DE60023402D1 - Herstellung von 3-amino-2-chlor-4-methylpyridin aus aceton und ethylcyanoacetat - Google Patents
Herstellung von 3-amino-2-chlor-4-methylpyridin aus aceton und ethylcyanoacetatInfo
- Publication number
- DE60023402D1 DE60023402D1 DE60023402T DE60023402T DE60023402D1 DE 60023402 D1 DE60023402 D1 DE 60023402D1 DE 60023402 T DE60023402 T DE 60023402T DE 60023402 T DE60023402 T DE 60023402T DE 60023402 D1 DE60023402 D1 DE 60023402D1
- Authority
- DE
- Germany
- Prior art keywords
- methylpyridine
- chloro
- acetone
- amino
- ethylcyanoacetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 title abstract 4
- UOBCYTOUXLAABU-UHFFFAOYSA-N 2-chloro-4-methylpyridin-3-amine Chemical compound CC1=CC=NC(Cl)=C1N UOBCYTOUXLAABU-UHFFFAOYSA-N 0.000 title abstract 2
- ZIUSEGSNTOUIPT-UHFFFAOYSA-N ethyl 2-cyanoacetate Chemical compound CCOC(=O)CC#N ZIUSEGSNTOUIPT-UHFFFAOYSA-N 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11670399P | 1999-01-22 | 1999-01-22 | |
| US116703P | 1999-01-22 | ||
| PCT/US2000/000261 WO2000043364A1 (en) | 1999-01-22 | 2000-01-06 | Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60023402D1 true DE60023402D1 (de) | 2005-12-01 |
| DE60023402T2 DE60023402T2 (de) | 2006-04-27 |
Family
ID=22368723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60023402T Expired - Fee Related DE60023402T2 (de) | 1999-01-22 | 2000-01-06 | Herstellung von 3-amino-2-chlor-4-methylpyridin aus aceton und ethylcyanoacetat |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6136982A (de) |
| EP (1) | EP1070053B1 (de) |
| JP (1) | JP2002535310A (de) |
| AT (1) | ATE307803T1 (de) |
| CA (1) | CA2318412A1 (de) |
| DE (1) | DE60023402T2 (de) |
| ES (1) | ES2251964T3 (de) |
| WO (1) | WO2000043364A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399781B1 (en) | 2000-10-10 | 2002-06-04 | Boehringer Ingelheim Chemicals, Inc. | Process for making 3-amino-2-chloro-4-methylpyridine |
| CN100358871C (zh) * | 2005-08-02 | 2008-01-02 | 江阴暨阳医药化工有限公司 | 氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法 |
| US8968779B2 (en) | 2010-06-16 | 2015-03-03 | Teijin Pharma Limited | Controlled release coat-core tablet |
| WO2016118586A1 (en) * | 2015-01-20 | 2016-07-28 | Virginia Commonwealth University | Lowcost, high yield synthesis of nevirapine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3133331B2 (ja) * | 1991-06-11 | 2001-02-05 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | ３―アミノ―２―クロロ―４―アルキルピリジン類の製造方法 |
| US5654429A (en) * | 1992-11-18 | 1997-08-05 | Boehringer Ingelheim Pharma | Method for the preparation of 3-amino-2-chloro-4-alkylpyridines |
| ATE192437T1 (de) * | 1993-12-02 | 2000-05-15 | Boehringer Ingelheim Pharma | Verfahren zur herstellung von 3-amino-2-chlor-4- alkyl- bzw. 4-cycloalkyl-pyridine |
-
2000
- 2000-01-06 EP EP00903131A patent/EP1070053B1/de not_active Expired - Lifetime
- 2000-01-06 WO PCT/US2000/000261 patent/WO2000043364A1/en not_active Ceased
- 2000-01-06 ES ES00903131T patent/ES2251964T3/es not_active Expired - Lifetime
- 2000-01-06 US US09/478,588 patent/US6136982A/en not_active Expired - Lifetime
- 2000-01-06 DE DE60023402T patent/DE60023402T2/de not_active Expired - Fee Related
- 2000-01-06 AT AT00903131T patent/ATE307803T1/de not_active IP Right Cessation
- 2000-01-06 CA CA002318412A patent/CA2318412A1/en not_active Abandoned
- 2000-01-06 JP JP2000594780A patent/JP2002535310A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1070053A4 (de) | 2001-04-18 |
| DE60023402T2 (de) | 2006-04-27 |
| ES2251964T3 (es) | 2006-05-16 |
| US6136982A (en) | 2000-10-24 |
| ATE307803T1 (de) | 2005-11-15 |
| JP2002535310A (ja) | 2002-10-22 |
| EP1070053A1 (de) | 2001-01-24 |
| EP1070053B1 (de) | 2005-10-26 |
| WO2000043364A1 (en) | 2000-07-27 |
| CA2318412A1 (en) | 2000-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |