DE1095076T1 - Ineinandergreifendes polymernetzwerk aus hydrophilen hydrogelen für kontaktlinsen - Google Patents

Ineinandergreifendes polymernetzwerk aus hydrophilen hydrogelen für kontaktlinsen

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Publication number
DE1095076T1
DE1095076T1 DE1095076T DE99933826T DE1095076T1 DE 1095076 T1 DE1095076 T1 DE 1095076T1 DE 1095076 T DE1095076 T DE 1095076T DE 99933826 T DE99933826 T DE 99933826T DE 1095076 T1 DE1095076 T1 DE 1095076T1
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DE
Germany
Prior art keywords
polymer
hydrogel composition
group
methacrylate
dry weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE1095076T
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English (en)
Inventor
R. Briggs
Hopin Hu
Tung Nguyen
Eilene Rossberg
Hue Tran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunsoft Corp
Original Assignee
Sunsoft Corp
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Filing date
Publication date
Application filed by Sunsoft Corp filed Critical Sunsoft Corp
Publication of DE1095076T1 publication Critical patent/DE1095076T1/de
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
    • C08F291/18—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00 on to irradiated or oxidised macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
    • C08F265/04—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00 on to polymers of esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
    • C08F271/02—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00 on to polymers of monomers containing heterocyclic nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C08F283/12—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polysiloxanes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Eyeglasses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Claims (14)

