DE19943743C2 - Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays - Google Patents
Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen ArraysInfo
- Publication number
- DE19943743C2 DE19943743C2 DE19943743A DE19943743A DE19943743C2 DE 19943743 C2 DE19943743 C2 DE 19943743C2 DE 19943743 A DE19943743 A DE 19943743A DE 19943743 A DE19943743 A DE 19943743A DE 19943743 C2 DE19943743 C2 DE 19943743C2
- Authority
- DE
- Germany
- Prior art keywords
- array
- ligate
- bound
- carrier material
- cell lysate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Classifications
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- C40—COMBINATORIAL TECHNOLOGY
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- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19943743A DE19943743C2 (de) | 1999-09-03 | 1999-09-03 | Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays |
| AU76442/00A AU7644200A (en) | 1999-09-03 | 2000-09-01 | Method for identifying binding partners with position-specific arrays |
| JP2001522083A JP2003511652A (ja) | 1999-09-03 | 2000-09-01 | 位置特異性配列を有する結合パートナーの特定方法 |
| EP00965834A EP1212622A2 (de) | 1999-09-03 | 2000-09-01 | Verfahren zur identifizierung von bindungspartnern mit positions-spezifischen arrays |
| PCT/DE2000/003071 WO2001018545A2 (de) | 1999-09-03 | 2000-09-01 | Verfahren zur identifizierung von bindungspartnern mit positions-spezifischen arrays |
| CA002386607A CA2386607A1 (en) | 1999-09-03 | 2000-09-01 | Method for identifying binding partners with position-specific arrays |
| DE10082703T DE10082703D2 (de) | 1999-09-03 | 2000-09-01 | Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays (kein Eintritt in die nationale Phase erfolgt) |
| CZ2002660A CZ2002660A3 (cs) | 1999-09-03 | 2000-09-01 | Způsob identifikace vazebných partnerů pozičně specifickým testem |
| HU0203074A HUP0203074A2 (hu) | 1999-09-03 | 2000-09-01 | Eljárás kötőpartnerek azonosítására helyspecifikus tömbökkel |
| PL00353995A PL353995A1 (en) | 1999-09-03 | 2000-09-01 | Method for identifying binding partners with position-specific arrays |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19943743A DE19943743C2 (de) | 1999-09-03 | 1999-09-03 | Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE19943743A1 DE19943743A1 (de) | 2001-03-15 |
| DE19943743C2 true DE19943743C2 (de) | 2002-02-07 |
Family
ID=7921806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19943743A Expired - Fee Related DE19943743C2 (de) | 1999-09-03 | 1999-09-03 | Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays |
| DE10082703T Expired - Lifetime DE10082703D2 (de) | 1999-09-03 | 2000-09-01 | Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays (kein Eintritt in die nationale Phase erfolgt) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10082703T Expired - Lifetime DE10082703D2 (de) | 1999-09-03 | 2000-09-01 | Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays (kein Eintritt in die nationale Phase erfolgt) |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1212622A2 (cs) |
| JP (1) | JP2003511652A (cs) |
| AU (1) | AU7644200A (cs) |
| CA (1) | CA2386607A1 (cs) |
| CZ (1) | CZ2002660A3 (cs) |
| DE (2) | DE19943743C2 (cs) |
| HU (1) | HUP0203074A2 (cs) |
| PL (1) | PL353995A1 (cs) |
| WO (1) | WO2001018545A2 (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10141464A1 (de) * | 2001-08-23 | 2004-03-04 | Genprofile Ag I.Ins. | Sequenzvarianten des für neuropsychiatrische Krankheiten verantwortlichen Gens 22444 und deren Verwendung |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1319954A1 (en) * | 2001-12-12 | 2003-06-18 | Centre National de Genotypage | Methods for protein analysis using protein capture arrays |
| US7504364B2 (en) | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
