DD292912A5 - Verfahren zur herstellung von thienylpiperazinen - Google Patents

Verfahren zur herstellung von thienylpiperazinen Download PDF

Info

Publication number: DD292912A5
Authority: DD; German Democratic Republic
Prior art keywords: compounds; general formula; formula; preparation; acid
Prior art date: 1989-03-22

Application number

DD90338856A

Other languages

German (de)

English (en)

Inventor

Rudi Beyerle

Ursula Schindler

Bernd Jablonka

Jeffery Troke

Karl Schoenafinger

Original Assignee

��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-22

Filing date

1990-03-19

Publication date

1991-08-14

1990-03-19 Application filed by ��@��k�� filed Critical ��@��k��

1991-08-14 Publication of DD292912A5 publication Critical patent/DD292912A5/de

Links

238000002360 preparation method Methods 0.000 title claims abstract description 16
238000000034 method Methods 0.000 title claims abstract description 8
230000008569 process Effects 0.000 title claims abstract description 5
150000003839 salts Chemical class 0.000 claims abstract description 27
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 7
239000001257 hydrogen Substances 0.000 claims abstract description 7
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 7
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 6
239000001301 oxygen Substances 0.000 claims abstract description 6
229910052760 oxygen Inorganic materials 0.000 claims abstract description 6
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
239000003814 drug Substances 0.000 abstract description 3
150000001875 compounds Chemical class 0.000 description 40
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
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GIWRVUADKUVEGU-UHFFFAOYSA-N 2-oxo-2-thiophen-2-ylacetic acid Chemical compound OC(=O)C(=O)C1=CC=CS1 GIWRVUADKUVEGU-UHFFFAOYSA-N 0.000 description 2
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 2
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229960001597 nifedipine Drugs 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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150000007524 organic acids Chemical class 0.000 description 1
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KQXKVJAGOJTNJS-HNNXBMFYSA-N penbutolol Chemical compound CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1 KQXKVJAGOJTNJS-HNNXBMFYSA-N 0.000 description 1
CYXKNKQEMFBLER-UHFFFAOYSA-N perhexiline Chemical compound C1CCCNC1CC(C1CCCCC1)C1CCCCC1 CYXKNKQEMFBLER-UHFFFAOYSA-N 0.000 description 1
229960000989 perhexiline Drugs 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000012071 phase Substances 0.000 description 1
WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
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ZLQMRLSBXKQKMG-UHFFFAOYSA-N rauniticine Natural products COC(=O)C1=CC2CC3N(CCc4c3[nH]c5ccccc45)CC2C(C)O1 ZLQMRLSBXKQKMG-UHFFFAOYSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
235000010288 sodium nitrite Nutrition 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
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229960004940 sulpiride Drugs 0.000 description 1
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238000003786 synthesis reaction Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
229960001722 verapamil Drugs 0.000 description 1
229960002726 vincamine Drugs 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

DD90338856A 1989-03-22 1990-03-19 Verfahren zur herstellung von thienylpiperazinen DD292912A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3909379A DE3909379A1 (de)	1989-03-22	1989-03-22	Thienylpiperazine, verfahren zu ihrer herstellung, ihre verwendung sowie diese enthaltende arzneimittel und deren herstellung

Publications (1)

Publication Number	Publication Date
DD292912A5 true DD292912A5 (de)	1991-08-14

Family

ID=6376934

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD90338856A DD292912A5 (de)	1989-03-22	1990-03-19	Verfahren zur herstellung von thienylpiperazinen

Country Status (11)

Country	Link
US (1)	US4987134A (fr)
EP (1)	EP0388750B1 (fr)
JP (1)	JP2981251B2 (fr)
KR (1)	KR0148124B1 (fr)
AT (1)	ATE100807T1 (fr)
CA (1)	CA2012661C (fr)
DD (1)	DD292912A5 (fr)
DE (2)	DE3909379A1 (fr)
HU (1)	HUT58085A (fr)
PT (1)	PT93532A (fr)
ZA (1)	ZA902167B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA018548B1 (ru)	2006-08-04	2013-08-30	Манус Фармасьютикалз (Канада) Лтд.	Полифункциональные биологически активные соединения

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2528843A2 (fr) *	1981-08-11	1983-12-23	Rhone Poulenc Sante	Nouveaux derives du dithiole-1,2 ylidene-3 ammonium, leur preparation et les medicaments qui les contiennent
DE3132882A1 (de) *	1981-08-20	1983-03-03	Cassella Ag, 6000 Frankfurt	Neue piperazinone, ihre herstellung und verwendung
DE3329028A1 (de) *	1983-08-11	1985-02-28	Cassella Ag, 6000 Frankfurt	Substituierte (2-amino-2-imidazolin-1-yl)-essigsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen
GB8427735D0 (en) *	1984-11-02	1984-12-12	Fujisawa Pharmaceutical Co	Piperazine compound
DE3817198A1 (de) *	1988-05-20	1989-11-30	Cassella Ag	Thienyl-piperazinone, ihre herstellung und verwendung

