DE60035687D1 - Bipolare lipide und ihre verwendung zum transport bioaktiver substanzen - Google Patents

Bipolare lipide und ihre verwendung zum transport bioaktiver substanzen

Info

Publication number
DE60035687D1
DE60035687D1 DE60035687T DE60035687T DE60035687D1 DE 60035687 D1 DE60035687 D1 DE 60035687D1 DE 60035687 T DE60035687 T DE 60035687T DE 60035687 T DE60035687 T DE 60035687T DE 60035687 D1 DE60035687 D1 DE 60035687D1
Authority
DE
Germany
Prior art keywords
lipids
bioactive substances
transport
bipolar
bipolar lipids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60035687T
Other languages
English (en)
Other versions
DE60035687T2 (de
Inventor
Ian Blagbrough
Andrew John Geall
Michael Anthony William Eaton
Timothy John Norman
Terence Seward The Mayes Baker
Andrew Neil Charles Weir
Catherine Fiona Catterall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma SA Belgium
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9909582.0A external-priority patent/GB9909582D0/en
Priority claimed from GBGB9924257.0A external-priority patent/GB9924257D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of DE60035687D1 publication Critical patent/DE60035687D1/de
Application granted granted Critical
Publication of DE60035687T2 publication Critical patent/DE60035687T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60035687T 1999-04-26 2000-04-26 Bipolare lipide und ihre verwendung zum transport bioaktiver substanzen Expired - Fee Related DE60035687T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9909582 1999-04-26
GBGB9909582.0A GB9909582D0 (en) 1999-04-26 1999-04-26 Chemical compounds
GBGB9924257.0A GB9924257D0 (en) 1999-10-13 1999-10-13 Chemical compounds
GB9924257 1999-10-13
PCT/GB2000/001613 WO2000064858A1 (en) 1999-04-26 2000-04-26 Bipolar lipids and their use for the delivery of bioactive substances

Publications (2)

Publication Number Publication Date
DE60035687D1 true DE60035687D1 (de) 2007-09-06
DE60035687T2 DE60035687T2 (de) 2008-06-05

Family

ID=26315471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60035687T Expired - Fee Related DE60035687T2 (de) 1999-04-26 2000-04-26 Bipolare lipide und ihre verwendung zum transport bioaktiver substanzen

Country Status (6)

Country Link
EP (1) EP1187807B1 (de)
AT (1) ATE368027T1 (de)
AU (1) AU4421200A (de)
DE (1) DE60035687T2 (de)
ES (1) ES2288472T3 (de)
WO (1) WO2000064858A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1129064T3 (da) 1998-11-12 2008-04-28 Invitrogen Corp Transfektionsreagenser
GB9919338D0 (en) 1999-08-16 1999-10-20 Celltech Therapeutics Ltd Biological products
FR2878846B1 (fr) 2004-12-07 2007-02-23 Enscr Composes analogues de lipides membranaires d'archaebacteries et compositions liposomiales integrant de tel composes
WO2016011203A1 (en) 2014-07-15 2016-01-21 Life Technologies Corporation Compositions with lipid aggregates and methods for efficient delivery of molecules to cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2727679B1 (fr) * 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
US6281371B1 (en) * 1997-08-13 2001-08-28 Biontex Laboratories Gmbh Lipopolyamines, and the preparation and use thereof
EP1070047A2 (de) * 1998-04-08 2001-01-24 Celltech Chiroscience Limited Lipide

Also Published As

Publication number Publication date
EP1187807A1 (de) 2002-03-20
ATE368027T1 (de) 2007-08-15
EP1187807B1 (de) 2007-07-25
AU4421200A (en) 2000-11-10
DE60035687T2 (de) 2008-06-05
WO2000064858A1 (en) 2000-11-02
ES2288472T3 (es) 2008-01-16

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: UCB PHARMA, S.A., BRUESSEL/BRUXELLES, BE

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee