DE2113281C3 - Verfahren zur Isolierung von Alkaloiden aus Mutterkorn - Google Patents
Verfahren zur Isolierung von Alkaloiden aus MutterkornInfo
- Publication number
- DE2113281C3 DE2113281C3 DE19712113281 DE2113281A DE2113281C3 DE 2113281 C3 DE2113281 C3 DE 2113281C3 DE 19712113281 DE19712113281 DE 19712113281 DE 2113281 A DE2113281 A DE 2113281A DE 2113281 C3 DE2113281 C3 DE 2113281C3
- Authority
- DE
- Germany
- Prior art keywords
- alkaloids
- ergot
- aluminum oxide
- petroleum ether
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930013930 alkaloid Natural products 0.000 title claims 19
- 238000000034 method Methods 0.000 title claims 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 12
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims 7
- 239000000284 extract Substances 0.000 claims 6
- 238000000605 extraction Methods 0.000 claims 6
- 239000003208 petroleum Substances 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 238000002955 isolation Methods 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 235000013325 dietary fiber Nutrition 0.000 claims 3
- 239000002244 precipitate Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims 2
- 150000003797 alkaloid derivatives Chemical class 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 239000003480 eluent Substances 0.000 claims 2
- 239000000835 fiber Substances 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims 1
- 239000003463 adsorbent Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 238000003795 desorption Methods 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 claims 1
- 229960004943 ergotamine Drugs 0.000 claims 1
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 238000006317 isomerization reaction Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000020477 pH reduction Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 238000001291 vacuum drying Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/183—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing an indolo[4,3-F,G]quinoleine nucleus, e.g. compound containing the lysergic acid nucleus as well as the dimeric ergot nucleus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Extraction Or Liquid Replacement (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU86870A YU34620B (en) | 1970-04-02 | 1970-04-02 | Process for the isolation of alcaloids from crude ergot of rye |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2113281A1 DE2113281A1 (de) | 1971-10-14 |
| DE2113281B2 DE2113281B2 (de) | 1973-07-26 |
| DE2113281C3 true DE2113281C3 (de) | 1974-03-14 |
Family
ID=25551779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712113281 Expired DE2113281C3 (de) | 1970-04-02 | 1971-03-19 | Verfahren zur Isolierung von Alkaloiden aus Mutterkorn |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS558512B1 (cs) |
| AT (1) | AT306917B (cs) |
| BE (1) | BE765139A (cs) |
| CS (1) | CS190357B2 (cs) |
| DE (1) | DE2113281C3 (cs) |
| ES (1) | ES389556A1 (cs) |
| HU (1) | HU165821B (cs) |
| NL (1) | NL7104484A (cs) |
| PL (1) | PL87281B1 (cs) |
| RO (1) | RO58840A2 (cs) |
| SE (1) | SE385216B (cs) |
| YU (1) | YU34620B (cs) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010060382B4 (de) | 2010-11-05 | 2013-05-29 | Bundesanstalt für Materialforschung und -Prüfung (BAM) | Analysenverfahren zur Isolierung von Mykotoxinen mit einer Ergolin-Grundstruktur, insbesondere von Ergotalkaloiden |
-
1970
- 1970-04-02 YU YU86870A patent/YU34620B/xx unknown
-
1971
- 1971-03-19 DE DE19712113281 patent/DE2113281C3/de not_active Expired
- 1971-03-22 AT AT242371A patent/AT306917B/de not_active IP Right Cessation
- 1971-03-25 ES ES389556A patent/ES389556A1/es not_active Expired
- 1971-03-30 JP JP1844771A patent/JPS558512B1/ja active Pending
- 1971-03-30 CS CS229171A patent/CS190357B2/cs unknown
- 1971-04-01 SE SE427371A patent/SE385216B/xx unknown
- 1971-04-01 BE BE765139A patent/BE765139A/xx not_active IP Right Cessation
- 1971-04-01 PL PL14729771A patent/PL87281B1/pl unknown
- 1971-04-02 RO RO66458A patent/RO58840A2/ro unknown
- 1971-04-02 HU HULE000610 patent/HU165821B/hu unknown
- 1971-04-02 NL NL7104484A patent/NL7104484A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL87281B1 (cs) | 1976-06-30 |
| YU86870A (en) | 1979-07-10 |
| HU165821B (cs) | 1974-11-28 |
| NL7104484A (cs) | 1971-10-05 |
| YU34620B (en) | 1979-12-31 |
| SE385216B (sv) | 1976-06-14 |
| DE2113281A1 (de) | 1971-10-14 |
| AT306917B (de) | 1973-04-25 |
| BE765139A (fr) | 1971-08-30 |
| RO58840A2 (ro) | 1975-07-07 |
| CS190357B2 (en) | 1979-05-31 |
| ES389556A1 (es) | 1973-06-16 |
| JPS558512B1 (cs) | 1980-03-04 |
| DE2113281B2 (de) | 1973-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 | ||
| EHJ | Ceased/non-payment of the annual fee |