1989
- 1989-03-22 DE DE3909379A patent/DE3909379A1/de not_active Withdrawn
1990
- 1990-03-12 DE DE90104645T patent/DE59004377D1/de not_active Expired - Lifetime
- 1990-03-12 AT AT90104645T patent/ATE100807T1/de not_active IP Right Cessation
- 1990-03-12 EP EP90104645A patent/EP0388750B1/fr not_active Expired - Lifetime
- 1990-03-16 US US07/494,606 patent/US4987134A/en not_active Expired - Lifetime
- 1990-03-19 DD DD90338856A patent/DD292912A5/de not_active IP Right Cessation
- 1990-03-20 JP JP2068561A patent/JP2981251B2/ja not_active Expired - Lifetime
- 1990-03-21 PT PT93532A patent/PT93532A/pt not_active Application Discontinuation
- 1990-03-21 KR KR1019900003797A patent/KR0148124B1/ko not_active Expired - Lifetime
- 1990-03-21 CA CA002012661A patent/CA2012661C/fr not_active Expired - Lifetime
- 1990-03-21 HU HU901631A patent/HUT58085A/hu unknown
- 1990-03-21 ZA ZA902167A patent/ZA902167B/xx unknown

Also Published As

Publication number	Publication date
ATE100807T1 (de)	1994-02-15
HUT58085A (en)	1992-01-28
CA2012661C (fr)	2000-08-08
EP0388750B1 (fr)	1994-01-26
PT93532A (pt)	1990-11-07
CA2012661A1 (fr)	1990-09-22
HU901631D0 (en)	1990-06-28
JPH02273674A (ja)	1990-11-08
DE3909379A1 (de)	1990-09-27
DE59004377D1 (de)	1994-03-10
ZA902167B (en)	1990-12-28
EP0388750A1 (fr)	1990-09-26
KR0148124B1 (ko)	1998-08-17
US4987134A (en)	1991-01-22
KR900014372A (ko)	1990-10-23
JP2981251B2 (ja)	1999-11-22

Legal Events

Date	Code	Title	Description
1995-04-13	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
EP0136658B1 (fr)	1989-04-26	-1-Benzyl-aminoalkyl-pyrrolidinones et leurs sels d'addition, procédé de préparation et médicaments les contenant
DE2460891A1 (de)	1976-07-01	Cyclische aminosaeuren
DE3026201C2 (fr)	1990-11-08
DE2543184A1 (de)	1976-04-01	Schwefelhaltige arylamine und diese enthaltende heilmittel
DE3587596T2 (de)	1994-05-11	Pyridazinon-Derivate, deren Herstellung und Verwendung.
DE3107933A1 (de)	1982-09-16	Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE1545925A1 (de)	1970-01-08	Neue Pyrrolidinderivate und Verfahren zur Herstellung derselben
DD229407A5 (de)	1985-11-06	Verfahren zur herstellung von piperidindion-derivaten, die als myocard-schutz eine antiarrhytmische aktivitaet aufweisen
CH629190A5 (en)	1982-04-15	Process for the preparation of 1-(triarylalkyl)-4-phenylpiperidine derivatives
DE2802023A1 (de)	1978-08-03	Neue ergotderivate, ihre herstellung und verwendung
EP0346683A1 (fr)	1989-12-20	Dérivés de pyrrole, leur préparation et leur utilisation comme agents pharmaceutiques
EP0388750B1 (fr)	1994-01-26	Thiényl-pipérazines, leur procédé de préparation, leur application ainsi que les médicaments les contenant et leur production
EP0387677B1 (fr)	1994-03-16	Dérivés de l'acide thiénylacétique, procédé pour leur préparation, leur application ainsi que médicaments les contenant et leur préparation
DE1643198A1 (de)	1972-05-04	Diarylcyclopropanderivate und Verfahren zu ihrer Herstellung
DD297813A5 (de)	1992-01-23	Verfahren zur herstellung von dihydropyridinamiden
DE19730990C2 (de)	2001-12-13	Oxopyrrolo-pyrrolderivate
DE2854341C2 (fr)	1990-05-23
EP0342536A1 (fr)	1989-11-23	Thienyl-piperaziones. leur préparation et application
EP0158312B1 (fr)	1990-09-12	Dérivés de la 1-cyclohéxyl-3,4-dihydroisoquinoléine, procédé pour leur préparation et médicament les contenant
DE2756852A1 (de)	1978-06-22	1-amino-niedrig-alkyl-3,4-diphenyl- 1h-pyrazole
DE3713725A1 (de)	1988-11-17	Pyrrolaldehyde, ihre herstellung und ihre verwendung
DE3813416A1 (de)	1989-11-02	3,4-dihydroxypyrrolidin-2-on-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
EP0581797B1 (fr)	1997-07-23	Nouveaux derives d'acide carboxylique de thiophene-2 et leur procede de preparation
CH658249A5 (de)	1986-10-31	Mutterkornalkaloide, verfahren zu deren herstellung sowie diese verbindungen enthaltende pharmazeutische zubereitungen.
CH464924A (de)	1968-11-15	Verfahren zur Herstellung von neuen Pyrrolidinderivaten