ES2060722T3 - Acidos 2-aminocarboxilicos y sus derivados, procedimiento para su obtencion y su empleo como medicamento. - Google Patents

Acidos 2-aminocarboxilicos y sus derivados, procedimiento para su obtencion y su empleo como medicamento.

Info

Publication number
ES2060722T3
ES2060722T3 ES89120142T ES89120142T ES2060722T3 ES 2060722 T3 ES2060722 T3 ES 2060722T3 ES 89120142 T ES89120142 T ES 89120142T ES 89120142 T ES89120142 T ES 89120142T ES 2060722 T3 ES2060722 T3 ES 2060722T3
Authority
ES
Spain
Prior art keywords
derivatives
procedure
obtaining
carboxylic acids
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89120142T
Other languages
English (en)
Inventor
Dr Uwe Trostmann
Dr Johannes Hartenstein
Dr Claus Rudolph
Dr Christoph Schachtele
Prof Dr Hartmut Osswald
Dr Gunter Weinheimer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Application granted granted Critical
Publication of ES2060722T3 publication Critical patent/ES2060722T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

EL INVENTO SE REFIERE A UN NUEVO ACIDO 2 - AMINOCARBONICO Y SU DERIVADO DE FORMULA (I); DESCRIBE LAS SALES FARMACOLOGICAS INOFENSIVAS DEL ACIDO 2 AMINOCARBONICO; RESEÑA UN PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO 2-AMINOCARBONICO Y TRATA DE MEDICAMENTOS QUE CONTIENEN EL ACIDO 2-AMINOCARBONICO Y SE UTILIZAN PARA LA INHIBICION DE LA PROTEINAQUINASA C Y PASA LA PREVENCION Y/O TRATAMIENTO DE ENFERMEDADES DEL CORAZON Y DE LAS ARTERIAS COMO TROMBOSIS, ARTERIOESCLEROSIS, HIPERTENSION, ALERGIAS, PROCESOS INFLAMABLES, CANCER Y DAÑOS DEGENERATIVOS DE LOS SISTEMAS NERVIOSOS CENTRALES. SIENDO: R1 UN GRUPO ALQUILO SATURADO O INSATURADO DE CADENA RECTA O RAMIFICADA DE 20 ATOMOS DE CARBONO; R (AL CUADRADO) Y R3 IGUALES O DIFERENTES PUEDEN SER HIDROGENO O UN GRUPO ALQUILO DE CADENA RECTA O RAMIFICADA; R4 HIDROGENO, BENCILO, HIDROXIBENCILO, UN GRUPO CARBOXILO, UN HIDROXIALQUILO O UN GRUPO ALCOXICARBONILO Y R5 HIDROGENO, O UN GRUPO ALQUILO DE CADENA RECTA O RAMIFICADA.
ES89120142T 1988-10-31 1989-10-30 Acidos 2-aminocarboxilicos y sus derivados, procedimiento para su obtencion y su empleo como medicamento. Expired - Lifetime ES2060722T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3836987A DE3836987A1 (de) 1988-10-31 1988-10-31 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES2060722T3 true ES2060722T3 (es) 1994-12-01

Family

ID=6366218

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89120142T Expired - Lifetime ES2060722T3 (es) 1988-10-31 1989-10-30 Acidos 2-aminocarboxilicos y sus derivados, procedimiento para su obtencion y su empleo como medicamento.

Country Status (15)

Country Link
US (1) US5401875A (es)
EP (2) EP0440731A1 (es)
JP (1) JPH04502149A (es)
KR (1) KR900701735A (es)
CN (1) CN1042347A (es)
AT (1) ATE99282T1 (es)
AU (1) AU635908B2 (es)
DD (1) DD289520A5 (es)
DE (2) DE3836987A1 (es)
DK (1) DK65691D0 (es)
ES (1) ES2060722T3 (es)
HU (1) HU896587D0 (es)
PT (1) PT92155B (es)
WO (1) WO1990005130A1 (es)
ZA (1) ZA898274B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3836987A1 (de) * 1988-10-31 1990-05-23 Goedecke Ag 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE4243321A1 (de) * 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
TW328914B (en) * 1996-02-06 1998-04-01 Ajinomoto Kk Surfactant, and toiletry or detergent composition containing the same
CN101906097B (zh) * 2009-06-02 2012-06-27 首都医科大学 1,3-二氧六环类化合物及其合成方法和在医学中应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB727482A (en) * 1952-03-11 1955-04-06 Dow Chemical Co Improvements in poly-valent metal ion chelating agents
DE1518362A1 (de) * 1963-07-10 1969-06-26 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen Hydroxylkylaminocarbonsaeuren
DD60382A (es) * 1967-04-13
US3647868A (en) * 1967-10-18 1972-03-07 Textilana Corp N-(2-hydroxyalkyl) sarcosine-n-oxides
DE1922003C3 (de) * 1969-04-30 1979-10-11 Boehringer Mannheim Gmbh, 6800 Mannheim N-(3-Aryloxy-2-hydroxypropyl)-aminocarbonsäuren, deren Ester, Amide und Salze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung von Herzinsuffizienz
JPS4835372B1 (es) * 1969-05-28 1973-10-27
DE2940509C2 (de) * 1978-10-06 1995-01-26 Nippon Paint Co Ltd Polymerisierbare Aminosäureverbindungen und ihre Verwendung
CA1146695A (en) * 1979-03-01 1983-05-17 Shinichi Ishikura Polymeric resin and coating composition comprising same
EP0053434B1 (en) * 1980-11-28 1986-08-27 American Hospital Supply Corporation Compounds and method for treatment or prophylaxis of cardiac disorders
US4450173A (en) * 1980-11-28 1984-05-22 American Hospital Supply Corporation Compounds and method for treatment or prophylaxis of cardiac disorders
SU1309904A3 (ru) * 1981-05-13 1987-05-07 Берол Кеми Аб (Фирма) Способ пенной флотации апатит-карбонатной руды
SE441740B (sv) * 1983-05-27 1985-11-04 Berol Kemi Ab Forfarande for flotation av fosfatmalm
SE452120B (sv) * 1984-04-04 1987-11-16 Berol Kemi Ab Forfarande for skumflotation samt flotationsmedel herfor
DE3625738A1 (de) * 1986-07-30 1988-02-11 Goedecke Ag 2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung
DE3836987A1 (de) * 1988-10-31 1990-05-23 Goedecke Ag 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
ATE99282T1 (de) 1994-01-15
KR900701735A (ko) 1990-12-04
US5401875A (en) 1995-03-28
WO1990005130A1 (de) 1990-05-17
DE58906571D1 (de) 1994-02-10
AU635908B2 (en) 1993-04-08
EP0440731A1 (de) 1991-08-14
EP0367205A1 (de) 1990-05-09
DK65691A (da) 1991-04-11
HU896587D0 (en) 1991-07-29
AU4514389A (en) 1990-05-28
CN1042347A (zh) 1990-05-23
DE3836987A1 (de) 1990-05-23
EP0367205B1 (de) 1993-12-29
JPH04502149A (ja) 1992-04-16
PT92155A (pt) 1990-05-31
DK65691D0 (da) 1991-04-11
ZA898274B (en) 1990-07-25
PT92155B (pt) 1995-07-18
DD289520A5 (de) 1991-05-02

Similar Documents

Publication Publication Date Title
ATE106867T1 (de) 13-trans-retinsäureester.
DK0383504T3 (da) Decahydroisoquinolin-derivater, fremgangsmåde til fremstilling deraf og anvendelse deraf som medicin
DE69428130D1 (de) Verwendung von bcl-2 zur herstellung von arzneimitteln zur therapeutischen behandlung und verhinderung von krankheiten
PL342078A1 (en) Inhibition of raf kinase using symmetrical and dissymmetrical substituted dimethylureas
CS145091A3 (en) Isoxazole-4-carboxamides and amides of hydroxyalkylidene cyanacetic acid, medicaments comprising said compounds and their application
ATE231885T1 (de) Verwendung von komplement-inhibitoren zur herstellung eines arzneimittels zur prophylaxe und therapie von entzündlichen darm- und hauterkrankungen sowie purpura
ATE188469T1 (de) Alkoxy-4(1h)-pyridon-derivative, verfahren zu deren herstellung und deren verwendung als arzneimittel
ATE145136T1 (de) Verwendung von ketoconazol und ein retinoid zur behandlung der akne vulgaris
IT1237472B (it) Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
ATE92061T1 (de) Substituierte tetraline, chromane und verwandte verbindungen fuer die behandlung von asthma, arthritis und verwandte krankheiten.
DE69320052D1 (de) Topoisomerase ii inhibitoren sowie deren therapeutische verwendung
IT7828313A0 (it) Procedimento per la produzione di acidi carbossilici e/o di loro esteri.
HUT50042A (en) Process for producing pharmaceutical compositions comprising p-chloro-n-(2-morpholinoethyl)-benzamide
IT8720149A0 (it) Procedimento per la sintesi di acidi 2-aril-propionici.
ES2060722T3 (es) Acidos 2-aminocarboxilicos y sus derivados, procedimiento para su obtencion y su empleo como medicamento.
IL83775A0 (en) Fumaramide derivatives and pharmaceutical compositions containing them for treating skin diseases
ATE169500T1 (de) Verwendung von guanosin zur herstellung von arzneimitteln zur behandlung von zerebralen funktionsstörungen
DE69431199D1 (de) Melatonin-Derivate zur Verwendung in der Behandlung von Schlafstörungen
ATE133157T1 (de) Arylalkylester der 4,5-dihydoxy-9,10-dihydro-9,10-dioxo-2-anthrace carbonsäure und deren therapeutische verwendung
ATE86611T1 (de) Topische vorstufen von arzneimitteln zur behandlung von akne und hautkrankheiten.
DE3873210D1 (de) Verwendung von benzylpyridin-derivaten zur herstellung eines arzneimittels zur behandlung der demenz.
ES2060440T3 (es) Derivados de acidos 1,4-dihidropiridin-dicarboxilicos aril-quinolil substituidos, procedimiento para su fabricacion y su uso en medicamentos.
DE69121999D1 (de) Verfahren und Produkt für die Behandlung von Magenkrankheiten
ATE99687T1 (de) Strobilurinderivate, ihre herstellung und verwendung.
MX9203208A (es) Composicion farmaceutica y metodo para el tratamiento de trastornos digestivos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 367205

Country of ref document: ES