DE19943743C2 - Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays - Google Patents

Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays

Info

Publication number
DE19943743C2
DE19943743C2 DE19943743A DE19943743A DE19943743C2 DE 19943743 C2 DE19943743 C2 DE 19943743C2 DE 19943743 A DE19943743 A DE 19943743A DE 19943743 A DE19943743 A DE 19943743A DE 19943743 C2 DE19943743 C2 DE 19943743C2
Authority
DE
Germany
Prior art keywords
array
ligate
bound
carrier material
cell lysate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19943743A
Other languages
German (de)
English (en)
Other versions
DE19943743A1 (de
Inventor
Eberhard Krause
Jens Schneider-Mergener
Thomas Bittorf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jerini AG
Original Assignee
JERINI BIOTOOLS GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19943743A priority Critical patent/DE19943743C2/de
Application filed by JERINI BIOTOOLS GmbH filed Critical JERINI BIOTOOLS GmbH
Priority to DE10082703T priority patent/DE10082703D2/de
Priority to CZ2002660A priority patent/CZ2002660A3/cs
Priority to JP2001522083A priority patent/JP2003511652A/ja
Priority to EP00965834A priority patent/EP1212622A2/de
Priority to PCT/DE2000/003071 priority patent/WO2001018545A2/de
Priority to CA002386607A priority patent/CA2386607A1/en
Priority to PL00353995A priority patent/PL353995A1/xx
Priority to AU76442/00A priority patent/AU7644200A/en
Priority to HU0203074A priority patent/HUP0203074A2/hu
Publication of DE19943743A1 publication Critical patent/DE19943743A1/de
Application granted granted Critical
Publication of DE19943743C2 publication Critical patent/DE19943743C2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • G01N33/6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE19943743A 1999-09-03 1999-09-03 Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays Expired - Fee Related DE19943743C2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DE19943743A DE19943743C2 (de) 1999-09-03 1999-09-03 Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays
AU76442/00A AU7644200A (en) 1999-09-03 2000-09-01 Method for identifying binding partners with position-specific arrays
JP2001522083A JP2003511652A (ja) 1999-09-03 2000-09-01 位置特異性配列を有する結合パートナーの特定方法
EP00965834A EP1212622A2 (de) 1999-09-03 2000-09-01 Verfahren zur identifizierung von bindungspartnern mit positions-spezifischen arrays
PCT/DE2000/003071 WO2001018545A2 (de) 1999-09-03 2000-09-01 Verfahren zur identifizierung von bindungspartnern mit positions-spezifischen arrays
CA002386607A CA2386607A1 (en) 1999-09-03 2000-09-01 Method for identifying binding partners with position-specific arrays
DE10082703T DE10082703D2 (de) 1999-09-03 2000-09-01 Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays (kein Eintritt in die nationale Phase erfolgt)
CZ2002660A CZ2002660A3 (cs) 1999-09-03 2000-09-01 Způsob identifikace vazebných partnerů pozičně specifickým testem
HU0203074A HUP0203074A2 (hu) 1999-09-03 2000-09-01 Eljárás kötőpartnerek azonosítására helyspecifikus tömbökkel
PL00353995A PL353995A1 (en) 1999-09-03 2000-09-01 Method for identifying binding partners with position-specific arrays

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19943743A DE19943743C2 (de) 1999-09-03 1999-09-03 Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays

Publications (2)

Publication Number Publication Date
DE19943743A1 DE19943743A1 (de) 2001-03-15
DE19943743C2 true DE19943743C2 (de) 2002-02-07

Family

ID=7921806

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19943743A Expired - Fee Related DE19943743C2 (de) 1999-09-03 1999-09-03 Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays
DE10082703T Expired - Lifetime DE10082703D2 (de) 1999-09-03 2000-09-01 Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays (kein Eintritt in die nationale Phase erfolgt)

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE10082703T Expired - Lifetime DE10082703D2 (de) 1999-09-03 2000-09-01 Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays (kein Eintritt in die nationale Phase erfolgt)