| US20030228709A1 (en) * | 2002-03-25 | 2003-12-11 | Kozlowski Roland Zbignieiw | Arrays |
| CN1665790A (zh) | 2002-05-03 | 2005-09-07 | 莫莱丘莱尔探针公司 | 用于检测和分离磷酸化分子的组合物及方法 |
| US7445894B2 (en) | 2002-05-03 | 2008-11-04 | Molecular Probes, Inc. | Compositions and methods for detection and isolation of phosphorylated molecules |
| US7469076B2 (en) | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
| EP1613737A4 (en) | 2003-03-28 | 2008-12-03 | Receptors Llc | ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS |
| US20040248323A1 (en) | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
| US7884052B2 (en) | 2004-09-03 | 2011-02-08 | Receptors Llc | Combinatorial artificial receptors including tether building blocks on scaffolds |
| EP1789792A2 (en) | 2004-09-11 | 2007-05-30 | Receptors LLC | Combinatorial artificial receptors including peptide building blocks |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4027675A1 (de) * | 1990-08-31 | 1992-03-12 | Biotechnolog Forschung Gmbh | Verfahren zur schnellen synthese von grossen zahlen traegergebundener oder freier peptide |
| US5821047A (en) * | 1990-12-03 | 1998-10-13 | Genentech, Inc. | Monovalent phage display |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834318A (en) * | 1995-05-10 | 1998-11-10 | Bayer Corporation | Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins |
| WO1997043301A2 (en) * | 1996-05-10 | 1997-11-20 | Novartis Ag | Identification of members of combinatorial libraries by mass spectrometry |
| US6207370B1 (en) * | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| GB9800378D0 (en) * | 1998-01-08 | 1998-03-04 | Univ Liverpool | Proteome analysis |
-
1999
- 1999-09-03 DE DE19943743A patent/DE19943743C2/de not_active Expired - Fee Related
-
2000
- 2000-09-01 DE DE10082703T patent/DE10082703D2/de not_active Expired - Lifetime
- 2000-09-01 CA CA002386607A patent/CA2386607A1/en not_active Abandoned
- 2000-09-01 AU AU76442/00A patent/AU7644200A/en not_active Abandoned
- 2000-09-01 WO PCT/DE2000/003071 patent/WO2001018545A2/de not_active Ceased
- 2000-09-01 EP EP00965834A patent/EP1212622A2/de not_active Withdrawn
- 2000-09-01 CZ CZ2002660A patent/CZ2002660A3/cs unknown
- 2000-09-01 JP JP2001522083A patent/JP2003511652A/ja active Pending
- 2000-09-01 HU HU0203074A patent/HUP0203074A2/hu unknown
- 2000-09-01 PL PL00353995A patent/PL353995A1/xx not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4027675A1 (de) * | 1990-08-31 | 1992-03-12 | Biotechnolog Forschung Gmbh | Verfahren zur schnellen synthese von grossen zahlen traegergebundener oder freier peptide |
| US5821047A (en) * | 1990-12-03 | 1998-10-13 | Genentech, Inc. | Monovalent phage display |
Non-Patent Citations (8)
| Title |
|---|
| Biospektrum 5/98, S. 39-44 * |
| Camp.Meth.Enzymol. 1994, Bd. 6, S. 388-395 * |
| Clin.Chem.Lab.Med., Bd. 36, November 1998, S. 233-236 * |
| Meth.Mol.Biol. 1998, Bd. 87, S. 25-39 * |
| Nature Biotechnology, Bd. 17, März 1999, S. 233-236 * |
| Tetrahedron Letters 40(1999), S. 4317-4318 * |
| Tetrahedron, Bd. 48, Nr. 42, 1992, S. 9217-9232 * |
| TIBTECH 1998, Bd. 16, S. 355-363 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10141464A1 (de) * | 2001-08-23 | 2004-03-04 | Genprofile Ag I.Ins. | Sequenzvarianten des für neuropsychiatrische Krankheiten verantwortlichen Gens 22444 und deren Verwendung |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001018545A2 (de) | 2001-03-15 |
| AU7644200A (en) | 2001-04-10 |
| DE19943743A1 (de) | 2001-03-15 |
| EP1212622A2 (de) | 2002-06-12 |
| WO2001018545A3 (de) | 2001-09-13 |
| DE10082703D2 (de) | 2002-02-14 |
| CZ2002660A3 (cs) | 2002-10-16 |
| JP2003511652A (ja) | 2003-03-25 |
| CA2386607A1 (en) | 2001-03-15 |
| PL353995A1 (en) | 2003-12-15 |
| HUP0203074A2 (hu) | 2002-12-28 |
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