytic effect Effects 0.000 claims abstract description 23
-1 quinoline thioethers Chemical class 0.000 claims abstract description 15
238000006243 chemical reaction Methods 0.000 claims description 17
229910052739 hydrogen Inorganic materials 0.000 claims description 15
239000001257 hydrogen Substances 0.000 claims description 15
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
229910052736 halogen Inorganic materials 0.000 claims description 8
150000002367 halogens Chemical class 0.000 claims description 8
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
239000004480 active ingredient Substances 0.000 claims description 6
230000010933 acylation Effects 0.000 claims description 6
238000005917 acylation reaction Methods 0.000 claims description 6
125000000217 alkyl group Chemical group 0.000 claims description 6
150000002431 hydrogen Chemical class 0.000 claims description 6
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IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 claims description 4
239000007858 starting material Substances 0.000 claims description 4
125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims description 3
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238000002474 experimental method Methods 0.000 description 12
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WRLGYAWRGXKSKG-UHFFFAOYSA-M phenobarbital sodium Chemical compound [Na+].C=1C=CC=CC=1C1(CC)C(=O)NC([O-])=NC1=O WRLGYAWRGXKSKG-UHFFFAOYSA-M 0.000 description 4
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ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
239000002168 alkylating agent Substances 0.000 description 3
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125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 2
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WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
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235000011181 potassium carbonates Nutrition 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
238000010992 reflux Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
239000012085 test solution Substances 0.000 description 1
238000010257 thawing Methods 0.000 description 1
238000001149 thermolysis Methods 0.000 description 1
150000003573 thiols Chemical class 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Quinoline Compounds (AREA)

DD88315011A 1987-04-24 1988-04-22 Verfahren zur herstellung neuer chinolinthioaether DD284676A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU871778A HU199424B (en)	1987-04-24	1987-04-24	Process for producing quinoline thioethers and pharmaceutical compositions comprising such compounds

Publications (1)

Publication Number	Publication Date
DD284676A5 true DD284676A5 (de)	1990-11-21

Family

ID=10956151

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD88315011A DD284676A5 (de)	1987-04-24	1988-04-22	Verfahren zur herstellung neuer chinolinthioaether

Country Status (26)

Country	Link
US (1)	US4921960A (pt)
JP (1)	JPS63280067A (pt)
KR (1)	KR880012557A (pt)
CN (1)	CN88102436A (pt)
AT (1)	AT394553B (pt)
AU (1)	AU602209B2 (pt)
CH (1)	CH675876A5 (pt)
DD (1)	DD284676A5 (pt)
DE (1)	DE3813675A1 (pt)
DK (1)	DK220388A (pt)
ES (1)	ES2009601A6 (pt)
FI (1)	FI881921A7 (pt)
FR (1)	FR2618431B1 (pt)
GB (1)	GB2204583B (pt)
GR (1)	GR1000471B (pt)
HU (1)	HU199424B (pt)
IL (1)	IL86148A (pt)
IT (1)	IT1217192B (pt)
NL (1)	NL8801063A (pt)
PH (1)	PH24864A (pt)
PL (1)	PL272026A1 (pt)
PT (1)	PT87311B (pt)
SE (1)	SE8801505L (pt)
SU (1)	SU1609446A3 (pt)
YU (1)	YU81688A (pt)
ZA (1)	ZA882862B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU199423B (en) *	1987-04-24	1990-02-28	Egyt Gyogyszervegyeszeti Gyar	Process for producing 3-amino-4-/ethylthio/-quinoline and pharmaceutical compositions comprising such compounds
RU2136679C1 (ru) *	1998-07-06	1999-09-10	Пермская государственная фармацевтическая академия	5-нитрофурфурилиденгидразид 2-амино-5,6,7,8-тетрагидрохинолин-3-карбоновой кислоты

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2918591A1 (de) *	1979-05-09	1980-11-20	Hoechst Ag	Neue 4-substituierte 5,6,7,8-tetrahydrochinoline, ihre herstellung und verwendung
FR2582514B1 (fr) *	1985-05-30	1988-02-19	Rhone Poulenc Sante	Medicaments a base d'amides, nouveaux amides et leur preparation
HU199423B (en) *	1987-04-24	1990-02-28	Egyt Gyogyszervegyeszeti Gyar	Process for producing 3-amino-4-/ethylthio/-quinoline and pharmaceutical compositions comprising such compounds

1987
- 1987-04-24 HU HU871778A patent/HU199424B/hu not_active IP Right Cessation
1988
- 1988-04-18 PH PH36809A patent/PH24864A/en unknown
- 1988-04-20 CH CH1477/88A patent/CH675876A5/de not_active IP Right Cessation
- 1988-04-22 FR FR888805337A patent/FR2618431B1/fr not_active Expired - Lifetime
- 1988-04-22 ES ES8801244A patent/ES2009601A6/es not_active Expired
- 1988-04-22 ZA ZA882862A patent/ZA882862B/xx unknown
- 1988-04-22 KR KR1019880004593A patent/KR880012557A/ko not_active Withdrawn
- 1988-04-22 PL PL27202688A patent/PL272026A1/xx unknown
- 1988-04-22 GR GR880100265A patent/GR1000471B/el unknown
- 1988-04-22 CN CN198888102436A patent/CN88102436A/zh active Pending
- 1988-04-22 IT IT20306/88A patent/IT1217192B/it active
- 1988-04-22 DD DD88315011A patent/DD284676A5/de not_active IP Right Cessation
- 1988-04-22 DE DE3813675A patent/DE3813675A1/de not_active Withdrawn
- 1988-04-22 DK DK220388A patent/DK220388A/da not_active Application Discontinuation
- 1988-04-22 IL IL86148A patent/IL86148A/xx unknown
- 1988-04-22 SE SE8801505A patent/SE8801505L/xx not_active Application Discontinuation
- 1988-04-22 JP JP63098434A patent/JPS63280067A/ja active Pending
- 1988-04-22 AT AT0103088A patent/AT394553B/de not_active IP Right Cessation
- 1988-04-22 US US07/184,796 patent/US4921960A/en not_active Expired - Fee Related
- 1988-04-22 NL NL8801063A patent/NL8801063A/nl not_active Application Discontinuation
- 1988-04-22 AU AU15105/88A patent/AU602209B2/en not_active Ceased
- 1988-04-22 PT PT87311A patent/PT87311B/pt not_active IP Right Cessation
- 1988-04-22 YU YU00816/88A patent/YU81688A/xx unknown
- 1988-04-22 FI FI881921A patent/FI881921A7/fi not_active IP Right Cessation
- 1988-04-22 SU SU884355577A patent/SU1609446A3/ru active
- 1988-04-22 GB GB8809520A patent/GB2204583B/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK220388A (da)	1988-10-25
GR880100265A (en)	1989-01-31
NL8801063A (nl)	1988-11-16
SU1609446A3 (ru)	1990-11-23
DK220388D0 (da)	1988-04-22
ZA882862B (en)	1989-01-25
IL86148A0 (en)	1988-11-15
GB2204583A (en)	1988-11-16
IL86148A (en)	1991-09-16
JPS63280067A (ja)	1988-11-17
DE3813675A1 (de)	1988-11-17
HUT49579A (en)	1989-10-30
GR1000471B (el)	1992-07-30
SE8801505L (sv)	1988-10-25
US4921960A (en)	1990-05-01
PH24864A (en)	1990-12-26
IT8820306A0 (it)	1988-04-22
PT87311B (pt)	1992-08-31
HU199424B (en)	1990-02-28
FR2618431A1 (fr)	1989-01-27
FR2618431B1 (fr)	1992-04-03
CN88102436A (zh)	1988-11-09
FI881921A7 (fi)	1988-10-25
FI881921A0 (fi)	1988-04-22
SE8801505D0 (sv)	1988-04-22
ATA103088A (de)	1991-10-15
AU1510588A (en)	1988-10-27
YU81688A (en)	1989-10-31
CH675876A5 (pt)	1990-11-15
ES2009601A6 (es)	1989-10-01
IT1217192B (it)	1990-03-14
PL272026A1 (en)	1989-01-23
GB8809520D0 (en)	1988-05-25
AT394553B (de)	1992-05-11
GB2204583B (en)	1991-03-27
KR880012557A (ko)	1988-11-28
AU602209B2 (en)	1990-10-04
PT87311A (pt)	1988-05-01

Legal Events

Date	Code	Title	Description
1995-08-17	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DE3638563A1 (de)	1987-06-25	Thiazolo(4,5-c)chinoline, verfahren zur herstellung derselben und diese enthaltende arzneimittel
DE3026201C2 (pt)	1990-11-08
CH642361A5 (de)	1984-04-13	4-anilinochinazolinderivate, ihre herstellung und diese enthaltende pharmazeutische praeparate.
DD216929A5 (de)	1985-01-02	Verfahren zur herstellung von thiazolidinderivaten
DE2236987A1 (de)	1973-03-01	Pyrazolo eckige klammer auf 1,5a eckige klammer zu -pyrimidine und verfahren zu ihrer herstellung
DE2322880A1 (de)	1973-11-22	Neue organische verbindungen und verfahren zu deren herstellung
DE3402060A1 (de)	1985-08-01	Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0073060A1 (de)	1983-03-02	Neue Imidazochinazolinderivate, ihre Herstellung und diese Derivate enthaltende Arzneimittel
DE1946315A1 (de)	1970-03-19	Neue heterocyclische Verbindungen
DE3617976A1 (de)	1988-01-14	1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
DD284676A5 (de)	1990-11-21	Verfahren zur herstellung neuer chinolinthioaether
EP0177907B1 (de)	1988-06-01	Neue 2-Pyridin-thiol-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE2536202A1 (de)	1976-03-04	Mittel zur behandlung der kokzidiose
CH640540A5 (de)	1984-01-13	Thieno-thiazinderivate.
DE2322561A1 (de)	1973-11-15	Trisubstituierte imidazole
DE2253748A1 (de)	1973-05-30	Carboxamidobenzoesaeuren
DE2259471C2 (de)	1982-08-19	2-Halogen-9-phenyl-5,6-dihydro-7H-pyrido [2,3-f] [1,4] diazepinderivate
DE2814798C2 (pt)	1988-05-26
DE2359359B2 (de)	1978-02-16	Fluor-substituierte thioxanthene, verfahren zu ihrer herstellung sowie diese enthaltende neuroleptische mittel
EP0273168A1 (de)	1988-07-06	Triazaspirodecanylmethylindolon-Derivate
DE2000775B2 (de)	1978-06-22	Substituierte 1,2,3,4-Tetrahydrobenzothieno [23-c] pyridin-Verbindungen, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung, die diese Verbindungen enthält
DE2656227C2 (de)	1985-07-04	Basisch alkylierte Diphenyldisulfid-2,2'-biscarbonsäureamide, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE3638573A1 (de)	1987-05-14	Arzneimittel, verwendung bei der zentralen daempfung sowie 2-(methyl)-thiazolo(4,5-c)chinolin-aethansulfonat und seine hydrate
DE3026964C2 (pt)	1990-11-15
DE2319281A1 (de)	1974-11-07	Diuretisches und antihypertensives mittel