Country Status (9)

Country Link
EP (1) EP1212622A2 (cs)
JP (1) JP2003511652A (cs)
AU (1) AU7644200A (cs)
CA (1) CA2386607A1 (cs)
CZ (1) CZ2002660A3 (cs)
DE (2) DE19943743C2 (cs)
HU (1) HUP0203074A2 (cs)
PL (1) PL353995A1 (cs)
WO (1) WO2001018545A2 (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141464A1 (de) * 2001-08-23 2004-03-04 Genprofile Ag I.Ins. Sequenzvarianten des für neuropsychiatrische Krankheiten verantwortlichen Gens 22444 und deren Verwendung

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1319954A1 (en) * 2001-12-12 2003-06-18 Centre National de Genotypage Methods for protein analysis using protein capture arrays
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
US20030228709A1 (en) * 2002-03-25 2003-12-11 Kozlowski Roland Zbignieiw Arrays
CN1665790A (zh) 2002-05-03 2005-09-07 莫莱丘莱尔探针公司 用于检测和分离磷酸化分子的组合物及方法
US7445894B2 (en) 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US7469076B2 (en) 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
EP1613737A4 (en) 2003-03-28 2008-12-03 Receptors Llc ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US7884052B2 (en) 2004-09-03 2011-02-08 Receptors Llc Combinatorial artificial receptors including tether building blocks on scaffolds
EP1789792A2 (en) 2004-09-11 2007-05-30 Receptors LLC Combinatorial artificial receptors including peptide building blocks

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4027675A1 (de) * 1990-08-31 1992-03-12 Biotechnolog Forschung Gmbh Verfahren zur schnellen synthese von grossen zahlen traegergebundener oder freier peptide
US5821047A (en) * 1990-12-03 1998-10-13 Genentech, Inc. Monovalent phage display

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834318A (en) * 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
WO1997043301A2 (en) * 1996-05-10 1997-11-20 Novartis Ag Identification of members of combinatorial libraries by mass spectrometry
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
GB9800378D0 (en) * 1998-01-08 1998-03-04 Univ Liverpool Proteome analysis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4027675A1 (de) * 1990-08-31 1992-03-12 Biotechnolog Forschung Gmbh Verfahren zur schnellen synthese von grossen zahlen traegergebundener oder freier peptide
US5821047A (en) * 1990-12-03 1998-10-13 Genentech, Inc. Monovalent phage display

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Biospektrum 5/98, S. 39-44 *
Camp.Meth.Enzymol. 1994, Bd. 6, S. 388-395 *
Clin.Chem.Lab.Med., Bd. 36, November 1998, S. 233-236 *
Meth.Mol.Biol. 1998, Bd. 87, S. 25-39 *
Nature Biotechnology, Bd. 17, März 1999, S. 233-236 *
Tetrahedron Letters 40(1999), S. 4317-4318 *
Tetrahedron, Bd. 48, Nr. 42, 1992, S. 9217-9232 *
TIBTECH 1998, Bd. 16, S. 355-363 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141464A1 (de) * 2001-08-23 2004-03-04 Genprofile Ag I.Ins. Sequenzvarianten des für neuropsychiatrische Krankheiten verantwortlichen Gens 22444 und deren Verwendung

Also Published As

Publication number Publication date
WO2001018545A2 (de) 2001-03-15
AU7644200A (en) 2001-04-10
DE19943743A1 (de) 2001-03-15
EP1212622A2 (de) 2002-06-12
WO2001018545A3 (de) 2001-09-13
DE10082703D2 (de) 2002-02-14
CZ2002660A3 (cs) 2002-10-16
JP2003511652A (ja) 2003-03-25
CA2386607A1 (en) 2001-03-15
PL353995A1 (en) 2003-12-15
HUP0203074A2 (hu) 2002-12-28

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8327 Change in the person/name/address of the patent owner

Owner name: JERINI AG, 12489 BERLIN, DE

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee