DD293498A5 - Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier - Google Patents

Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier Download PDF

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Publication number
DD293498A5
DD293498A5 DD89331051A DD33105189A DD293498A5 DD 293498 A5 DD293498 A5 DD 293498A5 DD 89331051 A DD89331051 A DD 89331051A DD 33105189 A DD33105189 A DD 33105189A DD 293498 A5 DD293498 A5 DD 293498A5
Authority
DD
German Democratic Republic
Prior art keywords
general formula
dideoxy
compound
methylcytidine
compounds
Prior art date
Application number
DD89331051A
Other languages
German (de)
English (en)
Inventor
Eckart Matthes
Martin Von Janta-Lipinski
Karen Reimer
Helga Meisel
Juergen Schildt
Christine Lehmann
Original Assignee
Zi Fuer Molekularbiologie Der Adw,De
Humboldt-Universitaet,Inst. F. Medizinische Virologie Der Charite,De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zi Fuer Molekularbiologie Der Adw,De, Humboldt-Universitaet,Inst. F. Medizinische Virologie Der Charite,De filed Critical Zi Fuer Molekularbiologie Der Adw,De
Priority to DD89331051A priority Critical patent/DD293498A5/de
Priority to EP19900113851 priority patent/EP0409227A3/de
Priority to JP2191856A priority patent/JPH03148292A/ja
Publication of DD293498A5 publication Critical patent/DD293498A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DD89331051A 1989-07-20 1989-07-20 Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier DD293498A5 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DD89331051A DD293498A5 (de) 1989-07-20 1989-07-20 Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
EP19900113851 EP0409227A3 (en) 1989-07-20 1990-07-19 Pyrimidine and purine nucleosides, their preparation and use as medicaments
JP2191856A JPH03148292A (ja) 1989-07-20 1990-07-19 Ｂ型肝炎に対する製薬剤として、ピリミジンヌクレオシド及びプリンヌクレオシドを製造する為の方法及びその使用法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD89331051A DD293498A5 (de) 1989-07-20 1989-07-20 Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier

Publications (1)

Publication Number Publication Date
DD293498A5 true DD293498A5 (de) 1991-09-05

Family

ID=5611053

Family Applications (1)

Application Number Title Priority Date Filing Date
DD89331051A DD293498A5 (de) 1989-07-20 1989-07-20 Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier

Country Status (3)

Country Link
EP (1) EP0409227A3 (fr)
JP (1) JPH03148292A (fr)
DD (1) DD293498A5 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728575A (en) 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
DE69324244T2 (de) * 1992-01-06 1999-09-30 The Wellcome Foundation Ltd., Greenford Therapeutische nukleoside der 2',3'-dideoxy-3'-fluor -purin reihe
GB9200150D0 (en) * 1992-01-06 1992-02-26 Wellcome Found Therapeutic nucleosides
NL9300058A (nl) * 1992-06-18 1994-01-17 Stichting Rega V Z W 1,5-anhydrohexitol nucleoside analoga en farmaceutisch gebruik daarvan.
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
TW374087B (en) * 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) * 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5869461A (en) * 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
WO1999043691A1 (fr) 1998-02-25 1999-09-02 Emory University 2'-fluoronucleosides
WO2000026225A2 (fr) 1998-11-05 2000-05-11 Centre National De La Recherche Scientifique Nucleosides possedant une activite dirigee contre le virus de l'hepatite b
JP2002528510A (ja) * 1998-11-05 2002-09-03 サントル・ナシオナル・ドウ・ラ・ルシエルシユ・シアンテイフイク ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
US7115584B2 (en) * 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7635690B2 (en) 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
WO2002032920A2 (fr) 2000-10-18 2002-04-25 Pharmasset Limited Nucleosides modifies pour traiter des infections virales et une proliferation cellulaire anormale
CA2439836A1 (fr) 2001-03-01 2002-09-12 Pharmasset, Inc. Procede de synthese de 2',3'-dideoxy-2',3'-didehydronucleosides
EP1478322A4 (fr) 2001-06-22 2007-08-08 Pharmasset Ltd Beta-2'-OU 3'-HALONUCLEOSIDES
AU2002365234B2 (en) 2001-12-14 2009-01-29 Pharmasset Inc N4-acylcytosine nucleosides for treatment of viral infections
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
CA2684061A1 (fr) 2007-04-10 2008-10-16 Emory University Nouvelle deletion d'un codon de la transcriptase inverse de vih-1 et son utilisation dans la gestion et le traitement des infections a vih
CN112979733B (zh) * 2021-04-25 2021-09-10 南京颐媛生物医学研究院有限公司 抗乙肝病毒的化合物及其制备方法和应用

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US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
ES8801303A1 (es) * 1985-05-15 1987-12-16 Wellcome Found Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido.
DE3650741T2 (de) * 1985-09-17 2000-10-12 The Wellcome Foundation Ltd., Greenford Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.
US4681933A (en) * 1986-05-01 1987-07-21 University Of Georgia Research Foundation, Inc. 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
SE8602981D0 (sv) * 1986-07-04 1986-07-04 Astra Laekemedel Ab Novel medicinal use
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
US4788181A (en) * 1986-09-29 1988-11-29 The United States Of America As Represented By The Department Of Health And Human Services 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
GB8629892D0 (en) * 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
JPH01265099A (ja) * 1987-10-08 1989-10-23 Stichting Rega Vzw 抗ｈｉｖ活性をもつ３’，−フルオロプリン−２’，３’−ジデオキシリボシド類
JPH01301690A (ja) * 1987-10-08 1989-12-05 Stichting Rega Vzw 抗ｈｉｖ活性をもつ３’−アジド−２，６−ジアミノプリン−２’，３’−ジデオキシリボシド
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
US4997926A (en) * 1987-11-18 1991-03-05 Scripps Clinic And Research Foundation Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy
JPH02152976A (ja) * 1988-05-06 1990-06-12 Bristol Myers Co ２´，３´―ジデヒドロ―２´，３´―ジデオキシヌクレオシドのプロドラッグ
EP0355031A3 (fr) * 1988-08-17 1990-12-27 MATTHES, Eckart, Dr. Nucléosides pyrimidiniques substitués, leur procédé de préparation et médicaments les contenant
AU4817490A (en) * 1988-11-29 1990-06-26 Institut Fur Molekularbiologie Und Analytik (Ima) G.M.B.H. 2',3'-dideoxyribofuranosides and process for producing them
WO1990006671A2 (fr) * 1988-12-12 1990-06-28 Palese Peter M Procedes et compositions pour la prophylaxie et le traitement d'infections dues au virus de l'hepatite b
JP2619710B2 (ja) * 1989-02-27 1997-06-11 日本製紙 株式会社 ２′，３′−ジデオキシプリンヌクレオシド類の製造方法

Also Published As

Publication number Publication date
JPH03148292A (ja) 1991-06-25
EP0409227A3 (en) 1991-12-04
EP0409227A2 (fr) 1991-01-23

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Legal Events

Date Code Title Description
A5 Published as prov. exclusive patent
RPI Change in the person, name or address of the patentee (searches according to art. 11 and 12 extension act)
ENJ Ceased due to non-payment of renewal fee