DD289520A5 - 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel - Google Patents

2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel Download PDF

Info

Publication number: DD289520A5
Authority: DD; German Democratic Republic
Prior art keywords: compounds; general formula; group; hydrogen; acid
Prior art date: 1988-10-31

Application number

DD89334041A

Other languages

German (de)

English (en)

Inventor

Uwe Trostmann

Johannes Hartenstein

Claus Rudolph

Christoph Schaechtele

Hartmut Osswald

Guenter Weinheimer

Original Assignee

��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-31

Filing date

1989-10-30

Publication date

1991-05-02

1989-10-30 Application filed by ��@��k�� filed Critical ��@��k��

1991-05-02 Publication of DD289520A5 publication Critical patent/DD289520A5/de

Links

238000000034 method Methods 0.000 title claims abstract description 14
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150000001875 compounds Chemical class 0.000 claims description 42
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239000001257 hydrogen Substances 0.000 claims description 20
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
125000004432 carbon atom Chemical group C* 0.000 claims description 10
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ARIYDCUSEOTQQV-UHFFFAOYSA-N 1-(methylamino)-3-octadecoxypropan-2-ol Chemical compound CCCCCCCCCCCCCCCCCCOCC(O)CNC ARIYDCUSEOTQQV-UHFFFAOYSA-N 0.000 description 2
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125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000000969 carrier Substances 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000007979 citrate buffer Substances 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
229960004106 citric acid Drugs 0.000 description 1
239000008139 complexing agent Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
230000001516 effect on protein Effects 0.000 description 1
HPCCEBOTEOTKOZ-UHFFFAOYSA-N ethyl 2-bromo-3-hydroxypropanoate Chemical compound CCOC(=O)C(Br)CO HPCCEBOTEOTKOZ-UHFFFAOYSA-N 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
239000012458 free base Substances 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
230000031146 intracellular signal transduction Effects 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
229960000448 lactic acid Drugs 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229940099690 malic acid Drugs 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000012452 mother liquor Substances 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
229910052763 palladium Inorganic materials 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
239000012071 phase Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229940090181 propyl acetate Drugs 0.000 description 1
108060006633 protein kinase Proteins 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N serine Chemical compound OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
ZNJHFNUEQDVFCJ-UHFFFAOYSA-M sodium;2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid;hydroxide Chemical compound [OH-].[Na+].OCCN1CCN(CCS(O)(=O)=O)CC1 ZNJHFNUEQDVFCJ-UHFFFAOYSA-M 0.000 description 1
ZEDAGFBWUVYFQU-UHFFFAOYSA-M sodium;3-morpholin-4-ylpropane-1-sulfonate;hydrate Chemical compound [OH-].[Na+].OS(=O)(=O)CCCN1CCOCC1 ZEDAGFBWUVYFQU-UHFFFAOYSA-M 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229960001367 tartaric acid Drugs 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

DD89334041A 1988-10-31 1989-10-30 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel DD289520A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3836987A DE3836987A1 (de)	1988-10-31	1988-10-31	2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Publications (1)

Publication Number	Publication Date
DD289520A5 true DD289520A5 (de)	1991-05-02

Family

ID=6366218

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD89334041A DD289520A5 (de)	1988-10-31	1989-10-30	2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Country Status (15)

Country	Link
US (1)	US5401875A (da)
EP (2)	EP0440731A1 (da)
JP (1)	JPH04502149A (da)
KR (1)	KR900701735A (da)
CN (1)	CN1042347A (da)
AT (1)	ATE99282T1 (da)
AU (1)	AU635908B2 (da)
DD (1)	DD289520A5 (da)
DE (2)	DE3836987A1 (da)
DK (1)	DK65691D0 (da)
ES (1)	ES2060722T3 (da)
HU (1)	HU896587D0 (da)
PT (1)	PT92155B (da)
WO (1)	WO1990005130A1 (da)
ZA (1)	ZA898274B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3836987A1 (de) *	1988-10-31	1990-05-23	Goedecke Ag	2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE4243321A1 (de) *	1992-12-21	1994-06-23	Goedecke Ag	Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
TW328914B (en) *	1996-02-06	1998-04-01	Ajinomoto Kk	Surfactant, and toiletry or detergent composition containing the same
CN101906097B (zh) *	2009-06-02	2012-06-27	首都医科大学	1,3-二氧六环类化合物及其合成方法和在医学中应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB727482A (en) *	1952-03-11	1955-04-06	Dow Chemical Co	Improvements in poly-valent metal ion chelating agents
DE1518362A1 (de) *	1963-07-10	1969-06-26	Thomae Gmbh Dr K	Verfahren zur Herstellung von neuen Hydroxylkylaminocarbonsaeuren
DD60382A (da) *	1967-04-13
US3647868A (en) *	1967-10-18	1972-03-07	Textilana Corp	N-(2-hydroxyalkyl) sarcosine-n-oxides
DE1922003C3 (de) *	1969-04-30	1979-10-11	Boehringer Mannheim Gmbh, 6800 Mannheim	N-(3-Aryloxy-2-hydroxypropyl)-aminocarbonsäuren, deren Ester, Amide und Salze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung von Herzinsuffizienz
JPS4835372B1 (da) *	1969-05-28	1973-10-27
DE2940509C2 (de) *	1978-10-06	1995-01-26	Nippon Paint Co Ltd	Polymerisierbare Aminosäureverbindungen und ihre Verwendung
CA1146695A (en) *	1979-03-01	1983-05-17	Shinichi Ishikura	Polymeric resin and coating composition comprising same
EP0053434B1 (en) *	1980-11-28	1986-08-27	American Hospital Supply Corporation	Compounds and method for treatment or prophylaxis of cardiac disorders
US4450173A (en) *	1980-11-28	1984-05-22	American Hospital Supply Corporation	Compounds and method for treatment or prophylaxis of cardiac disorders
OA06199A (fr) *	1981-05-13	1981-06-30	Berol Kemi Ab	Procédé de flottation de minéraux phosphatés et composé destiné à ce procédé.
SE441740B (sv) *	1983-05-27	1985-11-04	Berol Kemi Ab	Forfarande for flotation av fosfatmalm
SE452120B (sv) *	1984-04-04	1987-11-16	Berol Kemi Ab	Forfarande for skumflotation samt flotationsmedel herfor
DE3625738A1 (de) *	1986-07-30	1988-02-11	Goedecke Ag	2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung
DE3836987A1 (de) *	1988-10-31	1990-05-23	Goedecke Ag	2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