  1. • · · ■···■#
    DE/EP 1 095 076 T1
    Anmeldungs-Nr. 99 933 826.2 UB
    Veröffentlichungs-Nr.
    Patentansprüche
    1. Hydrogel-Zusammensetzung, umfassend:
    I. Wenigstens ein Polymer und
    II. wenigstens ein Mittel zur Erzeugung eines interpenetrierenden Polymernetzwerkes, das das wenigstens eine Polymer interpenetriert, ausgewählt aus der Gruppe bestehend aus:
    (A) wenigstens einem Polymer, umfassend eine oder mehrere Monomereinheiten, die wenigstens eine =N-C(=O)—Gruppe umfassen;
    (B) wenigstens einem Polymer, umfassend eine oder mehrere Einheiten, die wenigstens eine IM-Oxid-Gruppe umfassen;
    (C) wenigstens einem Polymer, das sowohl =N-C(=O)—Gruppen als auch N-Oxid-Gruppen von (A) und (B) umfasst, und
    (D) Mischungen davon und
    III. gegebenenfalls wenigstens ein Material, das aus der aus Monomeren, polymeren Vernetzungsmitteln, Polymerisationsinitiatoren, Ultraviolett absorbierenden Materialien, farbgebenden Mitteln, Antiseptika bestehenden Gruppe und Kombinationen davon ausgewählt ist.
    VEfEP T 095076 Tl
  2. 2. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das wenigstens eine Polymer wenigstens ein Polymer umfasst, das wenigstens ein Monomer umfasst, das ausgewählt ist aus der Gruppe bestehend aus: 2-Hydroxyethylmethacrylat, 2-Hydroxyethylacrylat, Methylmethacrylat; Methylacrylamid; Methacrylamid; &Ngr;,&Ngr;-Dimethyldiacetonacrylamid; 2-Phosphatoethylmethacrylat; Di-, Tri-, Tetra-, Penta-, ... Polyethylenglycolmonoacrylat und -Methacrylat; 4- und 2-Methyl-5-vinylpyridin; N-(3-methacrylamidopropyl)-N,N-dimethylamin; N-(3-methacrYlamidopropyl)-N,N,N-trimethylamin; 1-Vinyl- und 2-Methyl-l-vinylmidazol; N-(3-acrylamido-3-methylbutyl)-N,N-dimethylamin; N-Methylacrylamid; 3-Hydroxypropylmethacrylat; N-Vinylimidazol; N-Vinylsuccinimid; N-Vinyldiglycolylimid; N-Vinylglutarimid; N-Vinyl-3-morphoIinon; N-Vinyl-5-methyl-3-morpholinon; Propylmethacrylat; Propylacrylat; Butylmethacrylat; Butylacrylat; Pentylacrylat; Pentylmethacrylat; Dimethyldiphenylmethylvinylsiloxan; N-(I7I-dimethyl-3-oxobutyl)acrylamid; 2-Ethyl-2-(hydroxymethyl)-l,3-propandioltrimethacrylat; X-(Dimethylvinylsilyl)-(d-[(dimethylvinylsilyl)oxy]-dimethyldiphenylmethylvinylsiloxan; Butyl(meth)acrylat; 2-Hydroxybutylmethacrylat; Vinylacetat; Pentyl methacrylat; Vinylpropionat; 3-Hydroxy-2-naphthylmethacrylat; Vinylalkohol; N-(formylmethyl)acrylamid; 2-Ethoxyethylmethacrylat; 4-t-Butyl-2-hydroxycyclohexylmethacrylat; 2-(Methacryloyloxy)ethylvinylcarbonat; VinylCS-CS^^-trimethyl-l^-bisCtrimethylsiloxy)disiloxanyl]propyl]carbonat; 4,4'-(tetrapentacontmethylheptacosasiloxanylen)di-l-butanol; N-Carboxy-ß-alanin-N-vinylester; 2-Methacryloyloxyethylphosphorylcholin und Kombinationen davon.
  3. 3. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das wenigstens eine Mittel zur Erzeugung eines interpenetrierenden Polymernetzwerkes etwa 1 %, bezogen auf die Trockenmasse, bis etwa 14 %, bezogen auf die Trockenmasse, und vorzugsweise etwa 5 %, bezogen auf die Trockenmasse, bis etwa 10 %, bezogen auf die Trockenmasse, der Hydrogel-Zusammensetzung umfasst.
    "3" DE/EP 1 O95 O76 T1
  4. 4. Hydrogel-Zusammensetzung nach Anspruch 1, weiterhin umfassend wenigstens ein Sulfoxid enthaltendes Material, das aus der Gruppe bestehend aus Sulfoxid enthaltenden Methacrylaten, Sulfoxid enthaltenden Acrylaten und Kombinationen davon ausgewählt ist.
  5. 5. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das wenigstens eine Mittel zur Erzeugung eines interpenetrierenden Polymernetzwerkes eine Molmasse umfasst, die höher als etwa 10 000 ist.
  6. 6. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das polymere Vernetzungsmittel wenigstens eine Verbindung umfasst, die aus der aus wenigstens einem Monomer und wenigstens einem Polymer bestehenden Gruppe ausgewählt ist.
  7. 7. Hydrogel-Zusammensetzung nach Anspruch 6, wobei das wenigstens eine polymere Vernetzungsmittel ein Polymer mit einer Molmasse von etwa 300 bis etwa 1500 umfasst.
  8. 8. Hydrogel-Zusammensetzung nach Anspruch 6, wobei das wenigstens eine polymere Vernetzungsmittel etwa 0,1 %, bezogen auf die Trockenmasse, bis etwa 8 %, bezogen auf die Trockenmasse, und vorzugsweise etwa 0,5 %, bezogen auf die Trockenmasse, bis etwa 4 %, bezogen auf die Trockenmasse, des Hydrogels umfasst.
  9. 9. Hydrogel-Zusammensetzung nach Anspruch 6, wobei das polymere Vernetzungsmittel wenigstens eine Verbindung umfasst, die aus der aus Polyethylenglycoldimethacrylat und Ethylenglycoldimethacrlyat bestehenden Gruppe ausgewählt ist.
  10. 10. Hydrogel-Zusammensetzung nach Anspruch 1, wobei die optionalen Monomere wenigstens ein Monomer umfassen, das aus der aus Methylmethacrylat und N-Vinyllactamen bestehenden Gruppe ausgewählt ist.
    -«- DE/EP 1 O95 O78T1
  11. 11. Hydrogel-Zusammensetzung nach Anspruch 10, wobei das N-Vinyllactam N-Vinylpyrrolidon umfasst.
  12. 12. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das Mittel zur Erzeugung eines interpenetrierenden Netzwerkes wenigstens ein Mittel umfasst, das aus der aus Polyvinylpyrrolidon, Polyvinylpyrrolidoniod, PoIy-2-ethyl-2-oxazolin und Poly(4-vinylpyridin-N-oxid) bestehenden Gruppe ausgewählt ist.
  13. 13. Interpenetrierendes Polymernetzwerk, umfassend wenigstens ein Polymer und wenigstens ein Mittel zur Erzeugung eines interpenetrierenden Polymernetzwerkes, das das wenigstens eine Polymer interpenetriert, wobei das interpenetrierende Polymernetzwerk einen Wasserverlust von weniger als etwa 5,0 Gew.-% nach 5 min bei etwa 75 % Feuchtigkeit und etwa 24 °C aufweist, wobei das wenigstens eine Polymer vorzugsweise wenigstens eine Verbindung umfasst, die aus der aus HEMA und MAA bestehenden Gruppe ausgewählt ist und das Mittel vorzugsweise wenigstens eine Verbindung umfasst, die aus der aus Polyvinylpyrrolidon, Polyvinylpyrrolidoniod, Poly-2-ethyl-2-oxazolin und Poly(4-vinylpyridin-N-oxid) bestehenden Gruppe ausgewählt ist.
  14. 14. Hydrogel-Zusammensetzung, umfassend ein Sulfoxid umfassendes, interpenetrierendes Polymemetzwerk.
DE1095076T 1998-07-08 1999-07-08 Ineinandergreifendes polymernetzwerk aus hydrophilen hydrogelen für kontaktlinsen Pending DE1095076T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9210098P 1998-07-08 1998-07-08
PCT/US1999/015532 WO2000002937A1 (en) 1998-07-08 1999-07-08 Interpenetrating polymer network hydrophilic hydrogels for contact lens

Publications (1)

Publication Number Publication Date
DE1095076T1 true DE1095076T1 (de) 2002-04-04

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US (2) US20010044482A1 (de)
EP (1) EP1095076A4 (de)
AU (1) AU4980199A (de)
DE (1) DE1095076T1 (de)
WO (1) WO2000002937A1 (de)

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US20050148682A1 (en) 2005-07-07
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EP1095076A4 (de) 2002-11-06
US20010044482A1 (en) 2001-11-22
US7279507B2 (en) 2007-10-09

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