DE60200037D1 - Herstellung von (all-rac)-alpha-Tocopherol - Google Patents

Herstellung von (all-rac)-alpha-Tocopherol

Info

Publication number: DE60200037D1
Authority: DE; Germany
Prior art keywords: rac; tocopherol; alpha; production; reaction
Prior art date: 2001-01-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60200037T

Other languages

English (en)

Other versions

DE60200037T2 (de

Inventor

Werner Bonrath

Thomas Netscher

Ulrich Wietelmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

DSM IP Assets BV

Original Assignee

Roche Vitamins AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-18

Filing date

2002-01-14

Publication date

2003-10-30

2002-01-14 Application filed by Roche Vitamins AG filed Critical Roche Vitamins AG

2003-10-30 Application granted granted Critical

2003-10-30 Publication of DE60200037D1 publication Critical patent/DE60200037D1/de

2004-07-08 Publication of DE60200037T2 publication Critical patent/DE60200037T2/de

2022-01-15 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 2
239000001707 (E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol Substances 0.000 abstract 1
AUFZRCJENRSRLY-UHFFFAOYSA-N 2,3,5-trimethylhydroquinone Chemical compound CC1=CC(O)=C(C)C(C)=C1O AUFZRCJENRSRLY-UHFFFAOYSA-N 0.000 abstract 1
KEVYVLWNCKMXJX-ZCNNSNEGSA-N Isophytol Natural products CC(C)CCC[C@H](C)CCC[C@@H](C)CCC[C@@](C)(O)C=C KEVYVLWNCKMXJX-ZCNNSNEGSA-N 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
BLUHKGOSFDHHGX-UHFFFAOYSA-N Phytol Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)C=CO BLUHKGOSFDHHGX-UHFFFAOYSA-N 0.000 abstract 1
HNZBNQYXWOLKBA-UHFFFAOYSA-N Tetrahydrofarnesol Natural products CC(C)CCCC(C)CCCC(C)=CCO HNZBNQYXWOLKBA-UHFFFAOYSA-N 0.000 abstract 1
239000007983 Tris buffer Substances 0.000 abstract 1
229930003427 Vitamin E Natural products 0.000 abstract 1
BOTWFXYSPFMFNR-OALUTQOASA-N all-rac-phytol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)=CCO BOTWFXYSPFMFNR-OALUTQOASA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000006555 catalytic reaction Methods 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
BOTWFXYSPFMFNR-PYDDKJGSSA-N phytol Chemical compound CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CO BOTWFXYSPFMFNR-PYDDKJGSSA-N 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
229940046009 vitamin E Drugs 0.000 abstract 1
239000011709 vitamin E Substances 0.000 abstract 1
235000019165 vitamin E Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrane Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Catalysts (AREA)

DE60200037T 2001-01-18 2002-01-14 Herstellung von (all-rac)-alpha-Tocopherol Expired - Lifetime DE60200037T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01101026		2001-01-18
EP01101026		2001-01-18

Publications (2)

Publication Number	Publication Date
DE60200037D1 true DE60200037D1 (de)	2003-10-30
DE60200037T2 DE60200037T2 (de)	2004-07-08

Family

ID=8176233

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60200037T Expired - Lifetime DE60200037T2 (de)	2001-01-18	2002-01-14	Herstellung von (all-rac)-alpha-Tocopherol

Country Status (8)

Country	Link
US (1)	US6700002B2 (de)
EP (1)	EP1227089B1 (de)
JP (1)	JP2002284776A (de)
KR (1)	KR20020062203A (de)
CN (1)	CN1190431C (de)
AT (1)	ATE250596T1 (de)
DE (1)	DE60200037T2 (de)
DK (1)	DK1227089T3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19933898A1 (de) *	1999-07-22	2001-02-01	Chemetall Gmbh	Tris(oxalato)phosphate, Verfahren zu deren Herstellung und deren Verwendung
DE602005027439D1 (de) *	2004-02-04	2011-05-26	Dsm Ip Assets Bv	Verfahren zur herstellung von methylheptenon

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2230659A (en) *	1938-09-28	1941-02-04	Merck & Co Inc	Process of synthesizing alphatocopherol
GB811895A (en) *	1956-02-02	1959-04-15	Merck Ag E	Improvements in or relating to esters of -a-tocopherol
US5886196A (en) *	1996-01-12	1999-03-23	Roche Vitamins Inc.	Method of catalyzing condensation reactions

2002
- 2002-01-14 DE DE60200037T patent/DE60200037T2/de not_active Expired - Lifetime
- 2002-01-14 AT AT02000764T patent/ATE250596T1/de not_active IP Right Cessation
- 2002-01-14 EP EP02000764A patent/EP1227089B1/de not_active Expired - Lifetime
- 2002-01-14 DK DK02000764T patent/DK1227089T3/da active
- 2002-01-15 JP JP2002005681A patent/JP2002284776A/ja not_active Withdrawn
- 2002-01-17 CN CNB021020272A patent/CN1190431C/zh not_active Expired - Lifetime
- 2002-01-17 US US10/053,297 patent/US6700002B2/en not_active Expired - Lifetime
- 2002-01-17 KR KR1020020002778A patent/KR20020062203A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
EP1227089A1 (de)	2002-07-31
DE60200037T2 (de)	2004-07-08
US6700002B2 (en)	2004-03-02
CN1365977A (zh)	2002-08-28
JP2002284776A (ja)	2002-10-03
KR20020062203A (ko)	2002-07-25
DK1227089T3 (da)	2004-02-02
CN1190431C (zh)	2005-02-23
US20020161247A1 (en)	2002-10-31
ATE250596T1 (de)	2003-10-15
EP1227089B1 (de)	2003-09-24

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Legal Events

Date	Code	Title	Description
2004-06-17	8327	Change in the person/name/address of the patent owner	Owner name: DSM IP ASSETS B.V., HEERLEN, NL
2004-06-17	8328	Change in the person/name/address of the agent	Representative=s name: LEDERER & KELLER, 80538 MUENCHEN
2004-10-21	8364	No opposition during term of opposition