1988
- 1988-10-31 DE DE3836987A patent/DE3836987A1/de not_active Withdrawn
1989
- 1989-10-30 EP EP89912439A patent/EP0440731A1/de active Pending
- 1989-10-30 DD DD89334041A patent/DD289520A5/de not_active IP Right Cessation
- 1989-10-30 DE DE89120142T patent/DE58906571D1/de not_active Expired - Fee Related
- 1989-10-30 ES ES89120142T patent/ES2060722T3/es not_active Expired - Lifetime
- 1989-10-30 EP EP89120142A patent/EP0367205B1/de not_active Expired - Lifetime
- 1989-10-30 HU HU896587A patent/HU896587D0/hu unknown
- 1989-10-30 JP JP1511644A patent/JPH04502149A/ja active Pending
- 1989-10-30 WO PCT/EP1989/001293 patent/WO1990005130A1/de not_active Ceased
- 1989-10-30 US US07/681,500 patent/US5401875A/en not_active Expired - Fee Related
- 1989-10-30 PT PT92155A patent/PT92155B/pt not_active IP Right Cessation
- 1989-10-30 KR KR1019900701383A patent/KR900701735A/ko not_active Withdrawn
- 1989-10-30 AT AT89120142T patent/ATE99282T1/de not_active IP Right Cessation
- 1989-10-30 AU AU45143/89A patent/AU635908B2/en not_active Ceased
- 1989-10-31 CN CN89108252A patent/CN1042347A/zh active Pending
- 1989-10-31 ZA ZA898274A patent/ZA898274B/xx unknown
1991
- 1991-04-11 DK DK91656A patent/DK65691D0/da unknown

Also Published As

Publication number	Publication date
PT92155A (pt)	1990-05-31
AU635908B2 (en)	1993-04-08
DE3836987A1 (de)	1990-05-23
ATE99282T1 (de)	1994-01-15
CN1042347A (zh)	1990-05-23
DK65691A (da)	1991-04-11
PT92155B (pt)	1995-07-18
EP0367205B1 (de)	1993-12-29
JPH04502149A (ja)	1992-04-16
ZA898274B (en)	1990-07-25
WO1990005130A1 (de)	1990-05-17
DK65691D0 (da)	1991-04-11
EP0440731A1 (de)	1991-08-14
DE58906571D1 (de)	1994-02-10
ES2060722T3 (es)	1994-12-01
US5401875A (en)	1995-03-28
EP0367205A1 (de)	1990-05-09
HU896587D0 (en)	1991-07-29
AU4514389A (en)	1990-05-28
KR900701735A (ko)	1990-12-04

Legal Events

Date	Code	Title	Description
1995-06-22	ENJ	Ceased due to non-payment of renewal fee

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DE2610228C2 (da)	1990-04-05
EP0824530A1 (de)	1998-02-25	Arylglycinamidderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
EP1773801A1 (de)	2007-04-18	Verfahren zur gewinnung von reinem tetrahydrocannabinol
EP0434057A2 (de)	1991-06-26	Indolocarbazol-Derivate, Verfahren zu deren Herstellung und deren Verwendung
DE2847621A1 (de)	1979-05-17	Phthalazin-derivate, verfahren zu ihrer herstellung und solche derivate enthaltende arzneimittel
DE19824470A1 (de)	1999-12-02	Neue Neurokininantagonisten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE69002474T2 (de)	1994-03-10	Carboxyalkyl-ether von 2-Amino-7-hydroxytetralin.
DE69406779T2 (de)	1998-03-12	2-substituierte morpholin- und thiomorpholinderivate als gaba-b antagonisten
DE69913955T2 (de)	2004-12-16	Ein verbessertes synthese- und reinigungsverfahren für (r,r)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochlorid
DE69527786T2 (de)	2003-04-10	Diaminomethyliden-derivate
DD289520A5 (de)	1991-05-02	2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
EP0064685A1 (de)	1982-11-17	Dibenzo(de,g)chinolin-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
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